Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Effectiveness of Vitamin C

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                     Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The effective of Vitamin C against Asthma 
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.
Epidemiological studies, linking vitamin C in reduced risk and treatment of asthma have been inconclusive(a)(b)(c)(d).

The study of the effects of antioxidant nutritional status with allergic rhinitis (AR) in Korean schoolchildren aged 6-12 years, in a total of 4,554 children in Seoul, Korea, showed a positive effect of Vitamin C intake negatively associated with an increased risk of AR symptoms(1). According to the Rabin Medical Center, vitamin C also enhanced the protective effect on the hyperreactive airways of patients with exercise-induced asthma (EIA)(2). Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. According to Dr. Ruprai RK., in the study of the oxidative stress plasma malondialdehyde andascorbic acid (Vitamin C) showed an oxidative imbalance in asthmatic patients and antioxidant supply may have a beneficial impact on the free radical induced injury and improvement of respiratory reserve in Asthmatics(3)(4). In Saudi asthmatic patients, King Saud University study, exhibition of oxidative stress and defective antioxidant status of these patients suggested these may be primary causative factor in the pathogenesis of asthma(5).
In mega doses, vitamin C in asthmatic patients decreased airway hyperreactivity to methacholine, inflammatory cell numbers in brochoalveolar lavage fluid, and moderated reduction of perivascular and peribronchiolar inflammatory cell infiltration(6).

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References
(a) Vitamin C supplementation for asthma by Kaur B1, Rowe BH, Arnold E.(PubMed)
(b) Vitamin C supplementation for asthma by Ram FS1, Rowe BH, Kaur B(PubMed)
(c) Vitamin C for asthma and exercise-induced bronchoconstriction by Milan SJ1, Hart A, Wilkinson M.(PubMed)
(d) Vitamin C and common cold-induced asthma: a systematic review and statistical analysis by Hemilä H.(PubMed)
(1) Association of antioxidants with allergic rhinitis in children from seoul by Seo JH1, Kwon SO, Lee SY, Kim HY, Kwon JW, Kim BJ, Yu J, Kim HB, Kim WK, Jang GC, Song DJ, Shim JY, Oh SY, Hong SJ.(PubMed)
(2) Blocking effect of vitamin C in exercise-induced asthma by Cohen HA1, Neuman I, Nahum H.(PubMed)
(3) Plasma oxidant-antioxidants status in asthma and its correlation with pulmonary function tests by Ruprai RK.(PubMed)
(4) Antioxidant status in acute asthmatic attack in children by Al-Abdulla NO1, Al Naama LM, Hassan MK.(PubMed)
(5) Oxidative stress and antioxidant status in Saudi asthmatic patients by Al-Afaleg NO1, Al-Senaidy A, El-Ansary A.(PubMed)
(6) Mega-dose vitamin C attenuated lung inflammation in mouse asthmamodel by Jeong YJ1, Kim JH, Kang JS, Lee WJ, Hwang YI.(PubMed)