Cancers are class of medical condition characterized by cells growth disorderly and uncontrollably in any tissue and organs in the body. In most cases, at the later stage, cancerous cells can travel a distance away to infect other healthy cells and tissue.
Chemical carcinogens are types of chemical compounds that can cause cancer, mostly man-made.
According to the Universidade Federal de Ouro Preto, sulforaphane (SFN), the isothiocyanate (ITC) group of organosulfur compounds found in cruciferous vegetable expressed chemopreventive properties involved detoxification processes of chemical carcinogens.
Certain chemicals, such as benzene, beryllium, asbestos, vinyl chloride, and arsenic are known to induce human carcinogens.
This is tough to believe that exposure to chemical carcinogens in the outdoors, at home, and at work is associated to increase the risk of getting cancer.
According to the Agency for Toxic Substances and Disease Registry, "More than 100,000 chemicals are used by Americans, and about 1,000 new chemicals are introduced each year" and "These chemicals are found in everyday items, such as foods, personal products, packaging, prescription drugs, and household and lawn care products"(4).
The agency also suggested that some chemical carcinogens can be harmful, not all contact with chemicals is dangerous to health(4).
Risk of developing cancer is depended totally on how much, how long, how often, and when you are exposed to these chemicals.
It is true, long-term in contact with chemical carcinogens can lead to DNA alternation, the main cause of early onset of cancers(4).
Some researchers suggested that asbestos, nickel, cadmium, radon, vinyl chloride, benzidene, and benzene may act alone or with other carcinogens to increase the prevalent risk(4)
Occasional exposure to chemicals in adults may be harmful to health, but to induce gene change is impossible.
However, when you are exposed is important because a small exposure in the womb, for example, may be more serious than a small exposure as an adult.
Dr. de Figueiredo SM, the lead author said, " In a dose-dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation." and "Chemical carcinogens are types of cancer caused by chemical toxins in induction of cellular and chromosomes change, DNA damage,... ".
The chemoprotective activity of the vegetable is the result of the significant expression of the antioxidants in exhibited cell cycle arrest and apoptosis in cancer cells as well as acting as the post-initiation stages of carcinogenesis, as a 'suppressing' agent involving the ability to modulate the Nrf2 in reduced damage from oxidative damage.
In fact, besides used as a chemopreventive agent against chemical carcinogenesis, sulforaphane (SFN), the major chemical constituent of cruciferous vegetables also inhibited the drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites and protected normal healthy cells from environmental toxin-induced of cancers.
Furthermore, the phytochemical exhibited the molecular mechanisms responsible for the overall chemopreventive effects on selective cytotoxicity, in reduced oxidate stress, free radicals produced by lipid peroxidation in cells.
In the study of tobacco smoke carcinogens induced chemical tumors, cruciferous vegetable consumption has shown to inversely associate the development of cancer.
In animal experiments. the chemopreventive effects of isothiocyanates, another compound found in cruciferous vegetable, inhibited the metabolic activation of carcinogens by cytochrome P450s, enzymes with function in metabolized potentially toxic compounds.
Taking together, intake of cruciferous vegetables have potential health benefits against environment toxins in cancer development, but due to the small size of the sample, further studies are necessary to address its viability.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprotection by sulforaphane: keep one eye beyond Keap1 by Myzak MC1, Dashwood RH.(PubMed)
(2) The antioxidant properties of organosulfur compounds (sulforaphane) by de Figueiredo SM1, Binda NS, Nogueira-Machado JA, Vieira-Filho SA, Caligiorne RB.(PubMed)
(3) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane by Sharma R1, Sharma A, Chaudhary P, Sahu M, Jaiswal S, Awasthi S, Awasthi YC.(PubMed)
(4) Chemicals, Cancer, and You by Agency for Toxic Substances and Disease Registry
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