Regular Walking Reduces Symptoms and Early Onset of Rheumatoid Arthritis in Age of 50Plus

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of health benefits to reduced symptoms and risk of early onset of Rheumatoid Arthritis in the younger and older elderly have been controversial.

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than in men and generally occurs after the ages of 40 and diminishes the quality of life of many elders, leading to slowing joint damage progression(4).
In Europe, the disease has social consequences in constituted limitations in performing roles relating to working life as well as family and social life(3).

According to the School of Physiotherapy, University of Otago, Walking is a low-cost and low-impact activity, requiring little supervision and regular walking improved Quality of Life in managing pain symptoms for people with Rheumatoid Arthritis, such as pain(1), depending to walking route shape and the length of the walk(1).

On physical activity among patients with early RA, Dr. Silva CR and research team in the investigation of the Consensus of the Brazilian Society of (SBR) for the treatment of Rheumatoid Arthritis (RA) suggested, walking is one of the most often practiced exercise (80.64%) recommended(2).

Dr. Lusa AL and colleagues at the Columbia University, said, "Psychosocial factors and body composition are potentially reversible contributors to walking speed in RA. Relative to articular disease activity and damage, nonarticular indicators were collectively more potent indicators of an individual's mobility limitations"(5).

In fact, regular walking also reduces risk of early onset of Rheumatoid Arthritis through long-term anti-inflammatory effect but a single bout of walking as it does not lead to a change in various markers of inflammation or lymphocyte adherence to cultured endothelial cells. (6).

Nordic walking, in the study of overweight and obesity postmenopausal women, not only reduced inflammatory states but also led to favorable hormonal responses, as well as improvement in muscle integrity and nutritional benefits(7).

Dr. Dopheide JF and the research team at the University Medical Center of the Johannes Gutenberg-University Mainz said, "a reduced inflammatory state might be achieved by regular walking exercise, possibly in a dimension proportionately to changes in walking distance"(8).


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Walking is a Feasible Physical Activity for People with Rheumatoid Arthritis: A Feasibility Randomized Controlled Trial by Baxter SV1,2, Hale LA1, Stebbings S3, Gray AR3, Smith CM1, Treharne GJ2.(PubMed)
(2) Physical activity among patients from the Brasília cohort of early rheumatoid arthritis.
[Article in English, Portuguese] by Silva CR, Costa TF, de Oliveira TT, Muniz LF, da Mota LM.(PubMed)
(3) Social implications of rheumatic diseases by Kłak A1, Raciborski F1, Samel-Kowalik P2.(PubMed)
(4) Joint damage progression in patients with rheumatoid arthritis in clinical remission: do biologics perform better than synthetic antirheumatic drugs? by Ciubotariu E1, Gabay C2, Finckh A1; Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis.(PubMed)
(5) Indicators of walking speed in rheumatoid arthritis: relative influence of articular, psychosocial, and body composition characteristics by Lusa AL1, Amigues I, Kramer HR, Dam TT, Giles JT.(PubMed)
(6) Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect by Markovitch D1, Tyrrell RM, Thompson D.(PubMed)
(7) The effect of a 10-week Nordic walking training program on the level of GH and LH in elderly women by Hagner-Derengowska M1, Kałużny K2, Hagner W2, Plaskiewicz A2, Bronisz A3, Borkowska A1, Budzyński J4.(PubMed)
(8) Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study by Dopheide JF1, Scheer M, Doppler C, Obst V, Stein P, Vosseler M, Abegunewardene N, Gori T, Münzel T, Daiber A, Radsak MP, Espinola-Klein C.(PubMed)

Herbal Turmeric, a Natural Prevention and Treatment of Crohn's disease, Studies Showed

Crohn's disease is a type of inflammatory bowel disease caused by the inflammation in the gastrointestinal tract.

The exact cause of Crohn's disease is not identified. However, some researchers suggested that people with the compromised immune system and genetic preposition are prone to the disease onset compared to people who do not

Most common symptoms of Crohn's disease are abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

If you are experiencing symptoms of severe abdominal pain accompanied by blood in the stool and persistent diarrhea, please check with your doctor right the way.

Risk factors of Crohn's disease include aging, family and person history, ethnicity, smoking and long-term use of Nonsteroidal anti-inflammatory medications.
.
Out of many risk factors that cause the onset of the condition, some researchers suggested that your risk of Crohn's disease is depending on where you live.

Dr. Pascal Michel wrote, "Crohn's disease (CD) is clinically expressed as a chronic affection of the gastrointestinal tract currently known to have a multifactorial etiology involving a complex pathophysiological host response modulated by genetic susceptibilities, demographic determinants, and environmental factors. With more than 20 cases per 100,000 person-years, the province of Quebec, Canada is among regions of the world with the highest reported occurrence of CD in relation to other places where comparable estimates are available".


And, "These findings suggest that known populational and regional factors derived through census information only explain a limited fraction of the geographical variation of CD incidence and lead to speculate that the effects of these factors may be incompletely captured (imperfect construction of proxy variables) or that other important factors remain unmeasured".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural ingredient for the treatment of Crohn's disease (CD), researchers at the Grand Valley State University compared the effects of Remicade to curcumin for the treatment of the condition.

The review study includes the search in electronic databases (ProQuest Medical Library, CINAHL Complete, and PUBMED) to locate and identify articles to meet a predetermined set of inclusion criteria, including articles published after 2007 in human participants 18 years or older.


Compared to Remicade in reducing TNF-a, the protein associated with inflammation in adults with CD, curcumin induced a 55 points mean reduction in the Crohn's Disease Activity Index, reduced the expression of IL-1 and levels of C-reactive protein (CRP), associated with elevated levels of proinflammatory cytokines in the colon, particularly in the reduced levels of TNF-a and PPMTase involved in the improvement of colorectal cancer outcomes.


Based on the findings, researchers said, "...Preliminary data would suggest using both would reduce LOR. Curcumin, even by itself, was found to be a cheap and safe way to reduce CD symptoms and inflammatory markers"


Furthermore, according to the study conducted by the Medical School of Marília in the search for articles associating curcuminoids and CD and UC on the database of MEDLINE-PubMed, curcumin demonstrated an intestinal protective effect on reducing oxidative stress and inhibiting the migration of neutrophils and inducible nitric oxide synthase in the intestine.

Moreover, curcumin also improved micro and macroscopic lesions in the gut, prevented apoptosis of intestinal cells and induced the restoration of immune reaction.

Dr. Cunha Neto F, after taking into account of co and confounders wrote, "The use of curcumin is cheap, efficient and associated with no side effects, and may become an alternative to the IBD treatment".

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of Crohn's disease (CD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review by Schneider A1, Hossain I1, VanderMolen J2, Nicol K. (PubMed)
(2) Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn's disease and ulcerative colitis? by Cunha Neto F1, Marton LT1, de Marqui SV1, Lima TA1, Barbalho SM. (PubMed)
(3) Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada by Pascal Michel,1,2 Laurie St-Onge,1 Anne-Marie Lowe,3 Michel Bigras-Poulin,2 andPaul Brassard. (PMC)

Regular Walking Reduces Symptoms and Early Onset of Osteoarthritis(OA) in Population of 50Plus

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of health benefits of reduced risk of osteoarthritis in the younger and older elderly have been controversial.

Osteoarthritis (OA), a form of arthritis, is a condition or as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip and hand joints.

The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(10).

Moderate physical activity and walking programs had a positive effect on the quality of life of elderly individuals with knee OA, a new study suggested(5), through reduction of pain and improvement of physical function(6).

According to Dr. Evcik D and Dr. Sonel B., simple home-based exercise therapy and a regular walking program are effective in treating the symptoms of OA(7).

In older other with the preexisted condition of hip/knee OA, PA may reduce the risk of hip/knee OA, especially among women with no association between hip/knee OA and low joint stress(1).

In support to the effectiveness of physical exercise without increasing the risk of hip/knee OA and joint stress, Dr. Hootman JM and colleagues at the National Center for Chronic Disease Prevention and Health Promotion, said, "The joint stress PA score was not associated with an increased risk of hip/knee OA. Also, among walkers and runners, there was no association between the frequency, pace, or weekly training mileage and hip/knee OA"(2).


In fact, the 4316 people originally interviewed, 216 eligible cases (66 men, 150 women) were identified (mean age 57.1) insisted, there was little evidence to suggest that increased levels of regular physical activity throughout life lead to an increased risk of knee OA later in life(3) with exception to those of overweight(4).

Indeed, regular walking at one own pace is associated with a reduced risk of hip and knee osteoarthritis (OA)(8). Exercise and sport may probably be also a preventive tool against osteoarthritis, due to its positive effect on weight, muscle strength and possibly synovial inflammation(9).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) The association between joint stress from physical activity and self-reported osteoarthritis: an analysis of the Cooper Clinic data by Rogers LQ1, Macera CA, Hootman JM, Ainsworth BE, Blairi SN.(PubMed)
(2) Influence of physical activity-related joint stress on the risk of self-reported hip/kneeosteoarthritis: a new method to quantify physical activity by Hootman JM1, Macera CA, Helmick CG, Blair SN.(PubMed)
(3) A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey by Sutton AJ1, Muir KR, Mockett S, Fentem P.(PubMed)
(4) A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey by Sutton AJ1, Muir KR, Mockett S, Fentem P.(PubMed)
(5) Impact of an exercise and walking protocol on quality of life for elderly people with OA of the knee by Dias RC1, Dias JM, Ramos LR.(PubMed)
(6) Exercise for osteoarthritis of the knee by Fransen M1, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL.(PubMed)
(7) Effectiveness of a home-based exercise therapy and walking program on osteoarthritis of the knee by Evcik D1, Sonel B.(PubMed)
(8) Exercise and osteoarthritis by David J Hunter1,2 and Felix Eckstein3,4(PMC)
(9) [Exercise--sports and osteoarthritis].[Article in French] by Ziltener JL1, Leal S, Borloz S.(PubMed)
(10) Most Common diseases of elder: The Clinical Trials and Studies of Osteoarthritis Back by Respectable Institutions by Kyle J. Norton

Phytochemical 3,3'-Diindolylmethane Kills Triple Negative Breast Cancer Cells in Vivo and Vitro

Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancer, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Triple negative breast cancer shares the symptoms similar to those of breast cancer and risk factor except in the form of the genetic preposition.

According to Dr. Shimelis H, the lead scientist in the joint study led by the Mayo Clinic, said, "Pathogenic variants in BRIP1, RAD51C, and TP53 were associated with moderate risk (odds ratio > 2) of TNBC. Similar trends were observed for the African American population. Pathogenic variants in these TNBC genes were detected in 12.0% (3.7% non-BRCA1/2) of all participants".

And, "Multigene hereditary cancer panel testing can identify women with an elevated risk of TNBC due to mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D".

In other words, if you carry the mutated genes BARD1, BRCA1, BRCA2, PALB2, and RAD51D, you are at a higher risk of triple negative breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers reexamined the promising anticancer effects of novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 in aggressive triple negative breast cancer (TNBC, MDA-MB-231) models.

In vitro studies, novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 demonstrated strong anticancer effects.

NLC formulations. including DIM-10 and DIM-14 extended significant increase in oral bioavailability compared to poor permeability and poor oral bioavailability of DIM-10 and DIM-14 used alone in pharmacokinetic studies.

Futhermore, compared to DIM-10, DIM-10 used alone, the NLC formulation showed an increase in Cmax and AUC values by 4.73 and 11.19-folds.

Similar increased anti-aggressive triple negative breast cancer (TNBC) efficacy was also found in the DIM-14 NLC formulations.

In dogs, the DIM-10 NLC formulations showed an increase of 2.65 and 2.94-fold in Cmax and AUC, against triple negative breast cancer (TNBC) respectively.

Moreover, DIM-10 or DIM-14 NLC formulations demonstrated significant a reduction in tumor volumes TNBC models and treated animals.

Dr. Godugu C, the lead scientist after taking into account co and confounders wrote, "NLC formulation of both DIM-10 and 14 is effective in TNBC models".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of triple negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer by Godugu C1, Doddapaneni R2, Safe SH3, Singh M. (PubMed)
(2) Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing by Shimelis H1, LaDuca H2, Hu C1, Hart SN3, Na J3, Thomas A3, Akinhanmi M1, Moore RM3, Brauch H4,5,6, Cox A7, Eccles DM8, Ewart-Toland A9, Fasching PA10,11,12, Fostira F13, Garber J14, Godwin AK15, Konstantopoulou I13, Nevanlinna H16, Sharma P15, Yannoukakos D13, Yao S17, Feng BJ18, Tippin Davis B2, Lilyquist J3, Pesaran T2, Goldgar DE18, Polley EC3, Dolinsky JS2, Couch. (PubMed)

Regular Walking Reduces Symptoms and Risk of Low Back Pain

Chronic back pain is a significant problem worldwide. According to statistic, Low back pain is a Musculoskeletal disorder (MSDs, affecting over 80% of the population in the US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(5) prevalence in older adults was significantly higher than the 21-to-44-year age group

Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of health benefits of low back pain in the younger and older elderly have been lacking, probably due to body height and weight and other parameters(1), such as psychosocial factors(4).As available evidence on the association between physical activity (i.e. occupational load and non-occupational physical activities) and low back pain (LBP)(3).


But according to the review of the 2583 initially identified articles, 121 articles analyzed conducted by Fédération hospitals-Universitaire de médecine physique et de réadaptation Montpellier-Nîmes, suggested, " Moderate but regular physical activity( included walking) helps to improve fitness and does not increase the risk of acute pain in chronic LBP patients"(2).
In fact, in a systematic review of studies using pedometers, Dr. Mansi S and colleagues at the University of Otago said, ".....strong evidence for the effectiveness of pedometer walking interventions in increasing PA levels for patients with MSDs", using 11 electronic databases up to 20 February 2014(7).
In support of the effect of exercise, including walking the VA Ann Arbor Healthcare System insisted that exercise is an integral part of managing chronic back pain but to be effective requires that patients actively participate in the management process(6).


Does regular walking reduce risk of low back pain? the Cooper River Bridge Run Study said, "runners and walkers may have a lower relative risk for significant LBP" and " Prevalence of LBP at the time of survey completion was 13.6%"(9)in this population in comparison to the general statistic.

Indeed, walking 4 to 7 days per week is found to reduce the risk of LB disability onset by 50% to 80% on the older Black adults and 50% on older White adults(8), respectively.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Physical activity and low-back pain in schoolchildren by Skoffer B1, Foldspang A.(PubMed)
(2) Which physical activities and sports can be recommended to chronic low back pain patients after rehabilitation? by Ribaud A1, Tavares I, Viollet E, Julia M, Hérisson C, Dupeyron A.(PubMed)
(3) Physical activity and low back pain: a systematic review of recent literature by Heneweer H1, Staes F, Aufdemkampe G, van Rijn M, Vanhees L.(PubMed)
(4) Low back pain in schoolchildren: the role of mechanical and psychosocial factors by Watson KD1, Papageorgiou AC, Jones GT, Taylor S, Symmons DP, Silman AJ, Macfarlane GJ.(PubMed)
(5) Management of chronic low back pain by Nikolai Bogduk
(6) Veterans walk to beat back pain: study rationale, design and protocol of a randomized trial of a pedometer-based internet mediated intervention for patients with chronic low back pain by Krein SL1, Metreger T, Kadri R, Hughes M, Kerr EA, Piette JD, Kim HM, Richardson CR.(PubMed)
(7) A systematic review of studies using pedometers as an intervention for musculoskeletal diseases by Mansi S1, Milosavljevic S, Baxter GD, Tumilty S, Hendrick P.(PubMed)
(8) The effect of walking on lower body disability among older blacks and whites by Clark DO1.(PubMed)
(9) The Cooper River Bridge Run Study of low back pain in runners and walkers by Woolf SK1, Barfield WR, Nietert PJ, Mainous AG 3rd, Glaser JA.(PubMed)

Herbal Bilberry, A Natural Treatment for Peyronie's disease

Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.

Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.

Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.

Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.


Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment with significantly increase the likelihood of therapeutic success.

By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.

According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.

Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.

In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.

The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.

Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."

Taken altogether, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)

Herbal Turmeric, A Natural And Potential Treatment of Chagas Heart Disease

Chagas disease (CD) is a medical condition caused by the protozoan parasite Trypanosoma cruzi.

According to the statistics, approximately 6 million people worldwide are living Chagas disease. The majority of patients reside in Mexico, Central America, and South America,

Chagas heart disease can be classified into
* Acute Chagas heart disease is characterized by the inflammation of the heart, gastrointestinal tract (mainly esophagus and colon), meninges, and central and peripheral nervous tissues. Untreated symptomatic patients in this phase may face a roughly 1% chance of death in the acute period, usually the result of severe myocarditis or meningoencephalitis


* The indeterminate form of Chagas heart disease is characterized by small foci of mild chronic myocarditis, with interstitial edema, early fibrosis, and infiltration by lymphocytes, macrophages, and plasma cells. Most patients with the indeterminate form will progress to the chronic form of Chagas heart disease such as dilated cardiomyopathy, at a rate of 1.85% to 7% annually.

* The chronic form of Chagas heart disease is characterized by cardiomegaly and increased cardiac mass, thinning of the ventricular walls, and aneurysmal lesions in various regions of the LV and right ventricle (RV).

Dr. Edimar Alcides Bocchi, the lead scientist in the treatment of Chagas heart disease wrote, "Pharmacological treatment and antiarrhythmic therapy for ChHD is mostly based on results for other etiologies. Heart transplantation is an established, valuable therapeutic option in refractory ChHD".

And, "Implantable cardioverter-defibrillators are indicated for the prevention of secondary sudden cardiac death. Specific etiological treatments should be revisited and reserved for select patients. Understanding and management of ChHD need improvement, including the development of randomized trials".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi., researchers examined the anti-inflammatory and cardioprotective properties of curcumin (Cur).

The study included oral therapy with Cur on T. cruzi-mediated cardio-vasculopathy in acutely infected mice and in vitro, the response of parasite-infected human microvascular endothelial cells treated with this phytochemical.

According to the tested assays, oral Cur therapy showed a reduced inflammatory cell infiltration of myocardial arteries without lowering parasite levels in the tested infected mice.

Furthermore, mice treated with Cur showed significantly decreased vessel inflammation scores (p < 0.001), vascular permeabilities compared to mice treated with the phosphate-buffered saline-receiving group.

Moreover, levels of pro-inflammatory cytokines and ET-1 secretion involved in vascular constriction was also inhibited by the treatment of Cur.

Additionally, proteins and signaling pathways that promote the generation of inflammatory agents also inhibited by the injection of Cur.

In other words, curcumin (Cur) exerted the anti-inflammatory and cardioprotective properties against parasite-induced the onset of Chagas heart disease.

Based on the findings researchers wrote, "These findings identify new perspectives for exploring the potential of Cur-based interventions to ameliorate Chagas heart disease".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Chagas heart disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
(2) Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy by Hernández M1, Wicz S1, Santamaría MH2, Corral RS. (PubMed)
(3) Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management A Scientific Statement From the American Heart Association. (Circulation)
(4) Chronic Chagas Heart Disease Management
From Etiology to Cardiomyopathy Treatment by Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto and Victor Sarli Issa. (JACC)

Regular Walking Reduces risk of Osteoporosis

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of health benefits of the younger elderly have not been explored.

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(1).

Regular walking has shown to reduce the prevalence of osteoporosis in older adult by keeping older people mobile and independent(2). According to the joint study led by Manchester Metropolitan University, osteoporosis and muscular weakness are decreased by regularly completing activities ranging from low-intensity walking(2).
The American College of Sports Medicine in the study of physical activity for older adults, suggested "(physical activity)improved bone health and, thus, reduction in risk for osteoporosis; improved postural stability, thereby reducing the risk of falling and associated injuries and fractures" and "The benefits associated with regular exercise and physical activity contribute to a more healthy, independent lifestyle, greatly improving the functional capacity and quality of life in this population"(3).

Dr. Buchner DM at the University of Washington School of Medicine said, "Epidemiologic evidence strongly supports a role of regular physical activity in successful aging by preserving muscle performance, promoting mobility, and reducing fall risk"(4).

In fact, exercisers with distance walked in six minutes, not only improved (p < .05) scores on an observational gait scale, Isokinetic strength in knee flexion(5), but also promoted suppression of bone turnover and reduced risk of osteoporosis, according to the study of 50 postmenopausal women, aged 49-75 years, with osteopenia/osteoporosis recruited: 32 women enter the exercise program (the exercise group) and 18 served as controls (the control group)(6).
Unfortunately, University Department of Primary Care and Population Sciences after intensive studying of brisk walking in the prevention of postmenopausal osteoporosis. insisted that brisk walking in the older adult, although reduces risk bone turn over, it is associated to risk of falling, according to the result of an investigation of 165 women drawn from the local accident and emergency departments with a history of fracture of an upper limb in the previous 2 years(7).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(2) Physical activity in older age: perspectives for healthy ageing and frailty by McPhee JS1, French DP2, Jackson D3, Nazroo J4, Pendleton N5, Degens H6,7.(PubMed)
(3) American College of Sports Medicine Position Stand. Exercise and physical activity for older adults.[No authors listed](PubMed)
(4) Preserving mobility in older adults by Buchner DM1.(PubMed)
(5) Effects of a group exercise program on strength, mobility, and falls among fall-prone elderly men. by Rubenstein LZ1, Josephson KR, Trueblood PR, Loy S, Harker JO, Pietruszka FM, Robbins AS(PubMed)
(6) Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis by Yamazaki S1, Ichimura S, Iwamoto J, Takeda T, Toyama Y.(PubMed)
(7) Randomized placebo-controlled trial of brisk walking in the prevention of postmenopausal osteoporosis by Ebrahim S1, Thompson PW, Baskaran V, Evans K.(PubMed)

Phytochemical Lycopene Kills Head and Neck Cancer Cells, According to Study

Cancer is a group of disease caused by cell growth irregularly in the affected tissue caused by DNA alternation.

Head and neck cancer is a group of cancers originated from the mouth, nose, throat, larynx, sinuses, or salivary glands.

According to the statistics provided by the Canadian Cancer Society, approximately 4,300 Canadians are diagnosed with cancer of the head and neck every year. Head and neck cancer also cause the death of nearly 1,610 of Canadian.

The overall survival rate of 5 years after diagnosis is 62% tobacco use, alcohol consumption and viral infection including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer).
Some researchers suggested that diet pattern may have a strong impact on the onset of the disease.

Dr. Shu-Chun Chuang, the lead scientist wrote, "A dietary pattern score combining high fruit and vegetable intake and low red meat intake, was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random effects logistic regression model".

And, "Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR=0.90, 95% CI=0.84–0.97)".

In other words, if you are Western diet follower, you risk of head and neck cancer increased substantially compared to those who follow a traditional diet.

Most common symptoms of head and neck cancer are totally depending on the location of cancer including a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

In the urgency to find a potential compound for the treatment of head and neck cancer, researchers examined the lycopene overload and cytotoxic effects on HNSCC cells.

According to the cell analysis, lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner.

Furthermore, injection of lycopene not only provided the clearest increase in growth inhibition by cell apoptosis but also limited the cancer cell invasive activity at a dose of 25 µM.

More precisely, lycopene killed cancer cell by exhibiting the protein associated with cell death programming and apoptosis.

Dr. Ye M, the lead scientist after taking other factors into account wrote, " lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein".

Taken altogether, lycopene may be considered supplements for the prevention and treatment of head and neck cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene inhibits the cell proliferation and invasion of human head and necksquamous cell carcinoma by Ye M1, Wu Q1, Zhang M1, Huang J. (PubMed)
(2) Levels of fat-soluble micronutrients and 2,6-cyclolycopene-1,5-diol in head and neck cancer patients by Djuric Z1, Ronis DL, Fowler KE, Ren J, Duffy SA. (PubMed)
(3) Diet and the Risk of Head and Neck Cancer: A Pooled Analysis in the INHANCE Consortium by
Shu-Chun Chuang,1,2 Mazda Jenab,2 Julia E. Heck,3 Cristina Bosetti,4 Renato Talamini,5Keitaro Matsuo,6 Xavier Castellsague,7 Silvia Franceschi,2 Rolando Herrero,8Deborah M. Winn,9 Carlo La Vecchia,4,10 Hal Morgenstern,11 Zuo-Feng Zhang,3 Fabio Levi,12Luigino Dal Maso,5 Karl Kelsey,13 Michael D. McClean,14 Thomas Vaughan,15Philip Lazarus,16 Joshua Muscat,16 Heribert Ramroth,17 Chu Chen,15 Stephen M. Schwartz,15Jose Eluf-Neto,18 Richard B. Hayes,19 Mark Purdue,9 Stefania Boccia,20,21 Gabriella Cadoni,22David Zaridze,23 Sergio Koifman,24 Maria Paula Curado,2 Wolfgang Ahrens,25Simone Benhamou,26 Elena Matos,27 Pagona Lagiou,28 Neonilla Szeszenia-Dabrowska,29Andrew F. Olshan,30 Leticia Fernandez,31 Ana Menezes,32 Antonio Agudo,33Alexander W. Daudt,34 Franco Merletti,35 Gary J. Macfarlane,36 Kristina Kjaerheim,37Dana Mates,38 Ivana Holcatova,39 Stimson Schantz,40 Guo-Pei Yu,40 Lorenzo Simonato,41Hermann Brenner,42 Heiko Mueller,42 David I. Conway,43 Peter Thomson,44Eleonora Fabianova,45 Ariana Znaor,46 Peter Rudnai,47 Claire M. Healy,48 Gilles Ferro,2Paul Brennan,2 Paolo Boffetta,49,50 and Mia Hashibe. (PMC)

Regular Walking, The Easy Way for age 50 plus to Diseases Free of Age

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking in the younger elderly with contribution to longevity, diseases free and successful aging have not been studied.


According to the Hokkaido University Graduate School of Medicine, in the assessment of 1239 community-dwelling men aged 64/65 years, moderated walking showed to induce longevity and happy aging(1) with or without major critical diseases such as heart disease, cerebrovascular disease, or cancer.
In fact, in the 1990 study of 20,004 men and 21,159 women in Miyagi Prefecture in rural northern Japan (40-64 year of age) regular walking reduces the risk for all-cause mortality, particular among nonsmoking men and women(2).

Dr. Fortes C and colleagues at the joint study led by London School of Hygiene & Tropical Medicine said, " elderly people walking at open air for four times weekly had 40% decreased the risk of mortality" and " supports the encouragement of physical activity in advanced age for increasing longevity"(3). And high levels of walking activity are associated with better survival insisted by the Catholic University of Sacred Heart(4).

There is always a concern of elderly and caregivers regarded to the degeneration of cartilage in the advanced age in contribution to arthritic-inflammatory diseases(5). As the degeneration of cartilage due to aging may make cartilage more brittle, less elastic and less wearable. leading to the disease of bone and injuring the bone easily(6).

Over weight and obesity are found to associate the risk factors and risks of rapid progression of the disease(7)(8). In the discussion of obesity versus osteoarthritis, Dr. Sartori-Cintra AR and the research team at Universidade Estadual de Campinas, indicated that obesity is associated to wide range of diseases, such as osteometabolic diseases, including osteoporosis and osteoarthritis and suggested that physical activity combined with changes in diet composition can reverse the inflammatory and leptin resistance, reducing progression or preventing the onset of osteoarthritis(9).

Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans(10), a major component of joint cartilage(11). Intake of glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, or nutrients, such as antioxidants and omega-3 fatty acids showed to prevent cartilage degeneration and treat arthritis, according to study(11).

Without the concern of further damage to the cartilage, regular walking may lead you to a golden retirement with Diseases Free, passing Age of 100+.
For convenience, you may want to buy joint cartilage supplements from your local drug store to prevent cartilage degeneration

Kyle J. Norton does not receive a financial benefit from any nutritional supplement company,


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Health Benefits of Daily Walking on Mortality Among Younger-Elderly Men With or Without Major Critical Diseases in the New Integrated Suburban Seniority Investigation Project: A Prospective Cohort Study by Zhao W1, Ukawa S, Kawamura T, Wakai K, Ando M, Tsushita K, Tamakoshi A.(PubMed)
(2) Walking and mortality in Japan: the Miyagi Cohort Study by Fujita K1, Takahashi H, Miura C, Ohkubo T, Sato Y, Ugajin T, Kurashima K, Tsubono Y, Tsuji I, Fukao A, Hisamichi S.(PubMed)
(3) Walking four times weekly for at least 15 min is associated with longevity in a cohort of very elderly people by Fortes C1, Mastroeni S2, Sperati A3, Pacifici R4, Zuccaro P4, Francesco F5, Agabiti N5, Piras G5, Amleto D6, Ebrahim S7.(PubMed)
(4) Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study. by Landi F1, Russo A, Cesari M, Pahor M, Liperoti R, Danese P, Bernabei R, Onder G(PubMed)
(5) Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis by Houard X1, Goldring MB, Berenbaum F.(PubMed)
(6) [FTIR spectroscopic investigations on the difference in cartilage composition between youth and elder].[Article in Chinese] by Chen W1, Zhou M, Zuo J, Wang LN, Gao SQ, Lu GH, Li ZL, Li ZW.(PubMed)
(7) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis by Messier SP1, Gutekunst DJ, Davis C, DeVita P.(PubMed)
(8) Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(9) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(10) Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP by Little PJ1, Drennon KD, Tannock LR.(PubMed)
(11) Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acid by Jörg Jerosch(PubMed)

Herbal Aloe Vera, the Anti Skin Aging Functional Remedy with NO Side Effects, According to Studies

Scientists may have found a natural and potent herbal plant used for the delay of skin aging, according to the studies.

Skin aging is a natural and biological process of the human which can be stopped.

Long-term free radical damage to the skin through oxidative stress is the major cause of skin aging.

Exposure to the sun (photoaging) and pollution, and loss of subcutaneous support (fatty tissue between your skin and muscle) are some of the risk factors associated with the skin aging.

Some researchers suggested that skin expression may be considered as a refect of the general health of an individual. An unhealthy skin due to skin nutritional deficiency has been a target by the dermatology and cosmetic industries.

Dr.Silke K. Schagen in the study that links between nutrition and skin aging, said, "Vitamins, carotenoids, tocopherols, flavonoids and a variety of plant extracts have been reported to possess potent antioxidant properties and have been widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance".

The results strongly suggested that by providing enough nutrition to the skin needs, extrinsic causes of skin aging can be delayed

In skin wrinkle, according to the results of the studies by the Monash University, Melbourne, a high intake of certain food groups are associated with the speeding up of wrinkle, including meat, dairy, and butter. High intake of vegetables, legumes and olive oil appeared to be protective against cutaneous actinic damage.


Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.


The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

With an aim to find a natural ingredient or whole food for the delay of skin aging researchers at the Seoul National University Boramae Hospital examined the effect of aloe gel on the clinical signs and biochemical changes of aging skin.

The experiment included 30 healthy female subjects over the age of 45 given 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days with their baseline status as a control.


Aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group.

The injection of the gel also increased the skin photoprotection and the type I procollagen mRNA levels in controlling the rate of procollagen synthesis.


The results were accompanied by the matrix (MMP-1) mRNA levels associated with the breaking down the interstitial collagens, types I, II, and III, particularly in the higher-dose group.


Type I procollagen was substantially increased throughout the dermis in Aloe treatment of the group.

Dr. Cho S, the lead scientist said, "Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression".

The Kyung Hee University Global Campus in the investigation of the effects of Aloe vera on ultraviolet (UV) irradiation induces photo-damage of the skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in skin structure.


By the comparison of the baby Aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, protective effect on UVB-induced skin photoaging in normal human dermal fibroblasts (NHDFs). researchers found that NHDF cells treated UVB-irradiation suppressed the matrixes associated with the breaking down the interstitial collagens, types I, II, and III, and the levels of inflammatory cytokines similar to that of the above study, compared to the AE-treated cells.
BAE treatment elevated type I procollagen which was reduced in photodamaged skin. mediated by the increasing levels of TGF-β1 levels which is a multifunctional cytokine.


The findings clearly suggested that herbal Aloe vera may be considered an anti-aging functional remedy with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.




References
(1) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH. (PubMed)
(2) A Comparative Study of Baby Immature and Adult Shoots of Aloe Veraon UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY. (PubMed)
(3) Innovations in natural ingredients and their use in skin care.
(4) Discovering the link between nutrition and skin aging by Silke K. Schagen, † Vasiliki A. Zampeli, † Evgenia Makrantonaki, and Christos C. Zouboulis. (PMC)
(5) Skin wrinkling: can food make a difference? by Purba MB1, Kouris-Blazos A, Wattanapenpaiboon N, Lukito W, Rothenberg EM, Steen BC, Wahlqvist ML. (PubMed)
(6) Prevalence of Helicobacter pylori Infection in Patients with Peptic Ulcer Diseases and Non-Ulcer Dyspepsia by Hyo Rang Lee, M.D., Ki Soo Han, M.D., Byung Chul Yoo, M.D., and Sill Moo Park, M.D. (PMC)

Phytochemical 3,3'-Diindolylmethane Processes Hepatic Protective Activity

Scientists may have found a bioactive ingredient which processes liver protective activity with no side effects, according to studies.

Hepatic protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.

The liver is the largest internal organ with a function which filters the blood from the intestinal tract before passing them to the heart and other parts of the body.

Additonally, the liver also produces bile to aid digestion and cholesterol to build strong cell membranes, production of vitamin D and steroid hormones.

Liver disease is a broad term included any problems that cause the reduced function of the liver.

There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.

In other words, symptoms of liver disease can be felt only after more than 75% liver is damage.

Most common risk factors are a genetic preposition, viruses, and long-term excessive alcohol drinking.

Non-alcoholic fatty disease (NAFLD), a leading cause of cirrhosis, is one of the most common liver disease found in the Western world, affecting up to 25% of people in the United States.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency of finding a natural compound with liver protective activity, researchers examined the pharmacokinetics of I3C and its derivatives, including 3,3'-Diindolylmethane or DIM multiple protective roles in the processes of chronic liver diseases.

Administration of I3C and its derivatives relieved liver oxidative stress by regulating transcriptional factors and their respective signaling pathways associated with the synthesis of DNA to influence the activation, proliferation, and apoptosis of target cells.

Furthermore, indoles not only modulated the enzymes that are relevant to hepatitis viral replication, lipogenesis, and the metabolism associated with liver function but also protected the liver against hepatotoxicity (ethanol and some hepatotoxic substances).

In other words, the indoles exerted hepatoprotection by inhibiting pro-inflammatory cytokines and chemokines against microbial-induced liver injuries.

Based on the findings, Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".

And, " I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
(2) Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout by Takahashi N1, Stresser DM, Williams DE, Bailey GS. (PubMed)

Herbal Artichoke Normalizes the Levels of Serum Cholesterol in Vivo and Human Study

Hyperlipidemia is a chronic condition of abnormally high blood cholesterol in the bloodstream.

Cholesterol is a waxy substance produced by the liver or dietary intake that processes a significant activity in the improvement of the digestive system by breaking down food, in the production of vitamin D and steroid hormone, particularly in the building of strong cell membranes.

There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and high-density lipoprotein which returns cholesterol back to the liver for reuse.

However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.

According to the free radical theory, overexpression of cholesterol also increases the risk of lipid peroxidation, leading to the onset of various diseases.

Dr, Yagi K, at the Institute of Applied Biochemistry in the analysis of the lipid peroxides and human diseases, said, "The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity"

And. "Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders".

The findings clearly suggested that your risk of diseases is increased substantially if you have abnormally high blood cholesterol.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of abnormal blood cholesterol, researchers examined artichoke leaf extract (ALE) activity in lowering the plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols.

The study included 64 Golden Syrian hamsters (8 weeks old) fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.

There were no significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were after 21 days for ALE-fed animals compared with controls.

However, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls after 42 days.


Furthermore, the total neutral sterol and bile acids concentrations also increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls.

Dr. Qiang Z, after taking into account other factors, said, "he ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days".

In order to reveal more information about artichoke anti-high blood cholesterol property, researchers evaluated the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern,

The randomized, double-blind, placebo-controlled clinical trial included 92 overweight subjects with primary mild hypercholesterolemia for 8 weeks.

46 subjects were randomized to supplementation (age: 54.2 ± 6.6 years, body mass index (BMI): 25.8 ± 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 ± 9.0 years, BMI: 24.8 ± 1.6 kg/m(2), male/female: 21/25).


Artichoke leaf extract (ALE) supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004).


Moreover, ALE also significantly decreased the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001) comapred to control.


The findings clearly supported the use of artichoke leaf extract ALE for the treatment of patients with mild high blood cholesterol.

Taken altogether, artichoke may be considered a functional formula for the treatment of patients with high blood cholesterol with no side effects, pending to the validation of larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S.(PubMed)
(2) Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial by Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. (PubMed)
(3) Lipid Peroxidation Products in Human Health and Disease by Kota V. Ramana,1 Sanjay Srivastava,2 and Sharad S. Singha. (Hindawi)

Bioactive Compound Sinigrin, the Dietary Source of Antioxidants

Antioxidants are stable molecules which inhibit oxidation. Antioxidants are either produced by the host or from the dietary sources.

Under normal condition, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.

However, in people with the weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to depletion of the antioxidant enzymes.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order for them to maintain stable, they must either donate or intercept an electron from other molecules, leading a chain reaction that can not be stopped until they are either inhibited by antioxidant or electrons are paired.

Oxidative stress is an imbalance of the ratio of free radicals and antioxidant in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.

Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the major factors that contribute to the severity of the disease due to oxidative stress.


Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".

Researchers on finding a natural ingredient which processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.

Injection of sinigrin suppressed the nitric oxide (NO) production, a free radical although is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney and liver toxicity by reducing the levels of nitric oxide synthase.

In rat study. oral administration of the compound also showed reduced the levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radicals expression through its antioxidant activity.

In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.

Mitochondrial dysfunction is found to interfere with the function of cells in the production of energy for cell or organ needs.

Oxidative balance impairment is another term of oxidative stress.

More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced the host.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.


However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant dietary approach in treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)

Herbal Bilberry the Best for the Prevention and Treatment of Eye Disease

Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.

People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.

If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.

Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.

According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).

Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.


Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.

The findings support the regular use of bilberry anthocyanosides as a dietary source against the age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.

Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.

332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.

According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.


After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.


Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)