Herbal Angelica Improves the Mitochondrial Functioning

Mitochondria are power generators of the cell found abundantly in the liver and play a critical role in converting oxygen and nutrients to energy for the cell's metabolisms.

Mitochondrial permeability transition (MPT) and the mitochondrial generation of oxidative stress have been found to initiate hepatic mitochondrial dysfunction caused by hepatocellular necrosis and apoptosis.

Where, the protein mitochondrial permeability transition pore is formed in the inner membrane of the mitochondria under certain pathological conditions, including stroke, leading to symptoms of lethargy, hypotonia, vomiting, poor suck, and seizures.

Mitochondria bioenergetics play a critical for normal cell function and human health. The alternation of mitochondrion DNA has been found to induce a number of diseases.

More precisely, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people. Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer. including mitochondrial myopathy, diabetes mellitus, and deafness.

Most common symptoms of mitochondrial dysfunction include poor growth muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, mental retardation depending on the location of the infected cells.

According to the statistics, 1 in 5,000 individuals has a genetic mitochondrial disease. Each year, about 1,000 to 4,000 children in the United States are born with mitochondrial disease.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with mitochondrial dysfunction, the researchers examined the effects of Danggui Buxue Tang (DBT) on mitochondrial respiration of cultured H9C2 cardiomyoblasts.

According to the chemical analysis, DBT exerted a strong antioxidant and radical scavenging activity against oxidative stress, and protective effect in tert-butyl hydroperoxide (tBHP)-treated cultured cardiomyoblast.

Furthermore, the transcript expressions of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PCG-1α) and other genes, relating to mitochondria biogenesis were enhanced by the injection of the decoction.

Moreover, cultured cardiomyoblasts showed an improvement of total status under DBT treatment through a number of mechanisms, including an increase of basal respiration, proton leak, non-mitochondria, and adenosine triphosphate (ATP) production by stimulating the mitochondrial biogenesis and DNA replication

Taken altogether, Herbal Angelica may protect the mitochondrial functioning, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts by Kwan KKL1,2, Huang Y1,2, Leung KW1,2, Dong TTX1,2, Tsim KWK. (PubMed)