Herbal catnip may have a potential and substantial effect in reduced risk and treatment of breast cancer, some scientists suggested.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belongings to the family of Lamiaceae, native to Europe and Asia, use in herbal medicine as insect repellent and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..
Breast cancer is a medical condition characterized by irregular cell growth in the tissue of the breast. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.
According to statistics, approximately 1 in 8 U.S. women (about 12.4%) will develop invasive breast cancer over the course of their lifetime.
In a comparison of breast cancer cell lines (MCF-7, MDA-MB-231) to the non-cancer line (MCF-10A) to evaluate the cytotoxic and apoptogenic activity of EtOH 70%, hexane and aqueous extracts isolated from the herbal plant catnip, researchers showed that catnip inhibited the growth of malignant cells in a time and dose-dependent manner.
The hexane extract induced greater cytotoxicity in precipitated cancer cell apoptosis in compared to other extracts.
Further analysis, also indicated that at a dose of 60 μg/ml concentration of catnip hexane extract reduced the expression of mRNA of ornithine decarboxylase 1 in response to growth-promoting stimuli and exhibited a high turnover rate of breast cancer.
Over expressions of mRNA of tumor ornithine decarboxylase levels heterogeneity found in breast cell lines were associated to significantly increase the mean of tumor malignancy by 4.9 and 3.6 fold of adenosine deaminase, an E2 responsive in MCF-7 human breast cancer cells and by 3.5 and 2.6 in MCF-7 cell line and MDA-MB-231 cell line, respectively and in compared to control.
Tumor ornithine decarboxylase gene is also considered as a biomarker as a prognostic factor for breast cancer. Increased serum of adenosine deaminase is found to correlate to cancer progression and malignancy.
The results indicated that the application of catnip methanol hexane extract scores a high potential in modulating the expression of ornithine decarboxylase 1 and adenosine deaminase genes in breast cancer cells in inhibiting malignant cancer proliferation and induced apoptosis.
Moreover, the investigation of the anticancer activities of chloroform Nepeta deflersiana extract and various sub-fractions (ND-1-ND-15) of ND against human breast cancer cells (MCF-7) by the King Saud University suggested that applications of selected sub-fractions of the chloroform extract at dose of 10-1000 μg/ml for 24 hours, displays a significant reduction of the cell viability of MCF-7 cancer cell line and altered the cellular morphology in a concentration-dependent manner.
Additional analysis indicated that N-10 isolated from catnip expressed greater cytotoxicity in induced cancer death compared to other fractions according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
According to the neutral red uptake assay, ND-1 extract did not cause any cytotoxicity in MCF-7 cells exposed for 24 h. However, the ND-10 extract was found more toxic toward breast cancer cells.
Finally, in MCF-7 cells, application at doses at 500 and 1000 μg/ml concentrations of all extracts exhibited a huge activity on in reduced the normal morphology of the cells and cell adhesion capacity compared to the control.
And most of the breast cancer cells at 1000 μg/ml concentration lost their typical morphology and appeared smaller in size and shrunken.
Compared to cancer cell line A-549 cells, MCF-7 cells were less sensitive to growth inhibition by all the extracts.
Taken together, there is no doubt that catnip and its methanol extracts may be a potential and therapeutic source of pharmacologically active molecules for the development of the chemotherapeutic drug for the treatment of breast cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Growth inhibition of human breast cancer cells and down-regulation of ODC1 and ADA genes by Nepeta binaloudensis by Akbar Safipour, Afshar Fatemeh Saeid Nematpour, Mahshid Meshkani, and ArezosadatKhafi(Science Direct)
(2) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)
Friday, January 31, 2020
Herbal Burdock, The Natural Remedy Which Processes Anti- Inflammatory Activity
Scientists may have found a medicinal plant for the prevention and treatment of chronic inflammatory diseases with no side effects, according to studies.
Inflammation is a natural response of the human body against the foreign pathogens and stimuli that progress through many phases.
In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.
Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.
Other causes of chronic inflammation also include an autoimmune disorder, in which the immune system mistakenly attacking healthy tissue and long-term exposure to irritants, such as industrial chemicals or polluted air.
People with chronic inflammatory diseases such as "Rheumatoid arthritis (RA) is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity" Dr, Abou-Raya S and colleagues at the University of Alexandria, Alexandria, wrote, " The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The ingredients of herbal Burdock include carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural ingredient for the treatment of atopic dermatitis is a chronic, allergic inflammatory skin disease, researchers examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
On ConA-treated primary murine splenocytes, ALBE demonstrated significant inhibition of β-hexosaminidase release in RBL-2H3 cells by suppressing the mRNA expression in transmitting information between cells associated to the β-hexosaminidase release and proteins involved the production of inflammatory cytokines.
ALBE (100 μg/mL) suppressed not only the protein complex associated with transcription of DNA, cytokine production but also the pathway involved the regulation of pro-inflammatory cytokines in Concanavalin A (ConA) treated primary splenocytes.
Where Concanavalin-A is a lectin used in the experiment to trigger inflammatory responses.
Furthermore, in an experimental colitis model induced by 2,4,6 trinitrobenzene sulfonic acid, researchers evaluated ONP fraction (25 and 50 mg/kg/day) orally administered 48, 24 and 1 h prior to the induction of colitis and 24 h after.
Before the application of ONP, TNBS treatment group showed an increased colonic wall thickness, edema, diffuse inflammatory cell infiltration, observed by the increased production of inflammatory cytokines and enzymes.
Contrarily, ONP fraction (25 and 50 mg/kg) treatment significantly reduced the macroscopic inflammation scores (p<0.05 and p<0.01, respectively) and morphological alterations associated with an increase in the mucus secretion.
Injection of ONP fraction at 25 and 50 mg/kg also expressed significantly reduced levels of neutrophil infiltration and the cytokines, through their anti-inflammatory and antioxidant activities.
Compared to COX-2 overexpression of inflammation and pain in TNBS-treated rats, ONP fraction (50 mg/kg) administration reduced COX-2 overexpression.
The findings suggested that herbal Burdock fraction obtained from Arctium lappa processed gastrointestinal protective effects against acute colitis.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.
Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim SY.(PubMed)
(2) Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. by de Almeida AB, Sánchez-Hidalgo M, Martín AR, Luiz-Ferreira A, Trigo JR, Vilegas W, dos Santos LC, Souza-Brito AR, de la Lastra CA.(PubMed)
(3) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway by Zhao F, Wang L, Liu K.(PubMed)
(4) Chronic inflammatory autoimmune disorders and atherosclerosis by Abou-Raya S1, Abou-Raya A, Naim A, Abuelkheir H. (PubMed)
Inflammation is a natural response of the human body against the foreign pathogens and stimuli that progress through many phases.
In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.
In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.
However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.
Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.
Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.
Other causes of chronic inflammation also include an autoimmune disorder, in which the immune system mistakenly attacking healthy tissue and long-term exposure to irritants, such as industrial chemicals or polluted air.
People with chronic inflammatory diseases such as "Rheumatoid arthritis (RA) is associated with accelerated vascular risk resulting in an increased prevalence of CAD with attendant early mortality and excess morbidity" Dr, Abou-Raya S and colleagues at the University of Alexandria, Alexandria, wrote, " The implication is that inflammation may be the central link between the chronic inflammatory autoimmune disorders and atherosclerosis".
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. It has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The ingredients of herbal Burdock include carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
With an aim to find a natural ingredient for the treatment of atopic dermatitis is a chronic, allergic inflammatory skin disease, researchers examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
On ConA-treated primary murine splenocytes, ALBE demonstrated significant inhibition of β-hexosaminidase release in RBL-2H3 cells by suppressing the mRNA expression in transmitting information between cells associated to the β-hexosaminidase release and proteins involved the production of inflammatory cytokines.
ALBE (100 μg/mL) suppressed not only the protein complex associated with transcription of DNA, cytokine production but also the pathway involved the regulation of pro-inflammatory cytokines in Concanavalin A (ConA) treated primary splenocytes.
Where Concanavalin-A is a lectin used in the experiment to trigger inflammatory responses.
Furthermore, in an experimental colitis model induced by 2,4,6 trinitrobenzene sulfonic acid, researchers evaluated ONP fraction (25 and 50 mg/kg/day) orally administered 48, 24 and 1 h prior to the induction of colitis and 24 h after.
Before the application of ONP, TNBS treatment group showed an increased colonic wall thickness, edema, diffuse inflammatory cell infiltration, observed by the increased production of inflammatory cytokines and enzymes.
Contrarily, ONP fraction (25 and 50 mg/kg) treatment significantly reduced the macroscopic inflammation scores (p<0.05 and p<0.01, respectively) and morphological alterations associated with an increase in the mucus secretion.
Injection of ONP fraction at 25 and 50 mg/kg also expressed significantly reduced levels of neutrophil infiltration and the cytokines, through their anti-inflammatory and antioxidant activities.
Compared to COX-2 overexpression of inflammation and pain in TNBS-treated rats, ONP fraction (50 mg/kg) administration reduced COX-2 overexpression.
The findings suggested that herbal Burdock fraction obtained from Arctium lappa processed gastrointestinal protective effects against acute colitis.
Taken altogether, herbal Burdock may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of acute and chronic inflammatory diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa L.
Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim SY.(PubMed)
(2) Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. by de Almeida AB, Sánchez-Hidalgo M, Martín AR, Luiz-Ferreira A, Trigo JR, Vilegas W, dos Santos LC, Souza-Brito AR, de la Lastra CA.(PubMed)
(3) In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway by Zhao F, Wang L, Liu K.(PubMed)
(4) Chronic inflammatory autoimmune disorders and atherosclerosis by Abou-Raya S1, Abou-Raya A, Naim A, Abuelkheir H. (PubMed)
Cat's Claw, the Best Whole Herb medicine for Prevention and Treatment of Colorectal cancer
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Bowel cancer also is known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study led by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).
Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.
In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patients received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.
Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardization in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "
Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professionals; herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Bowel cancer also is known as colorectal cancer, is a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
Cat's Claw extract may have a role for cancer patients as a complementary therapy. According to the joint study led by the Federal University of Santa Maria (UFSM), Cat's Claw enhanced chemotherapy-induced apoptosis, with interference in cell cycle division in colorectal adenocarcinoma cells (HT29 cells).
Dr. Gurrola-Díaz CM, the lead researchers at the Centro Universitario de Ciencias de la Salud (CUCS) suggested, the anti-inflammatory and anti-proliferative properties of different alkaloids extracted from Cat's Claw may be resulted of the interfering the proteins that pass signals into a cell through cell surface receptors. Uncaria tomentosa is less toxic in non-cancer cells than in cancer cells.
In a randomized clinical trial conducted of Patients (43) undergoing adjuvant/palliative chemotherapy, patients received chemotherapy plus 300 mg of Uncaria tomentosa daily, showed to reduce side effects of chemotherapy with no toxic effect.
Dr. Valerio LG Jr and Dr. Gonzales GF. in the review of the toxicological aspects of the South American herbs cat's claw said, " An important finding unveiled by this review is the importance of standardization in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk" and " Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data... "
Therefore, the use of Cat's Claw as a whole herb medicine should be taken with care. The quantity intake can only be prescribed by professionals; herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis by Nogueira Neto J1, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E.(PubMed)
(2) Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway by Gurrola-Díaz CM1, García-López PM, Gulewicz K, Pilarski R, Dihlmann S.(PubMed)
(3) Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial by Farias IL1, Araújo MC, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, Flores NM, Durigon M, Cruz IB, Morsch VM, Schetinger MR.(PubMed)
(4) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis by Valerio LG Jr1, Gonzales GF.(PubMed)
Thursday, January 30, 2020
Bromelain Suppresses Rheumatic Disease with No Side Effects
Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
Most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.
* Gout mostly effected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
The most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.
Most common types of rheumatism are
* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.
* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.
* Gout mostly effected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.
* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
* Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.
* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of persistent joint swelling, pain, and stiffness
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.
The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).
According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995 registered by 380 physicians, both treatments yielded similar results.
However, there was a 50% higher success rate in OE than for NSAID, compared to the initial and treatment situations.
OE also scored higher stratification according to propensity score.
Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients' response compared to those of OE.
Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.
The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs
Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton
Herbal Bilberry, A Natural Prevention and Treatment of Alzheimer's disease (AD) with No Side Effects
Alzheimer's disease (AD) is a neurodegenerative disease found mostly in the aging population characterized by impaired memory, thinking, and behavior. caused by the gradual loss or death of neurons. These symptoms are slowly getting worse over time and becoming severe enough to interfere with daily activity.
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the number of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
In contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with the control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, the bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information about bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit significant activity in the prevention of cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
60 percent to 80 percent of dementia found in the US are involved in Alzheimer's disease (AD).
According to the statistics, the number of patients living with AD is growing fast, affecting over 5.5 million people age 65 and older. AD is a sith leading cause of death in the US. Most patients AD lives four to eight years after diagnosis. However, the years of survival rate is totally depending on other factors.
In contrast to general belief, getting old is a risk factor of AD but AD is not a disease of aging. Approximately 200,000 Americans under the age of 65 have younger-onset Alzheimer’s disease.
As of today, there is no cure for AD, the aim of treatment is to slow down the severity of the symptoms and delay the progression of the disease.
In other words, treatment is to improve the quality of life for both patients and their caregivers.
Besides aging, physically active, smoking, excessive alcohol drinking, medical conditions such as metabolic syndrome, stress are some of the prevalent risks of AD.
Some researchers in the investigation of the correlation between obesity and AD wrote, "There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway".
And, "Obesity prevention and treatment could prove to be an efficacious and safe approach to preventing AD, a serious and daunting epidemic disease".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In searching a natural ingredient for the treatment of Alzheimer's disease with no side effects, researchers at the effects of different polyphenols on neuroprotection and APP processing under different stress conditions in transgenic AD mice (APdE9).
Selected mice induced free radical toxicity and apoptosis in human SH-SY5Y neuroblastoma cells overexpressing APP751.
APdE9 mice fed with anthocyanin-rich bilberry showed the decreased Amyloid Precursor Protein (APP)APP C-terminal fragment levels, the indication of reduced death of neurons in the cerebral cortex compared to APdE9 mice fed with the control diet.
Furthermore, soluble Aβ40 and Aβ42 levels, the plaque in the brain associated with increased risk for AD, mild cognitive impairment, and cognitive decline were significantly decreased in bilberry-fed mice, compared to blackcurrant-fed mice.
Moreover, the bilberry diet protected the spatial working memory of aged APdE9 mice, compared to mice on the control diet, thus reducing the risk of deficits.
The results clearly suggested bilberry diet protects the integrity and viability of the neuron in the brain against the risk of AD.
Dr. Vepsäläinen S, the lead scientist said, "These data suggest that anthocyanin-rich bilberry and blackcurrant diets favorably modulate APP processing and alleviate behavioral abnormalities in a mouse model of AD".
In order to reveal more information about bilberry anti AD activity, researchers examined the anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the aggregation and deposition of the amyloid beta (Aβ1-42) peptide in fibrillar form.
According to the tested assays, injection of VMA protected Neuro2a cells by inhibiting the formation of Aβ peptide fibrils and reducing the toxicity of these aggregates in vitro.
A diet containing 1% VMA was found to exhibit significant activity in the prevention of cognitive degeneration in AD tested mice.
Interestingly, VMA promoted the cognitive ability accompanied not by a reduction in an aggregate deposition in brains, rather an increase in insoluble deposits compared to control diet mice.
In other words, bilberry protected the brain neuro against the risk AD by diverting Aβ aggregation to insoluble deposits, an alternate, non-toxic form.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment of AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in vitro and in vivo models of Alzheimer's disease by Yamakawa MY, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, Hongo K, Mizobata T, Kobayashi S, Nakashima K, Kawata, (PubMed)
(2) Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. (PubMed)
(3) Obesity as a risk factor for Alzheimer's disease: weighing the evidence by Alford S1, Patel D2,3, Perakakis N4, Mantzoros CS. (PubMed)
Herbal Ashwagandha Kills Osteosarcoma Cells in Vitro
Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.
Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.
According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.
The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.
Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",
And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".
The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% compared to localized cancer between 60% to 80%.
Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.
In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.
In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).
At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, compared to other cell lines.
Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.
In the safety analysis, if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.
Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.
Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".
Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)
Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.
According to the statistic from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these are in children and teens.
The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity and exposure to bone radiation are also some prevalent factors found in patients with the disease.
Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",
And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".
The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% compared to localized cancer between 60% to 80%.
Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy and radiation therapy.
In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of cancers, researchers examined evaluated the safety and pharmacokinetics of WA.
In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).
At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of U2OS cell line, compared to other cell lines.
Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.
In the safety analysis, if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.
Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.
Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".
Taken altogether, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)
Wednesday, January 29, 2020
Herbal Ashwagandha Protects the Kidneys Against Acute Toxicity
Kidneys, a pair of the bean-shaped organ in the human body only filter out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidney disease is a medical condition that causes the reduced function of the kidney due to damage.
In other words, the progression of kidney damage may affect the function of the kidney to filter blood
against toxins.
Most patients with chronic kidney disease also found to have conditions of diabetes or high blood pressure.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are asymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are asymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of kidney disease, researchers examined the effects of Withania somnifera on rats-induced nephrotoxicity.
The study included selected rat oral administrated by The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) for 14 days before GEN treatment and thereafter concurrently with GEN (100 mg/kg) for 8 days.
Based on the tested differentiation, GEN treatment group showed significant nephrotoxicity associated with kidney injury by an increase in kidney weight, urea, creatinine, urinary protein, and glucose, and a significant reduction in body weights and potassium by enhancing the overexpression of free radicals.
Compared to somnifera doses of W. somnifera at 250 and 750 mg/kg, the administration of 500 mg/kg showed the strongest effect in reversing the aforementioned changed observed by the microscopically antioxidant evidence.
In other words, W. somnifera protected the kidney against acute toxicity in a dose-dependent manner.
However, there were no significant changes in the levels of sodium in the experimental animals compared to control.
Based on the findings, researchers said, "nephroprotective effect of Withania somnifera, which could be by enhancing antioxidant activity with natural antioxidants and scavenging the free radicals".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats by Jeyanthi T1, Subramanian P. (PubMed)
(2) Nephroprotective effect of Withania somnifera: a dose-dependent study by Jeyanthi T1, Subramanian P. (PubMed)
Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidney disease is a medical condition that causes the reduced function of the kidney due to damage.
In other words, the progression of kidney damage may affect the function of the kidney to filter blood
against toxins.
Most patients with chronic kidney disease also found to have conditions of diabetes or high blood pressure.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are asymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are asymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of kidney disease, researchers examined the effects of Withania somnifera on rats-induced nephrotoxicity.
The study included selected rat oral administrated by The root extract of three different doses of W. somnifera (viz., 250, 500, and 750 mg/kg) for 14 days before GEN treatment and thereafter concurrently with GEN (100 mg/kg) for 8 days.
Based on the tested differentiation, GEN treatment group showed significant nephrotoxicity associated with kidney injury by an increase in kidney weight, urea, creatinine, urinary protein, and glucose, and a significant reduction in body weights and potassium by enhancing the overexpression of free radicals.
Compared to somnifera doses of W. somnifera at 250 and 750 mg/kg, the administration of 500 mg/kg showed the strongest effect in reversing the aforementioned changed observed by the microscopically antioxidant evidence.
In other words, W. somnifera protected the kidney against acute toxicity in a dose-dependent manner.
However, there were no significant changes in the levels of sodium in the experimental animals compared to control.
Based on the findings, researchers said, "nephroprotective effect of Withania somnifera, which could be by enhancing antioxidant activity with natural antioxidants and scavenging the free radicals".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera root powder on lipid peroxidation and antioxidant status in gentamicin-induced nephrotoxic rats by Jeyanthi T1, Subramanian P. (PubMed)
(2) Nephroprotective effect of Withania somnifera: a dose-dependent study by Jeyanthi T1, Subramanian P. (PubMed)
Cat's Claw, the Best Whole Herb medicine for Reduced Symptoms and Treatment of Inflammatory arthritis
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Arthritis is one common musculoskeletal disorders (MSDs) inflammatory diseases, affecting one or more joints with symptoms of joint pain and stiffness.
Cat's claw may be used for treatment in reduced symptoms of arthritis patients through interfering the regulated phosphohydrolytic activity in the prevention of arthritis induction causes to tissue damage.
In the review of 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study), the Bethesda North Hospital Pharmacy, suggested, cat's claw may be used as a nonsteroidal anti-inflammatory drug or steroid usage in some studies.
In a total of 50 patients with RA, undergoing sulfasalazine or hydroxychloroquine treatment enrolled in a randomized 52 week, 2 phase study, 24 weeks of treatment with the UT extract exhibited a reduction of the number of painful joints compared to placebo (by 53.2% vs 24.1%; p = 0.044),
In fact, " Cat's claw also exhibited antioxidant effect against inflammation through reduction of pro-inflammatory mediators and effectors" Dr. Hardin SR said.
Dr. Sandoval M.. the lead author at the Albany Medical College, suggested. oral pretreatment for UT protected against inflammatory disorders, through the interaction of the pro-inflammatory expression with its antioxidant properties.
Although Cat's claw may be effective for reduced symptoms and treatment of inflammatory arthritis. The use of the whole herb quantity should be taken with care as toxicity is found in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model by Castilhos LG1, Rezer JF2,3, Ruchel JB4,5, Thorstenberg ML6,7, Jaques JA8,9, Schlemmer JB10,11, Doleski PH12, Rossato MF13, da Silva MA14, Casalli EA15,16, da Cruz RC17, Ferreira J18, Athayde ML19, Gonçalves JF20,21, Leal DB22,2(PubMed)
(2) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(3) Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis by Mur E1, Hartig F, Eibl G, Schirmer M.(PubMed)
(4) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1(PubMed)
(5) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ.(PubMed)
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Arthritis is one common musculoskeletal disorders (MSDs) inflammatory diseases, affecting one or more joints with symptoms of joint pain and stiffness.
Cat's claw may be used for treatment in reduced symptoms of arthritis patients through interfering the regulated phosphohydrolytic activity in the prevention of arthritis induction causes to tissue damage.
In the review of 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study), the Bethesda North Hospital Pharmacy, suggested, cat's claw may be used as a nonsteroidal anti-inflammatory drug or steroid usage in some studies.
In a total of 50 patients with RA, undergoing sulfasalazine or hydroxychloroquine treatment enrolled in a randomized 52 week, 2 phase study, 24 weeks of treatment with the UT extract exhibited a reduction of the number of painful joints compared to placebo (by 53.2% vs 24.1%; p = 0.044),
In fact, " Cat's claw also exhibited antioxidant effect against inflammation through reduction of pro-inflammatory mediators and effectors" Dr. Hardin SR said.
Dr. Sandoval M.. the lead author at the Albany Medical College, suggested. oral pretreatment for UT protected against inflammatory disorders, through the interaction of the pro-inflammatory expression with its antioxidant properties.
Although Cat's claw may be effective for reduced symptoms and treatment of inflammatory arthritis. The use of the whole herb quantity should be taken with care as toxicity is found in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model by Castilhos LG1, Rezer JF2,3, Ruchel JB4,5, Thorstenberg ML6,7, Jaques JA8,9, Schlemmer JB10,11, Doleski PH12, Rossato MF13, da Silva MA14, Casalli EA15,16, da Cruz RC17, Ferreira J18, Athayde ML19, Gonçalves JF20,21, Leal DB22,2(PubMed)
(2) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(3) Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis by Mur E1, Hartig F, Eibl G, Schirmer M.(PubMed)
(4) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR1(PubMed)
(5) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ.(PubMed)
Herbal Burdock, the Potent Hepatoprotective Remedy
Herbal Burdock may process a liver protective activity against the onset of liver disease, according to the studies.
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of the non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non- alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The herbal plant contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
On finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet which did not contain absolute ethanol.
Before administrating of herbal Burdock, ethanol group and the groups receiving ethanol supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase is an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY.(PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY.(PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
The liver is a large organ that processes the function in detoxifying various metabolites, synthesizing proteins, and producing bile for digestion.
Liver diseases are medical conditions of liver damage, leading to reduced function of the liver.
There are many risk factors that cause liver diseases, including genetic preposition, viral infections and long-term use of medication and excessive alcohol drinking.
Liver diseases in most case progress slowly. However, over time the damage can lead to cirrhosis, the main cause of liver failure, and a life-threatening condition.
According to the statistic, in the US, cirrhosis and other chronic liver diseases are common disease-related causes of death. Approximately 31,000 people in the U.S. die each year from cirrhosis.
Sadly, approximately, 3.5 to 4.6 million people in the U.S. are chronically infected with the hepatitis C virus.
If you are experiencing symptoms of jaundice, persistent abdominal pain, and swelling, dark urine color, pale stool color, or bloody or tar-colored stool, please check with your doctor to rule out the possibility of liver diseases.
The most common cause of liver disease in the third world is hepatitis viral infection, it may be a result of drinking contaminated water and food and lack of clean water.
However, in the Western world, obesity is the major cause of nonalcoholic liver disease. Dr. Sandra Milić, the lead scientist in the concern of the non-alcoholic liver disease in obese wrote,
"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. Up to 80% of patients with NAFLD are obese, defined as a body mass index (BMI) > 30 kg/m2."
These results clearly suggested if you are obese you are at 80% most likely to be infected by non- alcoholic liver disease.
Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. The herbal has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and a blood purifying agent and to treat wounds and infections stomach ulcers and other digestive problems.
The herbal plant contains carbonated water, sugar,, manloid colorings, phosphoric acid, citric acid and a good amount of dietary fiber, calcium, potassium, and amino acids and chemicals compounds of guaianolide, arctinone, arctinal, methyl arctate，11-tridecadien-3，5，7，9-tetraynde-hydrocostus lactone，dehydrodihydrocostus lactone, 3-octenoic acid, 3-hexenoic acid etc.
On finding a natural remedy for the treatment of liver diseases, researchers at the Taipei Medical University examined the Arctium lappa Linne (burdock)hepatoprotective effects.
The experiment included a group of rats (n = 10) fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl(4)) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment).
Control group rats were given a liquid basal diet which did not contain absolute ethanol.
Before administrating of herbal Burdock, ethanol group and the groups receiving ethanol supplemented with CCl(4). showed significant damage to the liver.
However, treated rat groups with a dose of 300 mg/kg A. lappa administered orally 3 times per day in both the 1-day and 7-day displayed significantly improved various pathological and biochemical parameters which were worsened by ethanol plus CCl(4)-induced liver damage, including decreased levels of serum triglyceride and lipid peroxidation and serum transaminase levels.
Where the elevated levels of serum transaminase is an indication of liver damage.
The finding clearly suggested that hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.
Dr. Lin SC, the lead author wrote in the final report, "The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to another unknown protective mechanism(s)".
Moreover, in male ICR mice injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.) to induce liver damage, researchers found that injection of A. lappa significantly suppresses the serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) elevations induced by CCl4 or acetaminophen in a dose-dependent manner.
Furthermore, A. lappa also alleviated the severity of liver damage based on histopathological observations.
Where the elevation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is the indication of liver damage.
The efficacy of A. lappa in the in-depth analysis assays was found to attribute to the antioxidant activity in inhibiting the expression of free radicals induced by CCl4 or acetaminophen
A. lappa also was found to decrease the oxidative stress marker, malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice.
Dr. Lin SC the lead scientist after taking into account co and confounders said, "A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen".
Taken altogether, herbal Burdock may be considered a natural remedy for the prevention and treatment of liver disease without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride by Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY.(PubMed)
(2) Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage by Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY.(PubMed)
(3) Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations by Sandra Milić, Davorka Lulić, and Davor Štimac. (PubMed)
Tuesday, January 28, 2020
Eggplant, the Free Radical Scavengers Functional Food
Scientists may have found a whole vegetable which processes the function in balancing the ratio of free radicals and antioxidants, some studies suggested.
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to domino's effect that cannot stop until they are either pair or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administration with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radical can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the reaffirming of the effects of eggplant rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radical was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken all together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radical in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
Free radicals are unstable molecules with an unpaired electron in the outer ring. In order for them to become stable, free radicals always seek other atoms or molecules to bond to leading to domino's effect that cannot stop until they are either pair or inhibited by antioxidants
The continuation of this domino's effects is known to begin a process called oxidative stress. A prolonged period of overexpression of free radicals can cause oxidative stress, a major cause of some chronic diseases, including diabetes.
Truly, free radicals and oxidants play a dual role as both toxic and beneficial compounds. On the benefit side, according to Wanjek wrote in 2006, "The body's ability to turn air and food into chemical energy depends on a chain reaction of free radicals. Free radicals are also a crucial part of the immune system, floating through the veins and attacking foreign invaders".
Free radicals can promote toxicity to cancer cells, leading to antiproliferative and apoptotic effects without harming the nearby healthy cell if administration with dietary antioxidants or stimulated the production of antioxidants enzymes in the host through healthy food sources.
On the other hand, overexpression of free radical can be very harmful, Dr. Lien Ai Pham-Huy, the lead author in the study "Free Radicals, Antioxidants in Disease and Health" said, "When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases".
"The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements".
These analyses suggested that a healthy diet and lifestyle play a critical role in reducing the risk of imbalance of the ratio of free radicals and antioxidants by increasing the expression of antioxidants and decreasing the risk of overload of free radicals.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India. The plant has been cultivated in southern and eastern Asia since prehistory.
It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The vegetable chemical compounds include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the reaffirming of the effects of eggplant rich source of polyphenol compounds endowed with antioxidant properties, researchers launched an evaluation to compare the antioxidant activity of the extract polyphenols from eggplant entire fruit, pulp, or skin, both fresh and dry and conventional extraction and microwave-assisted extraction (MAE).
In the time exposure 15, 30, 60, and 90 min) and solvent water 100% or ethanol/water, researchers found that 50% dry peeled skin treated with 50% aqueous ethanol, exerted a good antioxidant activity expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation compared to another eggplant extract.
Furthermore, in the evaluation of the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG)(Eggplant) and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver, researchers showed that
* SAG exhibited potent and concentration-dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL).
* Reductive and iron chelation abilities also increase with an increase in SAG concentration.
* SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault.
The effect of eggplant in reducing the expression of free radical was attributed to the presence of major bioactive compounds, including gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
Dr. Elekofehinti OO, the lead scientist said, "SAG extract is a potential source of natural antioxidants that may be used not only in the pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress".
Taken all together, there is no doubt that eggplant processes a powerful antioxidants activity in the prevention of overexpression of free radical in the initiation of oxidative stress and combined with a primary theory for the treatment of oxidative stress-related diseases, depending on the confirmation of further data collection from the large example size and multi-center studies in human.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts by Salerno L, Modica MN, Pittalà V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R.(PubMed)
(2) African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling by Elekofehinti OO1, Kamdem JP, Bolingon AA, Athayde ML, Lopes SR, Waczuk EP, Kade IJ, Adanlawo IG, Rocha JB. (PubMed)
Herbal Ashwagandha, the Natural Depressant
Chronic stress is the response to emotional pressure in demanding situations over a period of time, leading to the release of hormone cortisol and adrenaline.
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.
Overtime unresolved chronic stress can cause a wide range of symptoms and increase the risk of depression.
Depression is a common and serious psychological illness, affecting the physical and mental functions of patients, including the patients feeling, thinking and acting.
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.
In severe case, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming his or herself.
According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.
Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to its relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants and monoamine oxidase inhibitors (MAOIs).
On finding a potent compound for the treatment of depression, researchers examined the effects of extracts of Withania somnifera (WSE)as an adjunctive treatment in patients with schizophrenia experiencing an exacerbation of positive symptoms.
The randomized, placebo-controlled, double-blind 12-week study included patients with schizophrenia who received 1,000 mg of standardized WSE. conducted by the University of Pittsburgh Medical Center.
Based on the 66 patients with depression symptoms, the Positive and Negative Syndrome Scale. showed the WSE exerted medium effect sizes of 0.683 (95% confidence interval [CI], 0.16 to 1.21) compared to placebo.
More importantly, the adverse effects were mild and transient, according to patient reports.
Collectively, researchers wrote after taking other factors into account, "WSE may hold promise in the treatment of depression... symptoms in schizophrenia".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention of depressive symptoms in patients with schizophrenia, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial by Gannon JM1, Brar J, Rai A, Chengappa KNR. (PubMed)
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.
Overtime unresolved chronic stress can cause a wide range of symptoms and increase the risk of depression.
Depression is a common and serious psychological illness, affecting the physical and mental functions of patients, including the patients feeling, thinking and acting.
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.
In severe case, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming his or herself.
According to the statistics provided by the Anxiety and Depression of Association of American, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.
Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to its relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants and monoamine oxidase inhibitors (MAOIs).
On finding a potent compound for the treatment of depression, researchers examined the effects of extracts of Withania somnifera (WSE)as an adjunctive treatment in patients with schizophrenia experiencing an exacerbation of positive symptoms.
The randomized, placebo-controlled, double-blind 12-week study included patients with schizophrenia who received 1,000 mg of standardized WSE. conducted by the University of Pittsburgh Medical Center.
Based on the 66 patients with depression symptoms, the Positive and Negative Syndrome Scale. showed the WSE exerted medium effect sizes of 0.683 (95% confidence interval [CI], 0.16 to 1.21) compared to placebo.
More importantly, the adverse effects were mild and transient, according to patient reports.
Collectively, researchers wrote after taking other factors into account, "WSE may hold promise in the treatment of depression... symptoms in schizophrenia".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention of depressive symptoms in patients with schizophrenia, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial by Gannon JM1, Brar J, Rai A, Chengappa KNR. (PubMed)
Green Tea: Wuyi Cliff Oolong tea and Tranquillizing Effects
Wuyi Cliff Oolong tea, the best of Oolong, one of 3 ingredients of Tava Tea, is a species of Camellia sinensis belonging to the family Theaceae, native the Wuyi Mountain area. Its leaves and leaf buds has been used as tea in Chinese culture and many places in the world, including Wuyi Rock Tea, Tie Guan Yin tea, Taiwan tea and oolong tea, Iron Goddess of Mercy and other products in Fujian, etc.. Oolong can be bought as green or black tea but it is best known as a black tea in the process of withering under the strong sun and oxidation before curling and twisting.
Health Benefits of Oolong Tea - Tranquillizing effects
In the evaluation of some fragrant compounds in oolong tea on the response of ionotropic gamma-aminobutyric acid (GABA) receptors (GABAA receptors) of the study of "Fragrances in oolong tea that enhance the response of GABAA receptors" Hossain SJ, Aoshima H, Koda H, Kiso Y.[13], researchers found that fragrant compounds were absorbed by the brain and thereby potentiated the GABAA receptor response. Both of these compounds may, therefore, have a tranquilizing effect on the brain.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Health Benefits of Oolong Tea - Tranquillizing effects
In the evaluation of some fragrant compounds in oolong tea on the response of ionotropic gamma-aminobutyric acid (GABA) receptors (GABAA receptors) of the study of "Fragrances in oolong tea that enhance the response of GABAA receptors" Hossain SJ, Aoshima H, Koda H, Kiso Y.[13], researchers found that fragrant compounds were absorbed by the brain and thereby potentiated the GABAA receptor response. Both of these compounds may, therefore, have a tranquilizing effect on the brain.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Monday, January 27, 2020
Herbal Bilberry the Best for the Prevention and Treatment of Eye Disease
Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).
Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.
Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.
The findings support the regular use of bilberry anthocyanosides as a dietary source against age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.
Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal-tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.
332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.
According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.
After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.
Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).
Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.
Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.
The findings support the regular use of bilberry anthocyanosides as a dietary source against age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.
Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal-tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.
332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.
According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.
After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.
Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
Bromelain, the Anti Acute Inflammation Whole Food
Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.
Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nervous system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.
Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.
According to the tested assays,* In vitro, bromelain modulated the immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.
* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.
* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.
In other words, through its anti-inflammatory activity, bromelain inhibited the primary long-term effect on the abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in the induction of inflammation.
Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).
Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).
Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nervous system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.
Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.
The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.
Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.
According to the tested assays,* In vitro, bromelain modulated the immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.
* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.
* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.
In other words, through its anti-inflammatory activity, bromelain inhibited the primary long-term effect on the abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in the induction of inflammation.
Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).
Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).
Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
Herbal Artichoke Promotes Healthy Levels of Triglycerides
On seeking natural therapy with no side effects, scientists may have a whole herb for the prevention and treatment of overexpression of triglycerides, according to studies.
Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acid.
The triglycerides are stored in your fat cells to energy in the future when the body needs.
Unlike cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D and aid digestive, the primary of triglycerides function is to store as unused calories and provide your body with energy.
In the health perspective, the levels of triglycerides can affect your health and risk of cardiovascular disease.
1. Normal, if your level is less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
2. Borderline high if your level is between 150 and 199 mg/dL (1.8 and 2.2 mmol/L)
3. High, if your level is between 200 and 499 mg/dL (2.3 and 5.6 mmol)
4. Very high, if your level is above 500 mg/dL (above 5.7 mmol/L)
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of obesity investigated the artichoke extract anti overexpression of triglycerides by reviewing the medical literature online.
From the databases of PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, RCTs satisfied the standard criteria and guidelines were selected to the investigation of the impact of artichoke extracts on plasma lipid levels.
According to the Meta-analysis of data from 9 trials including 702 subjects artichoke extract showed significant activity against the overexpression of plasma concentrations, including lowering the triglycerides by -9.2 mg/dL.
The injection of artichoke extract according to the selected studies did not exert any impact on the levels of high-density lipoprotein, compared to the strong effect on lowering the levels of low-density lipoprotein.
These results suggested that artichoke supplement reduced plasma lipid levels through inhibiting the levels of both total and LDL-C, and triglycerides.
Furthermore, in order to reveal more details of the artichoke effect on triglycerides, researchers examined fecal excretion of neutral bile acids and sterols in subjects after the artichoke leaf extract (ALE) intake.
The animal model study included 64 Golden Syrian hamsters (8 weeks old) fed randomly either a control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
According to the observation up to day 21, ALE injection showed no significant changes in plasma lipid levels, including non-HDL cholesterol triglycerides or fecal neutral sterols.
However, after day 42, ALE exerted a clinical significance in lowing the levels of triglycerides by 22% in males and 29% in female hamsters, compared to control.
The findings strongly suggested that ALE processes anti triglycerides accumulation by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.
According to the accumulated information, it is safe to say that artichoke may be considered a functional remedy for the treatment of elevated non-HDL cholesterol triglycerides with no side effects, pending to the validation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S. (PubMed)
Triglycerides are body fat found in humans derived from glycerol and saturated, monounsaturated, and polyunsaturated fatty acid.
The triglycerides are stored in your fat cells to energy in the future when the body needs.
Unlike cholesterol produced by the liver and absorbed through diet to build cell walls, produce steroid hormone and vitamin D and aid digestive, the primary of triglycerides function is to store as unused calories and provide your body with energy.
In the health perspective, the levels of triglycerides can affect your health and risk of cardiovascular disease.
1. Normal, if your level is less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
2. Borderline high if your level is between 150 and 199 mg/dL (1.8 and 2.2 mmol/L)
3. High, if your level is between 200 and 499 mg/dL (2.3 and 5.6 mmol)
4. Very high, if your level is above 500 mg/dL (above 5.7 mmol/L)
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of obesity investigated the artichoke extract anti overexpression of triglycerides by reviewing the medical literature online.
From the databases of PubMed-Medline, Scopus, Web of Science and Google Scholar databases up to March 28, 2017, RCTs satisfied the standard criteria and guidelines were selected to the investigation of the impact of artichoke extracts on plasma lipid levels.
According to the Meta-analysis of data from 9 trials including 702 subjects artichoke extract showed significant activity against the overexpression of plasma concentrations, including lowering the triglycerides by -9.2 mg/dL.
The injection of artichoke extract according to the selected studies did not exert any impact on the levels of high-density lipoprotein, compared to the strong effect on lowering the levels of low-density lipoprotein.
These results suggested that artichoke supplement reduced plasma lipid levels through inhibiting the levels of both total and LDL-C, and triglycerides.
Furthermore, in order to reveal more details of the artichoke effect on triglycerides, researchers examined fecal excretion of neutral bile acids and sterols in subjects after the artichoke leaf extract (ALE) intake.
The animal model study included 64 Golden Syrian hamsters (8 weeks old) fed randomly either a control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
According to the observation up to day 21, ALE injection showed no significant changes in plasma lipid levels, including non-HDL cholesterol triglycerides or fecal neutral sterols.
However, after day 42, ALE exerted a clinical significance in lowing the levels of triglycerides by 22% in males and 29% in female hamsters, compared to control.
The findings strongly suggested that ALE processes anti triglycerides accumulation by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.
According to the accumulated information, it is safe to say that artichoke may be considered a functional remedy for the treatment of elevated non-HDL cholesterol triglycerides with no side effects, pending to the validation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis by Sahebkar A1, Pirro M2, Banach M3,4, Mikhailidis DP5, Atkin SL6, Cicero AFG. (PubMed)
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S. (PubMed)
Sunday, January 26, 2020
The Effects of Calendula (Calendula officinalis) on Cancers
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Calendula (Calendula officinalis) and Cancers
The study of Calendula against the Angiogenesis for the growth, invasion, and metastasis of most solid tumors, indicated the positive effect through its antiangiogenic activity via exhibited selectivity against the endothelial cells proliferation(1). Its extract, according to Universidad de Granada, also showed to exhibit cytotoxic tumor cell activity and induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival day of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, Calendula officinalis flower extract showed to reduce the lung tumor nodules by 74% with 43.3% increase in life span, probably through the inhibition of key enzymes involved in processes of metastasis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Calendula (Calendula officinalis) and Cancers
The study of Calendula against the Angiogenesis for the growth, invasion, and metastasis of most solid tumors, indicated the positive effect through its antiangiogenic activity via exhibited selectivity against the endothelial cells proliferation(1). Its extract, according to Universidad de Granada, also showed to exhibit cytotoxic tumor cell activity and induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival day of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, Calendula officinalis flower extract showed to reduce the lung tumor nodules by 74% with 43.3% increase in life span, probably through the inhibition of key enzymes involved in processes of metastasis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Herbal Artichoke, Protects Your Upper Digestive Tract Against Functional Dyspepsia (FD)
Functional dyspepsia (FD) is a chronic condition characterized by burning sensation caused by uncoordinated and ineffectual emptying of the upper digestive tract with no measurable structural abnormalities.
Functional dyspepsia (FD) are subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
According to statistics, approximately 20-45% of Canadians have such condition, but only a low percentage of patients seek help from physicians. and functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients, compared to other races.
The exact causes of functional dyspepsia are unidentified. Some researchers suggested that excessive acid secretion, inflammation, food allergies, unhealthy lifestyle choice and long term use of medications may have strong implications in the onset of the syndrome.
Pain, digestive discomforts such as fullness and bloating, excessive burping, nausea, and sometimes vomiting GERD, a sour taste in the mouth are the most common symptoms of functional dyspepsia.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility.
Some researchers suggested that unhealthy dietary habits are one of the major risk factors associated with the onset of FD in the world.
Dr. Ji-Hao Xu, the lead scientist in the assessment of dietary habit in the risk of FD, wrote, "Unhealthy dietary habits were more prevalent in the FD group than in the control groups (75.86% versus 37.50%; p<0.001). FD was found to be associated with irregular mealtime, dining out, fatty food, sweet food, and coffee (p<0.05). The impact of each dietary factor varied with FD subtypes".
And, "Certain types of dietary habits were positively correlated with the prevalence of FD. FD subtypes showed relatively different associations with dietary factors".
The finding strongly suggested by following a healthy diet pattern, FD may be preventable.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On the finding a natural therapeutics for the treatment of functional dyspepsia (FD), researchers compared the efficacy of ginger and artichoke supplementation (SG) versus placebo in the treatment of FD.
The prospective multicentre, double-blind, randomized, placebo-controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks included 126 FD patients given 2 capsules/day (before lunch and dinner (supplementation/placebo: 65/61).
After 14 days, supplement treatment showed a significant amelioration of FD, compared to placebo.
SG treatment group also showed a significant reduction of nausea, epigastric fullness, epigastric pain, and bloating compared to placebo.
Dr.Giacosa A, the lead scientist wrote, "The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease".
In order to reveal more information about artichoke anti-FD property, researchers assessed the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD).
The double-blind, randomized controlled trial (RCT) included 247 patients with functional dyspepsia treated with either a commercial ALE preparation (2 x 320 mg plant extract t.d.s.) or a placebo.
ALE improved the overall symptom significantly over the 6 weeks compared to the placebo
Similarly, patients treated with ALE also showed significantly greater improvement in the global quality-of-life scores (NDI) compared to the placebo.
Dr. Holtmann G, the lead scientist after taking into account co and confounders wrote in the final report, "he ALE preparation tested was significantly better than the placebo in alleviating symptoms and improving the disease-specific quality of life in patients with functional dyspepsia".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of functional dyspepsia (FD), pending to the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial by Giacosa A1, Guido D2, Grassi M2, Riva A3, Morazzoni P3, Bombardelli E3, Perna S4
(2) Efficacy of artichoke leaf extract in the treatment of patients with functionaldyspepsia: a six-week placebo-controlled, double-blind, multicentre trial by Holtmann G1, Adam B, Haag S, Collet W, Grünewald E, Windeck T. (PubMed)
(3) Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area by Xu JH1, Lai Y1, Zhuang LP2, Huang CZ1, Li CQ1, Chen QK1, Yu T1. (PubMed)
Functional dyspepsia (FD) are subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
According to statistics, approximately 20-45% of Canadians have such condition, but only a low percentage of patients seek help from physicians. and functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients, compared to other races.
The exact causes of functional dyspepsia are unidentified. Some researchers suggested that excessive acid secretion, inflammation, food allergies, unhealthy lifestyle choice and long term use of medications may have strong implications in the onset of the syndrome.
Pain, digestive discomforts such as fullness and bloating, excessive burping, nausea, and sometimes vomiting GERD, a sour taste in the mouth are the most common symptoms of functional dyspepsia.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility.
Some researchers suggested that unhealthy dietary habits are one of the major risk factors associated with the onset of FD in the world.
Dr. Ji-Hao Xu, the lead scientist in the assessment of dietary habit in the risk of FD, wrote, "Unhealthy dietary habits were more prevalent in the FD group than in the control groups (75.86% versus 37.50%; p<0.001). FD was found to be associated with irregular mealtime, dining out, fatty food, sweet food, and coffee (p<0.05). The impact of each dietary factor varied with FD subtypes".
And, "Certain types of dietary habits were positively correlated with the prevalence of FD. FD subtypes showed relatively different associations with dietary factors".
The finding strongly suggested by following a healthy diet pattern, FD may be preventable.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On the finding a natural therapeutics for the treatment of functional dyspepsia (FD), researchers compared the efficacy of ginger and artichoke supplementation (SG) versus placebo in the treatment of FD.
The prospective multicentre, double-blind, randomized, placebo-controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks included 126 FD patients given 2 capsules/day (before lunch and dinner (supplementation/placebo: 65/61).
After 14 days, supplement treatment showed a significant amelioration of FD, compared to placebo.
SG treatment group also showed a significant reduction of nausea, epigastric fullness, epigastric pain, and bloating compared to placebo.
Dr.Giacosa A, the lead scientist wrote, "The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease".
In order to reveal more information about artichoke anti-FD property, researchers assessed the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD).
The double-blind, randomized controlled trial (RCT) included 247 patients with functional dyspepsia treated with either a commercial ALE preparation (2 x 320 mg plant extract t.d.s.) or a placebo.
ALE improved the overall symptom significantly over the 6 weeks compared to the placebo
Similarly, patients treated with ALE also showed significantly greater improvement in the global quality-of-life scores (NDI) compared to the placebo.
Dr. Holtmann G, the lead scientist after taking into account co and confounders wrote in the final report, "he ALE preparation tested was significantly better than the placebo in alleviating symptoms and improving the disease-specific quality of life in patients with functional dyspepsia".
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of functional dyspepsia (FD), pending to the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial by Giacosa A1, Guido D2, Grassi M2, Riva A3, Morazzoni P3, Bombardelli E3, Perna S4
(2) Efficacy of artichoke leaf extract in the treatment of patients with functionaldyspepsia: a six-week placebo-controlled, double-blind, multicentre trial by Holtmann G1, Adam B, Haag S, Collet W, Grünewald E, Windeck T. (PubMed)
(3) Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area by Xu JH1, Lai Y1, Zhuang LP2, Huang CZ1, Li CQ1, Chen QK1, Yu T1. (PubMed)
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