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Friday, October 21, 2016

Chinese Herbal Therapy – She Chuang Zi (Fructus Cnidii Monnieri)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

          She Chuang Zi (Fructus Cnidii Monnieri) 

She Chuang Zi is also known as Cnidium Fruit. The acrid, bitter and warm herb has been used in TCM as anti-histamine, anti-allergenic, anti arrhythmia, anti-fungal, anti-bacterial and sedative agent and to improve immune system, bone strength, etc., as it warms the Kidneys,strengthens the Yang, disperses Cold, expels Wind, dries Dampness, expels worms and parasites, etc. by enhancing the functions of kidney, triple warmer channels.

1. L-Pinene
2. Bornyl isovalarate
3. Osthol
4. Columbianadin
5. Berapten
6. Cnidiadin
7. Isopimpinellin
8. Etc.

Health Benefits
1. Anti-tumor activities
In recent years, rather active investigations of its anti-tumor were performed at home and abroad. C. monnieri possesses multi-aspect and comprehensive anti-tumor functions, involving directly tumor-inhibitory activity, anti-mutagenicity, reversing multi-drug tolerance of tumor, as well as improving immune functions and so on. In this review, chemical constituents, anti-tumor activities and relevant investigations of Fructus Cnidii were summarized recent decade(1).
2. Anti-allergic effects
In the study to investigate the anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri),on 48 h homologous passive cutaneous anaphylaxis (PCA), showed that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol(2).
3. Cytotoxic activity
In the investigation of five coumarins: osthol, imperatorin, bergapten, isopimpinellin, and xanthotoxin of the CmF(fruits of Cnidium monnieri) extract, among these compounds, osthol showed the strongest cytotoxic activity on tumor cell lines, imperatorin showed the highest sensitivity to HL-60 cells and the least cytotoxicity to normal PBMCs. Osthol and imperatorin both caused apoptotic bodies, DNA fragmentation, and enhanced PARP degradation in HL-60 cells by biochemical analysis. These results indicate that osthol and imperatorin can induce apoptosis in HL-60 cells(3).
4. Antifibrotic activity
In the investigation of activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10), showed that of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells(4).
5. Antiosteoporotic activity
In the study to evaluate the Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i. e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson, showed that among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoclasts derived from rat marrow cells(5).
6. Antipruritic effect
In the study of the Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae), found that in mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior(6).
7. Osteoporosis
In the study to compare the total coumarins from dried fruits of Cnidium monnieri (TCCM) and nilestriol (Nil) against osteoporosis, found that Ova reduced markedly the trabecular bone mass due to bone resorption excessed bone formation (% Tb. Ar -59%). Treatment with TCCM 67 partly suppressed bone turnover, but did not inhibit bone loss in Ova rats (% Tb.Ar -43%). Treatment with TCCM 200 and Nil 1 increased the trabecular area (% Tb. Ar +100% and +274%)(7).
8. Inhibition of itch-scratch response
In the study to screen the anti-itching activities of 33 herbal medicines in substance P (SP)-induced itching model mice, suggest that The chloroform-soluble fraction of the methanol extract of of fruits of Cnidium monnieri (Cnidii Fructus) markedly inhibited SP-induced scratching. Among 10 subfractions of the chloroform-soluble fraction, the CS-3 fraction had the most potent inhibitory effect on scratching(8).
9. Etc.

Side Effects
1. Do not use the herb in case of kidney Yin deficiency or liver fire ascending
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.


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