Saturday, September 17, 2016

Children Health: Precocious Puberty - Central precocious puberty

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Precocious Puberty 

 Precocious Puberty refers to the sexual and physical characteristics matureoccurring at an unusually early age such as before age 7 or 8 in girls and age 9 for boys.

                              Understand the process of puberty 

The process of puberty begins with production of gonadotropin-releasing hormone (Gn-RH) from the brain, which in turn stimulates the pituitary gland to produce the luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These two hormones again stimulates the ovaries in girls and testicles in boys to produce estrogen and testosterone responsible for the growth and development of girl and male sexual characteristics respectfully.

                                       Central precocious puberty

Central precocious puberty can be caused by abnormal function of hypothalamus in secretion of high-amplitude pulses of gonadotropin-releasing hormone (GnRH) by the hypothalamus, leading to high amount of female sexual characteristic, causing precocious puberty.
The high-amipliyude pulse of gonadotropin-releasing hormone (GnRH) by the hypothalamus can be result of
1. Damage to the inhibitory system of the brain as a result of infection, trauma, or irradiation.

2. McCune-Albright syndrome that effects the hormonal production.

3. Injure to the central nervous system
Injure to the central nervous system can result in disruption of production of certain hormones which can contribute to onset of early poverty.

4. Congenital adrenal hyperplasia due to inherited disorders causing the abnormal hormone production by the adrenal glands.

5. Congenital hypothyroidism
In the study of Precocious puberty with congenital hypothyroidism by Abdelrahman M Radaideh, Mohamad Nusier, Zeyad El-Akawi & Duried Jaradat, resaerchers conclude that where vaginal bleeding occurs in young girls,hypothyroidism should be considered especially when vaginal bleeding is accompanied with additional clinical presentations such as short stature, delayed boneage and multicystic ovaries. Thyroxin replacement therapy should lead to complete resolution of suchdisorder and promote normal physical and mental development of young girls.

6. Hypothalamic hamartoma
in an article of Precocious Puberty and Hypothalamic Hamartoma by Hillel I. Hochman, David M. Judge, Seymour Reichlin, indicated that The clinical, endocrinologic, and pathologic features of published cases of precocious puberty and hypothalamic hamartoma are reviewed. Advanced or rapidly progressive true precocious puberty in the very young with elevated concentrations of blood gonadotropins and gonadal steroids and positive pneumoencephalography appear to be characteristic.

7. Etc.

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