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Ren Dong Teng (Caulis Lonicerae)
Ren Dong Teng is also known as Japanese Honeysuckle Stem. The sweet and cold herb has been used in TCM as Anti-inflammatory and Anti-spasm agent and to enhance the heart function, lower blood cholesterol, etc. as it clears Heat, expels toxins, disperses Wind-Heat-Damp, calms pain, etc. by enhancing the functions of heart and lung channels.
Ingredients
1. Chlorogenic acid
2. Isochlorogenic acid
3. L:oganin
4. Secologanin dimethylacetal
5. Secologanin dimethylacetal
6. Vogeloside
7. Epi-vogeloside[2]
8. Hederagenin-3-O-α-L-rbinopyranoside
9. Hederagenin-3-O-β-D-glucopyranosyl(1→2)-α-L-arabinopyranoside
10. Hederagenin-3-O-α-L-arabinopyranosyl-28-O-β-D-glucopyranosyl(1→6)- β-D-glucopyranoside
11. Etc.
Health Benefits
1. Liver protective effects
In the study to investigate the Protective effects of 41 Taiwan crude drugs on rat hepatic injuries caused by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT)found that the methanol extracts of Elephantopi Herba and Lonicerae Flos inhibited the release of intrahepatic enzymes and histological changes by CCl4(1).
2. Phagocytosis
Twenty-six herbal preparations made from 24 medicinal herbs, categorized as antipyretics in Chinese materia medica, were tested in vitro to determine their effects upon phagocytosis of 32P-labelled Staphylococcus aureus by neutrophils isolated from bovine blood and milk, showed that when compared with PBSS (0.01 M phosphate buffered saline solution) controls, most of the herbs at high concentrations inhibited phagocytosis while at lower concentrations phagocytosis was increased. All 26 herbal preparations significantly increased blood neutrophil activity at their proper concentrations. The most active herbs in promoting blood neutrophil phagocytosis were observed for Herba verbenae, Flos chrysanthemi, Flos lonicerae, Radix sophorae flavescentis, Herba houttuyniae, Radix isatidis, Herba patriniae(2).
3. Inhibition of platelet activation
In the study to evaluate the effects of the polyphenolic compounds isolated from Lonicera japonica Thunb on platelet aggregation, platelet thromboxane biosynthesis and hydrogen peroxide-induced endothelial cell injury, showed that the inhibitory effect on platelet activation and the cytoprotective effect on hydrogen peroxide-induced cell injury may explain the possible role of polyphenolic compounds isolated from Lonicera japonica Thunb in maintaining vascular homeostasis(3).
4. Regulation of Proinflammatory Mediators
In teh study to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea L. japonica T. by nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinases (MAPKs) pathway, indicated that that polyphenol components isolated from Korea L. japonica T. should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-κB and p38 MAPK activity(4).
5. HepG2 Cells
In the study to investigate the anti-cancer and hepatic protective effect of Lonicera japonica Thunb. (L. japonica T.), found that Polyphenolic extract also decreased the expression of CDK1, CDC25C, cyclin B1, pro-caspases-3 and -9 and poly ADP ribose polymerase, and affected the levels of mitochondrial apoptotic-related proteins. The phosphorylation of extracellular signal-related kinase ½ (ERK 1/2), c-Jun N-terminal kinase (JNK), and p-38 mitogen-activated protein kinases (MAPKs) were increased in HepG2 cells treated with polyphenolic extract, whereas Akt was dephosphorylated. These results indicate that inhibition of PI3K/Akt and activation of MAPKs are pivotal in G2/M cell cycle arrest and apoptosis of human hepatocarcinoma cells mediated by polyphenolic extract(5).
6. Neuroprotective effects
in the investigation of the neuroprotective effects of Lonicera japonica THUNB. extract (LJ) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells, showed that LJ has a potent anti-parkinsonism; this effect was mediated, at least in part, by inhibition of neurotoxicity, apoptotic cascade events, and oxidative stress via activation of MAPKs, PI3K/Akt, and NF-κB(6).
7. Etc.
Side Effects
1. Do not use in case of spleen deficiency
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
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