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Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.
Human menopause gonadotrophins (HMG) Effects in Female Infertility
Human menopausal gonadotropins (HMG) contain both (LH) luteinizing hormone(LH) and follicle stimulating hormone(FSH) which are used for women with ovulation disorder by triggering the ovulation in production of follicle and egg. HMG is one of the fertility medical treatment which may be necessary for women, if artificial insemination is required such as IUI, IVF and other ART.
2. How HMG effects infertile women
By using the HMG to increase the levels of LH and FSH as resulting of inability of pituitary gland in LH, and FSH production, it helps to stimulate ovulation as we mentioned in previous article.
a) Ovulatory disorders
Ovulatory disorder ussually caused by low levels of LH and FSH as resulting in either of low levels of estrogen or damage of hypothalamus in releasing of GrNH, HMG increases the levels of LH and FSH directly without the need of hypothalamus secretion.
b) Pituitary gland abnormality
For what ever reason, some women's pituitary gland is not responsed to the secreting of the GrNH in production of LH and FSH or low levels of LH and FSH as resulting of pituitary gland malfunction. HMG increases levels of FH and FSH naturally, leading to ovulation.
c) Eggs production
HMG besides enhancing ovulation, it also acts directly to the ovarian in follicle and mature eggs production.
3. Side effects
a) Hyperovarian stimulation as resulting of over production of follicles inside of the ovaries.
b) Nervous disorder as resulting of interfering of hormone production. Symptoms include mood swing and depression.
Increasing the risk of multiple pregnancy by 40% of all pregnancies.
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