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Duodenal ulcers, a type of peptic ulcer is defined as a condition of a localized tissue erosion in the lining the duodenum as a result of bacteria Helicobacter pylori (H pylori) in most cases. According to the study by Department of Research, University Hospital, Basel, fasting gastrin and pepsinogen-I and -II concentrations were significantly higher in H pylori positive compared with H pylori negative subjects. Neither age nor sex affected basal gastrin and pepsinogen concentrations in H pylori negative subjects. Fasting gastrin, pepsinogen-I and -II concentrations in serum samples were similar in H pylori positive persons with no symptoms and those with duodenal ulcers suggesting that similar mechanisms are involved in increasing plasma concentrations of these variables in both populations. Hypergastrinaemia and hyperpepsinogenaemia are therefore probably secondary to active H pylori infection(1).
Herbal drugs have been proved to be very effective in treatment of hyperacidity, gastric and duodenal ulcer, include mucus: Lini semen, Psylli semen, Foenugraeci semen, Althaeae radix/folium, Sinapis albae semen; antiphlogistic volatile-oils: Chamomillae anthodium, Millefolii herba, moreover Glycyrrhizae radix, Aloe gel, according to the study of [Herbs and herbal preparations applied in the treatment of gastric hyperacidity, gastric and duodenal ulcer in cigarette smokers(34)].
2. Peloidin (Reloidinum).
Oral administration and electrophoresis of peloidin, extract from the silt mud are beneficial in the lesions of the gastric and duodenal mucosa. Plants infusions per os combined with the exposure to sinusoidal modulated currents can be recommended in the disease aggravations, scarry ulcerative deformities(35).
3. Spices, herbal xenobiotics
Despite a number of reports on the toxicity of herbs and spices, they are generally accepted as safer alternatives to conventional therapy against gastric ulcers. But excessive consumption of spices may favor the pathogenesis of gastric and duodenal ulcer and some studies have substantiated this common perception, according to the study of “Spices, herbal xenobiotics and the stomach: friends or foes”(36).
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