Thursday, August 15, 2019

Green Tea in Protection Against Chronological and Photo Aging

Although no one can avoid aging, the process can be slow down. Green tea may have a potential and positive effect in delay the process through its anti-aging phytochemicals, some scientists suggested.


The investigation of green tea properties in anti-aging effect was found to associate many different mechanisms involved the expression of some major polyphenols.

According to the investigation of the experiment of 45 male mice model divided into 5 groups induced aging through injection of d-galactose in the period of 8 weeks in compared to positive control fed with Vitamin C (VitC), mice treated with green tea, bioactive Epigallocatechin gallate(EGCG) once a day by subcutaneously inject after 5h of injecting d-galactose exerted a antioxidant effect in improved overall skin condition and whole structure of skin in compared to positive control at the end of study.


Further analysis also found that the chemical constituents of green tea inhibited the overproduction of oxidative stress caused by the injection of d-galactose through neutralized ROS insults to maintain good dermal health.


Interestingly, compared to control, green tea EGCG also increased the expression of epidermal growth factor in stimulated skin growth at the cellular level and increase collagen production in protecting skin against aging senility.



Moreover, the evaluated characteristics of human skin and how photo-aging (extrinsic aging) occur via the impact of ROS production by cascade signaling pathways indicated that administration of green tea extracts (GTEs) protects the affect of aging skin through inhibited cutaneous erythema induced of redness of the skin, thickening of the epidermis involved overexpression of CK5/6 in promoted cutaneous neoplasms, a new and abnormal growth of skin tissue and cytokeratin(CK16) in induction of expression in abnormal skin epithelial patterns.

Indeed, the expression green tea also showed a strong implication in reduced matrix metalloproteinases 2-9 (MMP-2, MMP-9) activities in elevated skin changes and depletion of CD1a(+) LCs in the induction of skin inflammation, caused by UVR application

In chronological (intrinsic) aging, administration of polyphenols, which are secondary plant metabolites also found to protect against skin aging through the exhibition of antioxidant and anti-inflammatory effects, according to the existing literature, linking skin aging and the ability of polyphenols as regulatory elements with function in maintained skin homeostasis.

Dr. Davinelli S, said at end of the study, "Polyphenols exert their influence mostly through their antioxidant and anti-inflammatory effects, thereby abrogating collagen degradation and/or increasing procollagen synthesis".

Finally, in the 33 healthy Asian subjects, all men enrolled after consent in a placebo-controlled comparative study with a split face design with one group applied multiple emulsions with green tea and the second group applied multiple emulsions with lotus extract, while a third group applied a multiple emulsion with a combination of both extracts, once daily over the 60-day treatment researchers found that all groups show a significant improvement in skin roughness (SEr), scaliness (SEsc), smoothness (SEsm), and wrinkling (SEw). In compared to the other 2 groups, green tea and lotus combined in multiple emulsions brought a superior synergistic anti-aging effect.

Dr. Mahmood T, the lead author, after taking into account of other confounders, said, "diverse anti-oxidant constituents in both plants have a potential influence on skin surface parameters, thus indicating these plants as the future of new anti-aging products".

Taken together, green tea bioactive polyphenols may be considered as a functional food used as a topical or oral injection to delay skin aging process through overexpression antioxidant in improved in both chronological (intrinsic) and photo-aging (extrinsic) aging.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Combined topical application of lotus and green tea improves facial skin surface parameters by Mahmood T1, Akhtar N.(PubMed)
(2) Protective effects of green tea extracts on photoaging and photommunosuppression by Li YH1, Wu Y, Wei HC, Xu YY, Jia LL, Chen J, Yang XS, Dong GH, Gao XH, Chen HD.(PubMed)
(3) Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d-Galactose by Chen J1, Li Y2, Zhu Q1, Li T1, Lu H1, Wei N2, Huang Y1, Shi R2, Ma X3, Wang X4, Sheng J5.(PubMed)
(4) Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage by
Davinelli S, et al. Curr Pharm Des. 2017(PMC)

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