Allergic diseases are a class of conditions characterized by an overreaction of the immune system to substances which cause little or no harm to the body.
Investigation of the effect of green tea bioactive compounds in reduced abnormal immune allergic expression was found to associate to certain mechanisms.
According to the Kyushu University, Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) isolated from cv. "Benifuuki" green tea expressed strong and positive activities in inhibited the mast cell production in precipitated allergic inflammatory responses and suppressed the high-affinity IgE receptor (FcεRI) function in the expression of immunoglobulin E (IgE), an antibody isotype involved allergy disorder through 67 kDa laminin receptor in the mediation of the suppressive effect by epigallocatechin-3-O-gallate.
Further analysis also found that the bioactive compound binds to 67 kDa laminin receptor to attenuate allergic expression induced by mast cell by suppressing the myosin light chain phosphorylation in regulated immune response to eosinophil (a type of disease-fighting white blood cell) migration in the tissue, a characteristic feature of allergic diseases and ERK1/2 phosphorylation signalling by modulation of inflammatory cytokines expression.
A double-blind clinical study of the green tea effect on subjects exposed to Japanese cedar pollinosis, administration of Benifuuki green tea containing O-methylated catechins showed a significantly relieving allergic symptoms induced by pollen such as nose blowing, eye itching in compared with the placebo group without effecting the normal immune responses.
More interestingly, in mouse bone marrow-derived mast cells activated by antigens, bioactive compound epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) in combination with ginger extract also demonstrated a strongly anti-delay-type allergic effect by suppressing cytokines secretion of tumor necrosis factor (TNF-α), a cell-signaling protein (cytokine) in response to systemic inflammation in the acute phase infection. and macrophage Inflammatory Proteins(MIP-1α), a chemokine involved host response to invading bacteria and virus.
In compared to the dose of 5.1 times higher in EGCG, injection of 8.5 mg of EGCG3″Me exhibited a much stronger anti-allergic activity than 43.5 mg of EGCG, observed by the area under curve AUC (area under the drug concentration-time curve; min μg/ml) of 6.72 ± 2.87 in EGCG and 8.48 ± 2.54 in EGCG3″Me.
Taken together, green tea with abundantly bioactive Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me) may be considered as a functional food for protection against autoimmune response stimulated by unharmful allergens.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Anti-Allergic Action of O-methylated EGCG in Green Tea Cultivar Benifuuki by MARI MAEDA-YAMAMOTO1 * AND HIROFUMI TACHIBANA2(Journal of Food and Drug Analysis, Vol. 20, Suppl. 1, 2012, Pages 313-317)
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)(2) In vitro and in vivo anti-allergic effects of ‘benifuuki’ green tea containing O-methylated catechin and ginger extract enhancement by Mari Maeda-Yamamoto,
1 Kaori Ema,1 and Ikuo Shibuichi2(PubMed)
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