Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.
The kidneys, a pair of bean-shaped organs on either side of your spine are the second detoxed organ after liver by removing wastes or toxins in the blood come from the normal breakdown of active muscle and from the food you eat.
Most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.
In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.
Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.
* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.
Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.
Conventionally, most cases of the renal toxicity are treated with cisplatin often associated with an acute kidney injury. Long-term intake of the aforementioned drugs has been found to elevate the risk of nausea and vomiting, kidney toxicity, hearing loss, ringing in the ears particularly blood abnormalities of low levels of magnesium, calcium, and potassium.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of renal toxicity scientists investigated the nephroprotective effect of essential oils from Nigeria ginger and turmeric rhizomes in cadmium-treated rats.
Injection of essential oils from ginger and turmeric rhizomes exerted a significant anti-inflammatory effect by preventing alterations of renal function markers induced by cadmium.
Futhermore, the combination also inhibited the levels of cytokines such as IL-6, IL-10, and TNF-Alpha) levels in Cd-treated rats.
Moreover, renal adenosine deaminase (ADA) activity. in Cd-treated rats also decreased by the injection of the combined essential oils from ginger and turmeric rhizome.
Based on the finding, researchers write in the final report, "inhibition of ADA activity and modulation of inflammatory cytokines could be suggested as the possible mechanism of action by which essential oils from ginger and turmeric rhizomes exert their nephroprotective activities".
Furthermore, in 1,350 participants selected to the study were randomly divided into either curry intake group with the consumption of a curry dish more than once a month over the previous year, or a non-curry intake group (n = 747), researchers found that according to the heavy metal analysis, the curry intake group showed significantly lower heavy metal blood concentrations (Pb, Hg, and Cd).
However, the levels of heavy metals in the patients with hypertension were significantly lower in curry intake group compared to the nonhypertension group.
The levels of blood concentrations of heavy metals induced toxicity associated with the induction of hypertension were significantly lower compared to the placebo.
In other words, turmeric has a potential effect on reducing renal toxicity.
In order to obtain more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced nephrosis.
Additionally, turmeric extract inhibited the DOX-induced increase in plasma creatine kinase (CK) associated with the increased risk of kidney disease.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the renal.....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Nephroprotective Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes against Cadmium-induced Nephrotoxicity in Rats. by Akinyemi AJ1, Faboya OL2, Paul AA3, Olayide I1, Faboya OA4, Oluwasola TA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
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