Wednesday, August 31, 2016

Herbal therapy: Popular Herbal Skullcap (Scutellaria)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                            Skullcap (Scutellaria)

Skullcap is a flowering plants in the genus Scutellaria, belonging to the family Lamiaceae, native to North America. The herb has been used in traditional medicine as anti-asthmatic, antifungal, antioxidative, and anti-inflammatory agent and to relieve tension, lower blood pressure, to treat nervous tension and eases muscle tension, spasms, etc.

Health Benefits
1. Breast cancer
In the investigation of The cytotoxicity of Pa-PDT (Pheophorbide-a (Pa)), an active component of Scutellaria barbatawas evaluated by using an estrogen receptor (ER)-negative human breast adenocarcinoma cell line MDA-MB-231, found that Pa-PDT exhibited its anti-tumor effects by the activation of mitochondria-mediated apoptosis and the ERK-mediated autophagy in MDA-MB-231 cells and concluded that suggested Pa-PDT is a potential protocol for the late phase human breast cancer, according to "Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231" by Bui-Xuan NH, Tang PM, Wong CK, Fung KP.(1)

2. Liver diseases
In the evaluation of the anti-proliferative effects on human hepatoma HepG2 and Hep3B cells of each fraction of Pheophorbide a, a major antitumor component purified from Scutellaria barbata, found that pheophorbide a induced apoptosis in Hep3B cells, a viral-induced hepatoma cell line. However, it was found to be non-toxic in normal human liver cells WRL-68. DNA fragmentation, sub-G1 cell cycle arrest, as well as suppression of the anti-apoptotic protein Bcl-2, release of cytochrome c to the cytosol, and activation of pro-caspase 3 and pro-caspase 9 were observed when Hep3B cells were treated with 40 microg/mL (i. e., 67.5 microM) pheophorbide a for 48 hours, according to "Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells" by Chan JY, Tang PM, Hon PM, Au SW, Tsui SK, Waye MM, Kong SK, Mak TC, Fung KP.(2)

3. Antitumor activity
In the testing of The IC(50) values of of an ethanol extract of SB on the cancer cell lines tested ranged from 16 to 70 microg/mL after 48 h of treatment, found that The antitumor activity of CE-SB in vivo was also evaluated. At 60 mg/kg/day, CE-SB significantly inhibited the solid tumor proliferation and increased the life span of ascites tumor bearing mice (p < 0.01). CE-SB was subjected to bioassay-guided isolation of the active compounds by chromatography on silica gel and Sephadex LH-20. Phytol, wogonin, luteolin and hispidulin were obtained as cytotoxic constituents, according to "Antitumor activity of chloroform fraction ofScutellaria barbata and its active constituents" by Yu J, Liu H, Lei J, Tan W, Hu X, Zou G.(3)

4. Cavernous smooth muscle
In the observation of o investigate whether an ethanol extract of Scutellariabaicalensis (ESB) relaxes penile corpus cavernosum muscle, found that suggest that ESB relaxed rabbit cavernous smooth muscle via the NO/cGMP system and Ca(2+)-sensitive K(+) channels in the corpus cavernosum, according to "Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle" by Li X, Oh HC, Son SB, Lee YJ, Kang DG, Lee HS.(4)

5. Cholesterol
In the evaluation of the effect of the Baikal skullcap root (Scutellaria baicalensis radix) on the cholesterol level and chemical composition of the hind leg muscles of rabbits, found that Using a Baikal skullcap root with hypercholesterolemic diet (group CH+SR) caused significant reduction (P < or = 0.05) in total cholesterol level in comparison with hypercholesterolemic diet (CH group), according to "Effect of baikal skullcap root (Scutellaria baicalensis radix) on cholesterol level and meat quality in rabbits fed a cholesterol rich diet" by Króliczewska B, Miśta D, Zawadzki W, Skiba T.(5)

6. Anticonvulsant activity
In the analyzing the chemical ingredients of American skullcap and to evaluate its anticonvulsant activity, found that (1) phenolic compounds, especially flavonoids, are the predominant constituents in American skullcap; (2) American skullcap products have similar constituents, but the content and relative proportions of the individual constituents varies widely; and (3) American skullcap has anticonvulsant activity in rodent models of acute seizures, according to "Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora)" by Zhang Z, Lian XY, Li S, Stringer JL.(6)

7. Antioxidants
In the Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellariaracemosa: genome size, antioxidant potential, found that Antioxidant potential studies showed that there were no significant differences in the 3 Scutellariaspecies. Phytochemical analyses detected and quantified the flavonoids baicalin, baicalein, scutellarin, and wogonin as well as the human neurohormones melatonin and serotonin in leaf and stem tissues from S. baicalensis, S. lateriflora, and S. racemosa, according to "Comparisons of Scutellaria baicalensis, Scutellarialateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry" by Cole IB, Cao J, Alan AR, Saxena PK, Murch SJ.(7)

8. Neurodegeneration diseases
In the study of flavones isolated from Scutellaria baicalensis root exhibit strong neuroprotective effects on the brain, found that Baicalein, the main flavone present in Scutellaria baicalensis root, strongly inhibited aggregation of neuronal amyloidogenic proteins in vitro and induces dissolution of amyloid deposits. It exerts strong antioxidative and anti-inflammatory activities and also exhibits anti-convulsive, anxiolytic, and mild sedative actions. Importantly, baicalein, and also another flavone: oroxylin A, markedly enhanced cognitive and mnestic functions in animal models of aging brains and neurodegeneration, according to "Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?" by Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Błach-Olszewska Z, Aliev G.(8)

9. Anti-inflammatory activity
In the investigation of the antioxidant, anti-inflammatory, and cytotoxic activities of water and ethanol extracts of 14 Chinese medicinal plants found that five plant extracts (S. baicalensis, T. chinensis, S. japonica, Mahonia fortunei , and Sophora flavescens ) exhibited significant anti-inflammatory activity by in vitro inhibition of the production of NO and TNF-α with low IC(50) values, according to "Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds" by Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Münch G, Wu MJ.(9)

10. Ageing-related cognitive impairment
In the research of the effects of flavonoid, isolated from aerial parts of Scutellariabaicalensis Georgi (SSF), on memory impairment, neuronal damage, free radicals and energy metabolite disorders in aged rats, found that beneficial effects of SSF on memory impairment and neuronal damage in aged rats may be important for the treatment of senile dementia and for delaying the ageing processes, according to "Scutellaria flavonoid supplementation reverses ageing-related cognitiveimpairment and neuronal changes in aged rats" by Song HR, Cheng JJ, Miao H, Shang YZ.(10)

11. Asthma
In the deiermination of the effects of Scutellaria Root, a major herb in Saiboku-to and its components such as baicalein and baicalin on eotaxin production by IL-4 plus TNF-alpha-stimulated human fibroblasts, found that the inhibitory effect of baicalein was expressed in a dose-dependent manner, and almost 50% inhibition was observed at 1.8 micrograms/ml. Furthermore, baicalein prevented human eotaxin mRNA expression in IL-4 plus TNF-alpha-stimulated human fibroblasts. These results help explain the pharmacological efficacy of Scutellaria Root in the treatment of bronchial asthma since it would suppress eotaxin associated recruitment of eosinophils, according to "Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts" by Nakajima T, Imanishi M, Yamamoto K, Cyong JC, Hirai K.(11)

12. Anti fungal effects
In the study of the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates of C. albicans, found that AmB increased the caspase activity and expression of the corresponding gene CaMCA1 in C. albicans. These effects were enhanced in the presence of BE. Deletion of CaMCA1 clearly attenuated AmB-induced apoptosis, indicating the involvement of CaMCA1-mediated caspase pathway in AmB-induced apoptosis and the synergistic action, according to "Combination of baicalein and Amphotericin B accelerates Candida albicans apoptosis" by Fu Z, Lu H, Zhu Z, Yan L, Jiang Y, Cao Y.(12)

13. Anxiolytic activity
In the investigation of the phytochemistry and biological activity of Scutellarialateriflora L. (American skullcap) which has been traditionally used as a sedativeand to treat various nervous disorders, found that these compounds may play a role in anxiolytic activity since baicalin and baicalein are known to bind to the benzodiazepine site of the GABAA receptor and since GABA is the main inhibitory neurotransmitter, according to "Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties" by Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z.(13)

14. Etc.

Side effects
1. Overdoses may cause nervous tension, including giddiness, stupor, confusion, irregular heartbeat and twitching.
2. Do not use the herb in new born, children or if you are pregnant or breast feeding without approval from the related field specialist.
3. Overdoses cam also toxic to liver (a)
4. Skullcap may interact with other medication such as sedatives
5. Etc.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20586134
(2) http://www.ncbi.nlm.nih.gov/pubmed/16450292
(3) http://www.ncbi.nlm.nih.gov/pubmed/17674423
(4) http://www.ncbi.nlm.nih.gov/pubmed/22235229
(5) http://www.ncbi.nlm.nih.gov/pubmed/22195472
(6) http://www.ncbi.nlm.nih.gov/pubmed/18786819
(7) http://www.ncbi.nlm.nih.gov/pubmed/18484546
(8) http://www.ncbi.nlm.nih.gov/pubmed/21222632
(9) http://www.ncbi.nlm.nih.gov/pubmed/22023309
(10) http://www.ncbi.nlm.nih.gov/pubmed/19191093
(11) http://www.ncbi.nlm.nih.gov/pubmed/11301858
(12) http://www.ncbi.nlm.nih.gov/pubmed/21415530
(13) http://www.ncbi.nlm.nih.gov/pubmed/14692724


Women Health: The Obesity and Anovulation Research and Studies of Early onset of obesity induces reproductive deficits

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

The Studies of Early onset of obesity induces reproductive deficits


The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions in reproduction. According to the study by Universidade Estadual do Oeste do Paraná (UNIOESTE), posted inPubMed, after weaning, female rats were treated with a cafeteria diet or a chow diet (control group) of which be able to induce obesity in female rats by increasing body and fat pad weight, which resulted in increased levels of triglycerides, total cholesterol, LDL and induced insulin resistance. The cafeteria diet also negatively affected female reproduction by reducing the number of oocytes and preantral follicles, as well as the thickness of the follicular layer. Obese females did not show preovulatory progesterone and LH surges, though plasma estradiol and prolactin showed preovulatory surges similar to control rats. Nevertheless, sexual receptiveness was not altered by cafeteria diet.

Overcome Infertility: Hypoosmotic swelling test (HOST) of Male Infertility In Conventional medicine Perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Overcome Infertility 

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

       Hypoosmotic swelling test (HOST) of  Male Infertility In Conventional medicine Perspective

I. Definition
Hypoosmotic swelling test (HOST) is the test used to identify sperm membrane for structure integrity by examining how the sperm tail reacts to special sugar and salt. Only healthy sperm can react in this circumstance.

II. Procedure
The HOS test was performed by mixing special sugar and salt in distilled water. The mixture was incubated and immediately examined under a microscope. The percentage of reacted sperm (curled tails) and non-reacted sperm (non-curled tails) were assessed.

III. Diagnosis
1. A sample sperm is considered normal if more than 60% response to the swollen spermatozoa. otherwise the tested sample is considered to have poor sperm membrane structure integrity. It is said the hypoosmotic swelling test result is predictive of the sperm penetration test. If the tested sample fail, it may need some other technical support to by-pass the sperm penetration process.

IV. Risk
Although the hypoosmotic swelling test is less time consuming and can help to determine the the sperm fertilization capacity, the result is not 100% guaranteed. For the couple to conceive, it take more than the hypoosmotic swelling test for a successful pregnancy, please make sure that other health problems have been taking care of.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine



Most Common Diseases of Ages of 50 Plus: Prostate Cancer - The Causes and risk factors

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Among elderly men, cancer of the prostate (451 per 100,000), the lung (449 per 100,000) and the colon (176 per 100,000) make up around half of all diagnosed cancers. Prostate cancer is around 22 times more frequent among elderly men than among younger men. The corresponding most frequent cancers among elderly women, making up 48% of all malignant cancers, are breast (248 per 100,000), colon (133 per 100,000), lung (118 per 100,000) and stomach cancer (75 per 100,000), According to the Danish Cancer Society, Institute of Cancer Epidemiology(PubMed)

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

                             Prostate Cancer

Prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of semen that carries sperm.


Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.



                 Causes and risk factors

1. Age
The risk of developing prostate cancer increases with age of over 45

2. Family history
Statistic showed that if one of your directed family member has prostate cancer, your are twice at risk to develop it as well.

3. Race
Prostate cancer are more likely to strike black and white or Hispanic men in the US.

4. Heredity
Certain genes mutation are associated in promoting the growth of prostate cancer, including Hereditary Prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or Transmembrane protease, serine 2-ETV1/4, etc.
Researcher found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are late event in pathology of prostate cancer.

5. Low levels of vitamin D in blood

Researcher found that men with deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.


6. Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with higher risk of prostate cancer as it interfere with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.

7. Enlarged prostate
Men with enlarged prostate are at high risk in developing prostate cancer.

8. Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with higher risk of the diseases.

9. Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Phytochemicals for Treatment of Breast Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

                      Breast cancer

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or thelobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

II. Types of Food to prevent and treat Breast cancer
1. Blueberry
In the study to investigate the chemopreventive activity of blueberry extract in triple-negative breast cancer cell lines in vitro and in vivo, showed that Blueberry decreased cell proliferation in HCC38, HCC1937, and MDA-MB-231 cells with no effect on the nontumorigenic MCF-10A cell line. Decreased metastatic potential of MDA-MB-231 cells by blueberry was shown through inhibition of cell motility using wound-healing assays and migration through a polyethylene terephthalate membrane. Blueberry treatment decreased the activity of matrix metalloproteinase-9 and the secretion of urokinase-type plasminogen activator while increasing tissue inhibitor of metalloproteinase-1 and plasminogen activator inhibitor-1 secretion in MDA-MB-231 conditioned medium as shown by Western blotting. Cell signaling pathways that control the expression/activation of these processes were investigated via Western blotting and reporter gene assay. Treatment with blueberry decreased phosphatidylinositol 3-kinase (PI3K)/AKT and NFkappaB activation in MDA-MB-231 cells, where protein kinase C and extracellular signal-regulated kinase (ERK) were not affected. In vivo, the efficacy of blueberry to inhibit triple-negative breast tumor growth was evaluated using the MDA-MB-231 xenograft model. Tumor weight and proliferation (Ki-67 expression) were decreased in blueberry-treated mice, where apoptosis (caspase-3 expression) was increased compared with controls. Immunohistochemical analysis of tumors from blueberry-fed mice showed decreased activation of AKT and p65 NFkappaB signaling proteins with no effect on the phosphorylation of ERK(1).

2. White button mushroom
Flavones and isoflavones have been shown to be inhibitors of aromatase, it is thought that vegetables that contain these phytochemicals can inhibit aromatase activity and suppress breast cancer cell proliferation. DR. Grube BJ, and the research team at Beckman Research Institute of the City of Hope, showed that The white button mushroom (species Agaricus bisporus) suppressed aromatase activity dose dependently. Enzyme kinetics demonstrated mixed inhibition, suggesting the presence of multiple inhibitors or more than one inhibitory mechanism. "In cell" aromatase activity and cell proliferation were measured using MCF-7aro, an aromatase-transfected breast cancer cell line. Phytochemicals in the mushroom aqueous extract inhibited aromatase activity and proliferation of MCF-7aro cells(2).

3. Rosemary and Sage
Carnosol found abundantly in Rosemary and sage has exerted the protective effect against several types of cancer, including prostate, breast, skin, leukemia, and colon cancer and has been evaluated for anti-cancer property in prostate,breast, skin, leukemia, and colon cancer with promising results. These studies have provided evidence that carnosol targets multiple deregulated pathways associated with inflammation and cancer that include nuclear factor kappa B (NFκB), apoptotic related proteins, phosphatidylinositol-3-kinase (PI3 K)/Akt, androgen and estrogen receptors, as well as molecular targets. In addition, carnosol appears to be well tolerated in that it has a selective toxicity towardscancer cells versus non-tumorigenic cells and is well tolerated when administered to animals(3).

4. Red wine
In study of red wine intake and its beneficial health effects on the proliferation of hormone-dependent breast cancer cells found that the estrogenic activity of PIC(piceatannol) and MYR(myricetin) might be considered at least as a potential factor in the association of red wine intake and breast tumors, particularly in postmenopausal women, according to "The red wine phenolics piceatannol andmyricetin act as agonists for estrogen receptor alpha in human breast cancercells" by Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò S.(4)

5. Soy
In a study of " Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women" , by A Cassidy, S Bingham and KD Setchell (Source from Dunn Clinical Nutrition Centre, Cambridge, UK. ) posted in The Americal Journal Clinical Nutrition, researchers indicated that these effects are presumed to be due to nonsteroidal estrogens of the isoflavone class, which behave as partial estrogen agonists/antagonists. The responses to soy protein are potentially beneficial with respect to risk factors for breast cancer and may in part explain the low incidence of breast cancer and its correlation with a high soy intake in Japanese and Chinese women(4). Other suggested high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk(6). One study indicated that Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species(7)


6. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health



Please follow me at http://twitter.com/kylejnortonSources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20388778
(2) http://www.ncbi.nlm.nih.gov/pubmed/11739882
(3) http://www.ncbi.nlm.nih.gov/pubmed/21382660
(4) http://www.ncbi.nlm.nih.gov/pubmed/16216908
(5) http://www.ajcn.org/content/60/3/333.abstract
(6) http://jcem.endojournals.org/content/89/7/3462.short
(7) http://www.ncbi.nlm.nih.gov/pubmed/21462322

Dietary Minerals Calcium: Ca(2+) waves regulate blood vessel tone and vasomotion

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Calcium

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

     Ca(2+) waves regulate blood vessel tone and vasomotion

Agonist-stimulated smooth muscle Ca(2+) waves regulate blood vessel tone and vasomotion.The Pharmacology, and Therapeutics, University of British Columbia, present a first report of endothelin-1 stimulated waves of Ca(2+) depletion from the sarcoplasmic reticulum of vascular smooth muscle cells using a calsequestrin-targeted Ca(2+) indicator and confirmed that these waves are due to regenerative Ca(2+)-induced Ca(2+) release by the receptors for inositol 1,4,5-trisphosphate(14).

Women Health: Menstrual Disorders -Menorrhagia - The Diagnosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.


                          The Diagnosis 

A. Primary menorrhagia
Girl with menorrhagia in the first 2 years of the menstruation may be tested
1. Red blood cell and fatty acid analysis
It is a blood test for cholesterol, triglyceride, HDL, and LDL. Occasionally, a lipoprotein electrophoresis or lipoprotein-a (Lp-a). The high levels of the test result may increase the risk of arachidonic acid cause of menorrhagia.
2. Red blood cells count
The aim of the blood test is to rule the case of amenia.
3. Hormone levels testing (FSH)
the aim of the test to check for hormone follicle stimulating hormone that may lead inovulation cause of heavy menstruation.
4. Serum vitamin levels
The test for certain vitamin levels is to rule out the heavy period is caused by vitamin deficiency.
5. Etc.

B. Secondary menorrhagia

1. Blood count
Test for blood count to rule out the amenia cause of menorrhagia.
2. Basal body temperature
In women, the record of basal body temperature is to rule out the anovulation cause of menorrhagia. Ovulation causes an increase of one-quarter to one-half degree Celsius in basal body temperature (BBT). It is one of self exam method commonly used by women to time of most fertility.
3. Thyroid function
In a study of Menorrhagia and hypothyroidism - Evidence supports association between hypothyroidism and menorrhagia by Andrew D Weeks, specialist registrar in obstetrics and gynaecology, researchers found that All the available evidence supports a causative association between hypothyroidism and excessive menstrual loss. Some of the study methods are weak by modern standards, but in the absence of evidence to the contrary the conclusion must be that hypothyroidism is a correctable cause of menorrhagia.
4. Ultrasound
Ultra sound to examine the pelvic region is to rule out certain types of abnormality cause of menorrhagia such as uterine fibrosis, polyps, ovarian tumors, endometriosis, etc..
5. Blood coagulation test
Abnormal process by which blood forms clots (coagulation) to prevent blood loss during menstruation can lead menorrhagia.
6. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Ma Bo (Fructificatio Lasiosphaerae seu Calvatiae)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                 
          Ma Bo (Fructificatio Lasiosphaerae seu Calvatiae)




Ma Bo is also known as Pearly puffball. The acrid and neutral herb has been used in TCM to treat pain in the throat, coarse voice, inhibit bacteria and use xternally for nose bleeding and bleeding due to injuries, etc., as it clears the Lungs, expels toxins stops bleeding, etc., by enhancing the function of lung channels.
Ingredients

Health Benefits
1. Anti-Cancer Effects
Researchers at the College of Life Sciences, National Chiayi University, in the study of Anti-Cancer Effects of Protein Extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea, found that The PO and VV protein extracts induced reactive oxygen species (ROS) production, glutathione (GSH) depletion and mitochondrial transmembrane potential (ΔΨ(m)) loss in SW480 cells. Pretreatment with N-acetylcysteine, GSH or cyclosporine A partially prevented the apoptosis induced by PO protein extracts, but not that induced by VV extracts, in SW480 cells. The protein extracts of CL, PO and VV exhibited therapeutic efficacy against human colorectal adenocarcinoma cells and human monocytic leukemia cells. The PO protein extracts induced apoptosis in SW480 cells partially through ROS production, GSH depletion and mitochondrial dysfunction. Therefore, the protein extracts of these mushrooms could be considered an important source of new anti-cancer drugs(1).

2. Human colorectal cancer
Scientists at the Toko University, Puzih City, in the investion of Calvatia lilacina protein-extract induces apoptosis through glutathione depletion in human colorectal carcinoma cells, reported that a novel protein extract isolated from Calvatia lilacina (CL) can induce cell death against four types of human colorectal cancer cells. Importantly, CL was shown to be free of apoptotic effects against normal rat liver cells. We have also identified that CL-induced glutathione (GSH) depletion is the major contributor responsible for the apoptotic cell death induction of SW 480 cells, as evidenced by the observation that exogenously added N-acetylcysteine (NAC), or GSH, but not vitamin C, could offer a near complete protection of CL-treated cells against apoptotic cell death. Furthermore, the participation of reactive oxygen species (ROS) evoked a drop in the transmembrane potential (Delta Psi(m)) in the CL-induced apoptotic cell death(2).

3. Antiproliferative and antimitogenic activities
In the study to exmaine the antiproliferative and antimitogenic activities of the extracted Fresh fruiting bodies of the mushroom Calvatia caelata, with 10 mM Tris-HCl buffer (pH 7.2) showed that Calcaelin inhibited translation in rabbit reticulocyte lysate with an IC 50 value of 4 nM and displayed a heat-labile RNase activity of 1.58 U/mg toward yeast tRNA. It exhibited an antimitogenic activity toward mouse splenocytes, and it reduced the viability of breast cancer cells. There was no hemagglutinating, antibacterial or antifungal activity(3).

4. Etc.

Side Effects
1. Do not use in case of voice loss as a result of wind cold
2. It may cause allergic reaction, including dizziness, throat feels swollen, heaviness in chest, itchiness , rash. etc.
3. Do not use the herb in newborn, children, or if you are pregnant or breast feeding with first consulting with the related field specialist.
4. Etc.


Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21792367
(2) http://www.ncbi.nlm.nih.gov/pubmed/19182949
(3) http://www.ncbi.nlm.nih.gov/pubmed/12677523



Overcome Infertility: Human Zona Pellucida Binding Test of Male Infertility In Conventional medicine Perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                    Overcome Infertility 

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist.

       Human Zona Pellucida Binding Test of  Male Infertility In Conventional medicine Perspective

I. Definition
The testes help to exam how the sperm bind to outer layer of the egg, including hemizona assay.

II. Procedure
The test is necessary if the men is found to be infertile with either reduced sperm count, motility and morphology alone, or in combination and is classified with unexplained causes. The sperm and egg are collected from a couple and is used to see the sperm penetration in IVF.

III. Diagnosis
The process of human fertilization, sperm must bind to the zona pellucida, undergo the acrosome reaction, penetrate the the out layer of the egg and then fuse with the oolemma. The process is observed and recorded. If the sperm can not penetrate the egg then other testes may be needed or conception may be required more technical support. If the sperm has no problem in egg penetrating, then IUI or IVF is the best choice in assisting the fertilization for a unfertilized couple.

IV. Risk
Although the successful rate to conceive is very high, if a couple pass the humanzona pellucida binding test, but it is not 100% guaranteed, since for a couple to get conceive, it takes more than human zona pellucida test.
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine



Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In traditional Chinese medicine perspective of Predominantly inattentive

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

           Attention Deficit Disorder (ADHD/ADD)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.


        Treatments  In traditional Chinese medicine perspective(66)

B. Predominantly inattentive as of result of Qi and blood deficiency of Spleen and Heart causes of failing to nourish the heart Mind
1. Symptoms
Beside the symptoms mentioned above, TCM also describes the physical appearance of the patient as follow
a. Pale face and lips
b. Overactive with low energy
c.Poor memory
d. Pale tongue and weak pulse
f. Etc.

2. Treatment
Gui Pi Tang helps to strengthens the spleen and the heart, nourishes blood and Qi, calms the mind. Ingredients include
a. Fu Ling
Fu Ling, fu shen or fu ling pi is also known as Poria. The bland, sweet and neutral herb has been used in TCM as as diuretics and to treat urinary difficulty, diarrhea, water retention, headache, dizziness, palpitations, etc., as it eliminates Water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels.

b. Bai Zhu
Bai Zhu is also known as Bighead atractylodes rhizome. The aromatic, slightly acrid and sweet herb has been used in TCM to treat children drooling, Meniere's disease, constipation, chronic back painm, acute infection of intestine, dizziness, palpitation, edema, instant sweating, etc., as it tonifies the spleen, augments qi, dries dampness, atabilizes the exterior, etc., by enhancing the functions of spleen and stomach channels.

c. Suan Zao Ren
Suan Zao Ren is also known as Sour jujube seed. The sweet, sour, neutral herb has been used in TCM to treat abnormal sweating, anxiety, insomnia, excessive dream, palpitation, weak memory, dizziness, night sweating, etc., as it nourishes heart and liver, calms spirit, etc., by enhancinf the functions of gallbladder, heart, liver and spleen channels.

d. Huang Qi
Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens proteinuria, improve endurance, protect liver function, regulate blood sugar, etc. as it tonifies Qi, raises Yang, strengthens the Defensive-Qi and the Exterior, expels toxins, etc. by enhancing the functions of lung and spleen channels.

e. Dang Shen
Dang Shen is also known as codonopsis root. The sweet and neutral herb has been used in TCM to enhance the immune and cetral nervous systems and blood coagulation, reduce fatigue, increases red and white blood cells, white blood cells, raise blood sugar, etc., as it tonifies the Middle, strengthens Qi, promotes generation of Body Fluids, nourishes Blood, etc., by promoting the functions of lung and spleen channels.

f. Long Yan
Long Yan or Long Yan Rou is also known as Longan. The aromatic and neutral herb has been used in TCM to treat neurasthenia, forgetfulness, palpitation, insomnia, etc., as it tonifies heart and spleen, nourishes blood, calms spirit, etc., by enhancing the functions of heart and spleen channels.

g. Da Jiao
Da Jiao or Da Zao also known as black jujube. The sweet and warm herb has been used in TCM to treat improves cAMP(cyclic adenosine mono phosphate) and strength of muscles, calms the central nervous system, inhibits histamine, IgE, and 5-HT, cell mutation and cancer cells, etc., as it tonifies the Middle Burnner, strengthens Qi, nourishes Blood, calms the Mind, regulates the nature of other herbs, etc., by enhancing the functions of stomach , spleen channels.

h. Dang Gui
Dang Qui is also known as Angelica Root. The sweet, bitter, acrid and warm herb has been used in TCM to regulate the menses, lower lipids, reduce platelet coagulation and swelling, expel pus, relieve pain, etc/, as it tonifies and moves Blood, calms pain, moistens the Intestines, etc., by enhancing the function of heart, liver and spleen channels.

i. Yuan Zhi
Yuan Zhi is also known as Turkey Tails. The sweet, bland and slightly cold herb has been used in TCM as antibiotic property, anti-viral property, and anti-tumor agent and to get rid of dampness, transform phlegm, treat lung disease, insomnia, mental confusion, seizures, palpitations, anxiety, restlessness, etc., as it calms the spirit, quiets the heart, expels phlegm, clears the heart orifices, etc., by enhancing the functions of liver, spleen and lung channels.

j. Gan Cao
Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy, anti inflammation, anti ulcer, anti convulsion and to treat stomach weakness, tired and lack of strength, palpitation and short of breath, cough with abundance of phlegm, stomach and solar plexus pain, etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels.

k. Sheng Jiang
Sheng Jiang is also known as Fresh Ginger root. The acrid and cool herb has been use in TCM as an anti inflammation, anti coagulation of platelets, anti allergy, anti tumors, etc, and to promote flowing of bile, protect liver, stimulate cardiac function, inhibit platelet coagulation, prevent dizziness, improve auto-immune function,etc., as it promotes sweating, releases the Exterior; warms the Middle Burner and the Lungs, stops vomiting, calms cough by enhancing the functions of lung, spleen and stomach channels.

l. Mu Xiang
Nu Xiang is also known as costus root. The acrid, bitter and warm hrtb has been used in TCM to treat flatulence and pain in the abdomen, diarrhea, bronchitis, digestive tract infection: yeast infection, dysentery, and lack of appetite, etc,, as it promotes the movement of Qi, alleviates pain, regulates stagnated Qi in the intestines, strengthens the spleen and prevents stagnation, etc., by enhancing the functions of gallbladder, large intestine, spleen and stomach channels.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Dietary Minerals Calcium: BK Channels in Cardiovascular Diseases and Aging

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Calcium

Calcium, a trace mineral plays an important role in build and maintain strong bones and teeth, found abundantly in meat, poultry, fish, nut, seeds, bean, etc. As we age, calcium is absorbed less effectively.

     BK Channels in Cardiovascular Diseases and Aging


Aging is a major risk factor for cardiovascular diseases, one of the main world-wide causes of death. Several structural and functional changes occur in the cardiovascular system during the aging process and the mechanisms. BK channels are transmembrane proteins that play a key role in many physiological processes, including regulation of vascular tone.In vascular smooth muscle cells, BK opening and the consequent efflux of potassium (K(+)) leads to membrane hyperpolarization, which is followed by the closure of voltage-dependent Ca(2+) channels, reduction of Ca(2+) entry and vasodilatation. BK regulates nitric oxide-mediated vasodilatation and thus is crucial for normal endothelial function(13).

Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.

The Studies of  Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)


Chronic low-grade subclinical inflammation has been increasingly recognized as an interposer in the endocrine, metabolic and reproductive disturbances that characterize the polycystic ovary syndrome (PCOS). Abdominal adiposity andobesity are often present in PCOS, According to study posted in PubMed, mounting evidence indicates that adipose tissue is involved in innate and adaptive immune responses. Continuous release of inflammatory mediators such as cytokines, acute phase proteins, and adipokines perpetuate the inflammatory condition associated with obesity in women with PCOS, possibly contributing to insulin resistance and other long-term cardiometabolic risk factors. Genetic variants in the genes encoding inflammation-related mediators underlie the development of PCOS and their interaction with environmental factors may contribute to the heterogeneous clinical phenotype of this syndrome.

Most Common Diseases of 50 Plus: Thyroid Disease : Euthyroid sick syndrome as a result of Sepsis - Treatments in Herbal medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                         Thyroid disease


Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.


             Euthyroid sick syndrome as a result of Sepsis

Sepsis is defined as a condition caused by chemicals released into the bloodstream to fight the infection trigger inflammation throughout the body as a result of severe infection(a)(b). according to the study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world. Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).


                                              The  Treatments 



Treatments in herbal medicine perspective
1. Taraxacum coreanum
Taraxacum coreanum Nakaiis a dandelion native to Korea and is widely consumed as an edible and medicinal herb. Treatment of primary macrophages with Taraxacum coreanum chloroform fraction(TCC) in vitro significantly inhibited all of the inflammatory parameters measured, including LPS-induced NO and PGE2 production, iNOS and COX-2 expression, IκBα degradation, IKK phosphorylation, and MAPK and STAT1 activation. In a mouse model of LPS-induced septic shock, TCC inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, and increased survival by 83%.Standard compounds (gallic acid, syringic acid) of Taraxacum coreanum were qualified by HPLC analysis, according to Kyung Hee University(62).

2. Chamaecyparis obtusa
β-thujaplicin, an active constituent from Chamaecyparis obtusa, has been shown to have acaricidal and antimicrobial effects. According to the study by the Chia-Nan University of Pharmacy and Science, the potential of β-thujaplicin in treatment of inflammation and sepsis. These effects occur through an efficient blockage of TNF-alpha and iNOS production. β-thujaplicin efficacy is comparable to that of indomethacin thus it can be a substitution but bear less depletion of PGE2, making this compound very promising in clinical applications(63).

3. Angelica sinensis
A low-molecular-weight (<10 kDa) fraction of A. sinensis extract significantly attenuated endotoxin-induced HMGB1 release in part through interfering with its cytoplasmic translocation in macrophage cultures. Prophylactic administration of an aqueous extract of A. sinensis significantly attenuated systemic HMGB1 accumulation in vivo, and conferred a dose-dependent protection against lethal endotoxemia. Furthermore, delayed administration of A. sinensis extract beginning 24 h after CLP attenuated systemic HMGB1 accumulation, and significantly rescued mice from lethal sepsis. Taken together, these data suggest that A. sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1, according to the New York University School of Medicine(64).

4. Green tea
Intraperitoneal administration of EGCG protected mice against lethal endotoxemia, and rescued mice from lethal sepsis even when the first dose was given 24 hours after cecal ligation and puncture. The therapeutic effects were partly attributable to: 1) attenuation of systemic accumulation of proinflammatory mediator (e.g., HMGB1) and surrogate marker (e.g., IL-6 and KC) of lethal sepsis; and 2) suppression of HMGB1-mediated inflammatory responses by preventing clustering of exogenous HMGB1 on macrophage cell surface, according to the study by the North Shore University Hospital-New York University School of Medicine(65).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/9086580
(b)http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/thyroid_disorders/euthyroid_sick_syndrome.html
(c) http://en.wikipedia.org/wiki/Euthyroid_sick_syndrome
(d) http://www.ncbi.nlm.nih.gov/pubmed/8028742
(62) http://www.ncbi.nlm.nih.gov/pubmed/23261487
(63) http://www.ncbi.nlm.nih.gov/pubmed/22507316
(64) http://www.ncbi.nlm.nih.gov/pubmed/16424112
(65) http://www.ncbi.nlm.nih.gov/pubmed/17987129


Women Health: Menstrual Disorders -Menorrhagia - Types and Symptoms

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Menorrhagia is defined as a condition of excessive bleeding in the menstruation phase of the menstrual cycle in the reproductive age of a woman leading to heavy blood loss that can interfere with the woman normal activities, as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs.

                            Types of menorrhagia 

1. Primary menorrhagia
Girls are especially prone to anovulatory cycles in the 2 years after the first menstrual as a result of the immature reproductive organs, which can lead to disturbance of protaglandins production, causing pains and heavy period.
2. Secondary menorrhagia
Secondary menorrhagia is a result of as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs, that lead menstrual cramps and pain and excessive bleeding. 


                           The Symptoms 

1. Spotting or bleeding between menstrual periods
2. Excessive menstrual bleeding
3. Heavy period
4. Symptoms of anemia (caused by loss of iron in the blood)
5. Constant pain in the lower abdomen during menstrual period
6. Irregular menstrual periods
7. Period with heavy period occurs almost in every period.
8. Blood loss from 30 to 44 milliliters
9. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Tuesday, August 30, 2016

Phytochemicals in Foods- The Effects of Apiole

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                      Apiole

Apiol, a phytochemical monophenols, is also known as parsley apiol, apiole or parsley camphor found mostly in celery, parsley seeds. It has been used as medicine to treat menstrual disorders.


Health Benefits
1. Antinociceptive and 2. anti-inflammatory effects
In the investigation of Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS, including myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%), apiol (8.82%) and isolongifolol (5.94%) found that the essential oil showed significantly antinociceptive and anti-inflammatory effects. The results indicate that the essential oil may contain the bioactive components of I. lanceolatum. This is the first report on the chemistry, antinociceptive and anti-inflammatory activities of I. lanceolatum, according to the study of "Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum" by Liang J, Huang B, Wang G.(1)

3. Antimicrobial and 4. antiproliferative activity
In the observation of Acetone extracts of leaves, flowers, and stems of A. sicula L., including apiol and myristicin and its effect on cancer cell lines found that antimicrobial activity of acetone extracts was carried out against bacterial and fungal strains and antiproliferative activity against a group of human cancer cell lines (K-562, NCI-H460, and MCF-7), according to "Antimicrobial and antiproliferative activity of Athamanta sicula L. (Apiaceae)" by Stefano VD, Pitonzo R, Schillaci D.(2)

5. Antifungal activity
In demonstration of the extracts prepared from 10 plant species and their effect on Paracoccidioidomycosis (PCM) which is a systemic granulomatous disease caused by Paracoccidioides brasiliensis Almeida (Onygenales) found that the major components of the hexane fraction of Piper regnellii were 1-methoxy-4-(1-propenyl) benzene (21.94%) and apiol (21.29%). The activities of these fractions against P. brasiliensis without evidence of cytotoxicity to macrophages justify their investigation as a potential source of new chemical agents for the treatment of PCM, according to the study of "Antifungal activity of extracts of some plants used in Brazilian traditional medicine against the pathogenic fungus Paracoccidioides brasiliensis" by Johann S, Cisalpino PS, Watanabe GA, Cota BB, de Siqueira EP, Pizzolatti MG, Zani CL, de Resende MA.(3)

6. Carcinogenesis
In the research of Alkoxy derivatives of allylbenzene, including safrole, estragole, methyleugenol, myristicin, dill apiol, and parsley apiol and their effects on DNA found that safrole, estragole, methyleugenol, myristicin, dill apiol, and parsley apiolare capable of altering the DNA in these cells and thus may contribute to human carcinogenesis, according to the study of "DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells" by Zhou GD, Moorthy B, Bi J, Donnelly KC, Randerath K.(4)

7. Cercaricidal effect
In analyzing the composition of the essential oil of the fresh aerial parts of Apium graveolens var. secalinum at its flowering stage, including the main components in the oil are: alpha- and beta-pinene, myrcene, limonene, cis-beta-ocimene, gamma-terpinene, cis-allo-ocimene, trans-farnesene, humulene, apiol, beta-selinene, senkyunolide and neocnidilide and its cercaricidal effect found that the essential oil showed in addition to a cercaricidal effect also a chemotactic effect, according to the study of "The essential oil of Apium graveolens var. secalinum and its cercaricidal activity" by Saleh MM, Zwaving JH, Malingré TM, Bos R.(5)

8. Etc.
Do not use Apiole without consulting with related field specialist as it can be toxic if overdosed

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine




Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21999530
(2) http://www.ncbi.nlm.nih.gov/pubmed/21472076
(3) http://www.ncbi.nlm.nih.gov/pubmed/20645716
(4) http://www.ncbi.nlm.nih.gov/pubmed/17948277
(5) http://www.ncbi.nlm.nih.gov/pubmed/4080514


Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Chamomile

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

           Attention Deficit Disorder (ADHD/ADD)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.


                 The Herbal medicine - Chamomile

a. Anti-allergic activity
The methanol extract of Matricaria recutita L. has shown anti-allergic activity by inhibition of histamine release from mast cells, according to the study of "Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model" by Chandrashekhar VM, Halagali KS, Nidavani RB, Shalavadi MH, Biradar BS, Biswas D, Muchchandi IS.(81)

b. Neuroprotective activity
German chamomile methanol extract (GCME) has shown shown the ability to treat neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total thiol levels, against AlF₄⁻- and may be used to treat oxidative brain damage, according to the study of "Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats" by Ranpariya VL, Parmar SK, Sheth NR, Chandrashekhar VM.(82)

c. Anxiety
Matricaria recutita (chamomile) extract therapy has exerted the modest anxiolytic activity in patients with mild to moderate generalized anxiety disorder, according to the study of "A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxietydisorder" by Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(83)

d. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health


Most Common Diseases of Ages of 50 Plus: Cancers - Types of factor that cause cancers

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Among elderly men, cancer of the prostate (451 per 100,000), the lung (449 per 100,000) and the colon (176 per 100,000) make up around half of all diagnosed cancers. Prostate cancer is around 22 times more frequent among elderly men than among younger men. The corresponding most frequent cancers among elderly women, making up 48% of all malignant cancers, are breast (248 per 100,000), colon (133 per 100,000), lung (118 per 100,000) and stomach cancer (75 per 100,000), According to the Danish Cancer Society, Institute of Cancer Epidemiology(PubMed)

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

             Types of factor that cause cancers

1. Aging: Due to weakened immune system as a result of wear and tear over years. Some researchers suspected that free radicals may be one of contributors.

2. Tobacco :Due to chemical causes of cells alternation.

3. Sunlight :Damage to skin as result of ultra violet.

4. ionizing radiation: Any types of hazard chemicals cause of gene mutation.

5. Virus and bacteria: As mentioned above.

6. Hormones: Abnormal production of certain hormones can increase the risk of sex-related cancers.

7. Family history : Check above.