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Thursday, August 25, 2016

Dietary Minerals Boron: The effects of Boronic acid on Antimalarials

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                      Boron

Boron, a vital trace mineral found abundantly in Almond, Red Apple, Apricots, Avocado, Banana, Red kidneyBeans, etc., is necessary for the normal growth and health of the body. Boric acid has antiseptic and antiviral activity. Its aqueous solutions have been used as mouth-washes, eye-drops, skin lotions and cosmetics(1).

             The effects of Boronic acid on Antimalarials  

The high rate of mortality due to malaria and the worldwide distribution of parasite resistance to the commonly used antimalarial drugs chloroquine and pyrimethamine emphasize the urgent need for the development of new antimalarial drugs. According to the study to test Proteasome inhibitor bortezomib (Velcade: [(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid), which has been approved for treatment of patients with multiple myeloma, and a second boronate analog Z-Leu-Leu-Leu-B(OH)2 (ZL3B), against four different strains of P. falciparum (3D7, HB3, W2 and Dd2) by University of Connecticut Health Center, found that the identification of bortezomib and its analog as potent antimalarial drugs will set the stage for the advancement of this class of compounds, either alone or in combination therapy, for treatment of malaria, and emphasize the need for large-scale screens to identify new antimalarials within the library of clinically approved compounds(11).

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