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Lu Feng Fang (Nidus Vespae)
Lu Feng Fang is also known as Honeycomb. The sweet, acrid, neutral and slightly toxic has been used to in TCM to treat treatment of cancer, bleeding in tumors, pain in eczema, etc., as it expels toxins, eliminates parasites, expels Wind, etc., by enhancing lung, liver, spleen, stomach and large intestine channels.
Ingredients
1. Evaporating oil
2. Bee wax
3. Calcium
4. Iron
5. Etc.
Health Benefits
1. Inhibitory effects on nitric oxide production
In the study to investigate 2 coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol (7), and (3S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-ol (8), were isolated from the 95% EtOH extract of nidus vespae, the nest of Polistes species, showed that compounds 5, 6, and 8 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC(50) values in the range of 13-17 μM, whereas the sesquiterpenes were inactive in this assay (>25 μM)(1).
2. Growth and cariogenic virulence factors of Streptococcus mutans
In the study to evaluate isolation of the chemical compounds of the Nidus Vespae Chl/MeOH extraction, tested their antimicrobial activity against six cariogenic bacteria and further evaluated the acid inhibition properties, anti-F-ATPase activity and anti-LDH activity against S. mutans, showed that The isolated flavonoids, quercetin and kaempferol, inhibited the growth of bacteria (S. mutans, Streptococcus sobrinus, Streptococcus sanguis, Actinomyces viscosus, Actinomyces naeslundii and Lactobacillus rhamnosus) with minimum inhibitory concentrations (MICs) ranging from 1 to 4 mg/ml and minimum bactericidal concentrations (MBCs) from 4 to 16 mg/ml. In addition, quercetin and kaempferol at sub-MIC levels significantly inhibited acidogenicity and acidurity of S. mutans cells. Treated with the test agents, the F-ATPase activity was reduced by 47.37% with 1mg/ml quercetin and by 49.66% with 0.5mg/ml kaempferol. The results showed that quercetin and kaempferol contained in Chl/MeOH extraction presented remarkably biological activity, suggesting that Nidus Vespae might be useful as a potential preventive and therapeutic agent in dental caries(2).
3. Growth and acidogenicity of oral microorganisms
In the evaluation of the antimicrobial activity and acid inhibition properties of extracts and chemical fractions of Nidus Vespae, showed that the chloroform/methanol (Chl/MeOH) fraction showed the highest antibacterial activities with a MIC of 8-16mg/ml and an MBC of 16-32mg/ml. In addition, the extract and chemical fractions of Nidus Vespae showed a remarkable capacity for inhibiting the acid production of common oral bacteria at sub-MIC concentrations. Sub-MIC levels of the petroleum ether/ethyl acetate fraction significantly inhibited acid production by Streptococcus mutans ATCC 25175. The significant antiacidogenic activity demonstrated by Nidus Vespae shows it to be a promising source of novel anticariogenic agents.(3).
4. HepG2 hepatoma cells
In the elucidation of whether and how NVP(1) modulates the proliferation of HepG2 cells. NVP(1) at a concentration of 6.6 microg/ml could arrest the cell cycle at stage G1 and inhibit the mRNA expression of cyclinB, cyclinD1 and cyclinE, found that NVP(1) suppressed cdk2 protein expression, but increased p27 and p21 protein expression. However, NVP(1) did not alter p16 protein expression levels. NVP(1) promoted apoptosis in HepG2 cells as indicated by nuclear chromatin condensation, and in addition, the extracellular signal-regulated kinase (ERK) signaling pathway was activated(4).
5. Oral bacteria
In the study to To inquire into the effect of different of Nidus Vespae extract (NVE) on growth and acid production of Streptococcus mutans, Streptococcus sanguis and Actinomyces viscosus, found that All of Nidus Vespae extracts could inhibit the growth the of the three strains, and NVE1, NVE3, NVE4 could inhibit the acid production of the three strains, NVE2 could inhibit the acid production of Actinomyces viscosus(5).
6. Etc.
Side Effects
1. Do not use the herb in case of Qi or Blood deficiency
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding with out approval first with the related field specialist
3. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22162164
(2) http://www.ncbi.nlm.nih.gov/pubmed/21498060
(3) http://www.ncbi.nlm.nih.gov/pubmed/16723116
(4) http://www.ncbi.nlm.nih.gov/pubmed/18989579
(5) http://www.ncbi.nlm.nih.gov/pubmed/15931873
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