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Thursday, September 1, 2016

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Hawthorn

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

           Attention Deficit Disorder (ADHD/ADD)

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.


                 The Herbal medicine - Hawthorn


a. Neuroprotective effects
In the investigation of the neuroprotective effects on PC12 cells from the methanol extracts of Spatholobus suberectus, Uncaria rhynchophylla, Alpinia officinarum, Drynaria fortunei, and Crataegus pinnatifida found that The CPE, SSE, and URE presented neurogrowth effects and neuroprotective activities on H(2)O(2)-induced PC12 cell death at 0.5-5.0 μg/mL. The CPE represents a promising medicinal plant source for the treatment of H(2)O(2)-induced neurodegenerative disease, because of its useful phytochemical characteristic, according to "Phytochemical characteristics, free radical scavenging activities, and neuroprotection of five medicinal plant extracts" by Chang CL, Lin CS, Lai GH.(84)

b. Immunomodulatory effect
In the determination of sheds more light on the extract's mechanism of neuroprotection, especially its immunomodulatory effect found that Hawthornextract helped alleviate pro-inflammatory immune responses associated with I/R-induced injury, boosted IL-10 levels, and increased Foxp3-positive T(regs) in the brain, which may have aided in suppression of activated inflammatory cells. Such treatment also minimizes apoptotic cell death by influencing STAT-3 phosphorylation and Bcl-xL expression in the brain. Taken together, the immunomodulatory effect of Hawthorn extract may play a critical role in the neuroprotection observed in this MCAO-induced stroke model, according to "Immunomodulatory effect of Hawthorn extract in an experimental stroke model" by Elango C, Devaraj SN.(85)

c. Prevention and treatment of cataracts
In the evaluation of the anticataract potential of Crataegus pinnatifida (hawthorntree) leaves and its extract in selenite-induced cataract in vivo and antioxidant effects in vitro, found that administration of C. pinnatifida leaves extract eye drops alternately three times a day in rat pups with selenite-induced oxidative stress significantly increased serum SOD and CAT activities, and tended to reduce MDA level compared with control group. The antioxidant enzyme SOD, CAT, and GSH activities in lens showed a significant increase. These results may be applied in the future for the prevention and treatment of cataracts, according to "Prevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro ofCrataegus pinnatifida leaves" by Wang T, Zhang P, Zhao C, Zhang Y, Liu H, Hu L, Gao X, Zhang D.(86)
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