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Friday, September 16, 2016

Dietary Minerals Cobalt: Inherited cobalamin malabsorption and Gene involved

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                                 Dietary Minerals 

Dietary Minerals are the group of minerals which is essential for our body to sustain normal functions and physical health.

                                        Cobalt

Cobalt is one of many essential mineral needed by our body in very small amounts to enhance productions of red blood cell and the formation of myelin nerve coverings It also is vital as a necessary cofactor for making the thyroid hormone thyroxine and stored in the red blood cells, the plasma, liver, kidney, spleen, pancreas, etc.

                          Inherited cobalamin malabsorption and Gene involved

Inherited malabsorption of cobalamin (Cbl) causes hematological and neurological abnormalities that can be fatal. According to the study by the Ohio State University, in the revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes. We identified mutations in 126/154 unrelated cases (82%). Fifty-three of 126 cases (42%) were mutated in CUBN, 45/126 (36%) were mutated in AMN, and 28/126 (22%) had mutations in GIF. We found 26 undescribed mutations in CUBN, 19 in AMN, and 7 in GIF for a total of 52 novel defects described herein. We excluded six other candidate genes as culprits and concluded that additional genes might be involved(4).

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