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Wednesday, September 7, 2016

Phytochemicals for Treatment of Mouth (Oral) cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Mouth (Oral) cancer

Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).

Types of foods to prevent and treat Oral cancer
1. Green tea
Green tea is important source of polyphenol antioxidants. Polyphenols including epigallocatechin 3 gallate (EGCG) constitute the most interesting components ingreen tea leaves. Green tea has the potential to protect against various malignant, cardiovascular and metabolic diseases. Dr. Narotzki B and the research team at the Technion-Israel Institute of Technology, indicated that Green tea protects against bacterial induced dental caries. Tea polyphenols possess antiviral properties, believed to help in protection from influenza virus. Additionally, greentea polyphenols can abolish halitosis through modification of odorant sulphur components. Oral cavity oxidative stress and inflammation, consequent to cigarette smoking and cigarettes' deleterious compounds nicotine and acrolein, may be reduced in the presence of green tea polyphenols. Generally, green teadefends healthy cells from malignant transformation and locally has the ability to induce apoptosis in oral cancer cells(1).

2. Milk thistle seeds
Silybin is aslo known as Silibinin (INN), the major active ingredient of silymarin,a flavanone, found in the milk thistle seeds has exerted the protective effect to cause oral cancer cells apoptosis. In the study of Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway, showed that molecular evidence associated with the anti-metastatic effect of silibinin by showing a marked inhibition of the invasion and motility of SCC-4 tongue cancer cells, with 89% and 66.4% of inhibition, respectively, by 100 microM of silibinin. This effect was associated with a reduced expression of MMP-2 and u-PA, together with an enhanced expression of TIMP-2 and PAI-1(2)

3. Turmeric
Curcumin, a major active component and principal curcuminoid of the popular Indian spice of turmeric, ,has been shown to have inhibitory effects on cancers. Dr. Kim JY, and scientists in the study of Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. indicated that curcumin induced reactive oxygen species (ROS) production and autophagic vacuoles formation bycurcumin was almost completely blocked in the presence of N-acetylcystein (NAC), an antioxidant. Rescue experiments using an autophagy inhibitor suppressed curcumin-induced cell death in OSCC, confirming that autophagy acts as a pro-death signal. Furthermore, curcumin shows anticancer activity against OSCC via both autophagy and apoptosis(4).

4. Green vegetables, citrus fruits and red grape wines
Resveratrol and quercetin are polyphenols which have been found in abundantly in significant amounts in green vegetables, citrus fruits and red grape wines. Quercetin exhibited a biphasic effect, stimulation at 1 and 10 microM, and minimal inhibition at 100 microM in cell growth and DNA synthesis. Combining 50 microM of resveratrol with 10, 25 and 50 microM of quercetin resulted in a gradual and significant increase in the inhibitory effect of quercetin on cell growth and DNA synthesis(4).

5. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22226360
(2) http://www.ncbi.nlm.nih.gov/pubmed/16498067
(3) http://www.ncbi.nlm.nih.gov/pubmed/22554995
(4) http://www.ncbi.nlm.nih.gov/pubmed/10211549


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