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Monday, September 12, 2016

Phytochemicals for Treatment of Thyroid Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Thyroid Cancer

Thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.

Thyroid cancer is defined as condition in which the cells in the thyroid gland have become cancerous.

Types of thyroid cancer
The most common types of thyroid cancer include
1. Papillary thyroid cancer
Papillary thyroid cancer, the most common type of thyroid cancer, makes up about 80 percent of all thyroid cancers. The cancer tends to develop in the women age group between 30-40 years of age and grow slowly. Papillary thyroid cancer can be cure if diagnosed early.
2. Follicular thyroid cancer
Follicular thyroid cancer, the second most common thyroid cancer, makes up about 15 percent of all case. It is a low grow cancer with peak onset ages 40 through 60. Follicular thyroid cancer can be treat successful, if diagnosed early.
3. Medullary thyroid cancer
Medullary thyroid cancer, third most common thyroid cance makes up about 3 percent of all cases, arise from thyroid hormone producing cells with abnormally high levels of calcitonin. Medullary thyroid cancer tends to grow slowly but it can spread to distant parts of the body, if not treated early.
4. Anaplastic thyroid cancer
Anaplastic thyroid cancer the rare case of thyroid cancer, makes up less than 2 percent of all cases. The cancer cells tend to grow and spread very quickly. Anaplastic thyroid cancer is deadly, with only 10% of alive rate, 3 years after it is diagnosed.

Types of food to prevent and treat thyroid cancer
1. Legumes, soy and peanut
Daidzein is a phytochemical in the Isoflavones, belonging to the group of Flavonoids (polyphenols), found abundantly in food of the family of legumes, soy, peanut, etc..In the study to explore whether or not human thyroid cancer cell growth can be curbed by a novel isoflavone derivative generated in our laboratory, the N-t-Boc-hexylenediamine derivative of 7-(O)-carboxymethyl daidzein (cD-tboc), showed that when nude mice carrying ARO thyroid xenografts were treated with cD-tboc, tumor volume decreased significantly, and no apparent toxicity was observed. These results suggest that cD-tboc may be a promising agent for therapy of thyroid carcinoma either alone or in combination with existing cytotoxic drugs(1).

2. Soybean
In the study to observe that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase-(TPO) catalyzed reactions essential tothyroid hormone synthesis, showed that In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction(2).

3. Green tea
Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, was shown to possess remarkable therapeutic potential against various types of human cancercells in in vitro and in vivo models. In the study to investigate the effect of EGCG on the proliferation and apoptosis of ARO cells--human ATC cells, showed that EGCG treatment inhibited the growth of ARO cells in a dose-dependent manner. Furthermore, EGCG suppressed phosphorylation of EGFR, ERK1/2, JNK, and p38. These changes were associated with increased p21 and reduced cyclin B1/CDK1 expression. In addition, EGCG treatment increased the accumulation of sub-G1 cell, activated caspase-3 and cleaved PARP(3).

4. Etc.


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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21600982
(2) http://www.ncbi.nlm.nih.gov/pubmed/9464451
(3) http://www.ncbi.nlm.nih.gov/pubmed/21725973


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