Phytochemicals for Treatment of Melanoma skin cancer ( Malignant Melanoma)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.


             Melanoma skin cancer ( Malignant Melanoma)

Melanoma is a kind of skin cancer but less common to other skin cancer as a result of malignancy of of melanocytes, which is the cell produced dark pigment for your skin. Approximate 120,000 new cases of melanoma in the US are diagnosed in a year. melanoma tends to spread along the skin in most of the cases, but also can grow downward to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.

Types of melanoma
1. Superficial spreading
This is a most common type of melanoma, accounted for over 70% of all cases. It usually starts with a normal mole, but for what ever reason, it begins to change malignantly with irregular borders, and has color variations.

2. Nodular type
This type of melanoma is more aggressive growth than superficial spreading and found most on the trunk, upper arms, and thighs. The nodular type of melanoma is usual detected as a lump with blue and black color.

3. Acral melanoma
Acral melanoma mostly founded on the hands, feet, and nail beds. The risk increases for people with darken-skin color.

4. Lentigo maligna melanoma
Found mostly on the face of elderly in the eye, back at the eye. around the mouth, the anus or vagina with great exposure to sunlight.

Types of foods to prevent and treat Melanoma skin cancer
1. green tea
In the study to determine the effect of green tea catechins on the invasive potential of human melanoma cells and the molecular mechanisms underlying these effects using A375 (BRAF-mutated) and Hs294t (Non-BRAF-mutated)melanoma cell lines as an in vitro model, showed that EGCG, a major green teacatechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of COX-2, PGE(2) receptors and epithelial-to-mesenchymal transition(1).

2. Grape seed
In the examined the effect of grape seed proanthocyanidins (GSPs) on melanomacancer cell migration and the molecular mechanisms underlying these effects using highly metastasis-specific human melanoma cell lines, A375 and Hs294t, indicated that GSPs have the ability to inhibit melanoma cell invasion/migration by targeting the endogenous expression of COX-2 and reversing the process of epithelial-to-mesenchymal transition(2).

3. Turmeric
Curcumin is a phytochemical found abundant in the plant. In acidic solutions (pH <7.4) it turns yellow, whereas in basic (pH > 8.6) solutions it turns bright red. In the successfully incorporated curcumin into a bilayer of dodecanoic acid attached to magnetite nanoparticles in an effort to maximize solubility and delivery efficiency, found that fluorescent microscopy revealed that curcumin associated magnetite nanoparticles were internalized by the melanoma cells and remained in the cytoplasm. The curcumin/magnetic nanoparticles synthesized in this study possess magnetic and water solubility properties making this a novel curcuminformulation with therapeutic potential(3).

4. Mango, Soy and Strawberries
Gallic acid (GA) is a phytochemical in the class of Phenolic acids, found abundantly in tea, mango, strawberries, soy, etc. In the study to examine the influence of GA on the protein levels and gene expression of MMP-2 and MMP-9 and in-vitro migration and invasiveness of human melanoma cells, showed that GA has antimetastatic potential by decreasing invasiveness of cancer cells. Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways resulting in inhibition of MMP-2 in A375.S2 human melanoma cells. These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells(4).

5. Etc.


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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22022384
(2) http://www.ncbi.nlm.nih.gov/pubmed/21738696
(3) http://www.ncbi.nlm.nih.gov/pubmed/20974686
(4) http://www.ncbi.nlm.nih.gov/pubmed/21734530