Herbal catnip was found to process certain chemical compounds that stimulate the immune function against microbial organisms in the acute and chronic phase of infection, some scientists suggested.
In human, anti-microbial activity is a natural reaction in which the macrophages of the immune system in the response to the early phase of infection stimulate the production of inflammatory cytokines which have a unique function in killing off foreign pathogens before they can cause harm to the body.
In plants, antimicrobial substances produced by the plant are served as plant defense mechanisms against predation by microorganisms.
However, overproduction of proinflammatory cytokines in many cases can mistakenly cause damage to healthy cells and tissue in the site of infection, leading to abnormal skin and scars formation.
There are 2 types of inflammatory cytokines: the proinflammatory (Isuch as IL-1β, IL-6. and TNF-α) and anti-inflammatory (such as IL-4, IL-6, IL-10, and IL-11) cytokines. Some cytokines process a duo inflammatory (such as IL-6) functions, under normal conditions, they act as the anti-inflammatory agents to protect against inflammation. Once they sense the danger to the body, they can quickly switch to pro-inflammatory cytokines.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The functional herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation, stimulate sweating, promote menstruation, etc..
Ingredients
Besides, having the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In the finding of the natural alternatives in replacement of traditional antibiotics with no side effects, researchers at the Shiraz University of Medical Sciences launched an evaluation to examine the antimicrobial activity of the essential oil derived from herbal Catnip.
Chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) isolated from the essential oil were effective in exerting their antimicrobial activity against all tested bacteria at concentrations of 0.125-4 μL/mL and the growth of Candida species at a concentration less than 1 μL/mL.
The essential oil chemical constituent nepetalactones are also found to process anti antibacterial, antifungal, insecticidal and antioxidant activities.
Terpenenes or terpenoids found abundant in Catnip are active against bacteria, fungi, viruses, and protozoa. According to the 1977 report, 60% of essential oil derivatives derived from terpenoids demonstrated inhibition of fungi and while only 30% inhibited bacteria.
Furthermore, the extract of catnip also displayed an inhibitory activity on growth, enzyme production and adhesion of some bacteria.
Moreover, the essential oil extract from Catnip also exhibited the anti bactericidal activity against Gram-positive bacteria at concentrations ranging from 0.5 to 8 μL/mL.
All of the Gram-negative bacteria were susceptible to the Catnip oils at concentrations of 0.25–32 μL/mL
The essential oil of Catnip from different growth stages exhibited bacteriostatic and bactericidal activities against the Shigella and Salmonella species at concentrations of 0.25–2 μL/mL and 0.5–8 μL/mL, respectively.
Additionally, the essential oil inhibited the growth of the standard species of Aspergillus at a concentration of 0.25–1 μL/mL.
In the comparison of the antibacterial effect of some herbs, including Catnip, researchers found that Lavender oil is more effective in the exhibited antibacterial ability than the Catnip essential oil, probably based on the concept of synergistic values of essential oil components.
Nevertheless, only a few published reports are available regarding the antimicrobial effects of the catnip EOs, especially against food-borne and resistant microorganisms, Dr. Zomorodian K, the lead author suggested.
Taken altogether, the essential oil derived from catnip may be considered an adjunct therapy for the treatment of microbial infection.
Today, mainstream medicine antibiotics have become less effective as many viral and bacteria have developed resistance to the application due to being overused.
Secondary metabolites of plants processed antimicrobial properties with no side effects have been promoted by some companies as natural alternatives to antibiotics. The general public must be aware that many of these compounds are currently available as unregulated botanical preparations.
Please make sure that you follow the guideline of the product closely, as acute liver toxicity has been reported in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
Saturday, November 30, 2019
Herbal Cinnamon, The Kitchen Spice in Prevention and Treatment of Alzheimer's Diseases
Adding spicy cinnamon into your diet may have a significant effect of blocking the onset of Alzheimer's Diseases, a new study suggested.
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated to the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules have been found in patients with Alzheimer's Disease.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated to the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules have been found in patients with Alzheimer's Disease.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Herbal Cat's claw Kills 90% of Breast Cancer Cells in Vitro
Scientists may have found a functional herb which has the potential to treat breast cancer without including any side effects, some studies suggested.
Most breast cancer irregular cell growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
At the later stage, after colonizing the most parts of breast tissue, malignant cells can travel a distance far way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.
In Canada, the risk of getting invasive breast cancer during the lifetime before the age of 90 of a woman is 1/11.
The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.
However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.
According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.
The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.
The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.
Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).
Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line
Furthermore, the Cat 's claw extracts a strong in antimutagenic activity by restoring the cell DNA to a healthy level.
Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking the cell division through cell cycle arrest.
Moreover, at the concentration of 100 mg/ml of two active fractions isolated from Cat's claw inhibited 90% of breast cancer cells in MCF7.
These results suggested Cat's extract and its active fractions may be considered secondary therapy for the treatment of breast cancer.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Most breast cancer irregular cell growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
At the later stage, after colonizing the most parts of breast tissue, malignant cells can travel a distance far way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.
In Canada, the risk of getting invasive breast cancer during the lifetime before the age of 90 of a woman is 1/11.
The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.
However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.
According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.
The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.
The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.
Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).
Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line
Furthermore, the Cat 's claw extracts a strong in antimutagenic activity by restoring the cell DNA to a healthy level.
Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking the cell division through cell cycle arrest.
Moreover, at the concentration of 100 mg/ml of two active fractions isolated from Cat's claw inhibited 90% of breast cancer cells in MCF7.
These results suggested Cat's extract and its active fractions may be considered secondary therapy for the treatment of breast cancer.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Herbal Cascara Sagrada's Emodin, the Anti Breast Cancer Bioactive Compound
Scientists may have found a natural ingredient isolated from a herbal plant which processes a significant effect in reducing the risk and treatment of breast cancer, some studies suggested.
Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases of breast cancer that start in other areas of the breast
The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
Dr. Manuel Picon‐Ruiz, the lead author, in the concern of the correlated increased incidence of breast cancer among obese women launched an investigation to examine whether obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages.
After taking into account co and confounder, the doctors wrote, "The Million Women Study followed 1.2 million UK women ages 50 to 64 years for a mean of 5.4 years, including 45,037 with breast cancer, and identified a nearly 30% higher risk of developing postmenopausal breast cancer with obesity". and "(But) a large body of evidence indicates that, although obesity is inversely associated with receptor‐positive breast cancer development before menopause".
Interestingly, the results strongly indicated, obesity is a risk factor of breast cancer in postmenopause but a reduced risk factor before menopause.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the finding a natural compound or whole food which process the potency for the treatment of breast cancer with little or no side effects compared to those of conventional chemo drug, researchers conducted a joint study led by the China Medical University to examine the anti-breast cancer effect of Emodin.
Human breast cancer cells Bcap-37 and ZR-75-30.were used in the study
The cell viability following emodin treatment was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Application of Emodin showed a strong effect in the inhibition of the growth and induction of apoptosis of breast cancer cells Bcap-37 and ZR-75-30 in a time- and dose-dependent manner.
The inhibitory activity was attributed to Emodin in reducing the level of a protein associated with inhibiting apoptosis and promoting oncogenesis, and proteins and antibodies associated with programming cell death and enhancing apoptosis.
Dr. CONG ZU the lead scientist, after taking into account co and confounders said, "These findings indicate that emodin induces growth inhibition and apoptosis in human breast cancer cells. Emodin may be a potential therapeutic agent for the treatment of breast cancer".
In mice bearing EO771 or 4T1 breast tumors, researchers at the University of South Carolina School of Medicine examine the effects of Emodin against breast cancer through varied mechanisms.
Application of Emodin showed a significant effect in the attenuation tumor growth by inhibiting macrophage infiltration and M2-like polarization, in promoting cancer cell growth, invasion, metastasis and accompanied by increased immune white blood cells in the host and reduced the new formation of blood vessels for the cancer proliferation.
The inhibition of the promotion of cancer cell growth, invasion, metastasis by emodin was associated with deactivation of genes on the promoters of M2-related genes in tumor-associated macrophages.
Dr. Iwanowycz S, at the final report, "emodin acts on both breast cancer cells and macrophages and effectively blocks the tumor-promoting feed-forward loop between the two cell types, thereby inhibiting breast cancer growth and metastasis".
Taken altogether, Herbal Cascara Sagrada processed abundant bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes by CONG ZU,1,* MINGDI ZHANG,2,* HUI XUE,3 XIAOPENG CAI,4 LEI ZHAO,5 ANNING HE,1GUANGYUAN QIN,1 CHUNSHU YANG,1 and XINYU ZHENG. (PMC)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
(3) Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages by Iwanowycz S1, Wang J1, Hodge J1, Wang Y1, Yu F2, Fan D. (PubMed).
Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases of breast cancer that start in other areas of the breast
The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
Dr. Manuel Picon‐Ruiz, the lead author, in the concern of the correlated increased incidence of breast cancer among obese women launched an investigation to examine whether obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages.
After taking into account co and confounder, the doctors wrote, "The Million Women Study followed 1.2 million UK women ages 50 to 64 years for a mean of 5.4 years, including 45,037 with breast cancer, and identified a nearly 30% higher risk of developing postmenopausal breast cancer with obesity". and "(But) a large body of evidence indicates that, although obesity is inversely associated with receptor‐positive breast cancer development before menopause".
Interestingly, the results strongly indicated, obesity is a risk factor of breast cancer in postmenopause but a reduced risk factor before menopause.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the finding a natural compound or whole food which process the potency for the treatment of breast cancer with little or no side effects compared to those of conventional chemo drug, researchers conducted a joint study led by the China Medical University to examine the anti-breast cancer effect of Emodin.
Human breast cancer cells Bcap-37 and ZR-75-30.were used in the study
The cell viability following emodin treatment was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Application of Emodin showed a strong effect in the inhibition of the growth and induction of apoptosis of breast cancer cells Bcap-37 and ZR-75-30 in a time- and dose-dependent manner.
The inhibitory activity was attributed to Emodin in reducing the level of a protein associated with inhibiting apoptosis and promoting oncogenesis, and proteins and antibodies associated with programming cell death and enhancing apoptosis.
Dr. CONG ZU the lead scientist, after taking into account co and confounders said, "These findings indicate that emodin induces growth inhibition and apoptosis in human breast cancer cells. Emodin may be a potential therapeutic agent for the treatment of breast cancer".
In mice bearing EO771 or 4T1 breast tumors, researchers at the University of South Carolina School of Medicine examine the effects of Emodin against breast cancer through varied mechanisms.
Application of Emodin showed a significant effect in the attenuation tumor growth by inhibiting macrophage infiltration and M2-like polarization, in promoting cancer cell growth, invasion, metastasis and accompanied by increased immune white blood cells in the host and reduced the new formation of blood vessels for the cancer proliferation.
The inhibition of the promotion of cancer cell growth, invasion, metastasis by emodin was associated with deactivation of genes on the promoters of M2-related genes in tumor-associated macrophages.
Dr. Iwanowycz S, at the final report, "emodin acts on both breast cancer cells and macrophages and effectively blocks the tumor-promoting feed-forward loop between the two cell types, thereby inhibiting breast cancer growth and metastasis".
Taken altogether, Herbal Cascara Sagrada processed abundant bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes by CONG ZU,1,* MINGDI ZHANG,2,* HUI XUE,3 XIAOPENG CAI,4 LEI ZHAO,5 ANNING HE,1GUANGYUAN QIN,1 CHUNSHU YANG,1 and XINYU ZHENG. (PMC)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
(3) Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages by Iwanowycz S1, Wang J1, Hodge J1, Wang Y1, Yu F2, Fan D. (PubMed).
Herbal Coltsfoot Protects Intestinal Mucosal Barrier Against the Risk of Colitis
Colitis is a condition characterized by the inflammation of the inner lining of the colon.
The disease can be caused by infection, such as inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases induced both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine and preserves the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the anti-colitis effect of Tussilagone (TSL), a major component of Tussilago farfara.
On mice subjected to acute colitis induced by dextran sulfate sodium (DSS), tussilagone showed a significant protective effect by ameliorating weight loss, and colonic inflammatory damage.
Proteins associated with pro-inflammatory cytokines such as the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were inhibited by tussilagone-treated mice.
Furthermore, tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) in the induction of cytokines and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) involved the production of antioxidant enzymes in nuclei of colonic tissues.
Based on the findings, researchers said, " tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for the treatment of intestinal ".
Taken altogether, coltsfoot may be considered a remedy for the treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis by Cheon HJ1, Nam SH1, Kim JK. (PubMed)
The disease can be caused by infection, such as inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases induced both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine and preserves the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the anti-colitis effect of Tussilagone (TSL), a major component of Tussilago farfara.
On mice subjected to acute colitis induced by dextran sulfate sodium (DSS), tussilagone showed a significant protective effect by ameliorating weight loss, and colonic inflammatory damage.
Proteins associated with pro-inflammatory cytokines such as the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were inhibited by tussilagone-treated mice.
Furthermore, tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) in the induction of cytokines and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) involved the production of antioxidant enzymes in nuclei of colonic tissues.
Based on the findings, researchers said, " tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for the treatment of intestinal ".
Taken altogether, coltsfoot may be considered a remedy for the treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis by Cheon HJ1, Nam SH1, Kim JK. (PubMed)
Friday, November 29, 2019
Anise, The Hepatoprotective Effects Functional Herb
Anise may have a potential and substantial protective effect to prevent liver damage and diseases, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Liver disease is a medical condition characterized by damage or injury of the liver tissues, affecting 1 in 4 Canadians, according to the statistic. The disease can also be inherited genetically from the parent.
In the evaluation of the liver protective effect of Anise in the mice induced liver toxicity by injection of carbon tetrachloride (CCl4), researchers found that Anise application significantly reduced production of reactive oxygen species in the liver tissue in initiated a chain reaction to induced tissue damage through its antioxidants activities, observed by oxidative stress markers.
The hepatoprotective effects of Anise not only protected against liver necrosis but also correlated with elevated serum IL-6 cytokine in response to infections and tissue injuries and in contributed to host defense through the stimulation of acute phase infection without inducing inflammation and activated hepatic STAT3 in facilitated lipid peroxidation.
Administered Anise also reduced oxidative stress in expression of several oxidative markers including liver Malondialdehyde (MDA), serum Alanine Aminotransferase (ALT) and aspartate aminotransferase (AST) levels through increased levels of hepatic antioxidants such as SOD and catalase in compared to non treated group.
Additionally, in the study of a total 36 Sprague-Dawley rats allocated into five groups with group I, II, and III received isotonic saline solution, olive oil, and CCl4, respectively and group IV received both Silibinin and CCl4 and group V with injection of Anise seed extract (PFO) and CCl4, researchers at the end study found that rats treated with CCL4 exhibited a significant liver damage through observation of levels of makers of liver AST and ALT.
Rats treated with Anise seed extract (PFO) revealed a lower serum AST and ALT levels in compared to those in the CCl4 group, although this was not as low as those in the silibinin group.
Moreover application of concentrations (1-1000 µg/ml) of essential oil and hydroalcoholic and n-hexane extracts isolated from Pimpinella anisum (anise), 1 h before the addition of 100 mM of CCl4, researchers indicated that liver cytotoxicity induced by injection of CCL4 was significantly decreased by antioxidant activity of n-hexane extract with concentrations of 10-50 µg/ml.
However, the administration of anise extracts and essential oil was found surprisingly in induced liver toxic effect with concentrations over 50 mµ/ml.
This result suggested that Pimpinella anisum. exhibited hepatoprotective effect against a foreign substance in precipitated liver damage in doses dependent manner.
In other words, overdoses of essential oil and hydroalcoholic and n-hexane extracts isolated from Anise can cause acute liver toxicity.
Taking all together, Anise with abundant phytochemicals may be considered as a functional herb for reduced risk and assisted standard therapy for the treatment of liver diseases, depending on further evaluation.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) An in vivo and in vitro investigation on hepatoprotective effects of Pimpinellaanisum seed essential oil and extracts against carbon tetrachloride-induced toxicity by Jamshidzadeh A1, Heidari R2, Razmjou M3, Karimi F3, Moein MR4, Farshad O5, Akbarizadeh AR6, Shayesteh MR3(PubMed)
(2) Hepatoprotective Effects of Pimpinella anisum Seed Extract in Rats Nureddin Cengiza Hanefi Özbekb, Aydın Himc(Pharmacologyonline 3: 870-874 (2008))
(3) Hepatoprotective effect of pimpinella anisum seed essential oil and extracts against CCl4 induced toxicity on HepG2 cellsby Akram Jamshidzadeh, Mahmoodreza Moein, Amin Reza Akbarizadeh, Niloufar Tahghighi Ahmadi(Research gate)
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Liver disease is a medical condition characterized by damage or injury of the liver tissues, affecting 1 in 4 Canadians, according to the statistic. The disease can also be inherited genetically from the parent.
In the evaluation of the liver protective effect of Anise in the mice induced liver toxicity by injection of carbon tetrachloride (CCl4), researchers found that Anise application significantly reduced production of reactive oxygen species in the liver tissue in initiated a chain reaction to induced tissue damage through its antioxidants activities, observed by oxidative stress markers.
The hepatoprotective effects of Anise not only protected against liver necrosis but also correlated with elevated serum IL-6 cytokine in response to infections and tissue injuries and in contributed to host defense through the stimulation of acute phase infection without inducing inflammation and activated hepatic STAT3 in facilitated lipid peroxidation.
Administered Anise also reduced oxidative stress in expression of several oxidative markers including liver Malondialdehyde (MDA), serum Alanine Aminotransferase (ALT) and aspartate aminotransferase (AST) levels through increased levels of hepatic antioxidants such as SOD and catalase in compared to non treated group.
Additionally, in the study of a total 36 Sprague-Dawley rats allocated into five groups with group I, II, and III received isotonic saline solution, olive oil, and CCl4, respectively and group IV received both Silibinin and CCl4 and group V with injection of Anise seed extract (PFO) and CCl4, researchers at the end study found that rats treated with CCL4 exhibited a significant liver damage through observation of levels of makers of liver AST and ALT.
Rats treated with Anise seed extract (PFO) revealed a lower serum AST and ALT levels in compared to those in the CCl4 group, although this was not as low as those in the silibinin group.
Moreover application of concentrations (1-1000 µg/ml) of essential oil and hydroalcoholic and n-hexane extracts isolated from Pimpinella anisum (anise), 1 h before the addition of 100 mM of CCl4, researchers indicated that liver cytotoxicity induced by injection of CCL4 was significantly decreased by antioxidant activity of n-hexane extract with concentrations of 10-50 µg/ml.
However, the administration of anise extracts and essential oil was found surprisingly in induced liver toxic effect with concentrations over 50 mµ/ml.
This result suggested that Pimpinella anisum. exhibited hepatoprotective effect against a foreign substance in precipitated liver damage in doses dependent manner.
In other words, overdoses of essential oil and hydroalcoholic and n-hexane extracts isolated from Anise can cause acute liver toxicity.
Taking all together, Anise with abundant phytochemicals may be considered as a functional herb for reduced risk and assisted standard therapy for the treatment of liver diseases, depending on further evaluation.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) An in vivo and in vitro investigation on hepatoprotective effects of Pimpinellaanisum seed essential oil and extracts against carbon tetrachloride-induced toxicity by Jamshidzadeh A1, Heidari R2, Razmjou M3, Karimi F3, Moein MR4, Farshad O5, Akbarizadeh AR6, Shayesteh MR3(PubMed)
(2) Hepatoprotective Effects of Pimpinella anisum Seed Extract in Rats Nureddin Cengiza Hanefi Özbekb, Aydın Himc(Pharmacologyonline 3: 870-874 (2008))
(3) Hepatoprotective effect of pimpinella anisum seed essential oil and extracts against CCl4 induced toxicity on HepG2 cellsby Akram Jamshidzadeh, Mahmoodreza Moein, Amin Reza Akbarizadeh, Niloufar Tahghighi Ahmadi(Research gate)
Cat's claw, The best Whole Herb Medicine for Prevention and Treatment of Cancers
Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has placed an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over the world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and pattern right to producers.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, becoming progressively worse and damaged other healthy tissues, sometimes spreading to other organs in the body via lymph or blood and results may be in death
The herbal whole herb medicine may be used for the treatment of various cancers. In a recent study, cat's claw chemotypes showed a directed influence on genotoxicity and cytotoxicity against nonmalignant and malignant human cell lines.
In T24 and RT4 human bladder cancer cell lines, bark samples extracted by dynamic maceration, alkaloids or isomerized derivative significant induced cytotoxic activity in dose-dependent
manner, leading to cell death in the tumor cell divisive process.
According to the Universidade Federal do Rio Grande do Sul (UFRGS) in joint study with other renowned institutions, Quinovic acid glycosides purified fraction (QAPF) of U.tomentosa found in Cat' claw decreased the growth and viability and protected against cell proliferation in both T24 and RT4 cell lines, through interfering with the inflammation, immunity, cell proliferation, differentiation pathway.
In a total of fifty-one volunteers recruited with the median age was 64 (range, 33-85) years, and 47% of patients were female, cat's claw improves quality of life and symptom of fatigue in patients with advanced cancer.
Dr. Dreifuss AA, the lead author at the Cayetano Heredia Peruvian University said, that In vivo, UT hydroalcoholic extract demonstration of both antitumoral and antioxidant effects. The antineoplastic activity may be the result in regulated redox and metabolism homeostasis as well as anti-neoplastic effects.
Taking together, the whole herb Cat's claw may be used for the prevention and treatment of cancers, but the prescribed quality must be given by the herbal doctor to reduce the risk of overdoses.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance by Kaiser S1, Carvalho ÂR2, Pittol V2, Dietrich F3, Manica F3, Machado MM4, de Oliveira LF4, Oliveira Battastini AM3, Ortega GG2.(PubMed)
(2) Cat's claw oxindole alkaloid isomerization induced by cell incubation and cytotoxic activity against T24 and RT4 human bladder cancer cell lines by Kaiser S1, Dietrich F, de Resende PE, Verza SG, Moraes RC, Morrone FB, Batastini AM, Ortega GG.(PubMed)
(3) Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line by Dietrich F1, Kaiser S2, Rockenbach L1, Figueiró F1, Bergamin LS1, da Cunha FM3, Morrone FB4, Ortega GG2, Battastini AM5.(PubMed)
(4) Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors by de Paula LC1, Fonseca F, Perazzo F, Cruz FM, Cubero D, Trufelli DC, Martins SP, Santi PX, da Silva EA, Del Giglio A.(PubMed)
(5) Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model by Dreifuss AA1, Bastos-Pereira AL, Avila TV, Soley Bda S, Rivero AJ, Aguilar JL, Acco A.(PubMed)
(6) Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity by Dreifuss AA1, Bastos-Pereira AL, Fabossi IA, Lívero FA, Stolf AM, Alves de Souza CE, Gomes Lde O, Constantin RP, Furman AE, Strapasson RL, Teixeira S, Zampronio AR, Muscará MN, Stefanello ME, Acco A.(PubMed)
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, becoming progressively worse and damaged other healthy tissues, sometimes spreading to other organs in the body via lymph or blood and results may be in death
The herbal whole herb medicine may be used for the treatment of various cancers. In a recent study, cat's claw chemotypes showed a directed influence on genotoxicity and cytotoxicity against nonmalignant and malignant human cell lines.
In T24 and RT4 human bladder cancer cell lines, bark samples extracted by dynamic maceration, alkaloids or isomerized derivative significant induced cytotoxic activity in dose-dependent
manner, leading to cell death in the tumor cell divisive process.
According to the Universidade Federal do Rio Grande do Sul (UFRGS) in joint study with other renowned institutions, Quinovic acid glycosides purified fraction (QAPF) of U.tomentosa found in Cat' claw decreased the growth and viability and protected against cell proliferation in both T24 and RT4 cell lines, through interfering with the inflammation, immunity, cell proliferation, differentiation pathway.
In a total of fifty-one volunteers recruited with the median age was 64 (range, 33-85) years, and 47% of patients were female, cat's claw improves quality of life and symptom of fatigue in patients with advanced cancer.
Dr. Dreifuss AA, the lead author at the Cayetano Heredia Peruvian University said, that In vivo, UT hydroalcoholic extract demonstration of both antitumoral and antioxidant effects. The antineoplastic activity may be the result in regulated redox and metabolism homeostasis as well as anti-neoplastic effects.
Taking together, the whole herb Cat's claw may be used for the prevention and treatment of cancers, but the prescribed quality must be given by the herbal doctor to reduce the risk of overdoses.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance by Kaiser S1, Carvalho ÂR2, Pittol V2, Dietrich F3, Manica F3, Machado MM4, de Oliveira LF4, Oliveira Battastini AM3, Ortega GG2.(PubMed)
(2) Cat's claw oxindole alkaloid isomerization induced by cell incubation and cytotoxic activity against T24 and RT4 human bladder cancer cell lines by Kaiser S1, Dietrich F, de Resende PE, Verza SG, Moraes RC, Morrone FB, Batastini AM, Ortega GG.(PubMed)
(3) Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line by Dietrich F1, Kaiser S2, Rockenbach L1, Figueiró F1, Bergamin LS1, da Cunha FM3, Morrone FB4, Ortega GG2, Battastini AM5.(PubMed)
(4) Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors by de Paula LC1, Fonseca F, Perazzo F, Cruz FM, Cubero D, Trufelli DC, Martins SP, Santi PX, da Silva EA, Del Giglio A.(PubMed)
(5) Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model by Dreifuss AA1, Bastos-Pereira AL, Avila TV, Soley Bda S, Rivero AJ, Aguilar JL, Acco A.(PubMed)
(6) Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity by Dreifuss AA1, Bastos-Pereira AL, Fabossi IA, Lívero FA, Stolf AM, Alves de Souza CE, Gomes Lde O, Constantin RP, Furman AE, Strapasson RL, Teixeira S, Zampronio AR, Muscará MN, Stefanello ME, Acco A.(PubMed)
Herbal Cascara Sagrada's Emodin Kills Non-small Cell Lung Cancer (NSCLC) Cells, in Vivo and Vitro
Herbal Cascara sagrada may be the next pharmaceutical target to identify the single ingredient for the treatment of non-small cell lung cancer (NSCLC), some scientists suggested.
Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancers is derived from epithelial cells.
According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.
In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.
Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.
The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.
Dr. Ryo Maeda MD, the lead scientists in the study to investigate the association between cigarette smoking and clinicopathological characteristics of patients with non-small cell lung cancer (NSCLC) and to evaluate its significance as a predictor of recurrence after resection showed that
* The 5 years of the survival rate of never and ever smokers in patients with stage I is 92%, compared to 76%, in smokers.
* The 5-year recurrence-free proportions (RFPs) for never and ever smokers were 89% compared to 80%, in smokers.
At the final report, the doctors wrote, "Smoking history showed the different impact on postoperative recurrence in patients with NSCLC between stage I and stages II and III, and depending on histology in stage I patients" and "Disease stages should be considered while evaluating smoking history as a predictor of recurrence".
These results not only indicated smoking has a strong impact on the increased incidence of non-small cell lung cancer (NSCLC) and but also reduces years of survival.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, Cascara sagrada also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
On finding a natural ingredient for the treatment of nonsmall cell lung cancer, researchers examined the effect of Emodin, a tyrosine kinase inhibitor is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants including herbal Cascara Sagrada.
Compared to the effect of cisplatin, a chemo drug, Emodin, exposure to the human NSCLC cells to emodin decreased cisplatin-elicited in the inhibition of the metaplasia and tumor development and increased the inability of a protein associated to cell DNA repaired.
Application of emodin alone or combined with cisplatin significantly decreased expression of cell repaired protein in carrying a portion of the code to other parts of the cell for processing.
Furthermore, the combination of Emodine and cisplatin decreased the proliferation and enhanced cisplatin-induced cytotoxicity in non-small cell lung cancer (NSCLC).
Although the study did not mention the effect of Emodin used combined with cisplatin have elicited the side effect caused by cisplatin, Emodin may lead to novel therapy in the future for NSCLC through the down-regulating expression of proteins associated to tumor spreading.
Further analysis of the Emodin effect on the non-small cell lung cancer (NSCLC) scientists at the Hsinchu Hospital investigates the role of ERCC1 and Rad51 in emodin-mediated cytotoxicity in human non-small cell lung cancer (NSCLC) cells.
Where ERCC1 is a protein associated with cell repair and DNA recombination and RAD51 is a protein associated with the assists in the repair of DNA double-strand breaks.
Injection of Emodin showed a reduction of the expression of ERCC1 and Rad51 protein levels as well as mRNA levels in four different NSCLC cell lines correlated with the inactivation of the MKK1/2-ERK1/2 pathway involving cells proliferation.
The result suggested that the application of Emodin exerts a similar effect as those of U0126, an MKK1/2 inhibitor used in conventional medicine for the inhibition of cellular ERCC1 and Rad51 protein and mRNA levels.
A combination of Emodin and U0126 could enhance emodin cytotoxic activity against the tested cell lines.
Dr. the lead scientist suggested these results showed that Emodin isolated from herbal Cascara Sagrada inhibited the nonsmall lung cancer through cytotoxic effect by blocking the protein associated with cell proliferation to induce apoptosis.
Taken altogether, herbal Cascara Sagrada processed the bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of non-small cell lung cancer (NSCLC)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2 by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Chiu YF, Kuo YH, Tsai MS, Lin YW. (PubMed)
(2). Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Lin YW. (PubMed)
(3) The Prognostic Impact of Cigarette Smoking on Patients with Non-small Cell Lung Cancer. (Research Gate)
Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancers is derived from epithelial cells.
According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.
In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.
Most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.
The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.
Dr. Ryo Maeda MD, the lead scientists in the study to investigate the association between cigarette smoking and clinicopathological characteristics of patients with non-small cell lung cancer (NSCLC) and to evaluate its significance as a predictor of recurrence after resection showed that
* The 5 years of the survival rate of never and ever smokers in patients with stage I is 92%, compared to 76%, in smokers.
* The 5-year recurrence-free proportions (RFPs) for never and ever smokers were 89% compared to 80%, in smokers.
At the final report, the doctors wrote, "Smoking history showed the different impact on postoperative recurrence in patients with NSCLC between stage I and stages II and III, and depending on histology in stage I patients" and "Disease stages should be considered while evaluating smoking history as a predictor of recurrence".
These results not only indicated smoking has a strong impact on the increased incidence of non-small cell lung cancer (NSCLC) and but also reduces years of survival.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, Cascara sagrada also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
On finding a natural ingredient for the treatment of nonsmall cell lung cancer, researchers examined the effect of Emodin, a tyrosine kinase inhibitor is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants including herbal Cascara Sagrada.
Compared to the effect of cisplatin, a chemo drug, Emodin, exposure to the human NSCLC cells to emodin decreased cisplatin-elicited in the inhibition of the metaplasia and tumor development and increased the inability of a protein associated to cell DNA repaired.
Application of emodin alone or combined with cisplatin significantly decreased expression of cell repaired protein in carrying a portion of the code to other parts of the cell for processing.
Furthermore, the combination of Emodine and cisplatin decreased the proliferation and enhanced cisplatin-induced cytotoxicity in non-small cell lung cancer (NSCLC).
Although the study did not mention the effect of Emodin used combined with cisplatin have elicited the side effect caused by cisplatin, Emodin may lead to novel therapy in the future for NSCLC through the down-regulating expression of proteins associated to tumor spreading.
Further analysis of the Emodin effect on the non-small cell lung cancer (NSCLC) scientists at the Hsinchu Hospital investigates the role of ERCC1 and Rad51 in emodin-mediated cytotoxicity in human non-small cell lung cancer (NSCLC) cells.
Where ERCC1 is a protein associated with cell repair and DNA recombination and RAD51 is a protein associated with the assists in the repair of DNA double-strand breaks.
Injection of Emodin showed a reduction of the expression of ERCC1 and Rad51 protein levels as well as mRNA levels in four different NSCLC cell lines correlated with the inactivation of the MKK1/2-ERK1/2 pathway involving cells proliferation.
The result suggested that the application of Emodin exerts a similar effect as those of U0126, an MKK1/2 inhibitor used in conventional medicine for the inhibition of cellular ERCC1 and Rad51 protein and mRNA levels.
A combination of Emodin and U0126 could enhance emodin cytotoxic activity against the tested cell lines.
Dr. the lead scientist suggested these results showed that Emodin isolated from herbal Cascara Sagrada inhibited the nonsmall lung cancer through cytotoxic effect by blocking the protein associated with cell proliferation to induce apoptosis.
Taken altogether, herbal Cascara Sagrada processed the bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of non-small cell lung cancer (NSCLC)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2 by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Chiu YF, Kuo YH, Tsai MS, Lin YW. (PubMed)
(2). Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells by Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Lin YW. (PubMed)
(3) The Prognostic Impact of Cigarette Smoking on Patients with Non-small Cell Lung Cancer. (Research Gate)
Herbal Calendula, the Natural and Potent Neuroprotective Functional Herb
Herbal Calendula may have a potential and profound effect in protecting the integrity of the neurons against the onset of neuroprotective effects.
The neuroprotective effect is a protection against the damage of the brain cells.
The nerve system is a complex network including the brain and spinal cord with a unique function in transmitting information or signals from and to the brain and spinal cord from different parts of the body.
The nerve system in the human has evolved over thousands of the year to enhance the survivals of the human species by the rapid response to the change of the environmental factors and adapting to the change of environment.
The causes of neuro diseases are associated with the damage or dysfunction of the central nervous system (CNS), including the brain, brainstem, and spinal cord.
However, some of the most common causes of neuro diseases are associated with neurotoxicity, the term which refers to damage to the brain or spinal cord caused by exposure to natural or man-made toxic substances, leading to gradual loss of neurons that interfere with the function of the nerve system in transmitting information to other parts of the body.
There are many factors associated with the onset of neurotoxicities, such as characteristics of the neurotoxin, the doses of exposure, and the ability to metabolize and excrete the toxin.
Accumulation of toxic chemicals over the long-term in the nerve system can overwhelm the protective factors, leading to neurotoxic symptoms of paralysis or weakness in the limbs. altered sensation, tingling, and numbness in the limbs, prolonged headache, and vision loss, depending on the brain area of toxicity.
In the elderly, the neuro-toxicity is also found to speed up the onset of neurodegenerative diseases, leading to symptoms of loss of memory and cognitive dysfunction, such as Alzheimer's disease.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal plant has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the concern that oxidative stress (OS) and nitric oxide mechanisms proposed in 3-nitropropionic acid (3-NP)-induced neurotoxicity, scientists at the Sree Siddaganga College of Pharmacy examined the antioxidant, anti-inflammatory and estrogenic effects of Calendula officinalis Linn. flower extract (COE) neuroprotective against the experimental model.
The study included numbers of rat induced neurotoxicity by the injection of 3-NP.
Observing behavioral changes, OS and striatal damage in rat brain suggested that neurotoxic rat was accompanied by significant alterations in animal behavior, oxidative defense system evidenced by raised levels of LPO and nitrite concentration, and depletion of antioxidant levels.
These examinations showed that 3-NP caused significant damage to the rat brain by increasing the expression of free radicals and suppressing the production of antioxidant enzymes by the host body.
The injection also enhanced the production of inflammatory cytokines which have a strong effect in the blood vessels constriction and the loss of neuronal cells in the striatal region
Application of the herbal extract significantly attenuated behavioral alterations, oxidative damage and striatal neuronal loss in 3-NP-treated animals.
These results showed that COE is protective against 3-NP-induced neurotoxicity in rats through its antioxidant, anti-inflammatory and estrogenic properties.
With an aim to determine the effect of Calendula officinalis Linn. flower extract (COE) in the inhibition of excess monosodium glutamate (MSG), a popular flavor enhancer used in food industries in the induction of neurotoxicity, researchers conducted an experiment to evaluate the neuroprotective effect of COE on MSG-induced neurotoxicity in rats.
Adult Wistar rats selected to the study were administered systemically for 7 days with MSG and after one h of MSG injection before treated with COE (100 and 200 mg/kg) orally.
Before treated with COE, an infected rat showed a significant alteration in animal behavior, oxidative defense (raised levels of LPO, nitrite concentration, depletion of antioxidant levels) and hippocampal neuronal histology.
These results indicated that MSG displays similar effects to those of 3-NP in facilitating the imbalance of the ratio of the free radicals and antioxidant enzymes in the tested rats.
Observation of the result after injection of COE, researchers found that COE only restores the balance of the free radicals and antioxidant ratio but also inhibits the death of neuron cells in the brain.
The neuroprotective effect of COE was attributed to the antioxidant and anti-inflammatory properties, suggested by Dr. Shivasharan BD, the lead scientist.
Taken altogether, Herbal Calendula may be considered a functional herb for the prevention of neurotoxicity and an adjunct therapy combined with the primary medicine for the treatment of neuro diseases induced by toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats by Shivasharan BD1, Nagakannan P, Thippeswamy BS, Veerapur VP, Bansal P, Unnikrishnan MK(PubMed)
(2) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats by Shivasharan BD, Nagakannan P, Thippeswamy BS, Veerapur VP(PubMed)
The neuroprotective effect is a protection against the damage of the brain cells.
The nerve system is a complex network including the brain and spinal cord with a unique function in transmitting information or signals from and to the brain and spinal cord from different parts of the body.
The nerve system in the human has evolved over thousands of the year to enhance the survivals of the human species by the rapid response to the change of the environmental factors and adapting to the change of environment.
The causes of neuro diseases are associated with the damage or dysfunction of the central nervous system (CNS), including the brain, brainstem, and spinal cord.
However, some of the most common causes of neuro diseases are associated with neurotoxicity, the term which refers to damage to the brain or spinal cord caused by exposure to natural or man-made toxic substances, leading to gradual loss of neurons that interfere with the function of the nerve system in transmitting information to other parts of the body.
There are many factors associated with the onset of neurotoxicities, such as characteristics of the neurotoxin, the doses of exposure, and the ability to metabolize and excrete the toxin.
Accumulation of toxic chemicals over the long-term in the nerve system can overwhelm the protective factors, leading to neurotoxic symptoms of paralysis or weakness in the limbs. altered sensation, tingling, and numbness in the limbs, prolonged headache, and vision loss, depending on the brain area of toxicity.
In the elderly, the neuro-toxicity is also found to speed up the onset of neurodegenerative diseases, leading to symptoms of loss of memory and cognitive dysfunction, such as Alzheimer's disease.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal plant has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the concern that oxidative stress (OS) and nitric oxide mechanisms proposed in 3-nitropropionic acid (3-NP)-induced neurotoxicity, scientists at the Sree Siddaganga College of Pharmacy examined the antioxidant, anti-inflammatory and estrogenic effects of Calendula officinalis Linn. flower extract (COE) neuroprotective against the experimental model.
The study included numbers of rat induced neurotoxicity by the injection of 3-NP.
Observing behavioral changes, OS and striatal damage in rat brain suggested that neurotoxic rat was accompanied by significant alterations in animal behavior, oxidative defense system evidenced by raised levels of LPO and nitrite concentration, and depletion of antioxidant levels.
These examinations showed that 3-NP caused significant damage to the rat brain by increasing the expression of free radicals and suppressing the production of antioxidant enzymes by the host body.
The injection also enhanced the production of inflammatory cytokines which have a strong effect in the blood vessels constriction and the loss of neuronal cells in the striatal region
Application of the herbal extract significantly attenuated behavioral alterations, oxidative damage and striatal neuronal loss in 3-NP-treated animals.
These results showed that COE is protective against 3-NP-induced neurotoxicity in rats through its antioxidant, anti-inflammatory and estrogenic properties.
With an aim to determine the effect of Calendula officinalis Linn. flower extract (COE) in the inhibition of excess monosodium glutamate (MSG), a popular flavor enhancer used in food industries in the induction of neurotoxicity, researchers conducted an experiment to evaluate the neuroprotective effect of COE on MSG-induced neurotoxicity in rats.
Adult Wistar rats selected to the study were administered systemically for 7 days with MSG and after one h of MSG injection before treated with COE (100 and 200 mg/kg) orally.
Before treated with COE, an infected rat showed a significant alteration in animal behavior, oxidative defense (raised levels of LPO, nitrite concentration, depletion of antioxidant levels) and hippocampal neuronal histology.
These results indicated that MSG displays similar effects to those of 3-NP in facilitating the imbalance of the ratio of the free radicals and antioxidant enzymes in the tested rats.
Observation of the result after injection of COE, researchers found that COE only restores the balance of the free radicals and antioxidant ratio but also inhibits the death of neuron cells in the brain.
The neuroprotective effect of COE was attributed to the antioxidant and anti-inflammatory properties, suggested by Dr. Shivasharan BD, the lead scientist.
Taken altogether, Herbal Calendula may be considered a functional herb for the prevention of neurotoxicity and an adjunct therapy combined with the primary medicine for the treatment of neuro diseases induced by toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats by Shivasharan BD1, Nagakannan P, Thippeswamy BS, Veerapur VP, Bansal P, Unnikrishnan MK(PubMed)
(2) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats by Shivasharan BD, Nagakannan P, Thippeswamy BS, Veerapur VP(PubMed)
Herbal Catnip, the Natural Insect Repellent, Scientists Suggested
Scientists may have found a natural repellent which protects our skin against insect biting without inducing any side effects, some scientists suggested.
In the rating of products that work best against mosquitoes and ticks, the consumer report found that deet (N, N-diethyl-meta-toluamide) is one of the best to protect us against mosquitoes and ticks, Any products that contain 15 to 30 percent deep can provide long-lasting protection.
However, large oral doses of deep were found to induce symptoms of nausea, vomiting, bradycardia, and seizures. In serious cases, deet can cause cardiotoxicity. Contact exposure to deet also has the potential for dermal effects, leading to numbness and redness of the applied area, according to the study "Neurotoxicity and Mode of Action of N, N-diethyl-meta-toluamide (DEET)" by Dr. Daniel R. Swale.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The herb has bused use in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In the study to evaluate the effects herbal Catnip as an effective mosquito repellent against several Aedes and Culex species, both topically and spatially, researchers launched a study of the essential oil of the herb in laboratory bioassays.
Catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, Stomoxys calcitrans (L.) and 79% against houseflies, Musca domestica (L.), respectively.
Catnip oil use as a potential biting and nuisance insect repellent in urban settings was a moderate irritant with non-irritating to the eye.
Dr. Zhu JJ, at the final report, said, " In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered a relatively safe repellent, which may cause minor skin irritation".
Additionally, in the findings of a safer fly control strategies, researchers at the U.S. Department of Agriculture (ARS-USDA) launched an investigation of the effectiveness of catnip (Nepeta cataria L.) oil and its constituent compounds, nepetalactones, as stable fly repellents.
Injection of essential oil of catnip reduced the feeding of stable flies by >96% in an in vitro bioassay system, compared with other sesquiterpene-rich plant oils.
After taking into account co and confounders Dr.Zhu JJ, the lead author said, " In field trials, two formulations of catnip oil provided >95% protection and were effective for up to 6 h when tested on cattle. Catnip oil also acted as a strong oviposition repellent and reduced gravid stable fly oviposition by 98%".
Taken all together, there is no doubt that Catnip essential oil can be considered an effective insect repellent natural remedy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)
In the rating of products that work best against mosquitoes and ticks, the consumer report found that deet (N, N-diethyl-meta-toluamide) is one of the best to protect us against mosquitoes and ticks, Any products that contain 15 to 30 percent deep can provide long-lasting protection.
However, large oral doses of deep were found to induce symptoms of nausea, vomiting, bradycardia, and seizures. In serious cases, deet can cause cardiotoxicity. Contact exposure to deet also has the potential for dermal effects, leading to numbness and redness of the applied area, according to the study "Neurotoxicity and Mode of Action of N, N-diethyl-meta-toluamide (DEET)" by Dr. Daniel R. Swale.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The herb has bused use in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In the study to evaluate the effects herbal Catnip as an effective mosquito repellent against several Aedes and Culex species, both topically and spatially, researchers launched a study of the essential oil of the herb in laboratory bioassays.
Catnip essential oil (at a dosage of 20 mg) resulted in average repellency rates of 96% against stable flies, Stomoxys calcitrans (L.) and 79% against houseflies, Musca domestica (L.), respectively.
Catnip oil use as a potential biting and nuisance insect repellent in urban settings was a moderate irritant with non-irritating to the eye.
Dr. Zhu JJ, at the final report, said, " In comparison with other U.S. Environmental Protection Agency-approved mosquito repellents (DEET, picaridin and p-menthane-3,8-diol), catnip oil can be considered a relatively safe repellent, which may cause minor skin irritation".
Additionally, in the findings of a safer fly control strategies, researchers at the U.S. Department of Agriculture (ARS-USDA) launched an investigation of the effectiveness of catnip (Nepeta cataria L.) oil and its constituent compounds, nepetalactones, as stable fly repellents.
Injection of essential oil of catnip reduced the feeding of stable flies by >96% in an in vitro bioassay system, compared with other sesquiterpene-rich plant oils.
After taking into account co and confounders Dr.Zhu JJ, the lead author said, " In field trials, two formulations of catnip oil provided >95% protection and were effective for up to 6 h when tested on cattle. Catnip oil also acted as a strong oviposition repellent and reduced gravid stable fly oviposition by 98%".
Taken all together, there is no doubt that Catnip essential oil can be considered an effective insect repellent natural remedy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)
Thursday, November 28, 2019
Herbal Andrographis, The Male Contraceptive Whole Herb Medicine?
Andrographis paniculata, the forgotten herb showed the ability to influence the male reproductive organ as a contraceptive option contradictively, a renowned institutes study suggested.
Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......
According to the Bharathidasan University, andrographolide, a major chemical constituent of andrographis paniculata affected the process in which spermatozoa are produced from spermatogonial stem cells in the testis by interring the dividing spermatogenic cell lines.
In a 3-month-old male Wistar albino rats at two dose levels, for 48 days, rats fed with andrographolide exerted contraceptive effects by inducing decreased sperm counts, increased in-motile spermatozoa, and several possessed abnormalities.
Dr. Akbarsha MA, the lead researcher said, "the study points to a male reproductive toxic effect of this compound(andrographolide) when used as a therapeutic".
Unfortunately, also in male Wistar albino rats study, orally administering extract of Andrographis paniculata of 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating, treated group showed no effect on testosterone levels and fertility indices and sperm count and sperm motility when compared with the control.
Furthermore, in the comparison of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus with Valeriana officinalis and Panax ginseng, Kan Jang decode exhibited no significant negative effect of Kan Jang on male semen quality and fertility, but rather a increased number of spermatozoids in the whole ejaculate in compared to others herbal treated group.
The conflict results of the above studies may be due to types of research design, small sample size and quality of herbal medicine used....., but regardless of the above conclusions, large sample size and multi centers studies are necessary to resolve this contradiction.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa by Akbarsha MA1, Murugaian P.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A1, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats by Allan JJ1, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)
Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......
According to the Bharathidasan University, andrographolide, a major chemical constituent of andrographis paniculata affected the process in which spermatozoa are produced from spermatogonial stem cells in the testis by interring the dividing spermatogenic cell lines.
In a 3-month-old male Wistar albino rats at two dose levels, for 48 days, rats fed with andrographolide exerted contraceptive effects by inducing decreased sperm counts, increased in-motile spermatozoa, and several possessed abnormalities.
Dr. Akbarsha MA, the lead researcher said, "the study points to a male reproductive toxic effect of this compound(andrographolide) when used as a therapeutic".
Unfortunately, also in male Wistar albino rats study, orally administering extract of Andrographis paniculata of 0, 20, 200, and 1000 mg/kg of body weight per day, for 65 days prior to mating and 21 days during mating, treated group showed no effect on testosterone levels and fertility indices and sperm count and sperm motility when compared with the control.
Furthermore, in the comparison of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus with Valeriana officinalis and Panax ginseng, Kan Jang decode exhibited no significant negative effect of Kan Jang on male semen quality and fertility, but rather a increased number of spermatozoids in the whole ejaculate in compared to others herbal treated group.
The conflict results of the above studies may be due to types of research design, small sample size and quality of herbal medicine used....., but regardless of the above conclusions, large sample size and multi centers studies are necessary to resolve this contradiction.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: effect on the testis and the cauda epididymidal spermatozoa by Akbarsha MA1, Murugaian P.(PubMed)
(2) A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects by Mkrtchyan A1, Panosyan V, Panossian A, Wikman G, Wagner H.(PubMed)
(3) Reproductive and fertility effects of an extract of Andrographis paniculata in male Wistar rats by Allan JJ1, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.(PubMed)
The Effects of Aloe vera gel (AVG) on Polycystic Ovarian Syndrome (PCOs)
Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and affecting fertility. It affects over 5% of women population or 1 in 20 women.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The effects
In the view, if certain side effects of several classes of pharmacological agents have been used to manage dyslipidemia in women with Polycystic Ovarian Syndrome (PCOs), some researchers have been studied through the alternative medicine with an aim to find a better treatment with less or no side effects. Aloe vera gel (AVG), has found to be effective in a reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol, reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities. Others in the study of the same but in comparison with Letrozole showed Aloe vera restored the estrus cyclicity, glucose sensitivity, and steroidogenic activity. Treatment combined with Letrozole prevented the development of the PCO phenotype. These results showed a positive anti-hyperlipidemic effect and may be used in managing PCOS associated metabolic complications and restoring the ovarian steroid status.
The Side effects
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The effects
In the view, if certain side effects of several classes of pharmacological agents have been used to manage dyslipidemia in women with Polycystic Ovarian Syndrome (PCOs), some researchers have been studied through the alternative medicine with an aim to find a better treatment with less or no side effects. Aloe vera gel (AVG), has found to be effective in a reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol, reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities. Others in the study of the same but in comparison with Letrozole showed Aloe vera restored the estrus cyclicity, glucose sensitivity, and steroidogenic activity. Treatment combined with Letrozole prevented the development of the PCO phenotype. These results showed a positive anti-hyperlipidemic effect and may be used in managing PCOS associated metabolic complications and restoring the ovarian steroid status.
The Side effects
1. The high amount of vitamin K may reduce the effectiveness of anticoagulation medicine
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. The herb may induce lupus erythematosus due to its chemical constituent L-canavanine.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(2) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. The herb may induce lupus erythematosus due to its chemical constituent L-canavanine.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(2) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(3) Drug-induced lupus: an update by Vasoo S.(PubMed)
Herbal Calendula (Calendula officinalis), May Process the Potency for Chronic Blepharitis
Herbal Calendula may have a potential effect in reducing the risk and treatment of chronic blepharitis, some scientists suggested.
Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of the clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.
Blepharitis can be classified into 2 types1. Acute blepharitis is referred to eyelid infection by bacterial, viral, or parasitic pathogens.
2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.
According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.
The most common causes of blepharitis are a bacterial infection. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.
If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.
Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the findings of the natural ingredient with potential for the treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti chronic blepharitis activity.
In a total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.
All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.
After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied on the eyelids in 25 patients.
In compared to massage, moist warm pads treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but the insignificant effect in patients with excessive meibomian gland secretion.
These results suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)
Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of the clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.
Blepharitis can be classified into 2 types1. Acute blepharitis is referred to eyelid infection by bacterial, viral, or parasitic pathogens.
2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.
According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.
The most common causes of blepharitis are a bacterial infection. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.
If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.
Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the findings of the natural ingredient with potential for the treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti chronic blepharitis activity.
In a total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.
All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.
After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied on the eyelids in 25 patients.
In compared to massage, moist warm pads treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but the insignificant effect in patients with excessive meibomian gland secretion.
These results suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)
Herbal Cat' claw, The Herb Which Balances the Levels of Free Radicals and Antioxidants in the Body
Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence the application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidants to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert a significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavonols isolated from the herb.
In vitro, application of alkaloids and flavonols isolated from the herb demonstrated the significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
In the immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along with a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exert higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence the application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidants to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert a significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavonols isolated from the herb.
In vitro, application of alkaloids and flavonols isolated from the herb demonstrated the significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
In the immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along with a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exert higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Herbal Cayenne on Weight Loss
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
Obesity is defined as a medical condition of excess body fat that has accumulated over time, while overweight is a condition of excess body weight relative to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese.
Ingredients
The chemical constituents of Cayenne include capsaicin, capsaicin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
The benefits
The prevalence of obesity is widespread in the Western world. In the US, approximately 68% of the population is either overweight or obese. Weight loss with little or no side effects of an organic chemical compound from plants has gone under extensive research.
Capsaicinoids are a group of chemicals found in Cayenne, may have potential benefits in relation to weight management. In fact, Capsaicinoids have exerted induced weight loss activities through increased energy expenditure, increased lipid oxidation and reduced appetite of which may be caused stimulation of the TRPV1 receptor.
Another in the study of the same suggested that a minimum dose of 2mg of capsaicinoids is needed to contribute to reductions in ad libitum energy intake and daily consumption of capsaicinoids may contribute to weight management through reductions in energy intake.
The Side Effects
1. It may cause an allergic reaction in young children
2. It may also cause a hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause a burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.
References
(1) "Severe pepper allergy in a young child" by Gimenez L, Zacharisen M(PubMed))
(2) Mechanisms underlying the hypertensive response induced by capsaicin" by Dutta A, Deshpande SB.(PubMed)
(3) Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures" by Gupta PJ.(PubMed)
(4) Capsaicinoids and capsinoids. A potential role for weightmanagement? A systematic review of the evidence by Whiting S, Derbyshire E, Tiwari BK.(PubMed)
(5) Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data.
Whiting S1, Derbyshire EJ2, Tiwari B3.(PubMed)
Obesity is defined as a medical condition of excess body fat that has accumulated over time, while overweight is a condition of excess body weight relative to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese.
Ingredients
The chemical constituents of Cayenne include capsaicin, capsaicin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
The benefits
The prevalence of obesity is widespread in the Western world. In the US, approximately 68% of the population is either overweight or obese. Weight loss with little or no side effects of an organic chemical compound from plants has gone under extensive research.
Capsaicinoids are a group of chemicals found in Cayenne, may have potential benefits in relation to weight management. In fact, Capsaicinoids have exerted induced weight loss activities through increased energy expenditure, increased lipid oxidation and reduced appetite of which may be caused stimulation of the TRPV1 receptor.
Another in the study of the same suggested that a minimum dose of 2mg of capsaicinoids is needed to contribute to reductions in ad libitum energy intake and daily consumption of capsaicinoids may contribute to weight management through reductions in energy intake.
The Side Effects
1. It may cause an allergic reaction in young children
2. It may also cause a hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause a burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.
References
(1) "Severe pepper allergy in a young child" by Gimenez L, Zacharisen M(PubMed))
(2) Mechanisms underlying the hypertensive response induced by capsaicin" by Dutta A, Deshpande SB.(PubMed)
(3) Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures" by Gupta PJ.(PubMed)
(4) Capsaicinoids and capsinoids. A potential role for weightmanagement? A systematic review of the evidence by Whiting S, Derbyshire E, Tiwari BK.(PubMed)
(5) Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data.
Whiting S1, Derbyshire EJ2, Tiwari B3.(PubMed)
Wednesday, November 27, 2019
Herbal Chamomile May Be the Next Generation of Whole Food Medicine for Treatment of Chronic Inflammatory Diseases
Herbal Chamomile may be the next generation of whole food medicine of blocking the onset of acute and chronic inflammatory diseases, some studies suggested.
Inflammation is a natural and systematic immune response to the body damage and injure. Upon received the information from the central nervous system, macrophages, the largest cells in the immune system stimulate the production of pro-inflammatory cytokines to the site of infection to protect against possible exposure to infectious agents.
The aim of these actions is to minimize the damage and speed up the healing processes. However, if the pro-inflammatory cytokines are overexpressed, they can cause damage to the nearby healthy and formation of the scars to the infected tissue.
Chronic inflammation is the condition when the immune system can not kill all infectious pathogens in the acute phase, leading to persistent low-grade inflammation, judged by a small rise in immune system markers found in blood or tissue.
The longterm low-grade inflammation has been found to trigger autoimmunity in which the immune system mistakenly attacks the body tissue in the damage site and other healthy tissue.
Most people with chronic inflammation are experiencing symptoms of body pain, persistent fatigue, and insomnia, psychological issues of depression, anxiety and mood disorders and long-term gastrointestinal discomfort, such as constipation, diarrhea, and acid reflux.
If you have some of the symptoms above, please check with your doctor. A blood test of inflammatory markers is necessary to rule out the possibility.
Chamomile is also known as camomile, a common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the study to reaffirm the inflammatory effect of chamomile used in traditional medicine for the treatment of inflammation-related disorders, researchers at the Case Western Reserve University conducted an examination of the herbal inhibitory effects on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and its potential anti-inflammatory mechanisms using RAW 264.7 macrophages.
In LPS-induced NO production, the application of chamomile significantly blocked the series of proinflammatory cytokine with the function to protect the cell against infection of LPS, namely, the IL-1β, IL-6, and TNFα in RAW 264.7 macrophages.
Furthermore, chamomile caused a reduction in LPS-induced iNOS mRNA and protein expression, a family of primary inflammatory response genes.
In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 in the prevention of the production of anti-inflammatory cytokines was significantly inhibited by chamomile.
Moreover, chamomile treatment also inhibited the release of LPS-induced prostaglandin E(2), a bioactive lipid that can elicit a wide range of biological effects associated with inflammation, in RAW 264.7 macrophages.
Interestingly, the anti-inflammatory effect of Chamomile was attributed to the inhibition of COX-2, the proinflammatory enzyme activity by blocking the reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression in the inflammatory response in comparison to the non-steroidal anti-inflammatory drug, sulindac.
These results suggested that chamomile processed a mechanism of action similar to those of non-steroidal anti-inflammatory drugs may be considered a functional food for the prevention and treatment of chronic inflammation.
However, due to limitations of the above study, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chamomile anti-inflammatory diseases possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N1, Shukla S, Srivastava JK, Gupta S.(PubMed)
(2) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity by Srivastava JK1, Pandey M, Gupta S.(PubMed)
Inflammation is a natural and systematic immune response to the body damage and injure. Upon received the information from the central nervous system, macrophages, the largest cells in the immune system stimulate the production of pro-inflammatory cytokines to the site of infection to protect against possible exposure to infectious agents.
The aim of these actions is to minimize the damage and speed up the healing processes. However, if the pro-inflammatory cytokines are overexpressed, they can cause damage to the nearby healthy and formation of the scars to the infected tissue.
Chronic inflammation is the condition when the immune system can not kill all infectious pathogens in the acute phase, leading to persistent low-grade inflammation, judged by a small rise in immune system markers found in blood or tissue.
The longterm low-grade inflammation has been found to trigger autoimmunity in which the immune system mistakenly attacks the body tissue in the damage site and other healthy tissue.
Most people with chronic inflammation are experiencing symptoms of body pain, persistent fatigue, and insomnia, psychological issues of depression, anxiety and mood disorders and long-term gastrointestinal discomfort, such as constipation, diarrhea, and acid reflux.
If you have some of the symptoms above, please check with your doctor. A blood test of inflammatory markers is necessary to rule out the possibility.
Chamomile is also known as camomile, a common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the study to reaffirm the inflammatory effect of chamomile used in traditional medicine for the treatment of inflammation-related disorders, researchers at the Case Western Reserve University conducted an examination of the herbal inhibitory effects on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and its potential anti-inflammatory mechanisms using RAW 264.7 macrophages.
In LPS-induced NO production, the application of chamomile significantly blocked the series of proinflammatory cytokine with the function to protect the cell against infection of LPS, namely, the IL-1β, IL-6, and TNFα in RAW 264.7 macrophages.
Furthermore, chamomile caused a reduction in LPS-induced iNOS mRNA and protein expression, a family of primary inflammatory response genes.
In RAW 264.7 macrophages, LPS-induced DNA binding activity of RelA/p65 in the prevention of the production of anti-inflammatory cytokines was significantly inhibited by chamomile.
Moreover, chamomile treatment also inhibited the release of LPS-induced prostaglandin E(2), a bioactive lipid that can elicit a wide range of biological effects associated with inflammation, in RAW 264.7 macrophages.
Interestingly, the anti-inflammatory effect of Chamomile was attributed to the inhibition of COX-2, the proinflammatory enzyme activity by blocking the reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression in the inflammatory response in comparison to the non-steroidal anti-inflammatory drug, sulindac.
These results suggested that chamomile processed a mechanism of action similar to those of non-steroidal anti-inflammatory drugs may be considered a functional food for the prevention and treatment of chronic inflammation.
However, due to limitations of the above study, additional data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chamomile anti-inflammatory diseases possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N1, Shukla S, Srivastava JK, Gupta S.(PubMed)
(2) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity by Srivastava JK1, Pandey M, Gupta S.(PubMed)
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