Scientists may have found a herbal medicine for the protection of the skin against the oxidative stress in the induction of skin diseases, with no side effects, some studies suggested.
What are the exact causes of skin damage? Some researchers suggested that long-term exposure to the sun is the most common cause of skin damage. UV rays can damage the DNA of skin cells, affecting the normal skin cell growth. UV rays have been linked to the early onset of skin cancer, epidemiologically.
Other causes of skin damage include chronic stress, skin diseases such as pimples, acne, or rosacea.
Truly, improper skincare and healing of a pimple, acne, and rosacea can damage the facial skin, leaving an uneven skin tone.
Dr. Ying Chen, the lead scientist in the study "Brain-Skin Connection: Stress, Inflammation and Skin Aging" wrote, "The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases".
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Ingredients
Besides having major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the study to reaffirm the sun-protective effects of essential oil extracted from Calendula flowers (Calendula officinalis L., Asteraceae).\in a cream formulation, researchers at the Bhagwant University launched an investigation using in vitro method employing UV-visible spectrophotometer (Shimazdu-1600).
Application of the cream exerted a significant effect in protecting the skin against UV radiations in the form of sunscreen cream and maintaining the natural pigmentation of the skin, without inducing no side effects.
Furthermore, the application of a cream (O/W) containing 4% and 5% of Calendula essential oil on biochemical parameters of the skin of albino rats against UV-B radiation also decreased the oxidative stress markers observed by a significant decrease in the malondialdehyde level.
Additional analysis suggested that 4% and 5% of Calendula essential oil inhibited the levels of oxidative stress and lipid peroxidation through stimulating the production of antioxidant enzymes such as catalase, glutathione, superoxide dismutase in the host and increasing the levels of ascorbic acid, and the total protein level after 1 month of daily irradiation and treatment, compared to untreated control groups.
Interestingly, the cutaneous application of the essential oil of Calendula prevents UV-B-induced alterations in the level of antioxidants in skin tissue.
These discoveries indicated reactive oxygen species (ROS) generated from UV-B radiation with the capacity to cause oxidative decomposition which leads to the formation of toxic components and lipid peroxidation is totally inhibited by the topical 4% and 5% of Calendula essential oil.
The Islamia University of Bahawalpur, launched an evaluation to test the effects of newly formulated topical cream of Calendula extract on the mechanical parameters, such as age-related changes in skin, skin elasticity, skin fatigue, skin hydration, and antiaging, using the Cutometer 580 MPA device designed to measure the mechanical properties of the skin in response to the application of negative pressure.
Two creams (base and formulation) prepared in the study were applied to the cheeks of 21 healthy human volunteers for a period of eight weeks. Every individual was asked to come on weeks 1, 2, 3, 4, 5, 6, 7, and 8 for measurements, using Cutometer MPA 580 every week.
At the end of the experiment, researchers found that newly formulated topical cream of Calendula extract exerts significant improvements only in hydration and firmness of the skin.
The findings suggested that Calendula essential oil and extract may have a potential effect in preventing skin damage by UV-B radiation and protecting the skin against damage due to oxidative stress.
However, due to the limitation of the above studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the exposure will be necessary to complete the picture of skin protective possibilities.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): a review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2) Assessment of In vitro Sun Protection Factor of Calendula Officinalis L. (Asteraceae) Essential Oil Formulation by Mishra A, Mishra A, Chattopadhyay P.(PubMed)
(3) Effects of Calendula Essential Oil-Based Cream on Biochemical Parameters of Skin of Albino Rats against Ultraviolet B Radiation by Mishra AK, Mishra A, Verma A, Chattopadhyay P.(PubMed)
(4) Calendula extract: effects on mechanical parameters of human skin by Akhtar N, Zaman SU, Khan BA, Amir MN, Ebrahimzadeh MA. (PubMed)
(5) Brain-Skin Connection: Stress, Inflammation and Skin Aging by Ying Chen* and John Lyga. (PMC)
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