Medical Advisor Journals : December 2015

Thursday, December 31, 2015

The smoothie tangerine peels, grape and cucumber for reduced risk and treatment of Acne

Kyle J. Norton(Scholar and Master of Nutrients) all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk and treatment of Acne

Yield: 2 serving (about 8 ounce each)

1 medium tangerine peels

1 cup grapes
1/2 cup of cucumbers
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Combination of tangerine peel(5), grape(1) and cucumber(7)may consist a potential of pharmaceutical values as the ingredients are found effectively in reduced risk and Acne in recent studies.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body. If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins. It is the internal causes of acne.

Acne is most common type of skin, affecting billions of people all over world. The dream of finding natural sources for reducing risk and treatment of acne may induce billions and billions dollars of commercial profits of discovered pharmaceutical companies,

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape, as an antimicrobial and anti-inflammatory substances may speed acne recovery from invaded and progression of acne(1), according to the University of Catania,

The phytochemical also has been found effectively in treating acne vulgaris due to its suppression of sebaceous growth by suppressing survival and growth in response to extracellular signals(2).

Dr. Taylor EJ and the research at the David Geffen School of Medicine, said," The ...antibacterial activity and reduced cytotoxicity.....demonstrated by resveratrol.... highlight its potential as a novel therapeutic option or adjuvant therapy in the treatment of acne vulgaris"(3).

Furthermore, resveratrol in the extracts from some herbal medicines also exhibited antibiofilm activity by inhibited the antimicrobial susceptibility of biofilm-associated cells induced the pathogenesis of acne vulgaris(4).

Tangerines, an orange-colored citrus fruit, a type of, mandarin orange originated to Tangier, Morocco, are now cultivated all over the world in suitable climate for commercial profits due to their health effects.
Nobiletin, a phytochemical compound from the group of flavonoid found abundantly in the citrus peels of tangerine exhibited the similar function of acne drugs 13-cis retinoic acid and all-trans retinoic acid(5), may be an effective candidate for acne therapy through reduction of sebocyte proliferation, sebum production and progression of cell apoptosis by suppressing survival and growth in response to extracellular signals(5).

Cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. Due to its silica in skin promotion health benefits, the fruits have been added to some cosmetic gel for treatment of skin diseases(6).According to the Harvard Medical School, topical silica–gold nanoshells at 800 nm exhibited mild anti inflammatory effects and decrease the pathophysiology of acne vulgaris in regulation of sebaceous gland of that induced an effective treatment of moderate-to-severe facial acne, depending to the assessments of disease severity(7).

In support to the above, the University of California study using 150nm silica-gold nanoshell, reduced the acne expression through inducing photothermal disruption of sebaceous glands without damaging collateral skin(8).

Acne Support Group. said,",,, used Silicol Skin for 6 weeks, ...statistically significant 86% overall improvement was reported, with most participants citing the chin as showing the greatest change"(9).

Taking altogether, smoothie with combine of Tangerine peel, grape and cucumber may be effective in reduced risk of the development and progression and treatment of patient with acne.

People with higher risk of acne due to family history, .... should drink 1 serving daily and people with acne should drink as much as they can depending to digestive toleration.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
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References

(1) Cosmetics for acne: indications and recommendations for an evidence-based approach by Dall'oglio F1, Tedeschi A, Fabbrocini G, Veraldi S, Picardo M, Micali G.(PubMed)

(2) Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway by Kim SY1, Hyun MY2, Go KC1, Zouboulis CC3, Kim BJ1.(PubMed)

(3) Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro by Taylor EJ1, Yu Y, Champer J, Kim J.(PubMed)

(4) Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin,resveratrol and salidroside as active compounds by Coenye T1, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(PubMed)

(5) A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters by Sato T1, Takahashi A, Kojima M, Akimoto N, Yano M, Ito A.(PubMed)
(6) Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice by Hirai T1, Yoshioka Y2,3,4, Takahashi H5,6, Ichihashi K7, Udaka A8, Mori T9, Nishijima N10, Yoshida T11, Nagano K12, Kamada H13,14, Tsunoda S15,16, Takagi T17,18, Ishii KJ19,20, Nabeshi H21, Yoshikawa T22, Higashisaka K23,24, Tsutsumi Y(PubMed)
(7) Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles by Paithankar DY1, Sakamoto FH2, Farinelli WA2, Kositratna G2, Blomgren RD1, Meyer TJ1, Faupel LJ1, Kauvar AN3, Lloyd JR4, Cheung WL5, Owczarek WD6,Suwalska AM6, Kochanska KB6, Nawrocka AK6, Paluchowska EB6, Podolec KM7, Pirowska MM7, Wojas-Pelc AB7, Anderson RR2.(PubMed)
(8) Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic by Paithankar D1, Hwang BH2, Munavalli G3, Kauvar A4, Lloyd J5, Blomgren R6, Faupel L6, Meyer T6, Mitragotri S7.(PubMed)
(9) The effects of Silicol Skin on moderate to severe acne: UK field survey by Acne Support Group(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Diagnosis

If you are experience some of the above symptoms and if your doctor suspects that you have asthma, after recording your family history and completing the physical exam, the test which your doctor orders include
1. Chest X-Ray
In the study of the medical records of 58 patients aged 18-40 with the diagnosis of mild to moderate asthmato assess the value of the chest X-ray in helping to make the diagnosis of asthma at the primary care level, researchers at theHarvard University Health Services, showed that the number of asthmatic patients with CXR+ and SPI – (n = 23) was significantly larger than the number with CXR- and SPI+ (n = 10), which indicates that for mild asthma the chest X-ray may be more sensitive than spirometry even though not as specific(28). Other suggested that the X-ray request was an action not based on sound clinical judgement. Cost savings and a reduction in radiation exposure can be made by eliminating unnecessary chest X-ray requests(29).
2. Spirometry
Spirometry is a lung (or pulmonary) function test to measure the lung function in studying the air volume and flow rate within the lungs. According to the study by Department of Community Medicine, University of Tromsø the ability of GPs to differentiate between asthma and COPD seems to have considerably improved during the last decade, probably due to the dissemination of spirometry and guidelines for COPD diagnosis(30).
3. Peak Flow Testing –
Peak Flow Testing is a self-assessment to evaluate lung function The peak expiratory flow (PEF), also known as peak expiratory flow rate (PEFR) is to measure the airway
obstruction.
4. Impulse oscillometry (IOS)
Impulse oscillometry is a noninvasive and rapid technique requiring only passive cooperation by the patient. Pressure oscillations are applied at the mouth to measure pulmonary resistance and reactance. It is employed by health care professionals to help diagnose pediatric pulmonary diseases such asthma and cystic fibrosis; assess therapeutic responses; and measure airway resistance during provocation testing(31).In the study to to evaluate whether impulse oscillometry, an easy-to-perform technique, can detect asthmatic airway obstruction stage, researchers at the Shanghai Pudong New Area People’s Hospital, found that IOS provides an accurate, reliable, and patient-friendly technique for classifying asthmatic airway obstruction(32).

5. Allergy Tests for Asthma
if you doctor suspects that your asthma may be triggered as a result of an allergic reaction. Allergy tests may be ordered to determine the exact cause of your allergy and asthma. In the study to determine the predictive value of allergy and pulmonary function tests for the diagnosis of asthma in athletes, showed that positive prick tests were recorded in 44.4% of athletes (in 60.5% of asthmatics, in 95.2% of rhinitics and in 21.0% of nonasthmatic – nonrhinitic subjects). Skin-tests positivity was not related to the abnormal spirometric data found in individual cases. Provocation tests with bronchodilators or exercise did not appear sensitive enough to diagnose mild forms of asthma in subjects with normal basal spirometric values(33).

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9643741
(29) http://www.ncbi.nlm.nih.gov/pubmed/8311783
(30) http://www.ncbi.nlm.nih.gov/pubmed/22135492
(31) http://www.ncbi.nlm.nih.gov/pubmed/21354020
(32) http://www.ncbi.nlm.nih.gov/pubmed/23189951
(33) http://www.ncbi.nlm.nih.gov/pubmed/17845586

Wednesday, December 30, 2015

The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Bone cancer

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of Bone Cancer and Bone Cancer

Yield: 2 serving (about 8 ounce each)
1 1/2 cups blackberry
1/3 tsp cucumin
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of ovarian cancer has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Blackberry(1), green tea and turmeric may be the next generation of pharmaceutical ingredients for reduced risk and treatment of bone cancer, recent study suggested

Bone cancer is an abnormal growth of cells within the bone that have became cancerous. Bone cancer may be classified as primary canceroriginated in the bone, and secondary cancer originated from elsewhere.

Black berry, a edible fruit produced species in the Rubus genus in the Rosaceae family has found to consist a various health effects including suppressing tumor growth through its antioxidants flavonols and ellagitannins(1). According to the joint study lead by the Universidade Estadual Paulista-UNESP, DNA damage in bone marrow and peripheral blood cells and chromosomal aberrations, was significant reduced in a 2000 mg/kg dose due to the presence of its phytochemical compounds tormentic acid, stigmasterol, quercitinglucoronide (miquelianin) and niga-ichigoside F1 (2).

Dr. Dai J and colleagues at the niversity of Kentucky, in support of the berry;s antiproliferative and anti-inflammatory properties disclosed," in a concentration-dependent manner, total anthocyanin concentrations in the range of 0-40 microg/mL suppressed both high-dose (10 microg/mL) and low-dose (0.1 microg/mL) lipid A-induced interleukin-12 release from mouse bone marrow-derived dendritic cells"(3).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

Curcumin, the main ingredient of turmeric has shown to induce cell apoptosis in human osteosarcoma, by inhibiting the over-expression of gene (Notch1) associated with tumor progression, according to Dr. Li Y, and scientists at the Qilu Hospital, Shandong University(4).

In chondrosarcoma, a soft tissue sarcoma, curcumin, an active compound induced tumor apoptosis and inhibited tumor proliferation, invasion, angiogenesis, and metastasis of cancer cells, through protein in regulated cell cycle and tumor suppression gene p53(5).

The joint study in support of the effect of curcumin in reduced risk and treatment of bone cancer, said," IL-1 signaling(in the regulation of immune and inflammatory responses) and VEGF-A expression(involved progression and prognosis of cancer) are blocked by Curcumin in chondrosarcoma cells" and "Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression" of that "may be an additional treatment option in chondrosarcoma"(6).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-gallate, the major ingredient found in green tea may be a potential anti-TNFα(inflammatory cytokine) as a therapeutic option for osteolytic painas it attenuated symptom of pain in bone cancer through inhibiting the pro inflammatory cytokines(7).

Dr. Jeong JY and the research team at the joint study by the National Institute of Animal Science discovered that Epigallocatechin-3-gallate (EGCG) inhibited the expression levels of various genes and proteins involved in adipogenesis of which involved the reduction of cell viability and arrested the cell cycle at the gap 2/mitosis phase in bone-marrow mesenchymal stem cells(8).

Furthermore, in support of the green tea effects on bone cancer cells, the University of Madras showed that Green tea, polyphenol exhibited antioxidant effect through a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity(9).

Taking altogether people who are at increased risk of Bone cancer due to family history or gene mutation .....should drink at least one serving daily and people with bone cancer should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

References

(1) The blackberry fruit: a review on its composition and chemistry, metabolism and bioavailability, and health benefits by Kaume L1, Howard LR, Devareddy L. (PubMed)

(2) In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage by Tolentino F1, Araújo PA1, Marques Ede S1, Petreanu M2, Andrade SF2, Niero R2, Perazzo FF3, Rosa PC4, Maistro EL5(PubMed)(3) Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. by Dai J1, Patel JD, Mumper RJ.(PubMed)
(4) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling by Li Y1, Zhang J, Ma D, Zhang L, Si M, Yin H, Li J.(PubMed)
(5) Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway by Lee HP1, Li TM, Tsao JY, Fong YC, Tang CH.(PubMed)
(6) Curcumin blocks interleukin-1 signaling in chondrosarcoma cells by Kalinski T1, Sel S2, Hütten H3, Röpke M4, Roessner A1, Nass N1.(PubMed)
(7) Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model by Li Q1, Zhang X2.(PubMed)
(8) Epigallocatechin-3-gallate-induced free-radical production upon adipogenic differentiation in bovine bone-marrow mesenchymal stem cells by Jeong JY1,2, Park MN2, Cho ES3, Jang HJ4, Park S5, Lee HJ6.(PubMed)
(9) Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats by Pandurangan AK1, Periasamy S, Anandasadagopan SK, Ganapasam S, Srinivasalu SD.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Causes

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.
Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Causes

1. Smoking and second hand smoke
Smoking is considered as one of major cause of lung diseases, including asthma. According to the study by Texas Tech University Health Science Center, Airway mucosal permeability is increased in smokers, which could lead to increased clearance of inhaled corticosteroids from the airways. Smokers also have decreased histone deacetylase activity, which is necessary for corticosteroids to fully suppress cytokine production, and can lead to corticosteroid resistance. The study also indicated that In asthmatic patients who smoke, disease control is poorer than in asthmatic nonsmokers. Of all forms of SHS, maternal exposure seems to have the largest impact on asthma by increasing the frequency and severity of the disease and decreasing lung function. Asthmatic children exposed to multiple household smokers face an increased risk for respiratory illness-related absences from school, and these effects persist during adolescence but weaken during adulthood(6).
2. Allergies
People who are sufferred from alergies are most likely to develop asthma. The allergic march is a progression of atopic disease from eczema to asthma, and then to allergic rhinoconjunctivitis. It appears to be caused by a regional allergic response with breakdown of the local epithelial barrier that initiates systemic allergic inflammation. Genetic and environmental factors predispose to developing the allergic march, according to the study by Department of Surgery, Cape Cod Hospital, Hyannis(7). Other indicated that Allergen exposure contributes to the risk of asthma exacerbations, but other precipitating factors, such as viruses, can interact and increase the risk. According to the study by hôpitaux universitaires de Strasbourg, deteriorating asthma can be related to increased exposure to allergens, particularly allergens from house dust mite, cockroach, cat, rodent, mold or pollen. Several studies have demonstrated that sensitization to respiratory allergens and allergen exposure increases the risk of exacerbation of asthma. When asthma exacerbations are work-related, occupational allergens may be implicated(8).

3. Occupational and environmental exposures
Occupational and exposure history may increase the risk of respiratory problems. According to a report by Dr, Hoy RF., there is a case of a man, 23 years of age and previously well, presents with 2 months of cough, shortness of breath and weight loss. Occupational and exposure history identifies him as commencing work at a mushroom farm 12 months ago where he is exposed to dust from the mixing of mushroom compost. He is not required to use respiratory protection at work. His cough and chest tightness usually start in the afternoon at work and persist into the evening. Some of the effects of exposures may be immediate, whereas others such as asbestos-related lung disease may not present for many decades. Airborne contaminants may be the primary cause of respiratory disease or can exacerbate pre-existing respiratory conditions such as asthma and chronic obstructive pulmonary disease(9).

4. Obesity
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. In the study to to examine the relationship between central obesity and asthma outcomes in a group of Iranian asthma patients, researchers showed that there is a significant association of WHR-based central obesity with forced expiratory volume in 1 s (FEV(1)) (β = -9.04; p-value = .044) and forced vital capacity (FVC) (β = -10.52; p-value = .012). Logistic regression analysis showed a significant increased risk of asthma attacks in 3 months with Asian WC-based central obesity [odds ratio (OR) = 6.31, 95% confidence interval (CI): 1.16-34.41]; emergency room (ER) visits with NIH WC-based (OR = 5.15, 95% CI: 1.36-19.55) and Asian WC-based (OR = 18.72, 95% CI: 1.92-182.63) central obesity; and hospitalization in 1 year with NIH WC-based (OR = 5.28, 95% CI: 1.28-21.84) and Asian WC-based (OR = 12.39, 95% CI: 1.29-119.53) central obesity(10).
Some study suggested that asthma in the obese patient might be more responsive to leukotriene modifiers, orchestrated by leptin and/or adiponectin derived from adipose tissue, than to inhaled corticosteroids, possibly reflecting differences in the underlying airway inflammation in obese vs. non-obese asthmatics(11).

5. Exercise-Induced Asthma
Vigorous exercise can cause a narrowing of the airways in asthma patient.There is a report of a 44-year-old man with a history of seasonal allergic rhinitis but no asthma, who reported difficulty breathing when playing tennis and a 45-year-old woman who presented with persistent, generally well-controlled asthma, who was now experiencing bouts of coughing and wheezing during exercise. EIB is a frequently encountered problem among patients presenting to primary care specialists. Affected patients should be made aware of the importance of proactive treatment with a short-acting beta agonist before initiating any exercise(12).

6. Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. It is considered as one the causes of asthma. There is a report of an 11-year-old boy who was referred to a pediatric respiratory clinic for asthma that was not responsive to inhaled medications. The child presented with a one-year history of dyspnea on exertion, cough and wheeze. He also complained of chronic dyspepsia. The presence of GI symptoms, in addition to abnormalities on chest radiograph and spirometry, suggested the presence of achalasia(13).

7. Sinusitis
Sinusitis is defined as a condition of inflammation of the paranasal sinuses of which can develop headache as a result of exposure to a cold or flu virus, or an allergic reaction to pollen, mold, dust or smoke, etc..Sinusitisaffects 37 million people each year. Some researchers suggested that there is a close relationship between allergic rhinitis and asthma, food allergy, and atopic dermatitis. Rhinitis and sinusitis often coexist and are commonly referred to with the term rhinosinusitis. These conditions are also linked in the so-called atopic march, which is the sequential appearance of atopic manifestations starting with atopic dermatitis and later followed by food allergy, allergic rhinitis, and asthma(14).

8. Upper Respiratory Infections
upper respiratory viral infections are strongly associated in time with hospital admissions for asthma in children and adults. Rhinoviruses were the major pathogen implicated, and the majority of viral infections and asthma admissions occurred during school attendance, according to the study by the Department of Medical Statistics and Computing, University of Southampton(15).

9. Irregular Mentruation
Irregular menstruation are associated with asthma. In the study of a total of 8588 women (response rate 77%) participated in an 8 year follow up postal questionnaire study of participants of the ECRHS stage I in Denmark, Estonia, Iceland, Norway, and Sweden. Only non-pregnant women not taking exogenous sex hormones were included in the analyses (n = 6137), showed that Irregular menstruation was associated with asthma (OR 1.54 (95% CI 1.11 to 2.13)), asthma symptoms (OR 1.47 (95% CI 1.16 to 1.86)), hay fever (OR 1.29 (95% CI 1.05 to 1.57)), and asthma preceded by hay fever (OR 1.95 (95% CI 1.30 to 2.96)) among women aged 26-42 years(16).

10. Sulphite additives
Topical, oral or parenteral exposure to sulphites (mainly from the consumption of foods and drinks that contain these additives) has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions(16a).

11. Cold air
Endurance athletes show an increased prevalence of airway hyperresponsiveness. In the study of a total, 64 elite athletes (32 swimmers and 32 cold-air athletes), 32 mild asthmatic subjects and 32 healthy controls underwent allergy skin prick testing, methacholine challenge and induced sputum analysis found that there is a significant airway inflammation only in competitive athletes with airway hyperresponsiveness. However, the majority of elite athletes showed evidence of bronchial epithelial damage that could possibly contribute to the development of airway hyperresponsiveness(17a).
11. Etc.

Tuesday, December 29, 2015

The Curable Smoothie of Papaya for Reduced Severity of Symptoms and Treatment of Anemia (β-thalassemia and sickle cell disease)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk of Anemia and Anemia
Yield: 2 serving (about 8 ounce each)
1 1/2 cups papaya

Recent studies suggested that chronic consumption of the combination of papaya(2) may be beneficiary to reduce symptoms and treatment for patients with anemia such as β-thalassemia and sickle cell disease.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries. Vitamin C found abundantly in papaya out of all fruits, according to the Chinese Academy of Medical Science, improved the levels of hemoglobin-based oxygen carriers (HBOCs) through the indication of the oxygen binding curves and the molecular weights(2).

In patients with sickle cell hemoglobin from both parents and are associated with unusually large numbers of immature blood cells, C. papaya seed oil significantly increased HbSSM and HbSSF human sickle cell blood peroxidase activity and hemoglobin concentration significantly, through exhibited particular antisickling properties and reduced oxidative stress in sickle cell patient(3).

In patients with beta-thalassemia major and intermedia and E-beta-thalassemia due to defects and mutations in the beta-globin gene, fermented papaya preparation (FPP) improve the status of anemia through increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased free radicals generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS) in beta-thal, major and intermedia, (in Israel) and E-beta-thal patients(4).

Dr. Olalla-Saad ST said, "... reduction of oxidative status in red blood cells of patients with β- and E-β-thalassemia (β-thal) treated with fermented papaya preparation"(5) of that reducing the severity of the symptoms of anemia(6).

In fact, on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples, long term consumption of tropical fruit extract, Carica papaya produced significant less numbers of sickle cells, the Covenant University study suggested(7).

People who are at increased risk of anemia due to family history, genetic mutation .....should drink at least 2 serving daily and people with chronic anemia should drink the juices as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway by Macari ER1, Lowrey CH.(PubMed)
(2) Antioxidant effects of vitamin C on hemoglobin-based oxygen carriers derived from human cord blood by Chen G1, Duan Y1, Liu J1, Wang H1, Yang C1,2.(PubMed)
(3) Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT.(PubMed)
(4) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation.
Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA.(PubMed)

(5) Fermented papaya preparation for β-thalassemia? by Olalla-Saad ST1.(PubMed)

(6) Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E.(PubMed)

(7) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)

The Smoothie of Broccoli, Cranberry and Green Tea for reduced Risk and Treatment of Ovarian Cancer

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of Ovarian Cancer and Ovarian Cancer

Yield: 2 serving (about 8 ounce each)
1/2 Broccoli
1 cup Cranberry
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place whole food papaya, cinnamon and green tea drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of ovarian cancer has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Recent study suggested that broccoli(1), cranberry(5) and green tea(8) may process phytochemicals and ingredients effectively in reduced risk and treatment of ovarian cancer.

Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe. According to the review of data base studies of Medline (Pubmed), Embase and Web of Science databases intake of cruciferous vegetables is associated to reduce risk of cancer.(4).

Sulforaphane, a major chemical constituent found in cruciferous vegetables, including broccoli, has exerted its anti ovarian cancer effects through induction of apoptosis and cell-cycle arrest in various mechanism which induced cancer cells growth(1). According to the Mount Sinai School of Medicine, the phytocemical inhibited cancer cell cycle phase progression through a decrease in the cell division in S and G2M phases with 18% of the cells underwent apoptosis after 2 days, 42% of the cells apoptosis after 3 days of incubation(2).

In ovarian cancer cell lines SKOV3, C3, and T3 cells, sulforaphane exhibited antiproliferative effects in all 3 ovarian cancer cell lines through tageting the signal transduction pathway Akt which promotes survival and growth of ovarian cells(3).

Cranberry is a species of Vaccinium oxycoccos, belong9ngs to the family Ericaceae, found in the cooler part of Northern America. The fruit has been found to process certain phytochemicals including flavonols and flavan-3-ols for SKOV-3 and OVCAR-8 in inhibiting reduction ovarian cancer cells, through cytotoxic and anti-proliferative properties(5).

According to the Women and Infants Hospital of Rhode Island study, proanthocyanidins isolated from cranberry, exerted significant potent anti ovarian cancer and anti-angiogenic properties, through blocking the vascular endothelial growth factor (VEGF) in blood circulation(6).

Furthermore, the fruit's polyphenolic extracts, also exhibited cell-line specific cytotoxicity, induced apoptosis of platinum-resistant ovarian cancer cells, SKOV-3 ovarian cancer cells(7).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.

Functional mutations in BRCA (breast cancer-gene) 1 or 2 is found to associated to 60 % risk of ovarian cancer. The Curtin University of Technology, drinking tea daily and drinking tea for >30 years exhibited a greatest risk declined in the development of ovarian cancer, in a study of a total of 652 controls comprised 340 hospital visitors, 261 non-neoplasm hospital outpatients conducted in China during 1999-2000(9).

According to the review of data based of Medline, EMBASE and SciVerse (last researched: July 2011), green tea inhibited the epithelial ovarian cancer cell lines, by downregulating the expression of inflammation, cell signalization, cell motility and angiogenesis proteins(8).

In a cohort study included 254 patients recruited during 1999-2000 with histopathologically confirmed epithelial ovarian cancer, after followed up for a minimum of 3 years, drinking green tea enhances survival of epithelial ovarian cancer in does dependent-manner(10).

Taking all together, women with high risk of ovarian cancer due to family history and gene mutation should drink at least a serving daily and those with ovarian cancer should drink as much as possible depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells by Bryant CS1, Kumar S, Chamala S, Shah J, Pal J, Haider M, Seward S, Qazi AM, Morris R, Semaan A, Shammas MA, Steffes C, Potti RB, Prasad M, Weaver DW,Batchu RB.(PubMed)

(2) Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells by Chuang LT1, Moqattash ST, Gretz HF, Nezhat F, Rahaman J, Chiao JW.(PubMed)

(3) Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells by Chaudhuri D1, Orsulic S, Ashok BT.(PubMed)

(4) Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis by Hu J1, Hu Y1, Hu Y1, Zheng S2.(PubMed)
(5) The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells by Wang Y1, Han A2, Chen E2, Singh RK2, Chichester CO3, Moore RG2, Singh AP1, Vorsa N1.(PubMed)
(6) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG.(PubMed)
(7) Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin by Singh AP1, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N.(PubMed)
(8) Green tea for ovarian cancer prevention and treatment: a systematic review of the in vitro, in vivo and epidemiological studies by Trudel D1, Labbé DP, Bairati I, Fradet V, Bazinet L, Têtu B.(PubMed)
(9) Tea consumption and ovarian cancer risk: a case-control study in China by Zhang M1, Binns CW, Lee AH.(PubMed)
(10) Green tea consumption enhances survival of epithelial ovarian cancer by Zhang M1, Lee AH, Binns CW, Xie X.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma - The Risk factors

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The Risk factors

1. Wheezing rhinovirus illnesses
Virus-induced wheezing episodes in infancy often precede the development of asthma. Researchers at the the Department of Pediatrics, University of Wisconsin-Madison, showed that Nearly 90% (26 of 30) of children who wheezed with RV in Year 3 had asthma at 6 years of age.From birth to age 3 years, wheezing with respiratory syncytial virus (RSV) (odds ratio [OR], 2.6), rhinovirus (RV) (OR, 9.8), or both RV and RSV (OR , 10) was associated with increased asthma risk at age 6 years. In Year 1, both RV wheezing (OR, 2.8) and aeroallergen sensitization (OR, 3.6) independently increased asthma risk at age 6 years. By age 3 years, wheezing with RV (OR, 25.6) was more strongly associated with asthma at age 6 years than aeroallergen sensitization (OR, 3.4)(17).

2. Airflow obstruction
Asthma and family history of allergic rhinitis are important risk factors associated with airflow. according to the Department of Pediatrics, Lerdsin General Hospitalobstruction(18).

3. Gender
If you are women, you are at increased risk to develop asthma. According to the study by the Department of Woman and Child Health, Karolinska Institutet, in adolescence, the pattern changes and onset of wheeze is more prevalent in females than males. Asthma, after childhood, is more severe in females than in males, and is underdiagnosed and undertreated in female adolescents(19).

4. Stress
Researchers at the Departments of Family Medicine and Pediatrics, University of Pittsburgh, suggested that stress, whether at the individual(i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence) or community (i.e.neighborhood violence; neighborhood disadvantage) level, influences asthma and asthma morbidity(20).

5. Gene
a study by National Taiwan University, showed that GSTP1, INSIG2 and IL4Ra may influence the lifetime asthma susceptibility through gene-gene interactions in schoolchildren. Home dampness combined with each one of the genes STAT6, IL13 and ADRB2 could raise the asthma risk(21). Other suggested that rs17880588 showed a significant association with asthma in the Saudi population due to the association of between asthma and 5 single-nucleotide polymorphisms (SNPs) in the interleukin 17 (IL17) gene. Levels of IL17A and IL17F were significantly upregulated in the asthma patients(22).

6. Airway inflammation and hyperreactivity
People with Air way hyperreactivity are at increased risk to develop asthma as a result of the immune system over response to allergan. Some study suggested that epidermal growth factor receptor (EGFR) signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model(23).

5. Atopy and viral infection
Atopy – such as eczema, allergic rhinitis, allergic conjunctivitis and virual infection are associated with higher risk to asthma development. According to the study by The University of Western Australia, suggested that underlying this bipartite process (Viral infections occurring against a background of allergic sensitization to aeroallergens as a uniquely potent risk factor for the expression of acute severe asthma-like symptoms and for the ensuing development of asthma that can persist through childhood and into adulthood) are a series of interactions between antiviral and atopic inflammatory pathways that are mediated by local activation of myeloid cell populations in the airway mucosa and the parallel programming and recruitment of their replacements from bone marrow(24).

6. Family history
Family history of asthma in one or more first-degree relatives was consistently identified as a risk factor for asthma. But although a positive family history predicts an increased risk of asthma, it identifies a minority of children at risk. Positive family history may have utility in targeting some individual prevention efforts, but the low positive predictive value limits its value as a means to direct environmental remediation efforts, according to the study the Department of Medical History and Ethics, University of Washington(25).

7. Smoke during Pregnancy
Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies.
During pregnancy, asthma exacerbations are more common and more severe in current smokers than never smokers. The risk of effects of maternal asthma on the fetus may be greater among smokers(26).

8. Low birth weight
There is a strong independent association between low birth weight and asthma. For 1988 national birth cohort, an estimated 4000 excess asthma cases were attributable to birth weight less than 2500 g(27).

9. Etc.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca p/general-health.html

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Monday, December 28, 2015

The Delicious Carrot and Cucumber for reduced risk and treatment of Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk Choriocarcinoma and Choriocarcinoma
Yield: 2 serving (about 8 ounce each)
3/4 cup carrot
3/4 cup cucumber

1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of fibromyalgia is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Cancer of Choriocarinma is a malignant and aggressive cancer, started from the abnormal and uncontrollable cells growth in the trophoblatistic tissue, that is part of embryo and normally become the placenta as a result of something going wrong during pregnancy due to random chance.
Placenta is the organ by which the fetus received nutrients and oxygen from the mother.

Molar pregnancy or Hydatidiffrom molebeginning from the trophoblastic tissue, normally is non cancerous but sometimes, but it may invade the uterine wall (invasive mole) as a result of a sperm fusing with an with nucleus or something going wrong during pregnancy causing forming of a mass resembling the bunch of grape.
Recent studies suggested that carrot(1) may be the combination ingredient with pharmateitic values for reduced risk and treatment of Choriocarinma. According to the University of Indonesia, retinoic acid, the derivative of vitamin A, in a a randomized clinical trial, double blind protocol attenuated cell proliferation and stimulate apoptosis in hydatidiform mole patients(1).

In a 72 women study of 24 healthy women in the first trimester of pregnancy (HP), 24 healthy non-pregnant women (NP) and 24 with complete hydatidiform mole (CHM), serum of vitamin A is found to lower in patients with complete hydatidiform mole (CHM)(2).
Dr. Berkowitz RS and colleagues in the study of risk factors for complete molar pregnancy, found that the development of complete molar pregnancy is found in women with diets deficient in the vitamin A precursor carotene. They also emphasized a significant trend for decreasing risk for molar pregnancy with increasing consumption of carotene(3).

Cucumber plant, a creeping vine with roots in the ground and grows up with the support of frames is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia.

According to Dr. Lu PX and Dr. Jin YC. phytochemical trichosanthin found in Chinese cucumber reduced amount of bleeding and malignant rate in changes some patients with hydatidiform mole(4).

Recently, the phytochemical is ls effectively used in the treatment of trophoblastic tumours, including hydatidiform mole, invasive mole and choriocarcinoma by exhibiting the selective cytotoxic effects(5).

In fact, trichosanthin has been used in traditional Chinese medicine for inducing abortion against trophoblastic neoplasms, a rare diseases with abnormal trophoblast cells growed inside the uterus after conception(6).

Taking altogether, intake of combination of carrot and cucumber showed to reduced risk and prevention of Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta)

People who are at risk of Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta) due to genetic reason, .......may drink one or 2 servings a day, people with

Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta) should drink as much as they can depending to the digestive alternation.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Prevention of post-mole malignant trophoblastic disease with vitamin A by Andrijono A1, Muhilal M.(PubMed)
(2) Catalase activity, serum trace element and heavy metal concentrations, vitamin A, vitamin D and vitamin E levels in hydatidiform mole by Kolusari A1, Adali E, Kurdoglu M, Yildizhan R, Cebi A, Edirne T, Demir H, Yoruk IH.(PubMed)
(3) Risk factors for complete molar pregnancy from a case-control study by Berkowitz RS, Cramer DW, Bernstein MR, Cassells S, Driscoll SG, Goldstein DP.(PubMed)
(4) Trichosanthin in the treatment of hydatidiform mole. Clinical analysis of 52 cases by Lu PX1, Jin YC.(PubMed)
(5) Selective killing of choriocarcinoma cells in vitro by trichosanthin, a plant protein purified from root tubers of the Chinese medicinal herb Trichosanthes kirilowii by Tsao SW, Yan KT, Yeung HW.(PubMed)
(6) Studies on the mechanisms of abortion induction by Trichosanthin by [No authors listed](PubMed)

The Smoothie of Blue berry, Carrot and Green tea for reduced risk and treatment of Cervical Cancer

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of cervical cancer

Yield: 2 serving (about 8 ounce each)
3/4 cup blueberry
3/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingradietns in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of cervical cancer without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.
Recent studies suggested that green tea(1), blueberry(5) and carrot(8) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression.

Cervical cancer is malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicine for treatment of variety of diseases, including cancers and heart diseases.(-)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, in human papillomavirus (HPV)-16 associated cervical cancer cell line, upregulated the genes expression in inhibition of cervical cancer cell growth through induction of apoptosis and cell cycle arrest(1).

The in the study of green tea effect in cervical cancer suggested that EGCG reactivate known tumor-suppressor genes (TSGs) in HeLa cells by by targeting epigenetic alterations including DNA methylation(2).

Green tea extract, strongly inhibited the growth of HeLa xenografts(a cancer cell line) in animal model when used conjunction with lysine, ascorbic acid, proline and other nutrients(3).

Dr. Shan HM and the research team at the Peking University said,"..., catechins interfere with the proper subcellular localization of PLK1, lead to cell-cycle arrest in the S and G2M phases, and induce growth inhibition of several human cancer cell types, such as breast adenocarcinoma (MCF7), lung adenocarcinoma (A549), and cervical adenocarcinoma (HeLa)"(4).

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America, was also found to process anti cancer properties, through its powerful antioxidant anthocyanin(5)

epidemiological studies suggested.

In the comparison of blueberry and blackcurrant juices on three tumor cell lines; B16F10 (murine melanoma), A2780 (ovarian cancer) and HeLa (cervical cancer), anthocyanin-rich fractions (ARFs) found in the juice exhibited antiproliferative effects through its antioxidant bioactive molecules(5).

According to the University of Mississippi research, ethanol extracts blueberry cultivars strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell line, through interfering to the direct-acting and metabolically activated carcinogens(6).
In fact, researchers at the Clemson University, in the evaluation of juice from strawberry, blueberry, and raspberry fruit showed that fresh juices and organic solvent extracts from the fruits exhibited the the formation of cancer is damage to the genome of a somatic cell producing a mutation in an oncogene or a tumor-suppressor genes(7).

Carrots with abundant carotenoid (α-carotene, β-carotene, and lutein/zeaxanthin) and tocopherol may also be considered for reducing risk and treatment of cervical cancer, according to the Xinjiang Medical Universit(8). As higher serum concentrations of some carotenoids and tocopherols are found to associate to lower risk cervical cancer among Chinese women(8).

Frequent intakes of carrot decreased the risk of cervical cancer(11).

In a total of 391 patients with cervical intraepithelial neoplasia (CIN) grade 1-2 lesions, high serum levels of alpha-tocopherol and medium level of serum beta-carotene were associate to the regression and progression of the diseases respectively(9).

The 32 women with incident cervical dysplasia, including cervical intraepithelial neoplasia (CIN) I, CIN II, and CIN III/carcinoma in situ, and 113 control women with normal cervical cytology in case-control study suggested ," among black women, lycopene and perhaps vitamin A may play a protective role in the early stages of cervical carcinogenesis"(10).

The combination of Blue berry, Carrot and Green tea smoothie may hold a key to reduce risk for women who are at higher risk of cervical cancer as well as for treatment of patient who have already developed the disease. Women with cervical cancer in any stage should drink as much as they can depending to the digestive toleration.

References

(1) A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression by Ahn WS1, Huh SW, Bae SM, Lee IP, Lee JM, Namkoong SE, Kim CK, Sin JI.(PubMed)

(2) (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells by Khan MA1, Hussain A2, Sundaram MK2, Alalami U1, Gunasekera D2, Ramesh L2, Hamza A2, Quraishi U2.(PubMed)
(3)
(4) Identification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1 by Shan HM1, Shi Y, Quan J.(PubMed)
(5) Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice by Diaconeasa Z1, Leopold L2, Rugină D3, Ayvaz H4, Socaciu C5.(PubMed)
(6) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells by Wedge DE1, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(7) Antimutagenic activity of berry extracts by Hope Smith S1, Tate PL, Huang G, Magee JB, Meepagala KM, Wedge DE, Larcom LL.(PubMed)
(8) Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women by Zhang YY1, Lu L, Abliz G, Mijit F.(PubMed)
(9) Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study by Fujii T1, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y,Nagai Y, Kitagawa T, Yoshikawa H.(PubMed)
(10) Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women by Kanetsky PA1, Gammon MD, Mandelblatt J, Zhang ZF, Ramsey E, Dnistrian A, Norkus EP, Wright TC Jr.(PubMed)
(11) [Hospital epidemiology--a comparative case control study of breast and cervical cancers].[Article in Japanese] by Tajima K1, Hirose K, Ogawa H, Yoshida M, Ohta M.(PubMed)

Most common diseases of 50 plus: Musculo-Skeletal disorders: Chronic Low back pain - Treatment in Herbal and Traditional Chinese medicine perspective

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

Treatment in Herbal and Traditional Chinese medicine perspective

B. In herbal medicine perspective
In a systematic review of randomized controlled trials to determine the effectiveness of herbal medicine compared with placebo, no intervention, or “standard/accepted/conventional treatments” for nonspecific low back pain, found that Two high-quality trials utilizing Harpagophytum procumbens (Devil’s claw) found strong evidence for short-term improvements in pain and rescue medication for daily doses standardized to 50 mg or 100 mg harpagoside with another high-quality trial demonstrating relative equivalence to 12.5 mg per day of rofecoxib. Two moderate-quality trials utilizing Salix alba (White willow bark) found moderate evidence for short-term improvements in pain and rescue medication for daily doses standardized to 120 mg or 240 mg salicin with an additional trial demonstrating relative equivalence to 12.5 mg per day of rofecoxib. Three low-quality trials using Capsicum frutescens (Cayenne) using various topical preparations found moderate evidence for favorable results against placebo and one trial foundequivalence to a homeopathic ointment(58).
C. In traditional Chinese medicine perspective
1. Acupuncture
In the study to investigate the efficacy of acupuncture for chronic low back pain of a
total of 640 participants (160 in each of four arms) between the ages of 18 and 70 years of age who have low back pain lasting at least 3 months recruited from integrated health care delivery systems in Seattle and Oakland, clarified that the value of acupuncture needling as a treatment for chronic low back pain(59). Others found that found there is little evidence for the existence of subgroups of patients with chronic back pain that would be especially likely to benefit from acupuncture. However, persons with chronic low back pain who had more severe baseline dysfunction had the most short-term benefit from acupuncture, according to the study of Characteristics of patients with chronic back pain who benefit from acupuncture(60).
2. Herbs
2.1. In a cross-sectional study carried out among 513 patients with CLBP in four hospitals affiliated with Yunnan University of Traditional Chinese Medicine, China, showed that they were eventually interpreted as (1) “Qi and/or Blood Stagnation,” which includes eight items such as piercing pain; activity limited by feeling of local heaviness, lumbar and flank stiffness with bending limitation and purple tongue, etc.; (2) “Cold/Damp,” which has seven items (for example, Cold/Damp pain, pallid face and greasy coating, etc.); (3) a part of “Kidney Deficiency,” which includes two items: “dull pain and recurrent vague pain”; (4) “Warmth/Heat,” which is related to three items (namely, purple tongue, yellow tongue coating, and burning pain). The four factors accounted for 12.7%, 8.2%, 8.2%, and 7.8% of the total variance, respectively. There are seven items with uniqueness over 0.8(61).
2.2. Herbal formula (Please consult with your traditional Chinese medicine practitioner before applying)
1. Shen Tong Zhu Yu Wan (Shen Tong Zhu Yu Pian)
a. promotes blood circulation and Qi, removes blood stasis and obstruction in the channels, alleviates blood-arthralgia and pain. It is used for shoulder pain, pain in the arm, lumbago, pain in the leg or pain in the entire body due to obstruction of the flow of Qi and blood in channels.
b. Ingredients
Ingredients: Radix Gentianae Macrophyllae (Qin Jiao), Rhizoma Chuanxiong (Chuan Xiong), Semen Persicae (Tao Ren), Flos Carthami (Hong Hua), Radix Glycyrrhizae (Gan Cao), Rhizoma Et Radix Notopterygii (Qiang Huo), Resina Commiphorae (Mei Yao), Radix Angelica Sinensis (Dang Gui), Rhizoma Cyperi (Xiang Fu), Radix Achyranthis Bidentatae (Niu Xi), Phertima (Di Long), Rhizoma Wenyujin Concisa (Jiang Huang), Rhizoma Corydalis (Yan Hu Suo)(61a).
2. Liu Wei Di Huang Wan (Kidney Yin deficiency)
a. Liu Wei Di Huang Wan can replenish Yin due to the Yin insufficiency of the kidney. The kidney is the innate foundation of all organs with respect to the Yin-Yang principles, Qi essence etc.
b. Ingredients
Radix Rehmanniae Preparata (Shu Di Huang), Fructus Corni Officinalis (Shan Zhu Yu), Cortex Moutan Radicis (Mu Dan Pi), Rhizoma Dioscoreae Oppositae (Shan Yao), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Alismatis Orientalis (Ze Xie)(61b).
3. Jin Kui Shen Qi Wan (Kidney Yang deficiency)
a. Jin Kui Shen Qi Wan can replenish Yang due to the Yang insufficiency of the kidney. The kidney is the innate foundation of all organs with respect to the Yin-Yang principles, Qi essence etc.
b. Ingredients
Radix Rehmanniae Preparata (Shu Di Huang), Fructus Corni officinalis (Shan Zhu Yu), Rhizoma Dioscoreae Oppositae ((Shan Yao), Cortex Moutan Radicis (Mu Dan Pi), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Alismatis Orientalis (Ze Xie), Cortex Cinnamomi Cassiae (Rou Gui), Radix Aconiti Lateralis Preparata (Zhi Fu Zi), Radix Achyranthis Bidentatae (Niu Xi), Radix Polygoni Multiflori (He Shou Wu), Fructus Lycii Chinensis (Gou Qi Zi), Fructus Schisandrae Chinensis (Wu Wei Zi(61c).
D. TCM and conventional medicine baclofen
According to the study of Reduction of chronic non-specific low back pain: A randomised controlled clinical trial on acupuncture and baclofen, after treatment, the baclofen, acupuncture and acupuncture + baclofen groups all had lower VAS and RDQ scores. Significantly higher reduction and improvement in VAS and RDQ scores were found in the acupuncture and acupuncture + baclofen groups compared to the baclofen group(62)
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Sources
Red flags*
Recent significant trauma, Milder trauma if age is greater than 50 years, Unexplained weight loss, Unexplained fever, Immunosuppression, Previous or current cancer, Intravenous drug use, Osteoporosis, Chronic corticosteroid use, Age greater than 70 years, Focal neurological deficit, Duration greater than 6 week(a)
(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(4) http://www.ncbi.nlm.nih.gov/pubmed/20714283
(58) http://www.ncbi.nlm.nih.gov/pubmed/17202897
(59) http://www.ncbi.nlm.nih.gov/pubmed/18307808
(60) http://www.ncbi.nlm.nih.gov/pubmed/19772583
(61) http://www.ncbi.nlm.nih.gov/pubmed/21204636
(61a) http://www.yinyanghouse.com/store/catalog/herbal-supplements/shen-tong-zhu-yu-wan-shoulder-leg-back-pain-herbal-formula
(61b) http://www.activeherb.com/yinvive/
(61c) http://www.activeherb.com/yanvive/
(62) http://www.cmjournal.org/content/5/1/15

Sunday, December 27, 2015

The Best Smoothie of Cooked Tomato, Grape and Green Tea for Protection against Cognitive Dysfunction

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk of Cognitive Dysfunction and Cognitive Dysfunction
Yield: 2 serving (about 8 ounce each)
3/4 cup cooked tomato
3/4 cup of grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. The fruit containing large amount of lycopene found in the skin has shown to protect our body against carious diseases, such as prostate cancer, enlarge prostate. For the release of lycopene and easy digestive absorption from the skin, tomato must be cooked.

In cognitive impairment in fructose-drinking insulin resistant rats, lycopene found in tomato is a phytochemicals in carotenoid family, exhibited anti cognitive impairment effects, through ameliorated anti-oxidative stress, anti-inflammatory reaction(1).

Dr. Prakash A and Dr. Kumar A. in the study of memory impairment and mito-oxidative damage induced by colchicine, showed that long term administration of lycopene significantly improved memory retention and attenuated mito-oxidative damage parameters, inflammatory markers of that induced cognitive function in colchicine damage animals(2).

Furthermore, according to the the joint study lead by the Sorbonne Paris Cité Université, dietary rich with carotenoid and providing sufficient quantity and variety of coloured fruits and vegetables may reduce risk of early onset of aging related cognitive function(3).

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey. Recent study suggested that its antioxidant resveratrol may be the next generation natural food source used for reduced risk and treatment in patinet with cognitive dysfunction(4).

Dr. Nooyens AC and the research team at the National Institute for Public Health and the Environment (RIVM) and Maastricht University said, "red wine(processed high amount of antioxidant resveratrol) was inversely associated with the decline of cognitive function", in the study of 2613 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline (1995-2002)(5). In prenatal stress-induced cognitive dysfunction animal model, oral administration of resveratrol in early and late gestational stress significantly reduced spatial learning and memory and cognitive deficit, through numbers of activity in brain homogenate(6)and against oxidative damage(7).

Green tea containing more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. according to epidemiological studies, chronic consumption of green tea is also associated to reduce risk of cognitive dysfunction due to aging.A double-blind placebo-controlled study conducted by LG Household and Health Care Co, green tea extract ant its antioxidant l-theanine exhibited cognitive alertness in cognitive impairment patients in brain theta waves expression(8).

In the cross-sectional data from a community-based Comprehensive Geriatric Assessment (CGA) conducted in 2002, high consumption of green tea was associated with a lower prevalence of cognitive impairment, the Tohoku University Graduate School of Medicine, insisted(9).

Dr Shimbo M and the research team at the Graduate School of Tokyo Medical and Dental University, said," ...., consumption of brewed green tea was not statistically associated with any decrease in risk of mental ill-health among either males or females"(10).

The finding of the effectiveness of Cooked Tomato, Grape and Green Tea for Protection against Cognitive Dysfunction, through theirs phytochemicals may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Cognitive Impairment.

People who are at high risk of Cognitive Impairment. such as aging, genetic mutation genes,.....should drink at least one cup daily and people with Cognitive Dysfunction should drink the juices as much as they can depending to digestive toleration.

Reference
(1) Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats by Yin Q1, Ma Y1, Hong Y1, Hou X1, Chen J1, Shen C2, Sun M1, Shang Y1, Dong S1, Zeng Z3, Pei JJ4, Liu X5(PubMed)

(2) Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: an evidence of nitric oxide signaling by Prakash A1, Kumar A.(PubMed)

(3) Carotenoid-rich dietary patterns during midlife and subsequent cognitive function by Kesse-Guyot E1, Andreeva VA1, Ducros V2, Jeandel C3, Julia C1, Hercberg S1, Galan P1.(PubMed)

(4) Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition by Granzotto A1, Zatta P2.(PubMed)

(5) Consumption of alcoholic beverages and cognitive decline at middle age: the Doetinchem Cohort Study by Nooyens AC1, Bueno-de-Mesquita HB1, van Gelder BM1, van Boxtel MP2, Verschuren WM1(PubMed)

(6) Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+), K(+)-ATPase activity by Sahu SS1, Madhyastha S, Rao GM.(PubMed)

(7) Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons by Madhyastha S, Sahu SS, Rao G.(PubMed)

(8) A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitiveimpairment: a double-blind placebo-controlled study by Park SK1, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS.(PubMed)

(9) Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. by Kuriyama S1, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H, Tsuji I.(PubMed)

(10) Green tea consumption in everyday life and mental health by Shimbo M1, Nakamura K, Jing Shi H, Kizuki M, Seino K, Inose T, Takano T.(PubMed)

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