The Best Smoothie of Cooked Tomato, Grape and Green Tea for Protection against Cognitive Dysfunction

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk of Cognitive Dysfunction and Cognitive Dysfunction 
Yield: 2 serving (about 8 ounce each)
3/4 cup cooked tomato
3/4 cup of grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)



1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. The fruit containing large amount of lycopene found in the skin has shown to protect our body against carious diseases, such as prostate cancer, enlarge prostate. For the release of lycopene and easy digestive absorption from the skin, tomato must be cooked. 

In cognitive impairment in fructose-drinking insulin resistant rats, lycopene found in tomato is a phytochemicals in carotenoid family, exhibited anti cognitive impairment effects, through ameliorated anti-oxidative stress, anti-inflammatory reaction(1).

Dr. Prakash A and Dr. Kumar A. in the study of memory impairment and mito-oxidative damage induced by colchicine, showed that long term administration of lycopene significantly improved memory retention and attenuated mito-oxidative damage parameters, inflammatory markers of that induced cognitive function in colchicine damage animals(2).

Furthermore, according to the the joint study lead by the Sorbonne Paris Cité Université, dietary rich with carotenoid and providing sufficient quantity and variety of coloured fruits and vegetables may reduce risk of early onset of aging related cognitive function(3).

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey. Recent study suggested that its antioxidant resveratrol may be the next generation natural food source used for reduced risk and treatment in patinet with cognitive dysfunction(4).

Dr. Nooyens AC and the research team at the National Institute for Public Health and the Environment (RIVM) and Maastricht University said, "red wine(processed high amount of antioxidant resveratrol) was inversely associated with the decline of cognitive function", in the study of 2613 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline (1995-2002)(5). In prenatal stress-induced cognitive dysfunction animal model, oral administration of resveratrol in early and late gestational stress significantly reduced spatial learning and memory and cognitive deficit, through numbers of activity in brain homogenate(6)and against oxidative damage(7).

Green tea containing more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. according to epidemiological studies, chronic consumption of green tea is also associated to reduce risk of cognitive dysfunction due to aging.A double-blind placebo-controlled study conducted by LG Household and Health Care Co, green tea extract ant its antioxidant l-theanine exhibited cognitive alertness in cognitive impairment patients in brain theta waves expression(8).

In the cross-sectional data from a community-based Comprehensive Geriatric Assessment (CGA) conducted in 2002, high consumption of green tea was associated with a lower prevalence of cognitive impairment, the Tohoku University Graduate School of Medicine, insisted(9).

Dr Shimbo M and the research team at the Graduate School of Tokyo Medical and Dental University, said," ...., consumption of brewed green tea was not statistically associated with any decrease in risk of mental ill-health among either males or females"(10).

The finding of the effectiveness of Cooked Tomato, Grape and Green Tea for  Protection against Cognitive Dysfunction, through theirs phytochemicals may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Cognitive Impairment.

People who are at high risk of Cognitive Impairment. such as aging, genetic mutation genes,.....should drink at least one cup daily and people with Cognitive Dysfunction  should drink the juices as much as they can depending to digestive toleration.

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Reference
(1) Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats by Yin Q1, Ma Y1, Hong Y1, Hou X1, Chen J1, Shen C2, Sun M1, Shang Y1, Dong S1, Zeng Z3, Pei JJ4, Liu X5(PubMed)

(2) Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: an evidence of nitric oxide signaling by Prakash A1, Kumar A.(PubMed)

(3) Carotenoid-rich dietary patterns during midlife and subsequent cognitive function by Kesse-Guyot E1, Andreeva VA1, Ducros V2, Jeandel C3, Julia C1, Hercberg S1, Galan P1.(PubMed)

(4) Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition by Granzotto A1, Zatta P2.(PubMed)

(5) Consumption of alcoholic beverages and cognitive decline at middle age: the Doetinchem Cohort Study by Nooyens AC1, Bueno-de-Mesquita HB1, van Gelder BM1, van Boxtel MP2, Verschuren WM1(PubMed)

(6) Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+), K(+)-ATPase activity by Sahu SS1, Madhyastha S, Rao GM.(PubMed)

(7) Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons by Madhyastha S, Sahu SS, Rao G.(PubMed)

(8) A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitiveimpairment: a double-blind placebo-controlled study by Park SK1, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS.(PubMed)

(9) Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. by Kuriyama S1, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H, Tsuji I.(PubMed)

(10) Green tea consumption in everyday life and mental health by Shimbo M1, Nakamura K, Jing Shi H, Kizuki M, Seino K, Inose T, Takano T.(PubMed)