Thursday, January 28, 2016

The Unbelievable Smoothie Green Tea and Grape for reduced risk and Treatment of Psoriasis

Kyle J. Norton (Scholar, and Master of nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about. In fact, it happens.  Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).

The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.

The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.

The smoothie for Prevention of the Early Onset and Treatment of Psoriasis

Yield: 2 serving (about 8 ounce each)
1 1/2  cups grape
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Recent studies by some renowned institutions suggested that green tea(1) and grape may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of psoriasis.

Psoriasis is an autoimmune diseases induced abnormal skin path with expression of redness, itchy, and scaly.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.According to the The Catholic University of Korea, epigallocatechin-3-Gallate (EGCG), a major polyphenolic component of green tea inhibited the pathogenesis of psoriasis through its anti pro inflammatory cytokine effects(1)(2).
In animal model of Psoriasis, the polyphenol, epigallocatechin-3-Gallate (EGCG) also exhibited protective effect on keratinocytes, the outermost layer of the skin, significantly reduced the symptoms of epidermal pathology in the flaky skin topically, through processing and reduction in proliferating cell nuclear antigen levels(3).
Dr. Zhao JF and colleagues at the Columbia University in the study of the treatment of psoriasis also suggested the efficiency of use of psoralens combined with exposure to ultraviolet A radiation through a standardized green tea extract in inhibition of DNA damage and the inflammatory effects(4).
Oxidative stress and inflammation play an important role in induced pathogenesis of psoriasis and its comorbidities(5)(6).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape, enhanced the protection of immune system against damage of keratinocytes caused by hyperproliferation, abnormal differentiation and inflammatory infiltration(7).
In animal model, resveratrol also express the significantly diminished severity of the psoriasis-like skin inflammation, through expression of retinoic acid stimulated genes in cell regulation and immune response, IL-17 signalling pathways(8).
Dr. Srivastava RK and colleagues at the The University of Kansas Medical Center said," regulation of FOXO transcription factors(The gene involved regulation and expression of cell growth, proliferation, differentiation, and longevity) by resveratrol may play an important role in angiogenesis which is critical for cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, and cardiovascular disorders"(9).

Taking altogether, people who are at increased risk of psoriasis due to family history .....should drink at least one cup daily and people with chronic psoriasis should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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(1) Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes by Yun M1, Seo G1, Lee JY1, Chae GT1, Lee SB2.(PubMed)
(2) Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions by Dombrowski Y1, Peric M, Koglin S, Kammerbauer C, Göss C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J.(PubMed)
(3) Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model by Hsu S1, Dickinson D, Borke J, Walsh DS, Wood J, Qin H, Winger J, Pearl H, Schuster G, Bollag WB.(PubMed)
(4) Green tea protects against psoralen plus ultraviolet A-induced photochemical damage to skin by Zhao JF1, Zhang YJ, Jin XH, Athar M, Santella RM, Bickers DR, Wang ZY.(PubMed)
(5) Effect of antipsoriatic therapy on oxidative stress index and sialic acid levels in patients with psoriasis by Rajappa M1, Shanmugam R2, Munisamy M2, Chandrashekar L2, Rajendiran KS1, Thappa DM2.(PubMed)
(6) Prolidase activity in chronic plaque psoriasis patients by Sürücü HA1, Aksoy N2, Ozgöztas O3, Sezen H2, Yesilova Y1, Turan E1(PubMed)
(7) Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1 by Lee JH1, Kim JS1, Park SY1, Lee YJ1.(PubMed)
(8) Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by Kjær TN1, Thorsen K2, Jessen N2, Stenderup K3, Pedersen SB1.(PubMed)
(9) FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol by Srivastava RK1, Unterman TG, Shankar S.(PubMed)

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