The Smoothie of Celery, Apple and Grape Juice for Prevention and Treatment of Gestational Hypertension

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Gestational Hypertension 
Yield: 2 servings (about 8 ounces each)
3/4 cup celery
3/4 apple with peel
1 cup organic grape drink

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Gestational hypertension is a condition of  of elevated blood pressure in pregnancy, effecting 6% of all pregnancies.
The finding the natural ingredients for treatment of Gestational Hypertension is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. According to study, hypertension in pregnancy reduced quality of life physically and psychologically(1).

Diet rich in fruits and vegetable and reduced intake of red meat, saturated fat and trans fat has shown to attenuated risk of hypertension(2). Recent study showed that celery(3) intake used conjunction with grape(10) and apple(8) may be the potential drink for prevention and treatment of hypertension.

Recent reports from numbers of well known institutions insisted, intake of celery, apple and berry may be the next generation ingredient to be used on prevention and treatment of Gestational Hypertension

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable. According to Chronic administration of hexanic, methanolic, and aqueous-ethanolic extracts of celery seed effectively exhibited an antihypertensive activity in chronic treatment of elevated BP in tested animals(5).

Dr. Dianat M and the research team at the Ahvaz Jundishapur University of Medical Sciences said," hydro-alcoholic celery leaf extract on systolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose"(5)
3‑n‑butylphthalide (NBP), an phytochemical found in celery seed used in traditional Chinese medicine exhibited significantly antihypertensive and attenuated progression of hypertensive effects through decreased oxidative stress and the expression of pro‑inflammatory cytokines(6). 

Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae. It is one of the most widely cultivated tree fruits. With phytochemical flavonoids, apple and its peel inhibited angiotensin converting enzyme (ACE) in promoted the development of high blood pressure, Dr Balasuriya N and Dr. Rupasinghe HP. Suggested(7)According to the Mount Sinai School of Medicine, "Flavonoid (found abundantly in fruits and vegetable)(9) intake has been inversely associated with mortality from coronary heart disease and stroke,..... Lowering blood pressure through increased dietary consumption of dietary antioxidants(such as flavonoid) may decrease the rate of end-organ damage that is secondary to hypertension"(8).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape expressed alterations in vascular responsiveness in spontaneously hypertensive rat in the development of hypertension(10). According to the joint study led by the The First Affiliated Hospital of Nanjing Medical University, also displayed the inhibition of trophoblast apoptosis through oxidative stress in preeclampsia-model rats(11).

The establishment of combined ingredients of Celery, Apple and Grape Juice in reduced risk and treatment of Gestational Hypertension may act as a cornerstone for in deep, large sample size and multi centers study to confirm its effectiveness.

Women who are at increased risk of Gestational Hypertensiondue to family history, obesity.....should drink at least one serving daily and women with Gestational Hypertension should drink no more than 4 servings a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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References
(1) Association between hypertension and quality of life in pregnancy by Patrícia Medeiros Falcão K1,2, Pedrozo Campos Antunes T3, do Nascimento Andrade Feitosa A1,3, Victor EG2, Nunes Alves de Sousa M1, de Abreu LC3,4,5,Vilar de Asis E1,3, Barros de Quental O1,3, Pinheiro Bezerra IM4,5, Azevedo de Freitas Junior H1.(PubMed)
(2) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(3) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(4) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors by Toh JY1, Tan VM, Lim PC, Lim ST, Chong MF.(PubMed)

(5) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(6) Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats by Zhu J1, Zhang Y1, Yang C1.(PubMed)
(7) Antihypertensive properties of flavonoid-rich apple peel extract by Balasuriya N1, Rupasinghe HP.(PubMed)
(8) Dietary flavonoids and hypertension: is there a link? by Moline J1, Bukharovich IF, Wolff MS, Phillips R.(PubMed)
(9) Antihypertensive effects of the flavonoid quercetin by Perez-Vizcaino F1, Duarte J, Jimenez R, Santos-Buelga C, Osuna A.(PubMed)

(10) Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development ofHypertension in Adult Offspring by Care AS1, Sung MM1, Panahi S1, Gragasin FS1, Dyck JR1, Davidge ST1, Bourque SL2.(PubMed)

(11) Resveratrol inhibits trophoblast apoptosis through oxidative stress in preeclampsia-model rats by Zou Y1, Zuo Q2, Huang S3, Yu X4, Jiang Z5, Zou S6, Fan M7, Sun L8.(PubMed)