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Thursday, March 17, 2016

The Smoothie of Tomato, Orange and Cooked Sweet Potato for Reduced Symptoms and Treatment of Variegate porphyria (VP)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Variegate porphyria (VP)
Yield: 2 servings (about 8 ounces each)
3/4 cup tomato
3/4 cup cooked sweet potato
1 cup orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Variegate porphyria (VP) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Variegate porphyria (VP) is the result of decreased protoporphyrinogen oxidase (PPOX) in in biosynthesis of protoporphyrin IX activity and results in accumulation of porphyrins and porphyrin precursors. According to the Universitat de les Illes Balears, oral intake of vitamins E and C supplementation restores PPOX expression in VP patients and enhances antioxidants Glutathione reductase (GRd) and superoxide dismutase (SOD) activity, of that suggested potential benefits of a diet rich in vitamins E(found abundantly in Sweet Potato) and C (found abundantly Orange)in these patients(1).
Dr, Ferrer MD and professor at the Universitat de les Illes Balears insisted, dietary supplementation with vitamin E (50 mg/d) andvitamin C (150 mg/d) for 6 months decreased plasma oxidative damage and enhanced the erythrocyte activities of CAT and GR. in patients with variegate porphyria (VP)(2).

Canthaxanthin, one of two major carotenoids found in tomato, significantly improved 2 out of 5 patients with Variegate porphyria (VP) according to Dr, Eales L.(3).

The effectiveness of Tomato, Orange and Sweet Potato may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for prevention and  treatment of Variegate porphyria (VP) with little or no adverse effects.

People who are at high risk of Variegate porphyria (VP)  due to family history, genetic mutation, ..... should drink at least one serving daily and people with Variegate porphyria (VP)  should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary patter change are recommended.


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References
(1) Antioxidants restore protoporphyrinogen oxidase in variegate porphyria patients. By Ferrer MD1, Tauler P, Sureda A, Palacín C, Tur JA, Pons A.(PubMed)
(2) Variegate porphyria induces plasma and neutrophil oxidative stress: effects of dietary supplementation with vitamins E and C. by Ferrer MD1, Tauler P, Sureda A, Palacín C, Tur JA, Pons A.(PubMed)
(3) The effects of canthaxanthin on the photocutaneous manifestations of porphyria. by Eales L.(PubMed)

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