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The finding of a natural source for treatment of Toxic Hepatitis has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Toxic liver is na inflammatory liver diseases caused by accumulation of chemicals, including drugs, medication, environment toxins. etc.....
The Smoothie for reduced risk and treatment of Toxic Hepatitis
Yield: 2 servings (about 8 ounces each)
1 1/2 cup grapes
1 tsp curcumin
1/2 cup peppermint herbal tea
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately
The finding the natural ingredient for prevention and treatment of Toxic Hepatitis to replace the medication from conventional has been facing many obstacles. Many initially potentially therapeutic values working in animal studies does not produce the same effectiveness in human trials.
Recent studies suggested that grape(1) and turmeric(4) and peppermint(7) may have a potential effect on treatment of patient with Toxic Hepatitis .
Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry associated to reduce risk and treatment of Toxic Hepatitis, according to the University of Rio Grande do Sul (PUCRS(1).In animal study, resveratrol effectively attenuated α-Naphthylisothiocyanate (ANIT) iinduced acute cholestasis and liver injury, through suppression of neutrophil infiltration induced by inflammation, as well as upregulation of expression of hepatic transporters and enzymes(2).
In acetaminophen-induced toxic liver, treatment with RES significantly induced SIRT1 (cell regulation)and then negatively regulated p53, antigne signaling to induce cell proliferation-associated proteins(3).
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. Its antioxidant, curcumin exhibited liver protective effects(4)(5) through attenuated proinflammatory cytokines(5) and improved antioxidant enzymes status(4).
In rat study, RES exhibited anti D-GalN/LPS-induced liver damage by by the enhancing antioxidant defense system, attenuating mitochondrial dysfunction and inhibiting apoptosis, the joint study lead by the Nanjing Agricultural University suggested(6).
Dr. Bulku E and professors at the Manchester College School of Pharmacy, insisted the effectiveness of RES in protective against chemicals induced liver damage may be due its function in modulating multiple pro-apoptotic and anti-apoptotic signaling pathways(7).
Silymarin, a phytochemical in the class of phenolic acids, found abundantly in peppermint exhibited hepatoprotective effect against antituberculosis drug-induced liver injury, through promotion of superoxide dismutase restoration(8).
In isonicotinylhydrazine-induced hepatotoxicity in rabbit model, combined isoniazid and silymarin significantly improved serum billirubin and serum alanine transaminase(9).
Dr. Gillessen A and colleagues said, "Silymarin is a safe and efficacious treatment option for patients with elevated liver enzymes. A benefit in terms of liver-related symptoms as well as quality of life and performance was demonstrated already after 2 months of treatment."(10).
The effectiveness of Grape, Curcumin and Peppermint Tea may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Toxic Hepatitis with little or no adverse effects.
People who are at high risk of Toxic Hepatitis due to medication, environment factors, .... should drink at least one serving daily and women with Toxic Hepatitis should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern(reduced intake of bad cholesterol)change are recommended.
The effectiveness of Grape, Curcumin and Peppermint Tea may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Toxic Hepatitis with little or no adverse effects.
People who are at high risk of Toxic Hepatitis due to medication, environment factors, .... should drink at least one serving daily and women with Toxic Hepatitis should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern(reduced intake of bad cholesterol)change are recommended.
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References
(1) Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation by Nicoletti NF1, Rodrigues-Junior V, Santos AA Jr, Leite CE, Dias AC, Batista EL Jr, Basso LA, Campos MM, Santos DS, Souto AA.(PubMed)
(2) Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms by Wang T1, Zhou ZX2, Sun LX3, Li X3, Xu ZM3, Chen M3, Zhao GL3, Jiang ZZ1, Zhang LY4.(PubMed)
(3) Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathwaysby Wang Y1, Jiang Y1, Fan X1, Tan H1, Zeng H1, Wang Y1, Chen P2, Huang M1, Bi H3.(PubMed)
(4) Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats by Kadasa NM1, Abdallah H, Afifi M, Gowayed S.(PubMed)
(5)Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. by Kheradpezhouh E1, Barritt GJ2, Rychkov GY3.(PubMed)
(6) Curcumin attenuates D-galactosamine/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice by Zhang J1, Xu L1, Zhang L1, Ying Z1, Su W1, Wang T2.(PubMed)
(7) Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity by Bulku E1, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD.(PubMed)
(8) A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury by Luangchosiri C1, Thakkinstian A2, Chitphuk S3, Stitchantrakul W3, Petraksa S1, Sobhonslidsuk A4,5.(PubMed)
(9) The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits by Jahan S1, Khan M1, Imran S1, Sair M1.(PubMed)
(10) [Effect of silymarin on liver health and quality of life. Results of a non-interventional study].[Article in German] by Gillessen A, Herrmann WA, Kemper M, Morath H, Mann K.(PubMed)
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