Monday, August 8, 2016

Men Health: Benign prostatic hyperplasia(BPH) - The Effect of Vitamin E

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                   Benign prostatic hyperplasia(BPH)

Benign prostatic hyperplasia(BPH) is defined as a condition of increased in the number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract. According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50. More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment. Suggestion of BPH is associated to nutritional status and eating habits, according to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, indicated improper nutritional status lead of incorrect nutritional habits which fail to improve their health status, may be the cause of the development of some diet-dependent diseases, such as BPH and prostate cancer(a). A proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from starting(b)(c).

Epidemiological studies, indicated intake of vegetables and fruits accompanied with healthy life style may be associated in prevented risk and treatment of enlarged prostate(d)(e)(f), it may due to enhancement of antioxidants effect on over production of prostate cells(g)(h).

                        The Effect of Vitamin E

Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Epidemiological studies, linking vitamin E in reduced risk and treatment of benign prostatic hyperplasia have not been consistent(1)(2)(3).
A composition, consisting cernitin, saw palmetto, B-sitosterol, vitamin E has shown to significantly reduce nocturia and frequency and diminish overall symptomatology of BPH, according to the Georgetown University Medical Center(4). Some researchers suggested that Benign prostatic hypertrophy (BPH) may be associated to the long-term exposure of the prostate to the strong androgen 5alpha-dihydrotestosterone (DHT) due to aging induced conversion of free testosterone. Food supplementation with extracts of Serenoa repens and a combination of the antioxidants selenium, (cis)-lycopene and natural vitamin E, together with fish oil rich in long-chain polyunsaturated essential fatty acids of the omega-3 group may be effective as pharmaceutical 5alpha-reductase inhibitors in partial androgen deficiency correct testosterone substitution(5). Vitamin E, as an antioxidant and free radical scavenger may be effective in reduced oxidative stress as patients with BPH were found with significant decrease in plasma alpha-Toc and Asc level(6)(7). Although diet and dietary supplement intervention appeared to slow BPH progression, over consumption of dietary supplements may be harmful(8).

Taken altogether, without going into reviews, vitamin E may be effective in reduced risk and treatment of patients with BPH. Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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(1) Preventing diseases of the prostate in the elderly using hormones and nutriceuticals by Comhaire F1, Mahmoud A.(PubMed)
(2) Diet, micronutrients, and the prostate gland by Thomas JA.(PubMed)
(3) Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy by Tavani A1, Longoni E, Bosetti C, Maso LD, Polesel J, Montella M, Ramazzotti V, Negri E, Franceschi S, La Vecchia C.(PubMed)
(4) Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH) by Preuss HG1, Marcusen C, Regan J, Klimberg IW, Welebir TA, Jones WA.(PubMed)
(5) Preventing diseases of the prostate in the elderly using hormones and nutriceuticals by Comhaire F1, Mahmoud A.(PubMed)
(6) Oxidative stress in benign prostate hyperplasia by Aryal M1, Pandeya A, Gautam N, Baral N, Lamsal M, Majhi S, Chandra L, Pandit R, Das BK(PubMed)
(7) Oxidative stress in patients with benign prostate hyperplasia by Aryal M1, Pandeya A, Bas BK, Lamsal M, Majhi S, Pandit R, Agrawal CS, Gautam N, Baral N.(PubMed)
(8) Diet and dietary supplement intervention appeared to slow disease progression by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)

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