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Nu Zhen Zi (Fructus Ligustri Lucidi)
Nu Zhen Zi is also known as Privet fruit. The bitter, sweet and neutral herb has been used in TCM as anti cancer, anti inflammatory and antioxidant agents and to lower blood sugar, enhance immune function, etc., as it tonifies the Liver and Kidneys, clears Heat, improves vision, etc., by enhancing the functions of liver and kidney channels.
Ingredients
1. Oleanolic acid
2. Ursolic acid
3. Apigenin-7-glucoside,
4. Luteolin-7-glucoside
5. Cyanidine-3-glucoside,
6. Cyanidine-3-rutinoside,
7. Malvidin-3-rutinoside-5-glucoside
8. Etc.
Health Benefits
1. Antiproliferative and Proapoptotic Activities
In the study to examine the growth inhibitory effects of methanolic leaf and fruit extracts of L. vulgare on HCT-116 cells over different time periods and their synergistic effect with a Pd(apox) complex, indicated that L. vulgare is a considerable source of natural bioactive substances with antiproliferative activity on HCT-116 cells and which have a substantial synergistic effect with the Pd(apox) complex(1).
2. Menopausal syndrome
In the study to observe of a total of 54456 prescriptions made for 15486 subjects in clinical visits, Salvia miltiorrhiza and Dan-zhi-xiao-yao-san were the most commonly prescribed single herb (SH) and herbal formula (HF), respectively. For combinations of two CHP, Salvia miltiorrhiza with Dan-zhi-xiao-yao-san, Zhi-bai-di-huang-wan with Dan-zhi-xiao-yao-san, and Ligustrum lucidum with Eclipta prostrata were the most frequently co-prescribed CHP couplets as SH-HF, HF-HF, and SH-SH, respectively, indicated that
Combinations of CHP are widely used for menopausal syndrome. Data mining analysis demonstrates the core formula and the commonly combined CHP in prescriptions. Further studies are needed to evaluate their efficacy for menopausal syndrome(2).
3. Human glioma cell
In the aim of study to examine the effect of Fructus ligustri lucidi (FLL) extracts on glioma cell growth and to determine the underlying mechanism by which FLL extracts exert anticancer properties in human U87MG glioma cells., showed that oral administration of FLL extracts in subcutaneous U87MG xenograft models reduced the glioma tumor volume. These findings indicate that the FLL extracts resulted in glioma cell death through regulation of the Akt/mTOR/survivin pathway in vitro and inhibited glioma tumor growth in vivo(3).
4. Etc.
Side Effects
1. Overdoses can cause diarrhea
2. Do not use the herb in case of Yang deficiency
3. Do not use the herb in case of diarrhea as a result of spleen deficiency
4. Do not use the herb in newborn. children or if you are pregnant or breast feeding without first consulting with the related field specialist.
5. Etc.
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