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Qi Pi (Citri Reticulatae Viride Pericarpium)
Qi Pi is also known as Green Tangerine Peel. The bitter, acrid and warm herb has been used in TCM to relieve pain as a result of chronic hepatitis, flatulence, weak digestion, pain in solar plexus, breast cancer, tuberculosis, etc., as it drains the Liver, eliminates Qi accumulation, disperses nodules, reduces stagnation, etc.by enhancing the functions of liver, stomach and gallbladder channels.
Ingredients
1. Chinensisol [1]
2. Aesculin and
3. Aesculotin
4. Etc.
Health Benefits
1. Hyperuricemia and renal dysfunction in mice
In the study to investigate the effects of cortex fraxini coumarines esculetin, esculin, fraxetin and fraxin on renal dysfunction and expression abnormality of renal organic ion transporters in hyperuricemic animals, showed that Esculetin and esculin up-regulated expressions of renal organic anion transporter 1 (mOAT1), organic cation and carnitine transporters (mOCT1-2 and mOCTN1-2), but failed to affect renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1) in this model. Fraxetin specifically inhibited renal mURAT1, while fraxin extensively interacted with renal mGLUT9, mURAT1, mOAT1 and mOCT1 in hyperuricemic mice. Furthermore, esculetin, fraxetin and fraxin increased mABCG2 mRNA expression and decreased its protein levels in renal apical membrane in hyperuricemic mice. These results indicate that esculetin and esculin have beneficial effects on hyperuricemia and renal dysfunction, resulting in restoration of mOAT1, mOCT1-2 and mOCTN1-2, and fraxetin and fraxin enhance urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice(1).
Ingredients
1. Chinensisol [1]
2. Aesculin and
3. Aesculotin
4. Etc.
Health Benefits
1. Hyperuricemia and renal dysfunction in mice
In the study to investigate the effects of cortex fraxini coumarines esculetin, esculin, fraxetin and fraxin on renal dysfunction and expression abnormality of renal organic ion transporters in hyperuricemic animals, showed that Esculetin and esculin up-regulated expressions of renal organic anion transporter 1 (mOAT1), organic cation and carnitine transporters (mOCT1-2 and mOCTN1-2), but failed to affect renal glucose transporter 9 (mGLUT9) and urate transporter 1 (mURAT1) in this model. Fraxetin specifically inhibited renal mURAT1, while fraxin extensively interacted with renal mGLUT9, mURAT1, mOAT1 and mOCT1 in hyperuricemic mice. Furthermore, esculetin, fraxetin and fraxin increased mABCG2 mRNA expression and decreased its protein levels in renal apical membrane in hyperuricemic mice. These results indicate that esculetin and esculin have beneficial effects on hyperuricemia and renal dysfunction, resulting in restoration of mOAT1, mOCT1-2 and mOCTN1-2, and fraxetin and fraxin enhance urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice(1).
2. Pharmacological effect
Cortex Fraxini is a commonly used traditional Chinese medicine. It has been indicated that Cortex Fraxini possess various pharmacological effects, including anti-pathogenic microorganism, anti-inflammatory, analgesic, anti-cancer, anti-oxidative stress, neuroprotective and vascular protect effects. Cortex Fraxini has been therapeutically used in the treatment of inflammations, bacillary dysentery, relieving fever, relieving cough and asthma(2).
3. Antibacterial activity
In the study of the antibacterial activity of 20 Chinese medicinal materials for helicobacter pylori in vitro and the culture of hylicobacter pylori, indicated that the detecting ratio of tomato juice culture medium to hylicobacter pylori was equal to that of skirrow culture medium; Radix Scutellariae, Flos Lonicerae, Radix Isatidis, Indigo Naturalis, Fructus Chebulae, Semen Ginkgo, Cortex Phellodendri, Rhizoma Corydalis and Cortex Fraxini have obvious effect of antibacterium to hyliocobater pylori(3).
4. Etc.
Side Effects
1. Do not use the herb in case of Qi deficiency
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without forst consulting with the related field specialist.
3. Etc.
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