Tuesday, September 13, 2016

Phytochemicals for Treatment of Ovarian Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

             Ovarian Cancer

The ovaries are oval shaped ovum-producing reproductive organ in part of a woman's reproductive system connected to the fallopian tubes and attached to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary takes turn to release an egg every month.

Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Types Ovarian cancer can be divided to the types below

A. Epithelial ovarian Cancer
Epithelial ovarian tumor also known as Surface epithelial-stromal tumor, as the name, it is a result of the cells on the surface of the ovary have become cancerous. Epithelial ovarian tumor is the most common form of ovarian cancer accounted for over 90% of ovarian cancer of all cases, including serous tumor, endometrioid tumor and mucinous cystadenocarcinoma.

B. Germ cell ovarian cancer
Germ cell ovarian tumor is a censer of the egg producing cells within the ovary and can be cancerous or non-cancerous tumors. It tends to occur in children and teens as a result of birth defects resulting from errors during development of the embryo.

C. Sex cord stromal ovarian cancer
Sex cord stromal ovarian tumor is a cancer of the tissue of the ovary accounted for 8% of ovarian cancers. The excess estrogen produced by Sex cord stromal ovarian tumor can lead to certain symptoms, such as adult granulosa cell tumours and thecomas, postmenopausal bleeding, menorrhagia, amenorrhea, endometrial hyperplasia, etc. The cancer tend to develop in older age group.

D. Secondary cancer
Due to distant spread from other cancer to the ovaries.

E. Etc.

Types of food to prevent and treat Ovarian cancer
1. Grapes and berries
Myricetin is a flavonol, belong to the flavonoid in Flavonoids (polyphenols), found in many grapes, berries, etc.. In the research of inverse associations with certain flavonoids or flavonoid subclasses (myricetin, kaempferol, quercetin, luteolin, and apigenin) and ovarian cancer risk, found that In analyses of each individual flavonoid, only intake of apigenin was associated with a borderline significant decrease in risk (RR, highest vs. lowest quintile = 0.79, 95% CI = 0.59-1.06; p-trend = 0.26), and this association was significant after adjustment for intake of the other 4 individual flavonoids (comparable RR = 0.72, 95% CI = 0.53-0.98; p-trend = 0.09), according to "Flavonoid intake and ovarian cancer risk in a population-based case-control study" by Gates MA, Vitonis AF, Tworoger SS, Rosner B, Titus-Ernstoff L, Hankinson SE, Cramer DW.(1)

2. Green tea
a. In prospective cohort study to investigate whether tea consumption can enhance the survival of patients with epithelial ovarian cancer conducted in Hangzhou, China, found that Compared to non-drinkers, the adjusted hazard ratios were 0.55 (95% CI = 0.34-0.90) for tea-drinkers, 0.43 (95% CI = 0.20-0.92) for consuming at least 1 cup of green tea/day, 0.44 (95% CI = 0.22-0.90) for brewing 1 batch or more of green tea/day, 0.40 (95% CI = 0.18-0.90) for consuming more than 500 g of dried tea leaves/year, and 0.38 (95% CI = 0.15-0.97) for consuming at least 2 g of dried tea leaves/batch. The corresponding dose-response relationships were significant (p < 0.05)(2).
b. Other suggested that studies on the health benefits of drinking tea, particularlygreen tea, are finding exciting results, particularly in cancer research. Modern studies in both Asia and the West have provided encouraging results indicating that drinking green tea contributes to fighting many different kinds of cancers including stomach, oesophageal, ovarian and colon(3).

3. Turmeric
a. In the study to analyze the impact of sphingosine kinase-1 (SphK-1) inhibition on ceramides production, and evaluated SphK1 inhibitor II (SKI-II) as a potentialcurcumin chemo-sensitizer in ovarian cancer cells, found that inhibition of SphK1 by SKI-II or by RNA interference (RNAi) knockdown dramatically enhancedcurcumin-induced apoptosis and growth inhibition in ovarian cancer cells. SKI-II facilitated curcumin-induced ceramides production, p38 activation and Akt inhibition. Inhibition of p38 by the pharmacological inhibitor (SB 203580), a dominant-negative expression vector, or by RNAi diminished curcumin and SKI-II co-administration-induced ovarian cancer cell apoptosis, and, to restore Akt activation by introducing a constitutively active Akt (CA-Akt), or to inhibit ceramides production by fumonisin B1 also inhibited curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect(4).

b. Others found that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). In addition, p53 knockdown or p53 inhibition did not diminish curcumin killing of HEY cells, confirming p53-independent cytotoxicity. Curcumin also killed OVCA429, and SKOV3 cells grown as multicellular spheroids(5).

4. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, 
particular in treatment of menstrual disorder in Women Health

(1) http://www.ncbi.nlm.nih.gov/pubmed/19117058
(2) http://www.ncbi.nlm.nih.gov/pubmed/15382073
(3) http://www.ncbi.nlm.nih.gov/pubmed/22039897
(4) http://www.ncbi.nlm.nih.gov/pubmed/22594559

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