Tongue cancer is a medical condition caused by irregular cell growth in the tissue of the tongue, due to the alternation of cell DNA.
Most cases of tongue cancer begin in the cells on the surface of the inner lining of the tongue. At the early stage, tongue cancer patients may not experience any size due to the very small of the tumors.
However, at the advanced stage, patients may experience symptoms of the persistent tongue and/or jaw pain as the tumor has pressed on the nearby nerve cells, a lump or tumor inside the mouth. a white or red patch on the gums, tongue, tonsil or lining in the mouth and persistent sore throat and difficulty swallowing or chewing.
If you have some of the above symptoms, please make sure to check with your doctor to rule out the possibility.
There are many risk factors associated with the disease, including long-term use of tobacco, excessive alcohol drinking, sun exposure to your lips.
Some researchers suggested that sexually transmitted virus human papillomavirus (HPV) and people with a weakened immune system also have been found in patients with tongue cancer.
The Cleveland Clinic wrote in the article of Oropharyngeal Human Papilloma Virus (HPV) Infection
"Human papillomavirus (HPV), commonly known as the virus that causes genital warts and cervical cancer in women, is increasingly being recognized now as a cause of infections that colonize the back of the mouth (throat or oropharynx), including the tongue base and tonsils, and potentially a cause of cancer of the head and neck".
The results strongly suggested that people who carry the HPV virus in their mouth are at an increased risk of tongue cancer, compared to those without.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on the searching natural compound with the inhibitory activity against the tongue
carcinogenesis examined the effects of indole-3-carbinol (I3C) and sinigrin (SIN) on the initiation and post-initiation phases of tongue cancer.
Selected male ACI/N rats. induced tongue cancer by the injection of by 4-nitroquinoline 1-oxide (4-NQO) divided into
* Group 1 was given 4-NQO (10 ppm) in the drinking water for 12 weeks, starting at 7 weeks of age;
* Groups 2 and 3 were given 4-NQO and fed the diets containing I3C (1,000 ppm) and SIN (1,200 ppm) for 14 weeks, respectively, starting at 6 weeks of age;
* Groups 4 and 5 were given 4-NQO and then they were fed I3C and SIN containing diets for 23 weeks, respectively, starting one week after 4-NQO exposure;
* Groups 6 and 7 were given I3C and SIN alone, respectively, during the experiment; and
* Group 8 served as an untreated control.
At the end of the experiment at week 37, the incidence of tongue neoplasms (squamous cell papilloma and carcinoma) in group 2 (1/15, 7%), group 3 (1/15, 7%), group 4 (3/15, 20%) or group 5 (2/15, 13%) was significantly smaller than that in group 1 (12/17, 71%).
Group groups 2, 3, and 5 showed no tongue carcinomas developed. In other words, the injection of I3C and SIN restored the infected cell to healthy levels induced by the 4-NQO.
Group treated with I3C and SIN also showed reduced levels of the incidence of preneoplastic lesions such as hyperplasia and dysplasia.
In other words, I3C and SIN not only are effective against tongue cancer but also inhibit the progression of preneoplastic lesions of the tongue in group 2 (11/15, 73%), group 3 (10/15, 67%), group 4 (11/15, 73%) or group 5 (10/15, 67%) was significantly lower than that in group 1 (17/17, 100%) (P = 0.04 or P = 0.02).
Furthermore, There were no tongue neoplasms in rats of groups 6, 7, and 8.
Moreover, the Administration of I3C and SIN also caused significant decreases in the number and area of silver-stained nucleolar organizer regions protein (AgNORs) in the expression of in the tongue tumor pathology.
Dr. Tanaka T and colleagues wrote in the final report, " I3C and SIN inhibited rat tongue carcinogenesis in both the initiation and post-initiation phases, when administered in these respective phases together with, or following treatment with, 4-NQO".
Taken altogether, sinigrin (SIN) used alone or combined with I3C may be effective for the prevention and treatment of tongue cancer, pending to the confirmation of large sample size and multicenter human study.
Intake of SIN in a form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tonguecarcinogenesis by Tanaka T1, Kojima T, Morishita Y, Mori H. (PubMed)
(2) Oropharyngeal Human Papilloma Virus (HPV) Infection by (Cleveland Clinic)
Tuesday, April 30, 2019
Herbal Artichoke Normalizes the Level of Total Lipids Profile
Total lipids profile is a lab test that measures the abnormal levels of cholesterol and triglycerides that can lead to cardiovascular disease.
The healthy level of low-density cholesterol is less than 70 mg/dL for those in very high-risk patients, 100 mg/dL for high-risk patients and 130 mg/dL for individuals who are at low risk for coronary artery disease.
The healthy level of high-density cholesterol is any number that is higher than 40 mg/dl.
The healthy level of triglycerides (TG) is any number that is less than 150 mg/dl.
Where dl is milligrams per deciliter
Total cholesterol is the total amount of cholesterol in the blood using the formula HDL level + LDL level + 20 percent of triglyceride level from the results of total lipids profile.
The healthy levels of total cholesterol can be classified as follows
Optimal level: Less than 200 mg/dL
Normal high level: 200-239 mg/dL
High level: 240 mg/dL and above
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
On finding a natural remedy in the reducing risk and treatment of cardiovascular disease, researchers examined the artichoke in the subjects with hypercholesterolemia.
After 2 months of treatment, injection of artichoke showed a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), compared to standard diet.
There were no side effects found in the tested subjects during the course of study.
Dr. Cicero AFG, the lead scientists wrote, " on the short-term, the tested nutraceutical has been shown to be well tolerated and effective, even if not containing any statin-like compound".
Dr. Santos HO in the study to investigate the effect of artichoke on lipid profile by searching the medical literature appraised the Cochrane, MEDLINE, and Web of Science databases, including articles published between 2000 and June 2018 on intervention in humans only.
The review on the selected studies suggested that
* ALE decreased serum LDL, total cholesterol and triglyceride concentrations.
* ALE showed no effect on the levels of HDL.
In details, according to the differentiation, ALE at doses of 2 to 3 g/d decreased 8-49 mg/dL for LDL concentration, 12-55 mg/dL for total cholesterol, and 11-51 mg/dL for triglycerides.
The improvement of the lipid profile of ALE was attributed to the components luteolin and chlorogenic acids found abundantly in artichoke.
Furthermore, the cardioprotective effect of ALE was associated with soluble fibers and inulin in the herb or food.
The findings clearly suggested that ALE protects the heart by improving the condition of the cluster associated with metabolic syndrome, particularly in blood cholesterol.
Taken together, artichoke may be considered a functional remedy for improving the lipid profile against diseases associated with hypercholesterolemia, pending to the confirmation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease by Cicero AFG1, Fogacci F2, Bove M2, Giovannini M2, Veronesi M2, Borghi C. (PubMed)
(2) The effect of artichoke on lipid profile: A review of possible mechanisms of action by Santos HO1, Bueno AA2, Mota JF. (PubMed)
Monday, April 29, 2019
3,3'-Diindolylmethane, the Natural Ingredient for the Treatment of Chronic Diseases
Chronic diseases are a group of medical conditions most commonly associated with aging, including
arthritis, cardiovascular diseases such as heart attacks and stroke, cancer, diabetes, epilepsy and seizures, and obesity.
The exacted causes of chronic diseases are not identified. Aging, unhealthy lifestyle such as excessive alcohol drinking smoking, poor diet, lack of physical activity are the most common risk factors associated with the onset of the disease.
According to the joint study led by the Fordham University, chronic diseases are among the most prevalent and costly health conditions in the US, affecting over 133 millions of the US population as many of them suffer from at least one chronic disease and the number is growing in the rapid rate.
Some chronic diseases such as cancer have been found to be the leading causes of hospitalization, long-term disability, reduced quality of life, and death.
According to the Centers for Disease Control, chronic diseases also are the major driver of health care costs accounted for nearly 75 percent of aggregate healthcare spending and increased absenteeism that impact workforce patterns.
Each chronic patient has cost the health care spending $5300 annually.
Believe it or not, chronic diseases in the US, chronic diseases are responsible for 7 out of 10 deaths yearly. In other words, chronic diseases kill more than 1.7 million Americans each year.
Some researchers suggested by changing unhealthy lifestyle pattern, chronic diseases may be preventable.
Dr. Walter C. Willett, the lead scientist in the concern about the risk chronic disease in poor lifestyle individuals wrote, "Several lines of evidence indicate that realistic modifications of diet and lifestyle can prevent most CAD, stroke, diabetes, colon cancer, and smoking-related cancers".
And, "Among U.S. adults, more than 90 percent of type 2 diabetes, 80 percent of CAD, 70 percent of stroke, and 70 percent of colon cancer are potentially preventable by a combination of nonsmoking, avoidance of overweight, moderate physical activity, healthy diet, and moderate alcohol consumption".
Researchers on finding a natural ingredient for the treatment of chronic diseases analyzed 3,3'-diindolylmethane (DIM) several biological activities on cellular and molecular levels against chronic diseases, including cancer.
DIM enhanced the function of the drug-metabolizing enzyme by blocking activity involved the promotion of cancer expression.
DIM affects multiple signaling pathways and target molecules which controls cell division, apoptosis, or angiogenesis deregulated in cancer cells.
DIM also prevented the development of hormone-dependent cancers.
Injection of DIM also was found to inhibit the onset of cardiovascular disease, obesity, and diabetes reduction through its antioxidant property in reducing oxidative stress caused by overexpression of free radical.
Dr. Licznerska B, the lead scientist after taking into account other factors wrote in the final report, "the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in the prevention of chronic diseases".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol and Its Role in Chronic Diseases by Licznerska B1, Baer-Dubowska W. (PubMed)
(2) An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health by Wullianallur Raghupathi1 and Viju Raghupathi. (PubMed)
(3) Prevention of Chronic Disease by Means of Diet and Lifestyle Changes by Walter C. Willett, Jeffrey P. Koplan, Rachel Nugent, Courtenay Dusenbury, Pekka Puska, and Thomas A. Gaziano. (PubMed)
arthritis, cardiovascular diseases such as heart attacks and stroke, cancer, diabetes, epilepsy and seizures, and obesity.
The exacted causes of chronic diseases are not identified. Aging, unhealthy lifestyle such as excessive alcohol drinking smoking, poor diet, lack of physical activity are the most common risk factors associated with the onset of the disease.
According to the joint study led by the Fordham University, chronic diseases are among the most prevalent and costly health conditions in the US, affecting over 133 millions of the US population as many of them suffer from at least one chronic disease and the number is growing in the rapid rate.
Some chronic diseases such as cancer have been found to be the leading causes of hospitalization, long-term disability, reduced quality of life, and death.
According to the Centers for Disease Control, chronic diseases also are the major driver of health care costs accounted for nearly 75 percent of aggregate healthcare spending and increased absenteeism that impact workforce patterns.
Each chronic patient has cost the health care spending $5300 annually.
Believe it or not, chronic diseases in the US, chronic diseases are responsible for 7 out of 10 deaths yearly. In other words, chronic diseases kill more than 1.7 million Americans each year.
Some researchers suggested by changing unhealthy lifestyle pattern, chronic diseases may be preventable.
Dr. Walter C. Willett, the lead scientist in the concern about the risk chronic disease in poor lifestyle individuals wrote, "Several lines of evidence indicate that realistic modifications of diet and lifestyle can prevent most CAD, stroke, diabetes, colon cancer, and smoking-related cancers".
And, "Among U.S. adults, more than 90 percent of type 2 diabetes, 80 percent of CAD, 70 percent of stroke, and 70 percent of colon cancer are potentially preventable by a combination of nonsmoking, avoidance of overweight, moderate physical activity, healthy diet, and moderate alcohol consumption".
Researchers on finding a natural ingredient for the treatment of chronic diseases analyzed 3,3'-diindolylmethane (DIM) several biological activities on cellular and molecular levels against chronic diseases, including cancer.
DIM enhanced the function of the drug-metabolizing enzyme by blocking activity involved the promotion of cancer expression.
DIM affects multiple signaling pathways and target molecules which controls cell division, apoptosis, or angiogenesis deregulated in cancer cells.
DIM also prevented the development of hormone-dependent cancers.
Injection of DIM also was found to inhibit the onset of cardiovascular disease, obesity, and diabetes reduction through its antioxidant property in reducing oxidative stress caused by overexpression of free radical.
Dr. Licznerska B, the lead scientist after taking into account other factors wrote in the final report, "the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in the prevention of chronic diseases".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of chronic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indole-3-Carbinol and Its Role in Chronic Diseases by Licznerska B1, Baer-Dubowska W. (PubMed)
(2) An Empirical Study of Chronic Diseases in the United States: A Visual Analytics Approach to Public Health by Wullianallur Raghupathi1 and Viju Raghupathi. (PubMed)
(3) Prevention of Chronic Disease by Means of Diet and Lifestyle Changes by Walter C. Willett, Jeffrey P. Koplan, Rachel Nugent, Courtenay Dusenbury, Pekka Puska, and Thomas A. Gaziano. (PubMed)
Phytochemical Sinigrin Protects Our Body Against the Onset of Chronic Inflammatory Diseases
Sinigrin may be used as a natural and bioactive compound against diseases associated with chronic inflammation, according to studies.
Acute inflammation that lasts a day or 2 mostly associated with proinflammatory response to tissue injury, usually appearing within minutes or hours, depending on the severity of the damage.
In other words, in the acute phase of inflammation, the immune systematic response of the macrophages stimulate the process of coagulation to cover the wound or injure and production of the inflammatory cytokines to destroy the foreign pathogens which try to enter the body through the wound or injury.
Most common symptoms of acute inflammation are a pain, redness, loss of function, swelling and heat.
In the acute phase of inflammation, overproduction of proinflammatory cytokines which protect our body against the foreign invasion may damage the nearby tissues and death of the healthy cell, leading to the abnormal formation of scars.
Chronic inflammation is a medical condition caused by the inability of the immune system to kill off all pathogens in the acute phase of inflammation, leading to the compromise of the immune system.
Chronic inflammation is a leading cause of various types of disease, including cancer, diabetes, cardiovascular disease, and arthritis.
Unlike the symptoms in the acute inflammation, symptoms of chronic inflammation are totally depending to the types of disease and location of the inflammation, including fatigue and unintended weight loss and loss of appetite in cancer, chest pain in chronic lung disease, and joint pain in RA.
On finding a natural compound for the treatment of diseases associated with chronic inflammation, researchers investigated the effect of sinigrin on macrophage function.
In RAW 264.7 cells in a concentration-dependent manner, sinigrin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory cytokines including nitric oxide (NO) and the expression of COX-2 and prostaglandin E2 (PGE2).
Injection of sinigrin significantly suppressed the production of pro-inflammatory tumor necrosis factor (TNF)-α and interleukin (IL)-6 by suppressing the protein in cellular response to oxidative stress and stimuli.
Additional analysis, sinigrin also processed a significant effect in inhibiting genes expression involved the mediation of innate immunity and inflammatory responses.
Dr. Lee HW, the lead scientist, wrote in the final report, " Our findings also provide evidence that the pharmacological modulation of sinigrin could have an anti-inflammatory effect".
In lipopolysaccharide (LPS)-induced neuroinflammation, AITC protected the microglial cells against neuroinflammation by inhibiting the cellular response against oxidative stress induced the production of pro-inflammatory cytokines such as cyclooxygenase-2 (COX-2) expression, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2).
In other words, AITC protects neuroblastoma cells by controlling with JNK/NF-κB/TNF-α cross-linking associated with the expression of the gene in inducing apoptosis.
Dr. Subedi L, the lead scientist, after taking into account co and confounders said, "These findings provide novel insights into the anti-neuroinflammatory effects of AITC on microglial cells, which may have clinical significance in neurodegeneration".
Taken altogether, sinigrin may be considered a functional supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages by Lee HW1, Lee CG1, Rhee DK1, Um SH2, Pyo S. (PubMed)
(2) Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling by Subedi L1, Venkatesan R2, Kim SY. (PubMed)
Acute inflammation that lasts a day or 2 mostly associated with proinflammatory response to tissue injury, usually appearing within minutes or hours, depending on the severity of the damage.
In other words, in the acute phase of inflammation, the immune systematic response of the macrophages stimulate the process of coagulation to cover the wound or injure and production of the inflammatory cytokines to destroy the foreign pathogens which try to enter the body through the wound or injury.
Most common symptoms of acute inflammation are a pain, redness, loss of function, swelling and heat.
In the acute phase of inflammation, overproduction of proinflammatory cytokines which protect our body against the foreign invasion may damage the nearby tissues and death of the healthy cell, leading to the abnormal formation of scars.
Chronic inflammation is a medical condition caused by the inability of the immune system to kill off all pathogens in the acute phase of inflammation, leading to the compromise of the immune system.
Chronic inflammation is a leading cause of various types of disease, including cancer, diabetes, cardiovascular disease, and arthritis.
Unlike the symptoms in the acute inflammation, symptoms of chronic inflammation are totally depending to the types of disease and location of the inflammation, including fatigue and unintended weight loss and loss of appetite in cancer, chest pain in chronic lung disease, and joint pain in RA.
On finding a natural compound for the treatment of diseases associated with chronic inflammation, researchers investigated the effect of sinigrin on macrophage function.
In RAW 264.7 cells in a concentration-dependent manner, sinigrin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory cytokines including nitric oxide (NO) and the expression of COX-2 and prostaglandin E2 (PGE2).
Injection of sinigrin significantly suppressed the production of pro-inflammatory tumor necrosis factor (TNF)-α and interleukin (IL)-6 by suppressing the protein in cellular response to oxidative stress and stimuli.
Additional analysis, sinigrin also processed a significant effect in inhibiting genes expression involved the mediation of innate immunity and inflammatory responses.
Dr. Lee HW, the lead scientist, wrote in the final report, " Our findings also provide evidence that the pharmacological modulation of sinigrin could have an anti-inflammatory effect".
In lipopolysaccharide (LPS)-induced neuroinflammation, AITC protected the microglial cells against neuroinflammation by inhibiting the cellular response against oxidative stress induced the production of pro-inflammatory cytokines such as cyclooxygenase-2 (COX-2) expression, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2).
In other words, AITC protects neuroblastoma cells by controlling with JNK/NF-κB/TNF-α cross-linking associated with the expression of the gene in inducing apoptosis.
Dr. Subedi L, the lead scientist, after taking into account co and confounders said, "These findings provide novel insights into the anti-neuroinflammatory effects of AITC on microglial cells, which may have clinical significance in neurodegeneration".
Taken altogether, sinigrin may be considered a functional supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages by Lee HW1, Lee CG1, Rhee DK1, Um SH2, Pyo S. (PubMed)
(2) Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling by Subedi L1, Venkatesan R2, Kim SY. (PubMed)
Sunday, April 28, 2019
Ginger, The Best Gastroprotective Functional Pungent Spice
Gastrointestinal disorders are medical conditions, involving the esophagus, stomach, small intestine, large intestine, and rectum.
Most common gastrointestinal disorders are very mild associated with digestive discomforts that can be resolved in a few days.
The gastroprotective effect is an action that protects the gastrointestinal tract against the onset of any disease, including infection and inflammation.
The causes of digestive disorders can be multiple. Most gastrointestinal disorders caused directly by the disorders of the digestive system such as poor diet pattern. However, long-term use of certain medication can also induce gastrointestinal disorders, including Manticholinergic medication, non-steroidal anti-inflammatory drugs, and antibiotics.
In the searching a diet therapy that can reverse and protect the digestive system against gastrointestinal disorder, researchers at the University of Florida, wrote, "Diet therapy through the elimination of offending foods such as wheat gluten or lactose, or inclusion of specialized products such as medium chain triglycerides or elemental formulas, can sustain nutritional status".
And "Dietary components such as insoluble fiber appear to have physiologic effects, while soluble fibers may have metabolic effects important to diabetes and cardiovascular disease".
Additionally, in the differentiation of types of diet may have a direct contribution to reduce the risk of gastrointestinal disorders, the authors continued, "Avoiding offending foods by Crohn's patients is an acceptable practice as long as entire categories of foods are not deleted. Avoiding all foods containing gluten from wheat, rye, barley, and oats, however, is a crucial prerequisite to recovery from celiac disease. Gluten is commonly used as a stabilizer, emulsifier, and extender in the food industry and is not always shown on food labels. Careful consultation with a registered dietitian can identify hidden sources of gluten in the diet.".
These results clearly indicated, depending on types of gastrointestinal disorder, diet therapy with modification could have a strong impact on the prevention of the onset of the disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food which processes gastrointestinal protective effects, researchers looked into rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, an important kitchen spice, possessing myriad health benefits.
In laboratory animals., ginger was shown to be effective in preventing gastric ulcers induced by nonsteroidal anti-inflammatory drugs [NSAIDs like indomethacin, aspirin], reserpine, ethanol, and acetic acid and Helicobacter pylori-induced gastric ulcerations.
The gastroprotective efficacy of ginger was attributed to its free radical scavenging, antioxidant; inhibition of lipid peroxidation activities.
Furthermore, in the evaluation of the gastroprotective effect to examine the turmeric (Curcuma longa) and ginger (Zingiber officianale), researchers conducted a study in the ethanol-induced ulcers animal model.
Selected rats were given 100, 500 and 1000 mg/kg body weight orally.
Application of TEO and GEO inhibited ulcer caused by injection of ethanol by 84.7% and 85.1%, respectively, as seen from the ulcer index.
The reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO.
Ethanol-induced lesions such as necrosis, erosion, and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.
These results strongly suggested, turmeric and ginger exerted a significant gastroprotective effect against gastrointestinal lesions with no side effects.
Taken altogether, ginger may be considered a functional for the prevention and combined with primary medicine for the treatment of gastrointestinal disorders,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe) by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Gastroprotective activity of essential oils from turmeric and ginger by Liju VB, Jeena K, Kuttan R. (PubMed)
(3) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats by Ko JK1, Leung CC. (PubMed)
(4) Dietary therapy in gastrointestinal disease by Anderson CR1, Cerda JJ. (PubMed)
Most common gastrointestinal disorders are very mild associated with digestive discomforts that can be resolved in a few days.
The gastroprotective effect is an action that protects the gastrointestinal tract against the onset of any disease, including infection and inflammation.
The causes of digestive disorders can be multiple. Most gastrointestinal disorders caused directly by the disorders of the digestive system such as poor diet pattern. However, long-term use of certain medication can also induce gastrointestinal disorders, including Manticholinergic medication, non-steroidal anti-inflammatory drugs, and antibiotics.
In the searching a diet therapy that can reverse and protect the digestive system against gastrointestinal disorder, researchers at the University of Florida, wrote, "Diet therapy through the elimination of offending foods such as wheat gluten or lactose, or inclusion of specialized products such as medium chain triglycerides or elemental formulas, can sustain nutritional status".
And "Dietary components such as insoluble fiber appear to have physiologic effects, while soluble fibers may have metabolic effects important to diabetes and cardiovascular disease".
Additionally, in the differentiation of types of diet may have a direct contribution to reduce the risk of gastrointestinal disorders, the authors continued, "Avoiding offending foods by Crohn's patients is an acceptable practice as long as entire categories of foods are not deleted. Avoiding all foods containing gluten from wheat, rye, barley, and oats, however, is a crucial prerequisite to recovery from celiac disease. Gluten is commonly used as a stabilizer, emulsifier, and extender in the food industry and is not always shown on food labels. Careful consultation with a registered dietitian can identify hidden sources of gluten in the diet.".
These results clearly indicated, depending on types of gastrointestinal disorder, diet therapy with modification could have a strong impact on the prevention of the onset of the disease.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food which processes gastrointestinal protective effects, researchers looked into rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, an important kitchen spice, possessing myriad health benefits.
In laboratory animals., ginger was shown to be effective in preventing gastric ulcers induced by nonsteroidal anti-inflammatory drugs [NSAIDs like indomethacin, aspirin], reserpine, ethanol, and acetic acid and Helicobacter pylori-induced gastric ulcerations.
The gastroprotective efficacy of ginger was attributed to its free radical scavenging, antioxidant; inhibition of lipid peroxidation activities.
Furthermore, in the evaluation of the gastroprotective effect to examine the turmeric (Curcuma longa) and ginger (Zingiber officianale), researchers conducted a study in the ethanol-induced ulcers animal model.
Selected rats were given 100, 500 and 1000 mg/kg body weight orally.
Application of TEO and GEO inhibited ulcer caused by injection of ethanol by 84.7% and 85.1%, respectively, as seen from the ulcer index.
The reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO.
Ethanol-induced lesions such as necrosis, erosion, and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.
These results strongly suggested, turmeric and ginger exerted a significant gastroprotective effect against gastrointestinal lesions with no side effects.
Taken altogether, ginger may be considered a functional for the prevention and combined with primary medicine for the treatment of gastrointestinal disorders,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe) by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Gastroprotective activity of essential oils from turmeric and ginger by Liju VB, Jeena K, Kuttan R. (PubMed)
(3) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats by Ko JK1, Leung CC. (PubMed)
(4) Dietary therapy in gastrointestinal disease by Anderson CR1, Cerda JJ. (PubMed)
Celery, the Potent Anti Hypertension Functional Food with No Side Effects
Celery, the tasty vegetable may be used for the prevention and treatment of hypertension, some scientists suggested.
Hypertension is the most common syndrome in the Western world caused by abnormally high blood pressure.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.
The veggie can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
There is no single cause of hypertension. Epidemiological studies suggested an unhealthy lifestyle such as a diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables, smoking, overweight and obesity contributes to the onset of hypertension.
In the differentiate the correlation between the Western diet which had been promoted by the industries over the last many decades and the risk of hypertension, researchers indicated, the Western diet is one of major culprit associated to the rise of high blood pressure incidence in the adults of the Western world.
In other words, if you follow the Western diet, you will have chronic high blood pressure developed in some points during your lifetime. Luckily, if you make a change to a healthy diet, your risk of high blood pressure is reduced.
Dr. Hojhabrimanesh A, the lead scientists in the metabolic team at the Shiraz University of Medical Sciences in the classification of dietary risk of hypertension wrote, " three major dietary patterns were identified, among which only the Western pattern (abundant in soft drinks, sweets and desserts, salt, mayonnaise, tea and coffee, salty snacks, high-fat dairy products, French fries, and red or processed meats) had a significant association with BP".
And " After adjusting for potential confounders in the analysis of covariance models, multivariable adjusted means of the systolic and mean BP of subjects in the highest tertile of the Western pattern score were significantly higher than those in the lowest tertile".
With an aim to find a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Mashhad University of Medical Sciences assessed the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP).
In animal study, elected rats were induced hypertension by the injection of deoxycorticosterone acetate.
The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally to examine the tested animal antihypertensive effects on BP and heart rate (HR), compared to the spironolactone as a diuretic and positive control.
Application of all extracts decreased BP and increased the HR in hypertensive rats, with no effect on normotensive rats.
In volume analysis, administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively.
The effects of celery seed extracted were found to process high amounts of n-butylphthalide (NBP), which has been proven epidemiologically an antihypertensive constituent.
According to the HPLC analysis data revealed that the hexanic extract demonstrated the greatest effect in normalizing the high blood pressure due to the containing the 3.7 and 4 times NBP greater than that of the methanolic and aqueous-ethanolic extracts.
Dr. Moghadam MH, the lead scientist wrote in the final report, " celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP" and, "can be considered an antihypertensive agent in the chronic treatment of elevated BP".
Additionally, in the study to evaluate the inverse associations of overall vegetable intake to blood pressure (BP); whether such relations prevail for both raw and cooked vegetables, researchers launched a review of the report of the cross-sectional associations of vegetable intakes with BP for 2195 Americans ages 40-59 in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP).
According to the multiple linear regression assay, intakes of both total raw and total cooked vegetables considered separately were inversely related to BP in multivariate-adjusted models.
There is no difference among commonly consumed individual raw and cooked vegetable in reducing high blood pressure, particularly in cooked celery.
Taken altogether, celery, cooked or raw processed high amounts of n-butylphthalide (NBP) is considered a functional food for the prevention and treatment of high blood pressure with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(3) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(4) A Western dietary pattern is associated with higher blood pressure in Iranian adolescents by Hojhabrimanesh A1, Akhlaghi M1,2, Rahmani E2, Amanat S2, Atefi M2, Najafi M2, Hashemzadeh M2, Salehi S2, Faghih S. (PubMed)
Hypertension is the most common syndrome in the Western world caused by abnormally high blood pressure.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.
The veggie can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
There is no single cause of hypertension. Epidemiological studies suggested an unhealthy lifestyle such as a diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables, smoking, overweight and obesity contributes to the onset of hypertension.
In the differentiate the correlation between the Western diet which had been promoted by the industries over the last many decades and the risk of hypertension, researchers indicated, the Western diet is one of major culprit associated to the rise of high blood pressure incidence in the adults of the Western world.
In other words, if you follow the Western diet, you will have chronic high blood pressure developed in some points during your lifetime. Luckily, if you make a change to a healthy diet, your risk of high blood pressure is reduced.
Dr. Hojhabrimanesh A, the lead scientists in the metabolic team at the Shiraz University of Medical Sciences in the classification of dietary risk of hypertension wrote, " three major dietary patterns were identified, among which only the Western pattern (abundant in soft drinks, sweets and desserts, salt, mayonnaise, tea and coffee, salty snacks, high-fat dairy products, French fries, and red or processed meats) had a significant association with BP".
And " After adjusting for potential confounders in the analysis of covariance models, multivariable adjusted means of the systolic and mean BP of subjects in the highest tertile of the Western pattern score were significantly higher than those in the lowest tertile".
With an aim to find a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Mashhad University of Medical Sciences assessed the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP).
In animal study, elected rats were induced hypertension by the injection of deoxycorticosterone acetate.
The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally to examine the tested animal antihypertensive effects on BP and heart rate (HR), compared to the spironolactone as a diuretic and positive control.
Application of all extracts decreased BP and increased the HR in hypertensive rats, with no effect on normotensive rats.
In volume analysis, administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively.
The effects of celery seed extracted were found to process high amounts of n-butylphthalide (NBP), which has been proven epidemiologically an antihypertensive constituent.
According to the HPLC analysis data revealed that the hexanic extract demonstrated the greatest effect in normalizing the high blood pressure due to the containing the 3.7 and 4 times NBP greater than that of the methanolic and aqueous-ethanolic extracts.
Dr. Moghadam MH, the lead scientist wrote in the final report, " celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP" and, "can be considered an antihypertensive agent in the chronic treatment of elevated BP".
Additionally, in the study to evaluate the inverse associations of overall vegetable intake to blood pressure (BP); whether such relations prevail for both raw and cooked vegetables, researchers launched a review of the report of the cross-sectional associations of vegetable intakes with BP for 2195 Americans ages 40-59 in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP).
According to the multiple linear regression assay, intakes of both total raw and total cooked vegetables considered separately were inversely related to BP in multivariate-adjusted models.
There is no difference among commonly consumed individual raw and cooked vegetable in reducing high blood pressure, particularly in cooked celery.
Taken altogether, celery, cooked or raw processed high amounts of n-butylphthalide (NBP) is considered a functional food for the prevention and treatment of high blood pressure with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(3) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(4) A Western dietary pattern is associated with higher blood pressure in Iranian adolescents by Hojhabrimanesh A1, Akhlaghi M1,2, Rahmani E2, Amanat S2, Atefi M2, Najafi M2, Hashemzadeh M2, Salehi S2, Faghih S. (PubMed)
Saturday, April 27, 2019
Herbal Artichoke Raises the Levels of "Good Bacteria" in the Gut
Gut microbiota is a complex community with over trillion microorganisms that live in our digestive tracts.
In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.
In fact, balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.
Use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illness such as inflammatory bowel disease, obesity, cancer, and autism.
Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.
Compared to probiotics, the prebiotics is compound in food that induce the growth or activity of beneficial microorganisms in the gut.
In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.
In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.
In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which promotes probiotics examined the artichoke preparation on microbiota ecology and immune status.
The study included 48 piglets divided into 6 groups (n = 8), which received from day 10 of life probiotic-unsupplemented (PU) or probiotic-supplemented (PS, containing 0.5 g/kg diet and contained: Lactococcus lactis, Carnobacterium divergens, Lactobacillus casei, Lactobacillus plantarum, and Saccharomyces cerevisiae) diets.
The PU and PS diets were formulated without prebiotic addition (control) or with the addition of 2% of inulin from chicory root (IN) or 4% of dried Jerusalem artichoke tubers (DJA).
Feeding DJA diets showed to improve the balance of the gut microbiota by increasing the caecal valeric acid level, and decreasing the concentration of isoacids in the colon,
Furthermore, DJA diets also reduced β-glucosidase and β-glucuronidase activity induced gut toxicity in the middle colon and increased Bifidobacterium spp. populations in the proximal and distal colon.
These results suggested that DJA modified the microbiota ecology in the large intestine of young pigs to a greater extent as a prebiotic.
Taken altogether, artichoke may be considered a functional remedy as a prebiotic for the treatment of patients with unbalanced gut microbiota with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
In healthy individuals, the ratio of good and bad microorganisms is balanced. In other words, healthy gut microbiota levels maintain the structure and function of the gastrointestinal tract.
In fact, balanced ratio of gut microbiota plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.
Use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illness such as inflammatory bowel disease, obesity, cancer, and autism.
Further, the unbalanced ratio of gut microbiota functions also alters immune homeostasis, leading to the onset of autoimmune disorders which in turn can affect the development of not only intestinal but also systemic autoimmune diseases.
Compared to probiotics, the prebiotics is compound in food that induce the growth or activity of beneficial microorganisms in the gut.
In other definition, it is a special form of dietary fiber that acts as a fertilizer that promotes the growth of good bacteria in your gut.
In the gastrointestinal tract, prebiotics can alter the composition of organisms in the gut microbiome.
In other words, prebiotics raises the levels of healthy bacteria against bad bacteria.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which promotes probiotics examined the artichoke preparation on microbiota ecology and immune status.
The study included 48 piglets divided into 6 groups (n = 8), which received from day 10 of life probiotic-unsupplemented (PU) or probiotic-supplemented (PS, containing 0.5 g/kg diet and contained: Lactococcus lactis, Carnobacterium divergens, Lactobacillus casei, Lactobacillus plantarum, and Saccharomyces cerevisiae) diets.
The PU and PS diets were formulated without prebiotic addition (control) or with the addition of 2% of inulin from chicory root (IN) or 4% of dried Jerusalem artichoke tubers (DJA).
Feeding DJA diets showed to improve the balance of the gut microbiota by increasing the caecal valeric acid level, and decreasing the concentration of isoacids in the colon,
Furthermore, DJA diets also reduced β-glucosidase and β-glucuronidase activity induced gut toxicity in the middle colon and increased Bifidobacterium spp. populations in the proximal and distal colon.
These results suggested that DJA modified the microbiota ecology in the large intestine of young pigs to a greater extent as a prebiotic.
Taken altogether, artichoke may be considered a functional remedy as a prebiotic for the treatment of patients with unbalanced gut microbiota with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Phytochemical Sinigrin, the Potential Anti Lung Cancer Bioactive Ingredient with No Side Effects, According to Medical Literature
Lung cancer is a chronic condition characterized by cells growth disorderly in the tissue of the lungs.
According to the statistic provided by the American Cancer Society, lung cancer is the leading cause of cancer death among both men and women. More people die of lung cancer than from colon, breast, and prostate cancers combined each year in the US.
In 2018, in the US 234,030 new cases of lung cancer were diagnosed in the US including 121,680 in men and 112,350 in women.
Most cases of lung cancers are diagnosed in people who are 65 or older. The lifetime risk of lung cancer in men is 1/15 and in women 1/17.
Certain risk factors such as long-term smoking, exposure to second-hand smoke, radon gas and toxic chemicals and family history are associated with the onset of lung cancer.
However, most people with some of the above risk factors do not develop lung cancer.
Some researchers suggested people with a weakened immune system such as elderly, long term use of antibiotic and immune suppressive medicine may be prone to getting lung cancer.
Dr. Joanna Domagala-Kulawik, in the examination of the role of the immune system in non-small cell lung carcinoma, wrote, "Very low and heterogonous antigenicity of lung cancer cells leads to passive escape from the anti-cancer immune defense. The cytotoxic lymphocytes (CTLs) that play a main role in the anticancer response are actively suppressed in the tumor environment and following regulatory mechanisms inhibit the recognition of tumor antigens by antigen presenting cells".
The results clearly suggested that immune cytotoxicity against cancer cells is suppressed in patients with lung cancer. In other words, by restoring the genes associated with programming cancer cell death and tumor suppression, lung cancer may be preventable.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on the finding a natural ingredient for the treatment of lung cancer examined the effects of dietary sinigrin or indole-3-carbinol on tumorigenicity in F344 rats.
During the experiment, dietary sinigrin at a concentration of 3 mumol/g diet decreased 7-methylguanine formation in hepatic DNA but had no effect on 7-methylguanine levels of lung or nasal mucosa DNA.
No effects on O6-methylguanine--DNA-transmethylase activity were observed in tissue extracts derived from the livers, lungs and nasal mucosae of rats fed diets containing sinigrin or I3C.
Where O6-methylguanine--DNA-transmethylase activity is a DNA repair protein.
The findings strongly suggested that dietary sinigrin or indole-3-carbinol do not inhibit lung cancer expression through DNA repair.
However, dietary sinigrin plus nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco cancer induced chemical resulted in a significant incidence of lung and nasal cavity tumors in F344 rats.
These results clearly suggested that dietary sinigrin inhibits lung cancer proliferation through some unknown mechanisms other than DNA methylation and O6-methylguanine repair.
Taken altogether, sinigrin may be used as a supplement for the prevention of lung cancer and combined with primary therapy for the treatment of lung cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats by Morse MA1, Wang CX, Amin SG, Hecht SS, Chung FL. (PubMed)
(2) The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention by Joanna Domagala-Kulawik. (PMC)
According to the statistic provided by the American Cancer Society, lung cancer is the leading cause of cancer death among both men and women. More people die of lung cancer than from colon, breast, and prostate cancers combined each year in the US.
In 2018, in the US 234,030 new cases of lung cancer were diagnosed in the US including 121,680 in men and 112,350 in women.
Most cases of lung cancers are diagnosed in people who are 65 or older. The lifetime risk of lung cancer in men is 1/15 and in women 1/17.
Certain risk factors such as long-term smoking, exposure to second-hand smoke, radon gas and toxic chemicals and family history are associated with the onset of lung cancer.
However, most people with some of the above risk factors do not develop lung cancer.
Some researchers suggested people with a weakened immune system such as elderly, long term use of antibiotic and immune suppressive medicine may be prone to getting lung cancer.
Dr. Joanna Domagala-Kulawik, in the examination of the role of the immune system in non-small cell lung carcinoma, wrote, "Very low and heterogonous antigenicity of lung cancer cells leads to passive escape from the anti-cancer immune defense. The cytotoxic lymphocytes (CTLs) that play a main role in the anticancer response are actively suppressed in the tumor environment and following regulatory mechanisms inhibit the recognition of tumor antigens by antigen presenting cells".
The results clearly suggested that immune cytotoxicity against cancer cells is suppressed in patients with lung cancer. In other words, by restoring the genes associated with programming cancer cell death and tumor suppression, lung cancer may be preventable.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on the finding a natural ingredient for the treatment of lung cancer examined the effects of dietary sinigrin or indole-3-carbinol on tumorigenicity in F344 rats.
During the experiment, dietary sinigrin at a concentration of 3 mumol/g diet decreased 7-methylguanine formation in hepatic DNA but had no effect on 7-methylguanine levels of lung or nasal mucosa DNA.
No effects on O6-methylguanine--DNA-transmethylase activity were observed in tissue extracts derived from the livers, lungs and nasal mucosae of rats fed diets containing sinigrin or I3C.
Where O6-methylguanine--DNA-transmethylase activity is a DNA repair protein.
The findings strongly suggested that dietary sinigrin or indole-3-carbinol do not inhibit lung cancer expression through DNA repair.
However, dietary sinigrin plus nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco cancer induced chemical resulted in a significant incidence of lung and nasal cavity tumors in F344 rats.
These results clearly suggested that dietary sinigrin inhibits lung cancer proliferation through some unknown mechanisms other than DNA methylation and O6-methylguanine repair.
Taken altogether, sinigrin may be used as a supplement for the prevention of lung cancer and combined with primary therapy for the treatment of lung cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats by Morse MA1, Wang CX, Amin SG, Hecht SS, Chung FL. (PubMed)
(2) The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention by Joanna Domagala-Kulawik. (PMC)
Friday, April 26, 2019
Herbal Cascara Sagrada (Rhamnus purshiana), the Potent Anti-Prostate Cancer Functional Herb, Researcher Suggested
Prostate cancer is a condition characterized by abnormal cells growth in prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.
Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Contrary to popular belief, as of today, prostate cancer no long is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.
According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately over 2.9 million men in who have been diagnosed with prostate cancer at some point are still alive today.
Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.
Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obesity or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables and whole grain are associated to the onset of prostate cancer.
Some researchers suggested ethnicity is a predictor involved the development of the disease due to a number of genetic mutations.
Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".
The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.
Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.
Furthermore, in vivo in an athymic nude mouse model, injection of Aloe-emodin also exhibited tumor suppression effects.
The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex which plays an important role in prostate cancer development.
The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cellular migration and invasion in prostate cells.
In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.
Futhermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells.
Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.
Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.
Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".
Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.
Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Contrary to popular belief, as of today, prostate cancer no long is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.
According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately over 2.9 million men in who have been diagnosed with prostate cancer at some point are still alive today.
Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.
Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obesity or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food and low fruits and vegetables and whole grain are associated to the onset of prostate cancer.
Some researchers suggested ethnicity is a predictor involved the development of the disease due to a number of genetic mutations.
Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".
The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.
Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.
Furthermore, in vivo in an athymic nude mouse model, injection of Aloe-emodin also exhibited tumor suppression effects.
The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex which plays an important role in prostate cancer development.
The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cellular migration and invasion in prostate cells.
In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.
Futhermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells.
Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.
Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.
Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".
Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)
Honey, the Potential Remedy in Speeding Up Bone Healing, According to Studies
Bone healing is a natural process of broken bone healing. The bone healing process goes through three overlapping stages, including inflammation, soft and callus production, and bone remodeling.
Improper bone healing occurred when two ends of the broken bone are not lined up properly, leading to the bone healing with a deformity called a malunion.
Most cases of improper bone healing have been found to involve angulation (bend) and/or rotation flexibility or extension. In some cases, improper bone healing can also cause stiffness in the finger, hand, wrist or elbow.
If you experience some of the above symptoms after a broken bone, you may have an improper bone healing. Please check with your doctor to rule out the possibility.
Some researchers in the concern of the risk of improper bone healing in obese patients wrote, "Obesity is a risk factor for various orthopedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influence the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing".
Luckily, the doctor continued, "Obese/overweight children did not have a delay in release to activities compared with children of normal weight".
The results strongly suggested the correlation between obese and the risk of bone fracture and fracture healing in children.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for speed-up bone healthy investigation honey activity on
alveolar osteitis (OA).
Alveolar osteitis (AO) is a complication of tooth extraction.
50 patients of AO were included in the study. After cleansing of the affected socket, honey dressings applied were changed daily for the first 2 days and then alternatively.
Honey application sped up the bone and granulation tissue healing and gingiva healing in about one week on most patients.
According to the reading of the CRP levels, treatment of AO with honey dressing showed a significant decrease from the pre-treatment values, an indication of fast recovery for inflammation.
The microbiological assay also showed the presence of normal commensal flora at AO sites including Streptococcus, Staphylococcus, and Enterococcus.
The results suggested that honey topical dressing speeds up bone healing and tissue recovery through inhibiting microbial overexpression and production of pro-inflammatory cytokines.
In order to reveal more information about bone healing of honey, researchers examined the honey on the healing of mandibular bone defects in a rat model.
24 wild-type Wistar rats included in the study were shaved, disinfected and extraoral incised with a 2 × 2 mm defect at mandibular angle. Only the experimental group defect was filled with sterile honey.
After 4 weeks, the defects were filled in four samples of the honey treatment group, compared to all samples of the control group which is still in the mineralization stage.
According to the histomorphometric assay, honey treatment showed a significant improvement in the mean new bone formation compared to those of the control group, both after 2 and 4 weeks.
Taken altogether, honey may speed up bone healing without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Topical Honey on Mandibular Bone Defect Healing in Rats by Hajizadeh F1, Derakhshan B2, Peimani A3, Abbasi Z. (PubMed)
(2) Effects of honey in the management of alveolar osteitis: A study by Soni N1, Singh V1, Mohammad S1, Singh RK1, Pal US1, Singh R2, Aggrwal J3, Pal M. (PubMed)
(3) Does obesity affect fracture healing in children? by Lee RJ1, Hsu NN, Lenz CM, Leet AI. (PubMed)
Improper bone healing occurred when two ends of the broken bone are not lined up properly, leading to the bone healing with a deformity called a malunion.
Most cases of improper bone healing have been found to involve angulation (bend) and/or rotation flexibility or extension. In some cases, improper bone healing can also cause stiffness in the finger, hand, wrist or elbow.
If you experience some of the above symptoms after a broken bone, you may have an improper bone healing. Please check with your doctor to rule out the possibility.
Some researchers in the concern of the risk of improper bone healing in obese patients wrote, "Obesity is a risk factor for various orthopedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influence the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing".
Luckily, the doctor continued, "Obese/overweight children did not have a delay in release to activities compared with children of normal weight".
The results strongly suggested the correlation between obese and the risk of bone fracture and fracture healing in children.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for speed-up bone healthy investigation honey activity on
alveolar osteitis (OA).
Alveolar osteitis (AO) is a complication of tooth extraction.
50 patients of AO were included in the study. After cleansing of the affected socket, honey dressings applied were changed daily for the first 2 days and then alternatively.
Honey application sped up the bone and granulation tissue healing and gingiva healing in about one week on most patients.
According to the reading of the CRP levels, treatment of AO with honey dressing showed a significant decrease from the pre-treatment values, an indication of fast recovery for inflammation.
The microbiological assay also showed the presence of normal commensal flora at AO sites including Streptococcus, Staphylococcus, and Enterococcus.
The results suggested that honey topical dressing speeds up bone healing and tissue recovery through inhibiting microbial overexpression and production of pro-inflammatory cytokines.
In order to reveal more information about bone healing of honey, researchers examined the honey on the healing of mandibular bone defects in a rat model.
24 wild-type Wistar rats included in the study were shaved, disinfected and extraoral incised with a 2 × 2 mm defect at mandibular angle. Only the experimental group defect was filled with sterile honey.
After 4 weeks, the defects were filled in four samples of the honey treatment group, compared to all samples of the control group which is still in the mineralization stage.
According to the histomorphometric assay, honey treatment showed a significant improvement in the mean new bone formation compared to those of the control group, both after 2 and 4 weeks.
Taken altogether, honey may speed up bone healing without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Topical Honey on Mandibular Bone Defect Healing in Rats by Hajizadeh F1, Derakhshan B2, Peimani A3, Abbasi Z. (PubMed)
(2) Effects of honey in the management of alveolar osteitis: A study by Soni N1, Singh V1, Mohammad S1, Singh RK1, Pal US1, Singh R2, Aggrwal J3, Pal M. (PubMed)
(3) Does obesity affect fracture healing in children? by Lee RJ1, Hsu NN, Lenz CM, Leet AI. (PubMed)
Thursday, April 25, 2019
Herbal Artichoke, the Best Hepatoprotecitve Functional Remedy, According to Studies
The hepatoprotective or liver protective effect is an action that maintains the liver healthy functioning against any harmful toxins.
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.
Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and tendency to bruise easily.
If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.
Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".
And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".
The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.
Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.
Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.
Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.
According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.
The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.
In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.
Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.
Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.
Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.
Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and tendency to bruise easily.
If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.
Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".
And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".
The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.
Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.
Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.
Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.
According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.
The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.
In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.
Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.
Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.
Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)
Curcumin, the Bioactive Compound of Turmeric Protects the Blood Vessels Against Cardiovascular Disease
Cardiovascular disease (CVD) refers to any conditions caused by the underlying damage of blood vessels and the heart.
In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.
According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.
Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.
Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.
Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".
And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".
The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.
According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.
In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.
The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).
Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.
* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.
* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.
* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).
* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.
Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".
Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)
In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.
According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.
Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.
Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.
Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".
And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".
The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.
According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.
In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.
The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).
Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.
* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.
* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.
* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).
* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.
Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".
Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)
Wednesday, April 24, 2019
Herbal Calendula, Protects Lipid, Protein and Cells DNA Against Damage Caused by Oxidative Stress
Scientists may have found a natural remedy for the prevention and treatment of the diseases associated with the expression of oxidative stress, according to studies.
Antioxidants are stable molecules that inhibit the oxidation induced by free radical.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme which protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress makers compared to untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, through enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Antioxidants are stable molecules that inhibit the oxidation induced by free radical.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme which protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress makers compared to untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, through enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Honey, the Best Remedy for the Prevention and Treatment of Diarrhea
Scientists may have found a natural alternative for the treatment of diarrhea, according to studies.
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North American that lasts in a very short time.
However, chronic diarrhea can be worrisome. Most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn disease and ulcerative colitis), malabsorption syndromes.
According to the statistics, acute diarrhea is one of the common cause of death among children younger than 5 years old worldwide.
The disease is associated mostly in the countries which poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune suppressive medicine and the elderly may also at a higher risk of diarrhea.
Dr. Bouchaud O in examing the risk immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because effective treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy has to be pragmatic in order to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial infected diarrhea.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on searching a natural compound for the treatment of diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it had worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacterias in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of its carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 andHouman Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North American that lasts in a very short time.
However, chronic diarrhea can be worrisome. Most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn disease and ulcerative colitis), malabsorption syndromes.
According to the statistics, acute diarrhea is one of the common cause of death among children younger than 5 years old worldwide.
The disease is associated mostly in the countries which poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune suppressive medicine and the elderly may also at a higher risk of diarrhea.
Dr. Bouchaud O in examing the risk immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because effective treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy has to be pragmatic in order to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial infected diarrhea.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on searching a natural compound for the treatment of diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it had worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacterias in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of its carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 andHouman Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Monday, April 22, 2019
Herbal Artichoke, The Best For the Treatment of Insulin Resistance (IR) in Patients with TCF7L2-rs7903146 Polymorphism
Scientists may have found a natural whole food for the treatment of insulin resistance with no side effects, according to studies.
Insulin resistance is a syndrome in which the cells in your muscles, fat, and liver do not respond well to insulin produced by the pancreas in converting glucose to energy, leading to high levels of sugar in the blood.
The causes of insulin resistance may be associated with the clogged up of the insulin receptor site that binds to insulin and passes its message to the cell.
Insulin resistance is a hallmark of diabetes.
Prediabetes is a term used to indicate a high level of blood glucose levels is higher compared to the normal range but not high enough to be diagnosed as diabetes.
The increase in age, family history, high blood pressure, high blood cholesterol, and abnormal waist-hip ratio are some prevalent risk factor of insulin resistance.
Interestingly, in the concern of long-term use of certain medication in the risk of insulin resistance such as glucocorticoids, antipsychotic, researchers at the Monell Chemical Senses Center,wrote, "Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes"
And, "olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones".
The doctor team continued, "Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease".
The findings suggested that if you are taking a certain medication for the treatment of anxiety, please make sure you discuss the side effects with your doctor for preventive measure.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of insulin resistance examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
The double-blind clinical trial included 80 patients with MetS in Sina Clinic, Khoy, Iran. randomly assigned to ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
According to the anthropometric indices, blood pressure, glucose and lipid profile levels measured before and after the study, injection of ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05).
The finding strongly suggested that artichoke extract inhibited the expression of insulin resistance in a 12 weeks study in patients with the TCF7L2-rs7903146 polymorphism.
In order to reveal more information about artichoke extract anti-insulin resistance, researchers once again investigated the effects of ALE supplementation on metabolic parameters in women with MetS.
This study included a total of 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups. with the "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and the "placebo group" (received placebo consisted of cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.
Surprisingly, in the carriers of A allele of the FTO-rs9939609, ALE supplementation showed a statistically significant decrease in serum triglyceride level compared with placebo without affecting the insulin parameter.
The results strongly suggested that ALE inhibited the insulin resistance selectively only on patients with the TCF7L2-rs7903146 polymorphism.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of insulin resistance in carriers of the TCF7L2-rs7903146 polymorphism, pending to the results of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial by Ebrahimi-Mameghani M1, Asghari-Jafarabadi M2, Rezazadeh K. (PubMed)
(2) Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms by Rezazadeh K1, Rahmati-Yamchi M2, Mohammadnejad L3, Ebrahimi-Mameghani M4, Delazar A. (PubMed)
(3) Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease by Teff KL1, Rickels MR, Grudziak J, Fuller C, Nguyen HL, Rickels K. (PubMed)
Insulin resistance is a syndrome in which the cells in your muscles, fat, and liver do not respond well to insulin produced by the pancreas in converting glucose to energy, leading to high levels of sugar in the blood.
The causes of insulin resistance may be associated with the clogged up of the insulin receptor site that binds to insulin and passes its message to the cell.
Insulin resistance is a hallmark of diabetes.
Prediabetes is a term used to indicate a high level of blood glucose levels is higher compared to the normal range but not high enough to be diagnosed as diabetes.
The increase in age, family history, high blood pressure, high blood cholesterol, and abnormal waist-hip ratio are some prevalent risk factor of insulin resistance.
Interestingly, in the concern of long-term use of certain medication in the risk of insulin resistance such as glucocorticoids, antipsychotic, researchers at the Monell Chemical Senses Center,wrote, "Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes"
And, "olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones".
The doctor team continued, "Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease".
The findings suggested that if you are taking a certain medication for the treatment of anxiety, please make sure you discuss the side effects with your doctor for preventive measure.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of insulin resistance examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
The double-blind clinical trial included 80 patients with MetS in Sina Clinic, Khoy, Iran. randomly assigned to ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
According to the anthropometric indices, blood pressure, glucose and lipid profile levels measured before and after the study, injection of ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05).
The finding strongly suggested that artichoke extract inhibited the expression of insulin resistance in a 12 weeks study in patients with the TCF7L2-rs7903146 polymorphism.
In order to reveal more information about artichoke extract anti-insulin resistance, researchers once again investigated the effects of ALE supplementation on metabolic parameters in women with MetS.
This study included a total of 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups. with the "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and the "placebo group" (received placebo consisted of cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.
Surprisingly, in the carriers of A allele of the FTO-rs9939609, ALE supplementation showed a statistically significant decrease in serum triglyceride level compared with placebo without affecting the insulin parameter.
The results strongly suggested that ALE inhibited the insulin resistance selectively only on patients with the TCF7L2-rs7903146 polymorphism.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of insulin resistance in carriers of the TCF7L2-rs7903146 polymorphism, pending to the results of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial by Ebrahimi-Mameghani M1, Asghari-Jafarabadi M2, Rezazadeh K. (PubMed)
(2) Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms by Rezazadeh K1, Rahmati-Yamchi M2, Mohammadnejad L3, Ebrahimi-Mameghani M4, Delazar A. (PubMed)
(3) Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease by Teff KL1, Rickels MR, Grudziak J, Fuller C, Nguyen HL, Rickels K. (PubMed)
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