Bilberry may be the potential target used by conventional medicine in the future for the treatment of cancer with no side effects, according to studies.
Cancer is a class of medical condition characterized by cell growth irregularly due to the alternation of cell DNA.
Most cases of cancers begin in the cells on the surface of the inner lining of the body tissues and do not cause any symptoms at the early stage.
However, invasive cancer at the advanced stage can cause localized symptoms accompanied by the cancer general symptoms and its cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading secondary metastasis.
According to the US government statistics, the prevalent risk of cancer development is 439.2 per 100,000 men and women per year based on 2011–2015 cases, causing the death of 163.5 per 100,000 men and women per year.
The exact causes of cancer are unknown. Epidemiologically, certain factors are associated with the prevalent risk of cancer including age, ethnicity, long-term exposure to toxic chemicals, and genetic preposition.
Some researchers suggested that the widespread obesity in the Western world, particularly in North America may have a strong impact on the increased risk of cancer. According to statistics, over 68% of American are either overweight or obese.
Dr. Giovanni De Pergola, the lead scientist in the assessment obese in cancer risk said, "The number of cancer cases caused by being obese is estimated to be 20% with the increased risk of malignancies being influenced by diet, weight change, and body fat distribution together with physical activity".
And, "Reports from the International Agency for Research into Cancer and the World Cancer Research Fund (WCRF) have shown that the strongest evidence exists for an association of obesity with the following cancer types: endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal, whereas the less common malignancies, are leukemia, non-Hodgkin's lymphoma, multiple myeloma, malignant melanoma, and thyroid tumors".
The results strongly clearly suggested if you are obese, your risk of cancer is increased substantially compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural and potential compound for the treatment of cancer examined the anthocyanins anticancer activity in rodent models of cancer in-vitro and in- vivo.
Bilberry anthocyanins as chemopreventive agents showed a significant effect in 25 colorectal cancer patients. The result has opened a new window of opportunity in translating the findings from laboratory to clinic.
According to the study, anthocyanins treated cancer cells by stimulating the production of the tumor suppressor genes.
Application of anthocyanins also inhibited the cancer cell proliferation through activating the protein associated with cell death programming.
Dr. Sehitoglu MH and colleagues wrote in the final report, "his review we bring to limelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways".
In order to reveal additional information about bilberry anti-cancer effects, researchers investigated the anthocyanins (A(V.uli)) bioactivity on suppressing cancer cells.
Malvidin, the major compound isolated from A(V.uli) at a dose-dependent inhibited cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml.
The findings strongly reconfirmed the anti-cancer effects of anthocyanin extraction. A(V.uli) from the bilberry.
Taken altogether, bilberry processed a high amount of bioactive compounds such as delphinidin, cyanidin, petunidin, peonidin, and malvidin may be considered a functional food for the prevention and treatment of cancer with no side effects, pending to the confirmation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanins: targeting of signaling networks in cancer cells by Sehitoglu MH1, Farooqi AA, Qureshi MZ, Butt G, Aras A. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. (PubMed)
(3) Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola* and Franco Silvestris. (PMC)
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