Scientists may have found a pungent spice which processes the potential for the prevention and treatment of gastric cancer, some studies suggested.
Gastric cancer is also known as stomach cancer, a medical and chronic condition caused by the cell growth irregularly and disorderly in the stomach tissues due to the alternation of DNA.
Researchers do not know the exact causes of gastric cancer, either they know people with the same health conditions, in the same family, some are susceptible to the DNA alternation, while others do not.
At the early stage, gastric cancer cell which has grown on the surface of the inner lining of the stomach does not cause any symptoms due to the very small size of the tumor.
However, at the later stage, the large tumor size may suppress the nearby blood vessels and nerve cells, leading to internal bleeding and severe pain. Also, cancer cells may also travel a distance away from the stomach to infect other healthy tissue and organs, leading to a secondary metastasis.
Common sites metastases of liver cancer are liver (48%), peritoneum (32%), lung (15%), and bone (12%).
According to the American Cancer Society, in 2018, approximately 26,240 new cases of gastric cancer will be diagnosed (16,520 in men and 9,720 in women), and gastric cancer causes the death of 10,800 people including 6,510 men and 4,290 women.
The 5 years survival rate of localized gastric cancer is 67%, compared to the advanced stage of only 31%.
Although there are many risk factors involved the onset of gastric cancer, epidemiologically, some researchers suggested the change of lifestyle associated with the promotion of the Western diet is the major prevalent risk factor in the Western world.
Dr, P. Bertuccio, the lead scientist in the compared the gastric cancer risk of the Western and ‘Prudent/healthy’ diet wrote, "A favorable role on GC emerged for the ‘Prudent/healthy’, with an odds ratio (OR) of 0.75 [95% confidence interval (CI): 0.63–0.90], for the highest versus the lowest category. Similar results emerged for separate anatomical subtypes. An unfavorable role on GC emerged for the ‘Western/unhealthy’ dietary pattern, with an OR of 1.51 (95% CI: 1.21–1.89)".
And, "There is a ∼2-fold difference in GC risk between a ‘Prudent/healthy’ diet-rich in fruits and vegetables, and a ‘Western/unhealthy’ diet-rich in starchy foods, meat, and fats".
The results strongly suggested the protective role of high fruits and vegetable diet against the onset of gastric cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of gastric cancer examined the role of ginger in combatting GI cancer, with little or no side effects.
Ginger and its active components including 6-gingerol and 6-shogaol exerted strong anticancer activities against GI cancer.
The anticancer activity of ginger and its isolated compounds attributed to the ability to modulation the proteins, cytokines, matrix, and enzymes associated with the pro-apoptosis, cancer cell cycle arrest anti-proliferation, and cell death programming.
In vitro, ginger extract and its active components also demonstrated the chemopreventive and chemotherapeutic potency against gastric cancer cell line.
In order to reveal more details of ginger and its bioactive against the gastric cancer cells, researchers assess the [6]-Gingerol anti-gastric tumor activity.
According to the A CCK-8 assay, [6]-gingerol inhibited the cell viability of HGC-27 cells in a dose-dependent manner.
The Colony formation assay indicated that pretreatment of [6]-gingerol prior to Ionizing radiation (IR) decreased the survival and proliferation of HGC-27 cells.
The combination of [6]-gingerol with IR enhanced IR-induced cell cycle arrest at the G2/M phase by 53.5% compared to 41.3% of IR alone.
Pretreatment of [6]-gingerol increased IR-induced apoptosis compared with IR alone.
The efficacy of [6]-gingrol in inhibiting gastric cancer cells was attributed to the interference of proteins associated with cancer cell survivals and proliferation and exhibiting the genes that suppress tumor growth, promote cancer cell degradation and program cancer cell death, observed by the Western blotting.
Dr. the lead scientist, after taking into account co and confounders, said, ":[6]-gingerol enhanced radiosensitivity of GC cells, and that the mechanisms involved at least G2/M phase arrest and apoptosis induction".
Taken altogether, ginger processed [6] gingerol may be considered a function remedy for the prevention and combined with the primary medicine for treatment of gastric cancer with no side effects, pending to the confirmation of a large size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer by Sahdeo Prasad * and Amit K. Tyagi. (PMC)
(2) [6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction by Luo Y1, Chen X1, Luo L1, Zhang Q1, Gao C1, Zhuang X1, Yuan S1, Qiao T. (PubMed)
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