Alfalfa, the Anti-inflammatory Natural Whole Food

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhanced digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North American aboriginals have used Alfalfa seed as food in making bread and mush.

Inflammation is the natural response of the immune system in regulated the production of white blood cells for protection against foreign organisms.

Alfalfa expressed significant anti-inflammatory effect through inhibited production of proinflammatory cytokines during injure, foreign invasion and free radical domino's action, etc....

According to the University of Maryland, a novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem, showed significant anti-inflammatory effect against mRNA expressions of the pro-inflammatory cytokine genes, especially for IL-1β antibody.


The chloroform extract of alfalfa aerial part also is found to inhibit the function of lipopolysaccharide (LPS) of Gram-negative bacteria in stimulating the immune responses in induced inflammation and suppressed LPS-mediated activation of the extracellular signal-regulated the proinflammatory and prothrombotic responses of nuclear factor kappa-B pathway.

The cinnamic acid derivatives and fatty acids active constituents of the extract have also been found to be effective in ameliorated inflammation and immune response through inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2) all involved in the development of inflammatory diseases.

Taking together, Alfalfa no doubt has processed anti-inflammatory effects by inhibited free radicals, proinflammatory cytokines and hormones involved the development of inflammatory and autoimmune diseases.


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Sources
(1) Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa(Medicago sativa L.) stem by Chen L, Liu J, Zhang Y, Dai B, An Y, Yu LL1.(PubMed)
(2) Chloroform extract of alfalfa (Medicago sativa) inhibits lipopolysaccharide-induced inflammation by downregulating ERK/NF-κB signaling and cytokine production by Choi KC1, Hwang JM, Bang SJ, Kim BT, Kim DH, Chae M, Lee SA, Choi GJ, Kim DH, Lee JC.(PubMed)
(3) Anti-Inflammatory Activities of Cinnamomum cassiaConstituents In Vitro and In Viv by Jung-Chun Liao,1 Jeng-Shyan Deng,2 Chuan-Sung Chiu,3,4(HindaWi)