The Best Smoothie of Sweet Potato, Tomato and Orange Juice for Prevention and Treatment of Granular cell tumor (GCT) of the breast, a benign breast disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of  Granular cell tumor (GCT) of the breast, a benign breast disease
Yield: 2 serving (about 8 ounce each)
1/8 cup cooked sweet potato
1/4 cup tomato
1 4/5 cups orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of Granular cell tumor (GCT) of the breast is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Granular cell tumor (GCT) of the breast, a benign breast disease is an abnormal growth of breast tissue, affecting 5% to 6% of all GCTs.  Although Granular cell tumor (GCT) of the breast is not a precursor of breast cancer, women with Granular cell tumor (GCT) of the breast are at increased risk of developed invasive breast cancer(1).

Women with benign breast disease(BBD) are found to have lower antioxidant status, probably to compensate for this elevated free radical production(3)

According to the, dietary supplement "Karinat" containing beta-carotene 2.5 mg, alpha-tocopherol 5 mg, ascorbic acid 30 mg and garlic powder 150 mg per one tablet in a total of 66 patients twice a day during 6 months exhibited anti benign breast disease up to 75.8% in comparison to placebo(2).

According to the Chinese University of Hong Kong, Intakes of vitamin E and individual carotenoids may associate to reduce risk proliferative BBD(4), particular in carotenoids intake in BBD of adolescent girls(5).

Dr. Ramaswamy G and Dr. Krishnamoorthy L. said, "Serum ascorbate levels were significantly lower in patients with benign diseases of the breast and cervix than in controls"(6).

The effectiveness of Sweet Potato(Vitamin E), Tomato(Vitamin A) and Orange Juice(Ascorbic Acid or Vitamin C )  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Granular cell tumor (GCT) of the breast, a benign disease of the breast with little or no adverse effects.

Women who are at increased risk of Granular cell tumor (GCT) of the breast may drink at least one serving daily and women with Granular cell tumor (GCT) of the breast may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References

(1) Benign breast disease and the risk of breast cancer in the next 15 years by Socolov D, Anghelache I, Ilea C, Socolov R, Carauleanu A.(PubMed)

(2) [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease].
[Article in Russian] by Bespalov VG, Barash NIu, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN.(PubMed)

(3) Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease by Gönenç A1, Erten D, Aslan S, Akinci M, Simşek B, Torun M.(PubMed)
(4) Intakes of fat and micronutrients between ages 13 and 18 years and the incidence of proliferative benign breast disease. by Su X1, Boeke CE, Collins LC, Baer HJ, Willett WC, Schnitt SJ, Connolly JL, Rosner B, Colditz GA, Tamimi RM.(PubMed)
(5) Adolescent carotenoid intake and benign breast disease by Boeke CE1, Tamimi RM2, Berkey CS3, Colditz GA4, Eliassen AH2, Malspeis S5, Willett WC6, Frazier AL7.(PubMed)
(6) Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix. by Ramaswamy G1, Krishnamoorthy L.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis Preventions – The Antioxidants

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

                                             Prevention

Antioxidants to prevent bronchitis
1. Antioxidant vitamins C, E and coenzyme Q10
In the study to to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC), showed that Administration of CoQ10 resulted in a significant increase in PaO2 values compared with the group I (p = 0.004). Levels of plasma MDA in group II were significantly higher than those in the group I (p = 0.01). Early administration of vitamin C, CoQ10, and Dxm significantly decreased the levels of MDA (p = 0.01). Lung contusion due to blunt trauma significantly decreased SOD activities in rat lung tissue compared with group I (p = 0.01). SOD levels were significantly elevated in animals treated with CoQ10, Vitamin E, or Dxm compared with group II (p = 0.01)(46).
2. Vitamin D
In the cohort to investigate the association of maternal vitamin D and maternal asthma and infant respiratory infection severity of 70% white, 19% African American, and 21% had asthma, found that
overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infant bronchiolitis score(47).
3. Curcumin
Curcumin derived from the rhizome of turmeric has been used for decades and it exhibits anti-inflammatory, anti-carcinogenic, immunomodulatory properties by downregulation of various inflammatory mediators,. according to the study by Panjab University(48)
4. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(46) http://www.ncbi.nlm.nih.gov/pubmed/23013526
(47) http://www.ncbi.nlm.nih.gov/pubmed/21658670
(48) http://www.ncbi.nlm.nih.gov/pubmed/16025962

****244 Breast hematoma The Smoothie of Orange, Spinach and Grape Juice for Prevention and Treatment of Breast Hematoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Breast hematoma
1  cup of organic orange
1/2 spinach
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of  Breast hematoma has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(such as Ginger, Alfalfa Sprout  and Orange) for reduced risk and treatment of Breast hematoma.

Breast hematoma is a collection of blood due to bleeding within the breast. According to the Penn State Milton S. Hershey Medical Center, "The probability of development of a non-clinically significant hematoma was 21.6% for patients taking antithrombotics and 13.0% for those not taking antithrombotics"(1).

Vitamin K, found abundantly in spinach has exerted its coagulation effects in reduced risk of (subdural) hematoma, in a randomized trials identified from the Cochrane Central Register of Controlled Trials(2).

The Fuwai Hospital joint study also suggested, the favorite uninterrupted vitamin K antagonists (VKAs), in comparison to anticoagulation in catheter ablation (CA) of atrial fibrillation (AF) in occurrence of stroke or transient ischemic attacks and major bleeding in test subjects(3).

Dr. Levi M said, "Bleeding is the most important adverse effect of antithrombotic treatment and may be a major cause of morbidity, longstanding debilitation, and even mortality....... can be neutralized by the administration of vitamin K or prothrombin complex concentrates"(4).

Vitamin C, a water soluble vitamin found in orange may also benefit women with breast hematoma by preventing the breaking off  capillaries, the small vessels in the breast inducing bleeding(5).

According to the University Clinic Muenster, Vitamin C was shown to be cerebroprotective in several animal models of stroke, through the expression and transport activity of SVCT2, :key proteins for vitamin C uptake. in brain capillary endothelial cells after transhwaient ischemia in mice(6).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape may also reduced risk of complications caused by severe hemorrhagic injury, including the Lung(8), intestines(9), cystitis(10),.....through both pro and anti-inflammatory pathways(7).

The effectiveness of Orange, Spinach and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Breast hematoma with little or no adverse effects.

Women who are at increased risk of Breast hematoma due to family history, aging,.....may drink at least one serving daily and women with  Breast hematoma may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Hematoma formation during breast core needle biopsy in women taking antithrombotic therapy by Chetlen AL1, Kasales C, Mack J, Schetter S, Zhu J.(PubMed)
(2) Vitamin K antagonists and risk of subdural hematoma: meta-analysis of randomized clinical trials by Connolly BJ1, Pearce LA1, Hart RG2.(PubMed)
(3) Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants Compared With UninterruptedVitamin K Antagonists in Patients Undergoing Catheter Ablation for Atrial Fibrillation. by Wu S1, Yang YM2, Zhu J1, Wan HB1, Wang J1, Zhang H1, Shao XH1.(PubMed)
(4) Emergency Reversal Strategies for Anticoagulation and Platelet Disorders by Levi M1.(PubMed)
(5) High-dose vitamin C treatment reduces capillary leakage after burn plasma transfer in rats by Kremer T1, Harenberg P, Hernekamp F, Riedel K, Gebhardt MM, Germann G, Heitmann C, Walther A.(PubMed)
(6) Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillaryendothelial cells after transient ischemia in mice by Gess B1, Sevimli S, Strecker JK, Young P, Schäbitz WR.(PubMed)
(7) Alteration of cytokine profile following hemorrhagic shock by Lu S1, Aguilar A1, Subramani K1, Poulose N1, Ayub A1, Raju R2.(PubMed)
(8) Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis by Lin ZS1,2, Ku CF1, Guan YF1, Xiao HT1, Shi XK1, Wang HQ2, Bian ZX1, Tsang SW1,3, Zhang HJ1.(PubMed)
(9) Effects of resveratrol on methotrexate-induced intestinal injury by Yulug E, Turedi S, Alver A, Turedi S, Kahraman C.(PubMed)
(10) Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna by Keles I1, Bozkurt MF, Cemek M, Karalar M, Hazini A, Alpdagtas S, Keles H, Yildiz T, Ceylan C, Buyukokuroglu ME.(PubMed)

The Best Smoothie of Coffee, Wolfberry and Honey for Reduced Risk and Treatment of Liver Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published
 on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of  Liver cancer
Yield: 2 servings (about 8 ounces each)
1/2  cup dried wolfberry (you can easily buy them in any Chinese grocery store)
1/4 cup honey
1 1/2 cup coffee

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately.

Liver cancer is a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
Back by well known institutions, according to the recent studies, coffee(1), wolfberry(4) and artichoke(7) may be next potential therapeutic target for producing a curable medication for reduced risk and treatment of liver cancer.
Coffee drink made from roasted coffee beans and considered as one most popular beverage in Western countries may consist the property in ameliorate risk of liver cancer. According to the joint study lead by the Harvard School of Public Health, intake of coffee regularly inversely associated to reduced HCC risk was partly accounted for by biomarkers of inflammation and hepatocellular injury(1).
In the Liver Cancer Pooling Project, a consortium of U.S.-based cohort studies, data from 1,212,893 individuals, higher coffee consumption was associated with lower risk of HCC, among women than men (HR>3 cups/day vs. non-drinker)(2).
Furthermore, according to a prospective study in Japan, risk of liver cancer in almost never drinkers in this population was 547.2 cases per 100,000 people over 10 years, in comparison of 214.6 cases per 100 000 people with drinking coffee on a daily basis(3).

Wolfberry is the common name for the fruit of two very closely related species, the genus of Lycium, belong to family Solanaceae, native to native to southeastern Europe and Asia. According to the General Hospital of Ningxia Medical University, Lycium barbarum berries, improved general wellbeing and immune functions and exhibited antitumor activities against various types of cancer cells through induction of apoptosis and cell cycle arrest(4).

On human hepatoma cells, Lycium barbarum polysaccharide (LBP) extracted, displayed anti proliferation of SMMC-7721 cells in a concentration and time dependent manner(5) and QGY7703 cells in increased intracellular calcium in apoptotic system(7).

Dr. Cui B and colleagues at the Sun Yat-sen University said," LCP exhibited remarkable protective effects against diethylnitrosamine (DEN)-induced oxidative hepatic injury in liver cancer rats(6).

Honey, the rich golden liquid, is the miraculous product made by bees using nectar from flowers. It is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people. According to State University of Campinas-UNICAM, honey treatment affect the tumor and host caused by oxidative stress through different mechanisms(8), such as decreasing cell proliferation and increasing apoptosis in tumour tissue(9).The study of bee honey and Nigella sativa on hepatocellular carcinoma cells BY THE Ain Shams University, showed a positive effects of honey in reducing the viability of HepG2 cells, improving their antioxidant status and inducing their apoptotic death(10).

The discovery of combined ingredients of wolfberry(4), coffee(1) and honey(8) may act as a cornerstone for induction of further investigation of the effectiveness of natural smoothie in reduced risk and treatment of liver cancer.

People who are at increased risk of liver cancer due to family history, gene mutation, obesity.....should drink at least one serving daily and people with liver cancer should drink no more than 4 servings daily, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition by Aleksandrova K1, Bamia C2, Drogan D3, Lagiou P4, Trichopoulou A2, Jenab M5, Fedirko V6, Romieu I5, Bueno-de-Mesquita HB7, Pischon T8, Tsilidis K9,Overvad K10, Tjønneland A11, Bouton-Ruault MC12, Dossus L12, Racine A12, Kaaks R13, Kühn T13, Tsironis C14, Papatesta EM14, Saitakis G14, Palli D15,Panico S16, Grioni S17, Tumino R18, Vineis P19, Peeters PH20, Weiderpass E21, Lukic M22, Braaten T22, Quirós JR23, Luján-Barroso L24, Sánchez MJ25,Chilarque MD26, Ardanas E27, Dorronsoro M28, Nilsson LM29, Sund M30, Wallström P31, Ohlsson B32, Bradbury KE33, Khaw KT34, Wareham N35, Stepien M5,Duarte-Salles T5, Assi N5, Murphy N36, Gunter MJ36, Riboli E36, Boeing H3, Trichopoulos D37.(PubMed)
(2) Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: TheLiver Cancer Pooling Project by Petrick JL1, Freedman ND2, Graubard BI2, Sahasrabuddhe VV2, Lai GY3, Alavanja MC2, Beane-Freeman LE2, Boggs DA4, Buring JE5, Chan AT6, Chong DQ7,Fuchs CS8, Gapstur SM9, Gaziano JM10, Giovannucci EL11, Hollenbeck AR12, King LY6, Koshiol J2, Lee IM5, Linet MS2, Palmer JR4, Poynter JN13, Purdue MP14, Robien K15, Schairer C2, Sesso HD5, Sigurdson AJ2, Zeleniuch-Jacquotte A16, Wactawski-Wende J17, Campbell PT9, McGlynn KA2.(PubMed)
(3) Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan by Inoue M1, Yoshimi I, Sobue T, Tsugane S; JPHC Study Group.(PubMed)
(4) An evidence-based update on the pharmacological activities and possible molecular targets ofLycium barbarum polysaccharides by Cheng J1, Zhou ZW2, Sheng HP3, He LJ4, Fan XW5, He ZX6, Sun T7, Zhang X8, Zhao RJ9, Gu L10, Cao C2, Zhou SF11(PubMed)
(5) Characterization of Lycium barbarum polysaccharide and its effect on human hepatoma cells by Zhang M1, Tang X, Wang F, Zhang Q, Zhang Z.(PubMed)
(6) Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats by Cui B1, Chen Y, Liu S, Wang J, Li S, Wang Q, Li S, Chen M, Lin X.(PubMed)
(7) Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis by Zhang M1, Chen H, Huang J, Li Z, Zhu C, Zhang S.(PubMed)
(8) Oral Administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and Honey Improves the Host Body Composition and Modulates Proteolysis Through Reduction of Tumor Progression and Oxidative Stress in Rats by Tomasin R1, de Andrade RS1, Gomes-Marcondes MC1.(PubMed)
(9) Oral administration of Aloe vera and honey reduces Walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue by Tomasin R1, Gomes-Marcondes MC.(PubMed)
(10) Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells BY Hassan MI1, Mabrouk GM, Shehata HH, Aboelhussein MM.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis Preventions – The Phytochemicals

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

                                             Prevention

Phytochemicals to prevent bronchitis
1. Quercetin
Mucus hypersecretion is a feature of many chronic airway diseases induced by cigarette smoke (CS), and evidence suggests that the antioxidant and anti-inflammatory flavonoid quercetin may protect against CS-induced respiratory pathology. According to the study by State Key Laboratory of Biotherapy and Department of Respiratory Medicine, West China Hospital, Sichuan University, quercetin attenuates CS-induced mucin protein synthesis in rat lung, possibly by inhibiting oxidative stress and inflammation via a mechanism involving NF-κB pathway activation and EGFR phosphorylation. These findings suggest that quercetin has a potential for treating chronic airway diseases(42).
2. Catechin
Catechin found abundantly in Actinidia callosa var. ephippioides extract also had good effects in the antioxidant and anti-inflammatory activities. Catechin might be an important bioactive compound in the stem of ACE. The above experimental data indicated that the stem of ACE is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds(43).
3. Eupafolin
Eupafolin found abundantly in Kalanchoe gracilis (L.) DC stem also had good pharmacological activity in the antioxidant, anti-inflammation and antiproliferative. Eupafolin might be an important bioactive compound in the stem of K. gracilis. The above experimental data indicated that the stem of K. gracilis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds(44).
4. Puerarin
Puerarin is a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), In the study to investigate the myocardial protective effect of puerarin injection (PI) in children with severe pneumonia, conducted by Hospital Affiliated to Weifang Medical College, indicated that
change of serum myocardial zymographic parameters was indirectly proportional to the severity of childrens condition. The reduction of myocardialcontrastive function was demonstrated by the change of cardiac blood flow parameters in Ultrasound Doppler examination (P < 0.01). Both PI and FDP had the effect in protecting myocardium and improving heart function, showing insignificant difference between their efficacy (P > 0.05), but PI had less stimulation to vessels and without any obvious adverse reaction(45).
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(42) http://www.ncbi.nlm.nih.gov/pubmed/22465384
(43) http://www.ncbi.nlm.nih.gov/pubmed/22928834
(44) http://www.ncbi.nlm.nih.gov/pubmed/22083996
(45) http://www.ncbi.nlm.nih.gov/pubmed/16025962

The Delicious Smoothie of Tomato, Sweet Potato and Orange Juice for Prevention and Treatment of Fibroadenomas

Kyle J. Norton(Scholar, master of nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Fibroadenomas
Yield: 2 servings (about 8 ounces each)
3/4 cup tomato

3/4 cup sweet potato

1 cup organic orange juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of fibroadenomas has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources( Tomato, Sweet Potato and Orange Juice) for reduced risk and treatment of fibroadenomas. According to the Dr. Bespalov VG and research team, dietary supplement "Karinat" containing beta-carotene 2.5 mg, alpha-tocopherol 5 mg, ascorbic acid 30 mg may be effective for prevention and treatment of patients with benign breast disease(1) including Fibroadenomas

Fibroadenomas are benign breast tumors composed of fibrous and glandular tissue which occur mostly in women 30 years old or younger. According to statistic, approximately 500,000-700,000 fibroadenomas are removed each year in US alone. The benign breast tumors are also called breast mice or a breast mouse due to their high mobility in the breast. They are general painless and may become tenderness or swelling just before the menstrual cycle. Women with multiple fibroadenomas may indicate a slightly increased risk of breast cancer.

Tomato, a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America,  containing high amount of beta-carotene, may be used for prevention and treatment of
Fibroadenomas(1). According to the Medical Academy of Bialystok, in Carotenoid pigments isolated, beta carotene, is associated to lower risk of benign changes of fibroadenoma(2).

α-Tocopherol is a type of tocopherol or vitamin E found abundantly in sweet potato may also be associated to risk of fibroadenomas(3). Sweet potato is a large, starchy, sweet tasting tuberous roots vegetable, genus Ipomoea, belongings to the family Convolvulaceae.

According to the Bandar Baru Bangi, higher adipose tissue concentrations of tocotrienols in benign patients provide support for the idea that tocotrienols may provide protection against breast cancer(4).

Ar. London SJ and research team at the said, " We observed no significant associations between serum levels of these micronutrients and risk of proliferative BBD or breast cancer. The risk of breast cancer was decreased among women in the highest quintile of intake of vitamin E from food sources only"(5).

Vitamin C, found abundantly in orange, is a water soluble vitamin with a chemical structure formula of C6H6O6 and cannot be stored in the body for more than 24 hours. We are required to take it regularly. According to Dr. Ramaswamy G and Dr. Krishnamoorthy L., serum ascorbate levels were significantly lower in patients with benign diseases of the breast and cervix(6).
The Medical College, in the review of data from January 1992-January 1998 of 1404 patients attended the "Breast Clinic" of R.N.T. Medical College M.B. Hospital, Udaipur, in comparison of patients had breast cancer (B.C.) and benign breast cancer (B.B.D.), depleted levels of ascorbic acid were found in most patients(7).

The combination of smoothie with ingredients Tomato, Sweet Potato and Orange Juice may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of fibroadenomas without induced adverse effects

Women who are at increased risk of fibroadenomas due to family history,... should drink at least one cup daily. Women with fibroadenomas, should drink no more than 4 serving daily depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease].[Article in Russian] by Bespalov VG, Barash NIu, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN.(PubMed)
(2) Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue by Czeczuga-Semeniuk E1, Wołczyński S, Markiewicz W.(PubMed)
(3) [Serum values of vitamins A, E, C and carotenoids in healthy adult subjects and those with breast neoplasia].[Article in Italian] by Audisio M, Mastroiacovo P, Martinoli L, Fidanza A, Cappelli L, Pasquali Lasagni R, Tirelli C, Jacobelli G.(PubMed)
(4) Tocotrienol levels in adipose tissue of benign and malignant breast lumps in patients in Malaysia by Nesaretnam K1, Gomez PA, Selvaduray KR, Razak GA.(PubMed)
(5) Carotenoids, retinol, and vitamin E and risk of proliferative benign breast disease and breast cancer. by London SJ1, Stein EA, Henderson IC, Stampfer MJ, Wood WC, Remine S, Dmochowski JR, Robert NJ, Willett WC.(PubMed)
(6) Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix by Ramaswamy G1, Krishnamoorthy L.(PubMed)
(7) Breast cancer in developing population: A nutrition caveat by Mehta G1, Kothari S, Singh PP.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis - The do and do not’s list

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

                                                Prevention
The do and do not’s list
1. Wash your hand thoroughly with soap and water 15-20 seconds can help to reduce the risk of catching common cold and influrenza. Use alcohol-based hand gels if washing is not possible.
2. Cover sneeze and coughing and prevent hand-to-hand passage.
3. Enhance your immune function to protect your body against invasion of foreign invasion, including bacteria and virus.
4. Traditional Mediterranean diet
Eating plenty of fruit, vegetables and fish keep lungs healthy. Those who follow a diet closest to this ” Mediterranean ” ideal are less likely as their peers with eating habits furthest from this pattern to develop chronic lung disease. A good amount of fresh vegetable juices are a good way to start healing, along with adding a variety of spices such as ginger, onions, and garlic. The emphasis should be on eating as healthy a diet as possible(36).
5. Eat your fruit and vegetables
Fruits and vegetables not only are very nutritional but also contains high amount of antioxidants which can combat against bacteria and virus invasion.
6. Stop smoking
As smoking is the main cause of chronic bronchitis.
7. Avoid occpupation and enviroment exposure to dust, chemical gas, air poplution, etc.
Strong evidances suggested that prolonged period of exposure to dust, chemical gas, air poplution, etc. are associated to the development of chronic bronchitis
8. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(36) http://www.raysahelian.com/lungdisease.html

The tasty Smoothie of Green Tea, Grape and Avocado for Reduced Risk and Treatment of Pelvic inflammation disease (PID)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of pelvic inflammation disease
Yield: 2 serving (about 8 ounce each)
1 cup grape
1/4 cup avocado
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of pelvic inflammation disease is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Pelvic inflammation disease (PID) is defined as condition caused by inflammation or infection of the female uterus, fallopian tubes, and/or ovaries as a result of scars and adhesion in the pelvic which in turn may prevent the implantation of egg during natural pregnancy process. It affects over 1 million women in U.S. every month and most of them are in their teen and twenties and over 100,000 women become infertile in the US alone each year.
Recent studies reported by some well known institution, green tea, may process the anti inflammatory diseases, including inhibition of pelvic inflammation disease (PID), as pelvic inflammatory disease is
associated to increased expressions of Th1 cytokine IFN-gamma, and Th2 cytokine IL-5, related to pro inflammatory pathways(2).

Recent studies back by renowned institution suggested, Green tea(1) and carrot, tomato(4) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression, recent studies suggested. According to The Catholic University of Korea, epigallocatechin-3-gallate attenuated the chronic inflammatory activities through educed the level of IFN-γ-induced priming signal in immune regulation via the down-regulation of pro-IL-1β and pro-capspase-1 in HEKn cell of proinflammatory cytokines(1).
Dr. and the colleagues at the Medical College of Ohio Ruppert proposed, theaflavins, amajor green constituent exhibited antioxidant, antineoplastic and antiinflammatory properties, including induction of IFNgamma mRNA of NF-kappaB for gene expression of pro - inflammatory pathway(3).Dr. Chen X, and professors Li W and Wang H.at the New York University School of Medicine, suggested that Green tea reduced endotoxin-induced release of (e.g., TNF, IL-1, and IFN-gamma) and (e.g., HMGB1) pro-inflammatory cytokines(4).

Avocado, a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae, is a commercially valuable fruit and cultivated in tropical climates throughout the world.

Omega-3 polyunsaturated fatty acids (PUFA) found abundantly in avocado may possess the most potent immunomodulatory activities, and among the omega-3 PUFA in reduced risk and treatment of inflammatory and auto immune diseases caused by the increased level of interleukin 1 (IL-1), a proinflammatory cytokine(5).
Dr. Calder PC. said, "n-3 PUFA can down regulate the activity of the nuclear transcription factor NFB" and "suppressed production of pro-inflammatory cytokines and can decrease adhesion molecule expression"(6).
According to Dr. Gouveia TL and research, omega 3 fatty acids plays an important role in activation of the immune system in the central nervous system in response to the release of pro inflammatory cytokines such as IL-1β, IL-6, and TNF-α(7) of which related to the occurance of pelvic inflammatory disease(2).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape may also expressed the inhibition of cytokines involved the progression of pelvic inflammation disease (PID), according to Dr. Inoue H and Dr. Nakata R. said, "Resveratrol is as a phytoalexin, cyclooxygenase (COX) suppressor, and an activator of peroxisome proliferatoractivated receptor (PPAR) and SIRT1."(8).According to the, resveratrol intake ameliorated, in a dose-dependent manner, pro-inflammatory cytokines IL-1β, TNF-α and IL-6 mRNA expression and promote the release of anti-inflammatory interleukin (IL)-10(9). of that related to reduced risk and treatment of inflammatory diseases.
In fact the effectiveness of resveratrol in reduced risk and treatment of chronic inflammatory diseases may be due to promotion of anti inflammatory and reduction of pro inflammatory properties(10).

The combination of Green Tea, Grape and Avocado smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Pelvic inflammation disease (PID) without inducing adverse effects.

Women who are at increased risk of Pelvic inflammation disease (PID), due to family history,... should drink at least one cup daily. Women with Pelvic inflammation disease (PID) should drink as much as they can depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Epigallocatechin-3-gallate attenuates the AIM2-induced secretion of IL-1β in human epidermal keratinocytes by Yun M1, Seo G1, Lee JY1, Chae GT1, Lee SB2.(PubMed)
(2) Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease by Chen KS1, Wang PH, Yang SF, Lin DB, Lin YJ, Kuo DY, Lin LY, Wu MT, Lin CW, Lee S, Chou MC, Tsai HT, Hsieh YS.(PubMed)
(3) Tea pigments inhibit the production of type 1 (T(H1)) and type 2 (T(H2)) helper T cell cytokines in CD4(+) T cells by Tomita M1, Irwin KI, Xie ZJ, Santoro TJ.(PubMed)
(4) More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines by Chen X1, Li W, Wang H.(PubMed)
(5) Omega-3 fatty acids in inflammation and autoimmune diseases by Simopoulos AP1.(PubMed)
(6) Dietary modification of inflammation with lipids by Calder PC1.(PubMed)
(7) High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process? by Gouveia TL1, Vieira de Sousa PV1, de Almeida SS2, Nejm MB1, Vieira de Brito JM1, Cysneiros RM3, de Brito MV4, Salu BR4, Oliva ML4, Scorza FA1, Naffah-Mazzacoratti Mda G5.(PubMed)
(8) Resveratrol Targets in Inflammation by Inoue H1, Nakata R.(PubMed)
(9) IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. by Cianciulli A1, Dragone T1, Calvello R1, Porro C2, Trotta T2, Lofrumento DD3, Panaro MA4.(PubMed)
(10) Resveratrol differentially modulates inflammatory responses of microglia and astrocytes by Lu X1, Ma L, Ruan L, Kong Y, Mou H, Zhang Z, Wang Z, Wang JM, Le Y.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis - The Diagnosis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

Diagnosis and tests
In the study to assess the practicability of a new algorithm in decreasing the rate of incorrect diagnoses and inappropriate antibiotic usage in pediatric Acute Respiratory Tract Infection (ARTI), by Shahid Beheshti University of Medical Sciences, indicated that upper Respiratory Tract Infection, Lower Respiratory Tract Infection, and undifferentiated ARTI accounted for 82%, 14.5%, and 3.5% of 1 209 cases, respectively. Antibiotics were prescribed in 33%; for: Common cold, 4.1%; Sinusitis, 85.7%; Otitis media, 96.9%; Pharyngotonsillitis, 63.3%; Croup, 6.5%; Bronchitis, 15.6%; Pertussis-like syndrome, 82.1%; Bronchitis, 4.1%; and Pneumonia, 50%. Implementation of the ARTIs algorithm is practicable and can help to reduce diagnostic errors and rate of antibiotic prescription in children with ARTIs(32). It is diffiucult in diffentiation between common cold and acute brochtitis in the early of the diseases. If your doctor suspected that you have brochitis, after recording the family history and a complete physical examination, the test which your doctor order may include
1. Chest X ray
The aim of the test is to exclude other conditions, such as bronchiectasis, which can mimic the disease clinically.
2. Sputum culture
The purpose of the test is to check for the presence of bacteria in sputum produced when you cough.
3. Pulmonary function test
In the study to evaluate the correlation of 6MWT and spirometric parameters in stable COPD with different severities. 6MWT data assessed included three variables: the 6-minute walk distance (6MWD), 6-minute walk work (6MWORK), and pulse oxygen desaturation rate (SPO(2)%), found that 6MWT correlated with the spirometric parameters in severe and very severe COPD patients. 6MWT may be used to monitor changes of pulmonary function in these patients(33).
Some studies suggested that Children with high pulmonary function would have lower risks on the development of bronchitis and asthma. The protective effect of high pulmonary function would be modified by traffic-related air pollution exposure(34).
According to the study by Dr. Albert RH. at the Hartford Hospital, Hartford,at in the differentiation of acute bronchitis, Cough is the most common symptom bringing patients to the primary care physician’s office, and acute bronchitis is usually the diagnosis in these patients. Acute bronchitis should be differentiated from other common diagnoses, such as pneumonia and asthma, because these conditions may need specific therapies not indicated for bronchitis. Symptoms of bronchitis typically last about three weeks. The presence or absence of colored (e.g., green) sputum does not reliably differentiate between bacterial and viral lower respiratory tract infections. Viruses are responsible for more than 90 percent of acute bronchitis infections(35).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(33) http://www.ncbi.nlm.nih.gov/pubmed/22932179
(34) http://www.ncbi.nlm.nih.gov/pubmed/21680243
(35) http://www.ncbi.nlm.nih.gov/pubmed/21121518

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis - The complications

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

The complications
1. Increased risk of early viral lower respiratory infections of the new born
There isan increased risk of hospitalisation for acute lower respiratory infection up to age 2 years in children delivered by elective caesarean section. In the study to examine the associations between the number of hospital admissions for bronchiolitis and pneumonia and elective caesarean delivery, showed that Delivery by elective caesarean was independently associated with infant admissions for bronchiolitis but not pneumonia. Elective caesareans or delivery without labour may result in impaired immunity in the newborn leading to increased risk of early viral lower respiratory infections(27).
2. Autoimmune rheumatic diseases
Patients suffering from autoimmune rheumatic diseases have significantly higher risk of developing various infections compared to the healthy population. In the study included patients suffering from systemic lupus erythematosus (n = 30), rheumatoid arthritis (n = 37) or Sjögren’s syndrome (n = 32), with stable underlying diseases status. In November 2010, 47 patients, including 35 subjects vaccinated annually during 2006-2010, found that the incidence of influenza or bacterial complications (bronchitis) among vaccinated patients was significantly lower, compared to the non-vaccinated group. Importantly, there was no case of exacerbation of the underlying disease. The last vaccination in 2010 reduced the risk of influenza by 87%, but previous bacterial infections (bronchitis and pneumonia) increased influenza risk significantly(28).
3. Asthma
In the study to investigate whether chronic bronchitis, asthma, or baseline methacholine airway responsiveness can explain the heterogeneity in lung function response to boilermaker work, showed that although chronic bronchitis and asthma were associated with a greater loss in lung function in response to hours worked as a boilermaker, and therefore they acted as effect modifiers of the exposure-lung function relationship, airway hyperresponsiveness did not. However, the high prevalence of airway hyperresponsiveness found in the cohort may be a primary consequence of long-term workplace exposure among boilermakers(29).
4. Bronchiectasis
According to the study of Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases by Rheumatology B Department, Cochin Hospital, Paris France, lower respiratory tract infectious events are frequent among patients receiving biologics for chronic inflammatory rheumatic disease associated with bronchiectasis. Biologic treatment and pre-existing sputum colonization are independent risk factors of infection occurrence(30).
5. Cystic fibrosis, airway hyperresponsiveness and neutrophilic bronchitis
There is a report of four patients with asthma, airway hyperresponsiveness and neutrophilic bronchitis who harboured abnormal cystic fibrosis transmembrance conductance regulator (CFTR) gene mutations. It serves both to alert clinicians to consider CFTR-related disease in both young and elderly patients with persistent neutrophilic bronchitis, and to highlight the potential utility of future genetic testing for CFTR abnormalities in patients with asthma and recurrent bronchitis or pansinusitis, and the role of nebulized hypertonic saline as a therapeutic option in these patients(31).
6. Recurrent haemoptysis
There is a report of an 8-year-old boy presented with recurrent chest pain and haemoptysis since 3 years of age. He had taken multiple courses of antitubercular treatment without any symptomatic relief. His chest x-ray showed opacity consistent with right sided lung collapse. Further detailed work-up including high-resolution CT scan of thorax, pulmonary angiogram and radionucleide study confirmed intrathoracic gastrogenic cyst(31a).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(27) http://www.ncbi.nlm.nih.gov/pubmed/22039179
(28) http://www.ncbi.nlm.nih.gov/pubmed/23221145
(29) http://www.ncbi.nlm.nih.gov/pubmed/12065377
(30) http://www.ncbi.nlm.nih.gov/pubmed/22046967
(31) http://www.ncbi.nlm.nih.gov/pubmed/22332135
(31a) http://www.ncbi.nlm.nih.gov/pubmed/23291818

The Fabulous Smoothie of Fermented Milk and Yogurt for Prevention and Treatment of Lactose Intolerance

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Lactose intolerance
Yield: 2 serving (about 8 ounce each)
3/4 cup fermented milk drink
1/2 cup yogurt
1 cup rice milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Lactose intolerance  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Lactose intolerance is a condition of the inability of the digestive system to digest lactose, a type of sugar found in milk and other dairy products. Chronic consumption of a probiotic may improve symptoms and decrease hydrogen production intake in lactose-intolerant patients, according to the State University of Campinas, Campinas(1).
Yogurt is a healthy foods produced by bacterial fermentation of milk. One of most common natural probiotic foods used to enhance function of digestive system may also be beneficiary for treatment of patients with Lactose intolerance. In the study of lactose intolerance in persistent diarrhoea during childhood, researchers at the The Aga Khan University suggested, a traditional rice-lentil (Khitchri) in combination of yogurt attenuated the 80% symptom of diarrhea in children with lactose intolerance(2).

Dr. Nizami SQ and professors at the Aga Khan University also said, " (the) cheap weaning diet made of locally available cereals and yogurt can be used effectively in management of secondary lactose intoleranceassociated with acute childhood diarrhoea"(3).

Furthermore, in a randomised, placebo-controlled, double-blind, 5-arm crossover study on 24 lactose malabsorbers with variable degrees of lactase deficiency, conducted by joint study lead by the Federal Research Centre for Nutrition and Food, confirmed "the combined administration of freeze-dried yogurt cultures and acid lactase increases lactose digestion more than either freeze-dried yogurt cultures or acid lactase alone, and more lactose malabsorbers may be benefits from this effect"(4).

Fermented milk  and fermented milk products, cultured dairy produced has been recommended to patient with lactose intolerance(5) as they are carriers of probiotics with function in improvement of digestive activity(6).
DR. Zhao XF and colleagues at the Chinese Center for Disease Control and Prevention said, "low lactose milks(fermented milk) and yogurt could reduce the LI incidence among LI children significantly"(7).

The finding of the effectiveness of fermented milk and yogurt may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Lactose intolerance.

People with Lactose intolerance should drink the juices as much as they can depending to digestive toleration.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References
(1) Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus casei Shirota and Bifidobacterium breve Yakult may persist after suspension of therapy in lactose-intolerant patients by Almeida CC1, Lorena SL, Pavan CR, Akasaka HM, Mesquita MA.(PubMed)
(2) Lactose intolerance in persistent diarrhoea during childhood: the role of a traditional rice-lentil (Khitchri) andyogurt diet in nutritional management by Bhutta ZA1, Nizami SQ, Isani Z.(PubMed)
(3) Efficacy of traditional rice-lentil-yogurt diet, lactose free milk protein-based formula and soy protein formula in management of secondary lactose intolerance with acute childhood diarrhoea by Nizami SQ1, Bhutta ZA, Molla AM.(PubMed)
(4) A combination of acid lactase from Aspergillus oryzae and yogurt bacteria improves lactose digestion in lactosemaldigesters synergistically: A randomized, controlled, double-blind cross-over trial by de Vrese M1, Laue C2, Offick B3, Soeth E4, Repenning F5, Thoß A5, Schrezenmeir J3.(PubMed)
(5) Fermented milks and milk products as functional foods--a review by Shiby VK1, Mishra HN.(PubMed)
(6) Probiotic bacteria in fermented foods: product characteristics and starter organisms by Heller KJ1.(PubMed)
(7) [The methods to reduce the prevalence of lactose intolerance in children].[Article in Chinese] by Zhao XF1, Pan LL, Meng J, Wang Y, Yin SA.(PubMed)

Most Common Diseases of elder: Lower respiratory tract infection (Respiratory Disease) – Bronchitis - Diseases associated with Bronchitis

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

                            Respiratory Disease 

Respiratory Disease is defined as medical conditions, affecting the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                     Lower respiratory tract infection

The lower respiratory tract infection are the infection consisting of the trachea (wind pipe), bronchial tubes, the bronchioles, and the lungs, including the bronchitis and pneumonia. According to The World Health Report 2004 – Changing History(1), in 2002 lower respiratory track infection were still the leading cause of deaths among all infectious diseases, and accounted for 3.9 million deaths worldwide and 6.9% of all deaths that year.

                             Bronchitis

Bronchitis is defined as a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma(7). Most cases of Bronchitis are as a result of recurrent injure to the airways caused by inhaled irritants and cigarette smoking(6). 

Diseases associated with Bronchitis
1. Diabetes mellitus
In the study of 311 patients with chronic occupational bronchitis associated with diabetes mellitus (or diabetes-free) revealed lipid metabolism disorders presenting with overweight, obesity, dyslipoproteinemia. Diabetes mellitus addition to chronic bronchitis increased frequency of lipid metabolism disorders and higher values of lipid state. The revealed lipid metabolism disorders were more marked in the females(23).
2. Upper Respiratory Tract Infection and Flu (Influenza)
In the study to examine the relationship between physician visit time and antibiotic prescribing for children with viral respiratory tract infection (RTI), found that in the 2739 visits from the NAMCS database, representing 119,926 visits nationally, met study criteria. Antibiotics were prescribed at 46,949 (39%) visits-75% with a diagnosis of bronchitis, 54% with bronchiolitis, and 30% with cold or URI. After adjusting for factors related to physician visit time, there was no difference in visit duration when antibiotics were or were not prescribed (13.6 +/- 8.4 and 13.3 +/- 9.6 minutes, respectively, P = 0.24)(24).
3. Lung cancer
In the study to clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, by conducting conducted a pooled analysis of studies in the International Lung Cancer Consortium, showed that a history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk(25).
4. Gastroesophageal Reflux Disease (GERD)
I According to the study in the evaluating the association between the frequency of acid reflux (AR) and weakly acid reflux (WAR) and specific respiratory symptoms (RS) in childhood, showed that a higher number of AR over WAR events was detected (p < 0.0001) but the WAR-to-AR events ratio progressively decreased with the age of the subjects (p < 0.01). Similar total number of reflux events was found in the three age group and in children with a more prevalent WAR or AR. The most prevalent RS, equally distributed among the three age groups, were persistent and/or nocturnal cough, wheezy bronchitis/asthma, and recurrent lower respiratory tract infections (RLRTI)(26).
5. Emphysema
Pulmonary emphysema, together with chronic bronchitis is a part of chronic obstructive pulmonary disease (COPD).
6. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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Sources
(1) http://www.who.int/whr/2004/en/
(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130746/
(7) http://www.lung.org/lung-disease/bronchitis-chronic/understanding-chronic-bronchitis.html
(23) http://www.ncbi.nlm.nih.gov/pubmed/23156061
(24) http://www.ncbi.nlm.nih.gov/pubmed/16713933
(25) http://www.ncbi.nlm.nih.gov/pubmed/22986146
(26) http://www.ncbi.nlm.nih.gov/pubmed/21334184

The Delicious Green Tea, Grape and Carrot smoothie for Reduced Risk and Treatment of Myeloma (Multiple Myenoma)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Myeloma (Multiple Myenoma)
Yield: 2 serving (about 8 ounce each)
1 1/4 cup grape
1/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of  myeloma is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Multiple myeloma (Myeloma) is a type of cancer originated from plasma cells in the bone marrow. It is a type of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.

The discovery of ingredients including green tea, may hold an interest key in establishment of a natural formula for reduced risk and treatment of myeonoma, according to the recent reports by some respectable institutions.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. Its polyphenol epigallocatechin-3-O-gallate (EGCG), inhibited the early onset and progression of myenoma through activation of antibody gene death-associated protein kinase 1 and in regulating normal cellular processes of RTK phosphorylation(1) as well as in promoting regulation of tumor expression of p53-targeting miRNAs in gene expression(2).

Dr. Ren L and research team at the Chonnam National University said," In IM9 multiple myeloma cells, EGCG acted in a dose- and time-dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin V (PrdxV) were selectively and significantly reduced by EGCG."(3).

Resveratrol, polyphenols found abundantly in grape, which is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey, is a phytochemical in the class of Stilbenoids also exhibited anti Myeloma effects(4). According ot he University of Pittsburgh, resveratrol exerts its chemotherapeutic effect on human MM cells through mechanisms involving suppression of of the pro-survival XBP1 signaling in cancer progression(4).

According to CellGen SA. resveratrol (trans-3,4',5-trihydoxystilbene) expessed stronger the antiproliferative and proapoptotic effects against myeloid cell lines through sell cycle pase I and II arrest in comparison with two of its naturally occurring oligomers, epsilon-viniferin (a dimer) and miyabenol C (a trimer)(5).

Dr. Sun CY and the research team at the Huazhong University of Science and Technology, said, " Resveratrol inhibits the proliferation of MM cells by inducing apoptotic cell death. Resveratrol also inhibits MM cell invasion. The inhibition of invasion may be associated with the attenuation of the enzymatic activities of MMP-2 and -9"(6).

Retinoic acid, a metabolite of vitamin A (retinol) found in a measure amount in carrot may also be a potential ingredient in prevention and treatment of Myeloma (Multiple Myenoma). According to the Turku University Central Hospital, all-trans retinoic acid (ATRA) is a derivative of vitamin A. inhibited the growth of human myeloma cell lines through down-regulating pro inflammatory( interleukin-6) receptor(7) and upregulation of CD38 expression, including cell adhesion, signal transduction and calcium signaling(8).

The combination of Green Tea, Grape and Carrot smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Myeloma (Multiple Myenoma) without inducing adverse effects.

People who are at higher risk of  Myeloma (Multiple Myenoma)  due to family history,.......should take at least one serving daily. People with Myeloma (Multiple Myenoma)r should drink as much as they can depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs by Tsukamoto S1, Huang Y1, Kumazoe M1, Lesnick C2, Yamada S1, Ueda N1, Suzuki T1, Yamashita S1, Kim YH1, Fujimura Y3, Miura D3, Kay NE2, Shanafelt TD2,Tachibana H4.(PubMed)
(2) Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology ofmultiple myeloma by Gordon MW1, Yan F2, Zhong X3, Mazumder PB4, Xu-Monette ZY5, Zou D5, Young KH5, Ramos KS1, Li Y1.(PubMed)
(3) The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death by Ren L1, Yang HY, Choi HI, Chung KJ, Yang U, Lee IK, Kim HJ, Lee DS, Park BJ, Lee TH.(PubMed)
(4) Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells by Wang FM1, Galson DL, Roodman GD, Ouyang H.(PubMed)
(5) Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: comparison with resveratrol by Barjot C1, Tournaire M, Castagnino C, Vigor C, Vercauteren J, Rossi JF.(PubMed)
(6) Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity by Sun CY1, Hu Y, Guo T, Wang HF, Zhang XP, He WJ, Tan H.(PubMed)
(7) Treatment of multiple myeloma with all-trans retinoic acid alone and in combination with chemotherapy: a phase I/II trial. by Koskela K1, Pelliniemi TT, Pulkki K, Remes K.(PubMed)
(8) Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab by Nijhof IS1,2,3, Groen RW1,4, Lokhorst HM1,3, van Kessel B1, Bloem AC5, van Velzen J5, de Jong-Korlaar R1, Yuan H6, Noort WA1, Klein SK7, Martens AC1,4,Doshi P8, Sasser K8, Mutis T1,2, van de Donk NW1.(PubMed)