Thursday, February 25, 2016

The Fabulous Smoothie of Green Tea, Cranberry and Carrot for Reduced Risk and Treatment of Pharynx (Throat) Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Pharynx (Throat) Cancer
Yield: 2 serving (about 8 ounce each)
1 gram of formula RRF(you cam buy them in any Chinese herbal store)
1 1/4  cup cranberry
1/4 cup of carrot
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced symptoms and treatment of Perimenopause  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potentials in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients of green tea(1) for reduced risk and treatment of Pharynx (Throat) Cancer.

Pharynx cvancer is the irregual cell growth in the curve area of the back of the mouth, located between esophagus and trachea connecting the nasal and oral cavities to the larynx. In the United States in 2010 alone, according to National cancer Institute, there were 12,660 new cases of pharyngeal cancer, resulting in deaths of 2,410 patients.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. According to Dr, Tian M and colleagues, green tea polyphenol significantly inhibited cell proliferation, induced cell apoptosis and decreased the migration and invasion ability of NPC cells in vitro(1).
In the study of nasopharyngeal carcinoma(NPC) cells HONE1 and CNE2, green tea also expressed anti proliferation activity through suppression of the growth of xenografts(2).
In the review of literature from data bases before January 2014 in MEDLINE and EMBASE, tea intake is associated to decrease risk of Pharynx Cancer with no evidence of publication bias.according to the Begg's funnel plot and the Egger's test(3).
The National Yang-Ming University study suggested, epigallocathechin gallate (EGCG), the major polyphenol in green tea inhibited sphere formation, eliminated the stem-like properties against nasopharyngeal carcinoma (NPC) through attenuaAT3 activation of cellular processes such as cell growth and apoptosis(4).

Cranberry is a species of Vaccinium oxycoccos, belong to the family Ericaceae found in the cooler part of Northern America. According to the Medical College of Wisconsin, phytochemicals found in cranberry inhibited esophageal adenocarcinoma in vitro assay and in vivo models(5).
Resveratrol, another major constituent found in cransberry, also inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation of cellular energy homeostasis(6) and activate caspase-3 in cell death and alter the Bax/Bcl-2 apoptotic signaling(6).
In  nude mice, resveratrol induced more sensitive of on human hypopharyngeal carcinoma to radiation therapy(7). Combination of radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64%, according to the joint study lead by the First Affiliated of Xi'an Jiao Tong University(7).

Retinoic acid, a metabolite of vitamin A (retinol) found in a measure amount in carrot may also be a potential ingredient in prevention and treatment of Pharynx Cancer. According to the Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, all-trans-retinoic acid-induced growth inhibition and differentiation in nasopharyngeal cancercells through suppression nasopharyngeal carcinoma (NPC) tumor formation by Human SPLUNC1 in expression in the upper airways and nasopharyngeal regions(8). In fact, plasma antioxidant vitamins like vitamin A were lower in oral cavity and oropharyngeal cancer patients than healthy controls, Dr. Marakala V and colleagues said(9).Use conjunction with cisplatin, all-trans retinoid acid (ATRA), the combination significantly inhibited the growth of both cell lines of (NPC-TW01 and NPC-TW04)(10).

The combination of Green Tea, Cranberry and Carrot smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Pharynx Cancer without inducing adverse effects.

People who are at higher risk of  Pharynx Cancer due to family history,.......should take at least one serving daily. People with Pharynx Cancer should drink as much as they can depending to the digestive toleration.

(1) [Tumor suppressive effect and relative mechanisms of tea polyphenol on nasopharyngeal carcinoma cells].[Article in Chinese] by Tian M, Yuan D, Zheng S, Li Q, Shi S, Xu Z.(PubMed)
(2) [The effects of tea polyphenols and Laminaria japonica polysaccharides on nasopharyngeal carcinoma cell HONE1 and CNE2].[Article in Chinese]by Sun W1, Wei Y, Zeng M, Zheng S, Xu Z.(PubMed)
(3) Tea intake and risk of oral, pharyngeal, and laryngeal carcinoma: a meta-analysis by Zhang W1, Geng T2, Han W1, Dou H3.(PubMed)
(4) EGCG inhibits the growth and tumorigenicity of nasopharyngeal tumor-initiating cells through attenuation of STAT3 activation by Lin CH1, Chao LK2, Hung PH3, Chen YJ4.(PubMed)
(5) Upper esophageal and pharyngeal cancers by Bock JM1, Howell AB, Johnston N, Kresty LA, Lew D.(PubMed)
(6) Resveratrol inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation by Cai Y, Zhao L, Qin Y, Zhang M, He Y.(PubMed)
(7) [Resveratrol enhances radiosensitivity of human hypopharyngeal carcinoma cell line in nude mice].[Article in Chinese] by Quan F1, Zhao Q, Shao Y, Li H, Zhao R.(PubMed)
(8) SPLUNC1 is associated with nasopharyngeal carcinoma prognosis and plays an important role in all-trans-retinoic acid-induced growth inhibition and differentiation in nasopharyngeal cancercells by Zhang W1, Zeng Z, Wei F, Chen P, Schmitt DC, Fan S, Guo X, Liang F, Shi L, Liu Z, Zhang Z, Xiang B, Zhou M, Huang D, Tang K, Li X,Xiong W, Tan M, Li G, Li X.(PubMed)
(9) Lipid peroxidation and antioxidant vitamin status in oral cavity and oropharyngeal cancerpatients. by Marakala V1, Malathi M, Shivashankara AR.(PubMed)
(10) Effect of all-trans retinoic acid on the growth of two nasopharyngeal cancer cell lines and its treatment potential in combination with cisplatin. by Hung SH1, Lee FP, Su CH, Tseng H.(PubMed)

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