Friday, February 26, 2016

The Delicious Green Tea, Grape and Carrot smoothie for Reduced Risk and Treatment of Myeloma (Multiple Myenoma)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Myeloma (Multiple Myenoma)
Yield: 2 serving (about 8 ounce each)
1 1/4 cup grape
1/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of  myeloma is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Multiple myeloma (Myeloma) is a type of cancer originated from plasma cells in the bone marrow. It is a type of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.
The discovery of ingredients including green tea, may hold an interest key in establishment of a natural formula for reduced risk and treatment of myeonoma, according to the recent reports by some respectable institutions.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. Its polyphenol epigallocatechin-3-O-gallate (EGCG), inhibited the early onset and progression of myenoma through activation of antibody gene death-associated protein kinase 1 and in regulating normal cellular processes of RTK phosphorylation(1) as well as in promoting regulation of tumor expression of p53-targeting miRNAs in gene expression(2).
Dr. Ren L and research team at the Chonnam National University said," In IM9 multiple myeloma cells, EGCG acted in a dose- and time-dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin V (PrdxV) were selectively and significantly reduced by EGCG."(3).

Resveratrol, polyphenols found abundantly in grape, which is a woody vines of the genus Vitis, belongings to the family Vitaceae, native to southern Turkey, is a phytochemical in the class of Stilbenoids also exhibited anti Myeloma effects(4). According ot he University of Pittsburgh, resveratrol exerts its chemotherapeutic effect on human MM cells through mechanisms involving suppression of of the pro-survival XBP1 signaling in cancer progression(4).
According to CellGen SA. resveratrol (trans-3,4',5-trihydoxystilbene) expessed stronger the antiproliferative and proapoptotic effects against myeloid cell lines through sell cycle pase I and II arrest in comparison with two of its naturally occurring oligomers, epsilon-viniferin (a dimer) and miyabenol C (a trimer)(5).

Dr. Sun CY and the research team at the Huazhong University of Science and Technology, said, " Resveratrol inhibits the proliferation of MM cells by inducing apoptotic cell death. Resveratrol also inhibits MM cell invasion. The inhibition of invasion may be associated with the attenuation of the enzymatic activities of MMP-2 and -9"(6).

Retinoic acid, a metabolite of vitamin A (retinol) found in a measure amount in carrot may also be a potential ingredient in prevention and treatment of Myeloma (Multiple Myenoma). According to the Turku University Central Hospital, all-trans retinoic acid (ATRA) is a derivative of vitamin A. inhibited the growth of human myeloma cell lines through down-regulating pro inflammatory( interleukin-6) receptor(7) and upregulation of CD38 expression, including cell adhesion, signal transduction and calcium signaling(8).

The combination of Green Tea, Grape and Carrot smoothie may hold a key in further studies in production of an effective natural ingredients for prevention and treatment of Myeloma (Multiple Myenoma) without inducing adverse effects.

People who are at higher risk of  Myeloma (Multiple Myenoma)  due to family history,.......should take at least one serving daily. People with Myeloma (Multiple Myenoma)r should drink as much as they can depending to the digestive toleration.

(1) Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs by Tsukamoto S1, Huang Y1, Kumazoe M1, Lesnick C2, Yamada S1, Ueda N1, Suzuki T1, Yamashita S1, Kim YH1, Fujimura Y3, Miura D3, Kay NE2, Shanafelt TD2,Tachibana H4.(PubMed)
(2) Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology ofmultiple myeloma by Gordon MW1, Yan F2, Zhong X3, Mazumder PB4, Xu-Monette ZY5, Zou D5, Young KH5, Ramos KS1, Li Y1.(PubMed)
(3) The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death by Ren L1, Yang HY, Choi HI, Chung KJ, Yang U, Lee IK, Kim HJ, Lee DS, Park BJ, Lee TH.(PubMed)
(4) Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells by Wang FM1, Galson DL, Roodman GD, Ouyang H.(PubMed)
(5) Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: comparison with resveratrol by Barjot C1, Tournaire M, Castagnino C, Vigor C, Vercauteren J, Rossi JF.(PubMed)
(6) Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity by Sun CY1, Hu Y, Guo T, Wang HF, Zhang XP, He WJ, Tan H.(PubMed)
(7) Treatment of multiple myeloma with all-trans retinoic acid alone and in combination with chemotherapy: a phase I/II trial. by Koskela K1, Pelliniemi TT, Pulkki K, Remes K.(PubMed)
(8) Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab by Nijhof IS1,2,3, Groen RW1,4, Lokhorst HM1,3, van Kessel B1, Bloem AC5, van Velzen J5, de Jong-Korlaar R1, Yuan H6, Noort WA1, Klein SK7, Martens AC1,4,Doshi P8, Sasser K8, Mutis T1,2, van de Donk NW1.(PubMed)

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