Wednesday, February 17, 2016

The smoothie Green Tea, Turmeric and Grape for reduced risk and treatment of Hodgkin's Lymphoma Back By Clinical Trials and Studies

Kyle J. Norton(Scholar, Master of Nutrients) All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Hodgkin's Lymphoma
Yield: 2 serving (about 8 ounce each)
1 1/2 cups grape
1/2 tsp curcumin
1 cup green tea drink (Make from 4 grams of green tea, a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The identification of the natural ingredients for treatment of Hodgkin's Lymphoma  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Recent studies back by well known institution suggested that the naturally potential ingredients green tea, Grape and Asparagus may be effective for reduced risk and treatment for Hodgkin's Lymphoma,

Hodgkin's Lymphoma, a type of lymphoma is also known as Hodgkin's Disease started from the lymph nodes in the chest, armpits and neck. It was named under Thomas Hodgkin, for first to describe the abnormalities of the lymph system in 1832. Hodgkin's lyphoma, is invasive and tends to spread orderly from one lymph node group to another. It is not a common disease with approximately 800 and 7000 of new cases reported every year in Canada and US accordingly and mostly occurs to young adults and after the age of 45.

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape and red wine may be a potential ingredient for risk reduction and treatment of Hodgkin's Lymphoma, through inhibited the metabolic activation of carcinogens, upregulated antioxidant and anti-inflammatory properties, decreased cell proliferation and induced apoptosis(1).
Dr. Frazzi R and colleagues at the Oncology Department, IRCCS - Arcispedale S. Maria Nuova, Reggio Emilia, Italy, the phytochemical also induced cell death in Hodgkin lymphoma (HL)-derived L-428 cells in a dose-dependent manner, through upregulating anti body and down regulating the inflammatory pathways(2).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. its phytochemical, Epigallocatechin-3-gallate (EGCG), a phytochemicals found abundantly in green tea has enhanced the protective effects against Lymphoma(3).
Dr. Renno WM and research team at the Kuwait University, also suggested, (-)-epigallocatechin-3-gallate (EGCG) inhibited Hodgkin's Lymphoma through reduced the expression of gene of glial fibrillary acidic protein of CNS and increased the expression of growth-associated protein 43, a marker of regenerating axons(4).
Saponin and phenolic compounds from green tea expressed immunomodulatory effect of tea saponin against Hodgkin lymphoma (HL) through regulation of cytokine response and mitogen-activated protein kinases (MAPK) signaling inflammatory pathway(5).

Turmeric, a principal curcuminoid of the popular Indian spice, a rhizomatousherbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia. Its chemical compound, curcumin, also process the potential effect against Hodgkin's Lymphoma through expression of down regulation of various inflammatory cytokine and related pathways(6).
Dr. Qiao Q and colleagues at the he First Hospital of China Medical University also said, curcumin inhibited constitutive and radiation-induced expression of the (Cell cycle) PI3K/AKT pathway and its downstream regulator nuclear factor kappaB (NF-κB)(Pro inflammatory pathways) in human Burkitt's lymphoma, a high-grade non-Hodgkin's lymphoma (NHL)(7)and gene expression of STAT3 in Chronic lymphocytic leukemia B cells in regulating the pro inflammatory pathways(8).

The identification of ingredient of Green Tea, Turmeric and Grape may serve as a foundation for establish a potential and natural source for reduced early onset and treatment of Hodgkin's Lymphoma in sometime in the future.
People who are at increased risk of Hodgkin's Lymphoma due to family history and aging should drink at least 2 servings a day and people with Hodgkin's Lymphoma should drink as much as they can, depending to the digestive toleration. Change of life style and dietary pattern are recommended.

(1) Wine and resveratrol: mechanisms of cancer prevention? by Bianchini F1, Vainio H.(PubMed)
(2) Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation by Frazzi R1, Valli R, Tamagnini I, Casali B, Latruffe N, Merli F.(PubMed)
(3) [Demethylation and transcription of p16 gene in malignant lymphoma cell line CA46 induced by EGCG].[Article in Chinese] by Yu AF1, Shen JZ, Chen ZZ, Fan LP, Lin FA.(PubMed)
(4) (-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Rao MS, Khraishah H.(PubMed)
(5) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(6) Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells by Mackenzie GG1, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI.(PubMed)
(7) Inhibition of the PI3K/AKT-NF-κB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma by Qiao Q1, Jiang Y, Li G.(PubMed)
(8) Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells by Mackenzie GG1, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI.(PubMed)

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