Friday, February 19, 2016

The smoothie Green Tea, Legume and Grape for reduced risk and treatment of Non Hodgkin's Lymphoma Back By Clinical Trials and Studies

Kyle J. Norton(Scholar, Master of Nutrients) All right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of Non Hodgkin's Lymphoma
Yield: 2 servings (about 8 ounce each)
1 cups grape
1/2 cup cauliflower
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The identification of the natural ingredients for treatment of Non Hodgkin's Lymphoma  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Non-Hodgkin's lymphoma is cancer originated from white blood cells in the lymphatic system with incidence increased more than 70% in last 25 years.

Recent studies back by well known institutions suggested that the naturally potential ingredients green tea, Grape and Legume may be effective for reduced risk and treatment for Non Hodgkin's Lymphoma.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.According to the IRCCS European Institute of Oncology, green tea consumption may prevent or delay the growth of non-Hodgkin's lymphoma through induced atoposis of human non-Hodgkin's lymphoma (NHL) cell lines, RAP1-EIO and HS-Sultan tumor growth(1).
In dietary factors and non-Hodgkin's lymphoma, conducted by the College of Medicine Mayo Clinic,, green tea consumption is associated to reduced risk of the disease(2).

Isoflavones, found abundantly in legume, in a 110,215 eligible members of the California Teachers Study cohort study, dietary intake of isoflavones, may be associated to reduced risk of non-Hodgkin's lymphoma(3)
Genistein, another isoflavones found in legume and soy also exhibited anti non-Hodgkin's lymphoma effects, through induced apoptosis against the GL-1 and 17-71 cell lines(4).
Dr. Park SS and the research team at the Seoul National University College of Medicine said, "Inhibition of the Akt signaling pathway and induction of apoptosis by genistein could be used as a new treatment modality for the prevention and/or treatment of t(2;5) ALCL and other hematopoietic malignancies"(5).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly grape also expressed anti
non Hodgkin's Lymphoma effects through attenuateing doxorubicin-induced cardiomyocyte apoptosis in lymphoma in animal model(6).
According to the King Faisal Specialist Hospital and Research Center study, resveratrol suppressed AKT/PKB pathway in regulating the cell cycle induced cancer cell apoptosis in in diffuse large B cell lymphoma cell lines(DLBCL) through induction  generation of ROS(7).
Furthermore, in anaplastic large-cell lymphoma cell line SR-786. resveratrol triggered cellular apoptosis through elevated expression of T cell differentiation markers CD2, CD3, and CD8(8).

The identification of ingredient of Green Tea, legume and Grape may serve as a foundation for establish a potential and natural source for reduced risk of early onset and treatment of non-Hodgkin's lymphoma sometimes in the future.
People who are at increased risk of non-Hodgkin's lymphoma due to family history and aging should drink at least 2 servings a day and people with non-Hodgkin's lymphoma(3) should drink as much as they can, depending to the digestive toleration. Change of life style and dietary pattern are recommended.

(1) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)
(2) Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health Study by Thompson CA1, Habermann TM, Wang AH, Vierkant RA, Folsom AR, Ross JA, Cerhan JR.(PubMed)
(3) Dietary phytocompounds and risk of lymphoid malignancies in the California Teachers Study cohort by Chang ET1, Canchola AJ, Clarke CA, Lu Y, West DW, Bernstein L, Wang SS, Horn-Ross PL.(PubMed)
(4) Soy-derived isoflavones inhibit the growth of canine lymphoid cell lines by Jamadar-Shroff V1, Papich MG, Suter SE.(PubMed)
(5) Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma by Park SS1, Kim YN, Jeon YK, Kim YA, Kim JE, Kim H, Kim CW.(PubMed)
(6) Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude mice by heme oxygenase-1 induction by Gu J1, Song ZP, Gui DM, Hu W, Chen YG, Zhang DD.(PubMed)
(7) Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines by Hussain AR1, Uddin S, Bu R, Khan OS, Ahmed SO, Ahmed M, Al-Kuraya KS.(PubMed)
(8) Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells by Ko YC1, Chang CL, Chien HF, Wu CH, Lin LI.(PubMed)

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