The Delicious Smoothie of Green Tea, Aloe Vera juice and Grape for Prevention and Treatment of Pyoderma gangrenosum

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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The smoothie for prevention and treatment of Pyoderma gangrenosum
Yield: 2 servings (about 8 ounces each)
1 cup grape
1 1/2 cups grape
1/2 cup Aloe Vera juice
1/2 cup green tea drink (Make from 2 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  pyoderma gangrenosum has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Pyoderma gangrenosum, a rare inflammatory skin disorder causes death of the skin tissues induced the development of large, painful sores (ulcers) to your skin, most often on your legs.

According to the University of Louisville, licorice, green tea, pomegranate, turmeric may be sued for treatment of pyoderma gangrenosum, due to its powerful anti inflammatory effect(1).

Dr. Wu J said, "active ingredients, anti-inflammatory properties, clinical effects, and therapeutic potential(rosacea, atopic dermatitis, sensitive and irritated skin, drug-induced skin eruptions, and psoriasis) of colloidal oatmeal, feverfew, licorice, aloe vera, chamomile, and turmeric"(2).

Recent studies by some renowned institutions suggested that green tea(3), Aloe Vera juice(7) and grape(5) may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of pyoderma gangrenosum.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. 

Green tea epigallocatechin gallate (EGCG), a flavonoid belongings to catechins exhibited potent antioxidant and anti-inflammatory diseases, including Pyoderma gangrenosum(1), according to the joint study lead by Federal University of Mato Grosso (UFMT).

Pu-erh tea, made from the leaves of Camellia sinensis, also possessed activities beneficial for human health, including anti-inflammatory, anti-oxidant, and anti-obesity properties, suggested by Dr. Cai X and colleagues(4).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape also exhibited anti inflammatory effect against pro inflammatory cytokines(5). According to the investigated the effect of resveratrol on skin lesion, in an atopic dermatitis (AD) mouse model, showed that the phytochemical inhibited the prto inflammatory pathways against skin diseases through modulating the HMGB1 protein expression, a cytokine mediator of inflammation(6).

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. According to the University of Pretoria, the herb has been used in treatment of skin disorders, through ts moisturizing and anti-inflammatory effects in modulating the IgE levels of mouse model of atopic dermatitis (AD)(7).

Dr. Benson KF and colleagues in the Aloe vera-based extract of Nerium oleander leaves against skin diseases, said, "NAE-8(®), a novel component of a commercial cosmetic product, showed beneficial antioxidant protection in several cellular models, without the induction of leukocyte activation and secretion of inflammatory cytokines"(8).

Taking altogether, The combination of Green Tea, Aloe Vera juice and Grape may offer the potential effect not only in prevention of the onset and treatment of Pyoderma gangrenosum
 People who are at increased risk of Pyoderma gangrenosum are wise to drink at least one serving daily. People with  Pyoderma gangrenosum, should drink the juice as much as they can, depending to the toleration of digestive system.

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References

(1) Innovations in natural ingredients and their use in skin care by Fowler JF Jr1, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)

(2) Anti-inflammatory ingredients by Wu J1.(PubMed)
(3) Epigallocatechin gallate and mitochondria-A story of life and death by Oliveira MR1, Nabavi SF2, Daglia M3, Rastrelli L4, Nabavi SM2.(PubMed)
(4) Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice by Cai X1,2,3, Fang C2,4, Hayashi S2,3, Hao S5, Zhao M6, Tsutsui H2,3, Nishiguchi S7, Sheng J8.(PubMed)
(5) One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease by Tomé-Carneiro J1, Larrosa M, Yáñez-Gascón MJ, Dávalos A, Gil-Zamorano J, Gonzálvez M, García-Almagro FJ, Ruiz Ros JA, Tomás-Barberán FA, Espín JC, García-Conesa MT.(PubMed)
(6) Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice by Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M, Miyashita S,Suzuki K, Watanabe K.(PubMed)
(7) A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice by Finberg MJ1, Muntingh GL1, van Rensburg CE2.(PubMed)
(8) Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8(®)) by Benson KF1, Newman RA2, Jensen GS1.(PubMed)