Andrographis paniculata, the forgotten herbal medicine may have a potential effect in delay skin aging, however, its therapeutic properties have rarely been applied in the field of skincare.
Skin aging, a natural biological process caused by thinning of the layer just underneath the skin can not be prevented but delayed
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
According to of the joint study lead by the Biospectrum Life Science Institute, in vitro, ex vivo, and in vivo, Andrographis paniculata extract (APE) exhibited a significant anti-aging activity through ameliorating the process of loss of human epidermal stem cells (EpSCs).
Truly, the epidermal stem cells (EpSCs). treated with Andrographis paniculata extract (APE) exerted an anti-aging effect by increased cell quantity significantly in the G2/M and S stages in cell division in a dose-dependent manner.
The study also found that APE-treated EpSCs enhanced Type 1 collagen production in normal human fibroblasts (NHFs). and improved skin hydration, dermal density, wrinkling, and sagging significantly.
In UV-Induced Skin, Photoaging Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide increased the function of antioxidants in attenuated oxidative stress and inflammation responsible for ultraviolet (UV) irradiation causing skin damage and premature aging.
Dr. the lead author in the study of ultraviolet (UV) induced skin aging said, "topical administration of ASB suppressed the UV-induced skin thickness, elasticity, wrinkles, and water content, while ASB, especially at dose of 3.6 mg/mouse, increased the skin collagen content by about 53.17%, decreased the epidermal thickness by about 41.38%, and prevented the UV-induced disruption of collagen fibers and elastic fibers"
Furthermore, the study also proposed, the anti-aging effect of the herbal Andrographis may be attributed to anti enzymes in inhibited free radicals induced by oxidative stress and reduced the expression of pro-inflammatory cytokines.
Taking together, Andrographis paniculata expressed significantly anti-skin aging effects through various mechanisms, but the intake of the large amounts should be taken with care.
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Sources
(1) The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness by You J1, Roh KB2, Li Z3, Liu G4, Tang J5, Shin S6, Park D7, Jung E8.(PubMed)
(2) Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation by Janis Ya-Xian Zhan,1 Xiu-Fen Wang,1 Yu-Hong Liu,1 Zhen-Biao Zhang,1 Lan Wang,2 Jian-Nan Chen,1 Song Huang,1 Hui-Fang Zeng,2 and Xiao-Ping Lai1(Hindawi)
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