Andrographis, The Best Whole Herb Medicine for Treatment of Ulcerative Colitis

Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

In a randomized, double-blind, placebo-controlled trial in evaluating the efficacy of A. paniculata extract (HMPL-004) in 224 adults with mild-to-moderate ulcerative colitis. with patients randomized to A. paniculata extract (HMPL-004) 1,200 mg or 1,800 mg daily or placebo for 8 weeks, patients treated with A. paniculata extract (HMPL-004) at a dose of 1,800 mg daily achieve clinical response than those receiving placebo.

The study also discovered that 60 and 53% of patients treated with A. paniculata groups experienced adverse effects at doses of 1,200 mg and 1,800 mg daily respectively in comparison to 60% in the placebo group.

Dr. Sandborn WJ, the lead author in the study said, "Andrographis paniculata has in vitro inhibitory activity against TNF-α, IL-1β, and NF-κB. A pilot study of A. paniculata extract (HMPL-004) suggested similar efficacy to mesalamine for ulcerative colitis."



Other study involved herbal extract HMPL-004 also support the use of herbal extract for treatment in patients with mild-to-moderate ulcerative colitis, according to the randomized, double-blind, multicentre, 8-week parallel-group study conducted using HMPL-004 with 1200 mg/day in compared with 4500 mg/day of slow-release mesalazine (mesalamine) granules in the same group.

In fact, in comparison to mesalazine, HMPL-004 exhibited a 21% and 76% of more efficacy in treated patients, compared to 16% and 82% of mesalazine-treated patients through the colonoscopy, remission, and response.

Although HMPL-004 may be an efficacious alternative to mesalazine in treating ulcerative colitis, the herbal medicine can only be prescribed by herbalists to prevent overdose toxicity.


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Sources
(1) Andrographis paniculata extract (HMPL-004) for active ulcerative colitis by Sandborn WJ1, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T.(PubMed)
(2) Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine by Tang T1, Targan SR, Li ZS, Xu C, Byers VS, Sandborn WJ.(PubMed)