Andrographis paniculata showed to improve the gastric tone and prevent gastric dysfunction through the protection of its antioxidants, the renowned institute suggested.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
The gastroprotective effect is a condition involved that enhances the function of the digestive system against the harmful organisms in induced chronic indigestion.
In the study of gastric ulcer induced by ethanol, aspirin, pylorus ligation, and cold restraint stress models, rats treated with rats pretreated with HAEAP (100,200,500mg/kg b. wt for 30 days) of Andrographis paniculata expressed a significant ulcer reduction, in a dose-dependent manner, according to the Bharathi Women's College.
Dr. Panneerselvam S, the lead author said, "The ulcer preventing effect of HAEAP may partly be due to its regulating effect on H(+)K(+)ATPase activity and /or mucin preserving effects" and "The flavonoids present in the HAEAP might be responsible for the gastroprotective action probably by maintaining the antioxidants and thiol status in the gastrointestinal tract".
In support of the above differentiation, the review of a period of 1 year from 2014-2015, using semi-structured questionnaires from different traditional Bengali people having knowledge on medicinal plants, out of 49 plants under 46 genera belonging to 33 families, Andrographis paniculata is one of the most prominent plants used among the people of Southern Assam for treating digestive system disorders (DSD).
Furthermore, seed ethyl acetate, acetone and methanol extracts of Andrographis paniculata (Burm.f.) Wall. ex Nees has drawn a lot of scientists' attention due to the limit success of chemical anthelmintics, a group of antiparasitic drugs (levamisole, flubendazole, and thiabendazole) in reduced gastrointestinal diseases.
In animal controls, ED(50), an ethanol extract of A. paniculata at a dose of 2.90 mg/ml, and in larval development assay at ED(50) of dose 4.26 mg/ml, showed significant effects against sheep parasite, Haemonchus contortus.
Taking together, there is no doubt that Andrographis paniculata consisted of a strong gastroprotective effect against the activities of harmful organisms, including parasites and may be used as a functional food in improving digestive functions.
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Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) A biochemical study on the gastroprotective effect of hydroalcoholic extract ofAndrographis paniculata in rats by Panneerselvam S, Arumugam G(PubMed).
(2) Plant utilization against digestive system disorder in Southern Assam, India by Choudhury PR1, Choudhury MD1, Ningthoujam SS2, Mitra A1, Nath D3, Talukdar AD4.(PubMed)
(3) Anthelmintic activity of botanical extracts against sheep gastrointestinalnematodes, Haemonchus contortus by Kamaraj C1, Rahuman AA, Elango G, Bagavan A, Zahir AA.(PubMed)
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