Arnica may have a positive and therapeutic effect in reduced risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue.
According to general belief, 1 in 8 women will be diagnosed with breast cancer during her lifetime.
The causes of the breast are unknown. Researchers do not know why some women are susceptible to DNA alternated in healthy breast tissue while others do not. Truly, many women who have risk factors never develop breast cancer.
Some researchers suggested that family history, early puberty and late onset of menopause, having high breast density, excessive alcohol drinking,.... and aging are associated to increase the risk of breast cancer
Furthermore, women who have inherited the gene mutation from the parent, have previous cancer,..and have taken certain medications such as diethylstilbestrol (DES) are also associated with risk of the disease.
Today modern technology is developed to detect breast cancer in an early stage, but self-examination is still one of the best methods to catch cancer before they can become invasive.
The survival rates of breast cancer have also increased, and the number of deaths associated is steadily decreasing, largely due to factors that women are more aware of the early onset of the disease.
If you experience of some symptoms such as breast lump, nipple changes, breast change in the size, shape, inverted nipple, breast skin peeling, scaling, flaking of the pigmented area of skin surrounding the nipple, please check with your doctor to rule out the possibility
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia. The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.
According to the evaluation of cytotoxic chemotherapeutic agents with efficacy without inducing adverse effects from major compounds extracted from Arnica helenalin and to exam whether the compound activity was maximized by encapsulation in β-cyclodextrin nanoparticle, application of β-cyclodextrin nanoparticle alone exerted a significantly inhibitory property against breast cancer cells.
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide comprising seven D-glucopyranoside units, linked through 1,4-glycosidic bonds.
Interestingly, when helenalin was encapsulation in β-cyclodextrin nanoparticle, the combination demonstrated a significant effect in the induction of breast cancer cell cytotoxicity in compared to administration of helenalin alone.
These results suggested that certain compounds in β-cyclodextrin may have potential in stimulated and enhanced the helenalin action through some unknown interacted mechanisms.
In T47D breast cancer cell line, injection of β-cyclodextrin- helenalin complexes inhibited the preoperative effect in the prevented expanse of the colony in a dose-dependent manner.
Some researchers suggested that the induction of breast cancer cell apoptosis and proliferation may be attributed to helenalin antioxidants activity in restricting the growth of cells through its stimulation of ROS in facilitated cell death.
More importantly, the application of β-cyclodextrin- helenalin also improved the ratio of antioxidant and ROS in the infectious cell line. These results were observed in the expression of the telomerase gene through the r q-PCR.
Truly, the length of the terminal transferase was shortening in the treated cell lines compared to untreated control.
Furthermore, application of Arnica also expressed a profound effect in reduced blood and serum volumes and pain, and the presence of bruising or hematomas during the period of drainage.
According to study of 53 women, undergoing unilateral total mastectomy, selected from 2012 to 2014 randomly assigned to A. Montana or placebo and followed up for 5 days, conducted by the Niguarda Ca' Granda Hospital, Milan, Arnica treatment of group displayed a strong reduction of the of mean volume of blood and serum collected in drainages in compared to control group observed by the per-protocol analysis.
Analysis of the questionnaire returned from the patients, researchers found that patient weight showed a statistically significant difference in favor in the use of Arnica, according to the regression model including treatment, volume collected in the drainage on the day of surgery.
Moreover, the blood and serum volumes collected on the day of surgery and the following days were significantly lower with Arnica at days 2 in compared to untreated patients.
Dr.Sorrentino L , the lead author, after taking into account other co and confounders said, " reduce post-operative blood and seroma collection in women undergoing unilateral total mastectomy".
The findings suggested that Arnica and its major bioactive helenalin may be used as a secondary herbal treatment or combination with standard medicine for the treatment of breast cancer and speeding up recovery after post total mastectomy.
Intake of herbal supplement should be taken with extreme care to prevent acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment with Arnica montana to reduce post-operative seroma and bleeding in patients undergoing total mastectomy by Sorrentino L1, Piraneo S1, Riggio E1, Basilicò S2, Sartani A1, Bossi D3, Corsi F4.(PubMed)
(2) Inhibitory effects of β-cyclodextrin-helenalin complexes on H-TERT gene expression in the T47D breast cancer cell line - results of real time quantitative PCR by Ghasemali S1, Nejati-Koshki K, Tafsiri E, Rahmati-Yamchi M, Akbarzadeh A, Alizadeh E, Abbasi M, Barkhordari A, Tozihi M, Kordi S, Zarghami N.(PubMed)
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