Wednesday, July 27, 2016

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Feng Xian Hua (Herba Impatiens balsamina)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Feng Xian Hua (Herba Impatiens balsamina)

Feng Xian Hua is also known as balsamina. The bitter, slightly sweet, acrid, toxic and neutal herb has been used in TCM to treat rheumatoid arthritis, tumors, bruises, swelling, expel phlegm, get rid of toxin, , promote menses, help deliveries, etc., as it , by enhancing the functions of liver, spleen and kidney channels.

1. Kaempferol-3-monoglucosides
2. Quercetin 3. Pelargonidin
4. D-hydroxy pheny acid
5. Ferulic acid
6. Sinapic acid
7. Caffeic acid
8. Scopoletin
9. Etc.

Health Benefit
1. Antimicrobial activities
In the evaluation of Lawsone (1), lawsone methyl ether (2), and methylene-3,3′-bilawsone (3) are the main naphthoquinones in the leaf extracts of Impatiens balsamina L. (Balsaminaceae) for theirs’ Antimicrobial activities three naphthoquinones against dermatophyte fungi, yeast, aerobic bacteria and facultative anaerobic and anaerobic bacteria, found that Compound 1 showed only moderate antimicrobial activity against dermatophytes (MICs and MFCs in the ranges of 62.5-250 and 125-250 µg mL(-1), respectively), but had low potency against aerobic bacteria, and was not active against C. albicans and facultative anaerobic bacteria. In contrast, 3 showed significant antimicrobial activity only against Staphylococus epidermidis and Bacillus subtilis (MIC and MBC of 46.9 and 93.8 µg mL(-1), respectively), according to “Comparison of antimicrobial activities of naphthoquinones from Impatiens balsamina” by Sakunphueak A, Panichayupakaranant P.(1).

2. Antipruritic and antidermatitic effect
In the examination of the effects of a 35% ethanol extract (IB) from the petals of Impatiens balsamina L. and the principal active compounds from IB on chronic and serious pruritus and the development of dermatitis using NC mice, a model of atopic dermatitis, found that IB at 100 mg/kg significantly inhibited serious scratching behaviour in the NC mouse with established dermatitis when administered i.v. 1 h before, or p.o. 24 h before the measurement. A 10 microg/kg dose of kaempferol 3-rutinoside and 2-hydroxy-1,4-naphthoquinone (lawsone) isolated from IB also inhibited scratching behaviour in the NC mouse with established dermatitis. When 4-week-old NC mice with no symptoms were administered orally 100 mg/kg/day of IB until 13 weeks of age, protection was also noted against scratching behaviour during the development of dermatitis. IB was effective for the prevention and treatment of atopic dermatitis, according to “Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice” by Oku H, Ishiguro K.(2).

3. Anti multiple antibiotic-resistant Helicobacter pylori
In the study of isolated anti-H. pylori compounds of 2-methoxy-1,4-naphthoquinone (MeONQ) and stigmasta-7,22-diene-3beta-ol (spinasterol) from the pods and roots/stems/leaves of I. balsamina L., found that in the ranges of 20-80 mug ml(-1) both of MICs and MBCs for spinasterol against antibiotic (clarithromycin, metronidazole and levofloxacin) resistant H. pylori. Notably, the activity of MeONQ was equivalent to that of amoxicillin (AMX). The bactericidal H. pylori action of MeONQ was dose-dependent, according to “In vitro activity of 2-methoxy-1,4-naphthoquinone and stigmasta-7,22-diene-3{beta}-ol from Impatiens balsamina L. against multiple antibiotic-resistant Helicobacter pylori” by Wang YC, Li WY, Wu DC, Wang JJ, Wu CH, Liao JJ, Lin CK.(3).

4. Anti tumors
In the examination of the The ethanol extracts separated into five fractions according to polarity. An MTT assay indicated that two of the fractions had anti-tumor activity and that the petroleum ether fraction (PEF) was the most active. But the available quantities of both the PEF and chloroform fractions (CHF) were limited. In the final seperation, 2-methoxy-1,4-naphthoquinone, followed by TLC and MTT assay confirmation, showed that 2-methoxy-1,4-naphthoquinone has intensive in vitro anti-tumor activity against HepG2 cells, according to “Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina“by Ding ZS, Jiang FS, Chen NP, Lv GY, Zhu CG.(4).

5. Testosterone 5alpha-reductase inhibitor
In the examnation of the 35% EtOH extract of aerial parts of Impatiens balsamina L. for activity against testosterone 5alpha-reductase, found that 3-hydroxy-2-{[3-hydroxy-1,4-dioxo (2-naphthyl)] ethyl} naphthalene-1,4-dione exhibited significant testosterone 5alpha-reductase inhibitory activity, according to “Testosterone 5alpha-reductase inhibitor bisnaphthoquinone derivative from Impatiens balsamina” by Ishiguro K, Oku H, Kato T.(5).

6. Etc.

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