Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, The plants have been cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.
The immunomodulatory effect is a function of the immune system involved many reactions, including antimicrobial organisms against infection and inflammation, modulated genes expression.......This modulation may also be induced by the neurohormonal system.
Alfalfa may be a potential herbal medicine used for enhanced immune systems for fighting against the forming of free radicals and invasion of foreign substances through its immunomodulatory effects.
Polysavone, a natural extract from alfalfa, induced the proliferation of T and B white blood cells, lymphocytes and improved antibody against viral invasion significantly in comparison to the control group, according to the animal study.
Dr. Xiaofang Dong at the Qiqihar University said, " Polysavone may decrease abdominal fat deposition and enhance immunity without an adverse effect on the performance of broiler chickens"
In a total of A total of 360 1-d-old male commercial Arbor Acre broiler chickens, dietary polysavone (Alfalfa extract) in comparison to chlortetracycline supplementation, polysavone group showed a excellent scavenging activity in inhibited free radical expression, particular for 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radicals, through it The immunomodulatory effects in improved immune function in compared chlortetracycline supplementation group.
Furthermore, alfalfa flavonoids extract (AFE) also promoted immune function in regulating the population of microbe, enhancing antioxidant properties by increasing antioxidase activity and affecting immunity by changing the proportion of white blood cells and Innate immunity.
Taking all together, alfalfa may be effective in the promoted immune system fighting against the forming of free radical and microbial infection, but human trials are necessary to confirm this validation.
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Sources
(1) Effect of Polysavone (Alfalfa Extract) on Abdominal Fat Deposition and Immunity in Broiler Chickens(Researchgate)
(2) Effects of dietary polysavone (Alfalfa extract) and chlortetracycline supplementation on antioxidation and meat quality in broiler chickens by Dong XF1, Gao WW, Su JL, Tong JM, Zhang Q.(PubMed)
(3) Effects of alfalfa flavonoids on the production performance, immune system, and ruminal fermentation of dairy cows by Zhan J1, Wu C1, Liu M1, Su X1, Zhan K1, Zhang C1, Zhao G1.(PubMed)
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