Upper respiratory tract infections are the infection of the airway above the glottis or vocal cords, including the nose, sinuses, pharynx, and larynx, tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media, etc,.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
According to the joint study lead by the ilpakorn University in the review of the existing data of the literature and meta-analysis of randomized controlled trials, Andrographis paniculata exerted a strong implication n the symptomatic treatment of uncomplicated upper respiratory tract infection by measuring the reduction in symptom severity scores.
In a total of 433 patients reported in three trials included in the statistical analysis, patients treated with a combination of Andrographis aniculata, Acanthopanax senticosus and Andrographis aniculata alone exhibited a significant improvement of 2.13 points and 10.85 points on the symptom severity score in compared placebo.
Dr. Poolsup N, the lead author said, "A. paniculata extract alone or in combination with A. senticosus extract may be more effective than placebo and maybe an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection".
Furthermore, in the review to prevent the over-prescription of antibiotics and absence from work due to acute upper respiratory tract infection, A. paniculata is found to be more superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection.
The study also indicated that all review trials scored at least three, out of a maximum of five, for methodological quality on the Jadad scale.
More importantly, the efficacy of A. paniculata in relieving symptoms of uncomplicated upper respiratory tract infection only induced generally mild and infrequent adverse effects.
Further in supporting the Andrographis aniculata's anti upper respiratory tract infection property, a total of 223 patients of both sexes randomized in two groups which received either KalmCold (200 mg/day) or placebo in a double-blind manner showed a promising result of A. paniculata in ameliorating symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue and sleep disturbance from day 1 to day 3 of treatment in comparison to placebo group.
Additionally, The overall efficacy of extract of Andrographis paniculata was found to be 2.1 times (52.7%) higher than the placebo.
Taking together, there is no doubt that Andrographis aniculata has a potency used as a therapeutic agent for relieving symptoms and treatment of upper respiratory tract infection but intake of large doses and long term intake should be taken with care.
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Sources
(1) Andrographis paniculata in the symptomatic treatment of uncomplicated upperrespiratory tract infection: systematic review of randomized controlled trials by Poolsup N1, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U.(PubMed)
(2) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy by Coon JT1, Ernst E.(PubMed)
(3) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upperrespiratory tract infection by Saxena RC1, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A.(PubMed)
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